• 대한공업교육학회지
• /
• v.34 no.1
• /
• pp.238-251
• /
• 2009

The noise itself that affects the sensor array is defined as the noise which happens in the place where the system is installed and the circumference noise which comes from the ocean. The array structure for detecting acoustic signal in the underwater effected turbulent layer flow noise. In this paper to design the conformal array spectral density function was introduced and several cases of flow induced noise which affect transfer function were simulated. Modified Corcos wall pressure model was used as turbulent boundary layer flow noise. The effect of noise has been reduced as integrated sum of transfer function has been reduced by decreasing elastomer thickness and density when kx is in low wave number area. Also the characteristics of transfer function by Corcos wall pressure displayed the product of frequency density function. This simulation results can be applied to the conformal array design in unmmaned underwater vehicle in the near future.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.1
• /
• pp.23-29
• /
• 2015

Background: Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge-scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.40 no.8
• /
• pp.721-724
• /
• 2016

Because of the inherent uncertainties caused by the manufacturing process variations, future loading conditions, and incomplete damage models, the lifetimes of mechanical structures under field conditions are significantly different from the results obtained in the laboratories. In this study, a dual sensor was developed to prognosticate the fatigue failure of structures under these uncertain conditions, and its effectiveness was demonstrated on a rectangular columnar structure under repeated uni-axial loading. The dual sensor is a slightly weaker structure embedded in the target structure, so that failure occurs in the sensor earlier than in the target structure. From the signal differences in the strain gauges in the embedded dual sensor, it is possible to differentiate between the normal status and warning status, even under variable loads.

• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.11
• /
• pp.1714-1724
• /
• 2020

Objective: MicroRNAs (miRNAs) are the most abundant small RNAs. Approximately 2,000 annotated miRNAs genes have been found to be differentially expressed in ovarian follicles during the follicular development (FD). Many miRNAs exert their regulatory effects on the apoptosis of follicular granulosa cells (FGCs) and FD. However, accurate roles and mechanism of miRNAs regulating apoptosis of FGCs remain undetermined. Methods: In this review, we summarized the regulatory role of each miRNA or miRNA cluster on FGCs apoptosis and FD on the bases of 41 academic articles retrieved from PubMed and web of science and other databases. Results: Total of 30 miRNAs and 4 miRNAs clusters in 41 articles were reviewed and summarized in the present article. Twenty nine documents indicated explicitly that 24 miRNAs and miRNAs clusters in 29 articles promoted or induced FGCs apoptosis through their distinctive target genes. The remaining 10 miRNAs and miRNAs of 12 articles inhibited FGCs apoptosis. MiRNAs exerted modulation actions by at least 77 signal pathways during FGCs apoptosis and FD. Conclusion: We concluded that miRNAs or miRNAs clusters could modulate the apoptosis of GCs (including follicular GCs, mural GCs and cumulus cells) by targeting their specific genes. A great majority of miRNAs show a promoting role on apoptosis of FGCs in mammals. But the accurate mechanism of miRNAs and miRNA clusters has not been well understood. It is necessary to ascertain clearly the role and mechanism of each miRNA or miRNA cluster in the future. Understanding precise functions and mechanisms of miRNAs in FGCs apoptosis and FD will be beneficial in developing new diagnostic and treatment strategies for treating infertility and ovarian diseases in humans and animals.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.49 no.4
• /
• pp.509-515
• /
• 2016

At the first time in South Korea, the state of the art acoustic systems were mounted on the R/V Tamgu 21. The acoustic systems are an EK80 broadband echosounder (18, 38, 70, 120, 200 and 333 kHz) which has two beam modes such as continuous wave (narrowband) and frequency modulation (broadband), an ME70 multibeam echosounder (70-120 kHz), and a SH90 sonar (111.5-115.5 kHz). Acoustic data from broadband mode have a very short range resolution, a large detection range, a high signal to noise ratio, and a wide and consecutive frequency response. In ME70, each individual beam consisted in a multibeam plays a role as a spilt beam. The first trial of the cutting edge acoustic system installed on the R/V Tamgu 21 was conducted from 15 Feb to 29 Feb 2016 in East Sea, South Sea and East China Sea. The properties of the acoustic systems were elucidated and exploratory results from three systems were exhibited. Lastly, issues which should be considered and future research plan are mentioned.

• Fisheries and Aquatic Sciences
• /
• v.19 no.9
• /
• pp.41.1-41.7
• /
• 2016

Background: The transgenic approach using estrogen-responsive regulator in fish has been given much attention as a potential means to detect and/or address estrogen-related aquatic pollutions. In order to address the development stage- and reproduction status-dependent expression patterns of the chgH-rfp transgene (red fluorescent protein transgene driven by choriogenin H promoter) in marine medaka Oryzias dancena, naturally occurring red fluorescent protein (RFP) signals under non-exposed conditions as well as the transgenically induced RFP signals under estrogen-exposed conditions were assayed. Results: Female transgenics begun to show naturally occurring RFP signals from the age of 7 weeks post hatching (WPH) without experimental estrogen exposure. Afterward, these RFP signals in female transgenics became robust with the progress of ovarian maturation. On the other hand, male transgenics did not show any naturally occurring RFP signal under non-exposed conditions irrespective of developmental stages and maturation statue. Upon exposures using estradiol-$17{\beta}$ (E2) and $17{\alpha}$-ethinylestradiol (EE2), RFP signals were significantly induced specifically in the livers of transgenic males. Conclusions: Male chgH-rfp transgenics were able to keep the "off" state of RFP expression during their entire life cycle unless exposed to exogenous estrogens. Owing to their tight regulation capability of estrogen-responsive transgene, transgenesis of chgH-rfp in male marine medaka could offer a useful model system for future ecotoxicogenomic studies regarding estrogenicity-related issues in aquatic and marine environments.

• Journal of Advanced Navigation Technology
• /
• v.14 no.2
• /
• pp.151-160
• /
• 2010

For the realization of future intelligent transportation systems, fine-grained lane-by-lane traffic monitoring and control functionalities are among the most important technology barriers to overcome. To satisfy the accuracy requirement for traffic monitoring, a GNSS receiver network is designed. The designed receiver network consists of three different types of entities; reference server, broadcaster, and client. For deployment flexibility, all the entities utilize the international message standard RTCM SC-104 version 3.0. For fine-grained traffic monitoring, the client is designed to utilize position-domain carrier-smoothed-code filters to provide accurate vehicle coordinates in spite of frequent addages and outages of visible satellites. An experiment result is presented to evaluate the positioning accuracy of the proposed method.

• Journal of Broadcast Engineering
• /
• v.15 no.5
• /
• pp.642-652
• /
• 2010

Recently, DVC (Distributed Video Coding) techniques are drawing a lot of interests as one of the future research works to achieve low complexity encoding in various applications. But, due to the limited computational complexity, the performances of DVC algorithms are inferior to those of conventional international standard video coders, which use zig-zag scan, run length code, entropy code and skipped macroblock. In this paper, in order to overcome the performance limit of the DVC system, the distortion for every block is estimated when side information is found at the decoder and then we propose a new selective block encoding scheme which provides the encoder side with the motion information for the highly distorted blocks and then allows the sender to encode the motion compensated frame difference signal. Through computer simulations, it is shown that the coding efficiency of the proposed scheme reaches almost that of the conventional inter-frame coding scheme.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.37B no.12
• /
• pp.1119-1127
• /
• 2012

The one of features of M2M communications, which are recently attracted attention as a future business of mobile communications, is that there is a large number of devices compared with traditional communication services. Hence, the control signal that are generated by the M2M devices may cause a significant congestion in the network and in order to solve this problem, a standardization is progressing for reducing the redundant signaling by managing M2M devices as a group in 3GPP standardization. In this paper, we propose a method of group based mobility management by managing M2M devices that have the same mobility as a group. In the proposed method, M2M devices that have the same mobility are grouped by the Mobility Management Entity (MME) and the MME elects a group header among the M2M devices in the group. Then, the group header performs the Tracking Area Update (TAU) on behalf of the group members to reduce the signaling overhead of mobility management. With the proposed method, we can achieve 80% decrease of the signaling overhead of mobility management compared with the case where each M2M device individually performs its TAU procedure.

• Ocean and Polar Research
• /
• v.27 no.2
• /
• pp.189-195
• /
• 2005

Several models predict large and potentially abrupt ocean circulation changes due to anthropogenic greenhouse-gas emissions. These circulation changes drive-in the models-considerable oceanic oxygen trend. A sound estimate of the observed oxygen trends can hence be a powerful tool to constrain predictions of future changes in oceanic deepwater formation, heat and carbon dioxide uptake. Estimating decadal scale oxygen trends is, however, a nontrivial task and previous studies have come to contradicting conclusions. One key potential problem is that changes in the historical observation network might introduce considerable errors. Here we estimate the likely magnitude of these errors for a subset of the available observations in the Southern Ocean. We test three common data analysis methods south of Australia and focus on the decadal-scale trends between the 1970's and the 1990's. Specifically, we estimate errors due to sparsely sampled observations using a known signal (the time invariant, temporally averaged, World Ocean Atlas 2001) as a negative control. The crossover analysis and the objective analysis methods are for less prone to spatial sampling location biases than the area averaging method. Subject to numerous caveats, we find that errors due to sparse sampling for the area averaging method are on the order of several micro-moles $kg^{-1}$. for the crossover and the objective analysis method, these errors are much smaller. For the analyzed example, the biases due to changes in the spatial design of the historical observation network are relatively small compared to the tends predicted by many model simulations. This raises the possibility to use historic oxygen trends to constrain model simulations, even in sparsely sampled ocean basins.