• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.596-608
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• 2017

In 2002, the government arranged an institutional strategy to make it possible for a consumers to make a claim for damages caused by product defects against a business that produces and sells a product by enforcing the Product Liability Law(hereinafter referred to as 'PL'). On the other hand, due to the recent humidifier sterilizer accident, approximately 12 cases of related bills, such as a revised bill for the product liability law, have been proposed to the National Assembly at present in an effort to introduce the group action system and punitive compensation system for the purpose of the strengthening of the corporate product liability, and consumer damage relief. Ironically, as much as 62.6% of small & medium businesses, which are actual interested parties to this bill, are unaware of this. Many companies are responding to PL with the rationalization of document preparation & storage, clarification of responsibility relations with related business operators, and PL insurance policy purchase, or securing compensation funds as a means of Product Liability Defense(PLD), but the methods of preparation such as this leave much room for limits on the considerations of product design and product safety. This paper presents the individual management system model with more focus on product safety by looking into the clear concept of PL and the countermeasures against it, grasping the relevance between the PL system and individual management system, and integrating the PL response system in preparation for the PL. It is hoped that the result of this research objective will be evaluated as a rational countermeasure for small & medium businesses to respond effectively to the PL.

• Korean Journal of Remote Sensing
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• v.26 no.5
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• pp.593-603
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• 2010

Most spatial data acquisition systems employing a set of frame cameras may have suffered from their small fields of view and poor base-distance ratio. These limitations can be significantly reduced by employing an omni-directional camera that is capable of acquiring images in every direction. Bundle Block Adjustment (BBA) is one of the existing georeferencing methods to determine the exterior orientation parameters of two or more images. In this study, by extending the concept of the traditional BBA method, we attempt to develop a mathematical model of BBA for omni-directional images. The proposed mathematical model includes three main parts; observation equations based on the collinearity equations newly derived for omni-directional images, stochastic constraints imposed from GPS/INS data and GCPs. We also report the experimental results from the application of our proposed BBA to the real data obtained mainly in urban areas. With the different combinations of the constraints, we applied four different types of mathematical models. With the type where only GCPs are used as the constraints, the proposed BBA can provide the most accurate results, ${\pm}5cm$ of RMSE in the estimated ground point coordinates. In future, we plan to perform more sophisticated lens calibration for the omni-directional camera to improve the georeferencing accuracy of omni-directional images. These georeferenced omni-directional images can be effectively utilized for city modelling, particularly autonomous texture mapping for realistic street view.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.6
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• pp.581-588
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• 2018

The aim of this study is to propose a fine co-registration approach for multi-temporal satellite images acquired from RapidEye, which has an advantage of availability for time-series analysis. To this end, we generate multitemporal ortho-rectified images using RPCs (Rational Polynomial Coefficients) provided with RapidEye images and then perform fine co-registration between the ortho-rectified images. A DEM (Digital Elevation Model) extracted from the digital map was used to generate the ortho-rectified images, and the RNCC (Registration Noise Cross Correlation) was applied to conduct the fine co-registration. Experiments were carried out using 4 RapidEye 1B images obtained from May 2015 to November 2016 over the Yeonggwang area. All 5 bands (blue, green, red, red edge, and near-infrared) that RapidEye provided were used to carry out the fine co-registration to show their possibility of being applicable for the co-registration. Experimental results showed that all the bands of RapidEye images could be co-registered with each other and the geometric alignment between images was qualitatively/quantitatively improved. Especially, it was confirmed that stable registration results were obtained by using the red and red edge bands, irrespective of the seasonal differences in the image acquisition.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.2
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• pp.83-91
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• 2022

Seismic design and analysis of nuclear power plant components are performed based on an decoupled model. However, this decoupled analysis has a limitation in that it generates inaccurate results compared to the coupled analysis because it cannot simulate actual phenomena such as the interaction between structures and components. Thus, this study performed seismic coupled and decoupled analysis on an existing nuclear containment structure and related components, considering the mass and natural frequency ratios. And based on these results, comparative analyses of responses of components were conducted. Consequently, the seismic coupled analysis result generally gave a smaller value than the decoupled analysis result. These results were similar to the analysis results for the simple coupled model, which was an existing study, but the difference in component responses was much more pronounced. Also, this was influenced by the installation location of the component rather than the influence of the input frequency of the input seismic motions. Finally, the difference between the decoupled and coupled seismic analysis occurred in the region where the mass ratio of the components was large, and the natural frequencies were almost similar due to the considerable dynamic interaction between the structure and the component in this realm.

• Tunnel and Underground Space
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• v.31 no.6
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• pp.549-560
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• 2021

Forces exerted on a shield TBM (tunnel boring machine) such as cutter head torque, thrust force, chamber pressure, and upward force are key factors determining TBM performance. However, the forces acting on the TBM when tunnelling the mixed ground have different tendencies compared to that of the uniform ground, which could impair TBM performance. In this study, the effect of mixed ground tunnelling was numerically investigated with torque, thrust force, chamber pressure, and upward force. A coupled discrete element method (DEM) and finite difference method (FDM) model for TBM driving model was used. This numerical study simulates TBM tunnelling in mixed ground composed of upper weathered granite soil and lower weathered rock. The effect on the force acting on the TBM according to the location and slope of the boundary of the mixed ground was numerically examined.

• BMB Reports
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• v.56 no.4
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• pp.234-239
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• 2023

Thioredoxin-like protein 1 (TXNL1), one of the thioredoxin superfamily known as redox-regulator, plays an essential in maintaining cell survival via various antioxidant and anti-apoptotic mechanisms. It is well known that relationship between ischemia and oxidative stress, however, the role of TXNL1 protein in ischemic damage has not been fully investigated. In the present study, we aimed to determine the protective role of TXNL1 against on ischemic injury in vitro and in vivo using cell permeable Tat-TXNL1 fusion protein. Transduced Tat-TXNL1 inhibited ROS production and cell death in H₂O₂-exposed hippocampal neuronal (HT-22) cells and modulated MAPKs and Akt activation, and pro-apoptotic protein expression levels in the cells. In an ischemia animal model, Tat-TXNL1 markedly decreased hippocampal neuronal cell death and the activation of astrocytes and microglia. These findings indicate that cell permeable Tat-TXNL1 protects against oxidative stress in vitro and in vivo ischemic animal model. Therefore, we suggest Tat-TXNL1 can be a potential therapeutic protein for ischemic injury.

• Korean Journal of Animal Reproduction
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• v.25 no.4
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• pp.389-397
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• 2001

Cocaine-amphetamine regulated transcript (CART), a satiety factor regulated by leptin, is associated with food intake and motor behavior. In knock out studies, Leu34Phe mutation of human CART gene resulted in obese phenotype but mice carrying a targeted deletion of the CART gene exhibited no dramatic increase of body weight on normal fat diet. To establish a new transgenic mouse model for determining the function of CART on feeding behavior in vivo, we constructed the fusion gene, CART gene under the control of neurofilament light chain promoter, which regulates gene expression at the stage of neuronal differentiation. Transgenic mice were generated by microinjection method and screened by PCR and Southern blot analyses. In these transgenic mice, overexpression of CART was detected by in situ hybridization in spinal cords and brains at 13.5 days post-coitum embryos. At six weeks of age, RT-PCR analysis showed that exogenous CART mRNA was expressed strongly in brains and spinal cords, but not much in other tissues. Our results suggest that these transgenic mice provide a new model to investigate the function of CART gene in neuronal network associated with feeding behavior.

• Korean Journal of Remote Sensing
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• v.39 no.6_1
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• pp.1185-1193
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• 2023

The increasing interest in soil moisture data from satellite imagery for applications in hydrology, meteorology, and agriculture has led to the development of methods to produce variable-resolution soil moisture maps. Research on accurate soil moisture estimation using satellite imagery is essential for remote sensing applications. The purpose of this study is to generate a soil moisture estimation map for a test area using KOMPSAT-3/3A and KOMPSAT-5 SAR imagery and to quantitatively compare the results with soil moisture data from the Soil Moisture Active Passive (SMAP) mission provided by NASA, with a focus on accuracy validation. In addition, the Korean Environmental Geographic Information Service (EGIS) land cover map was used to determine soil moisture, especially in agricultural and forested regions. The selected test area for this study is the western part of Jeju, South Korea, where input data were available for the soil moisture estimation algorithm based on the Water Cloud Model (WCM). Synthetic Aperture Radar (SAR) imagery from KOMPSAT-5 HV and Sentinel-1 VV were used for soil moisture estimation, while vegetation indices were calculated from the surface reflectance of KOMPSAT-3 imagery. Comparison of the derived soil moisture results with SMAP (L-3) and SMAP (L-4) data by differencing showed a mean difference of 4.13±3.60 p% and 14.24±2.10 p%, respectively, indicating a level of agreement. This research suggests the potential for producing highly accurate and precise soil moisture maps using future South Korean satellite imagery and publicly available data sources, as demonstrated in this study.

• Journal of the Microelectronics and Packaging Society
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• v.25 no.1
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• pp.1-10
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• 2018

Recently, there has been rapid development in the field of flexible electronic devices, such as organic light emitting diodes (OLEDs), organic solar cells and flexible sensors. Encapsulation process is added to protect the flexible electronic devices from exposure to oxygen and moisture in the air. Using numerical simulation, we investigated the effects of the encapsulation layer on mechanical stability of the silicon chip, especially the fracture performance of center crack in multi-layer package for various loading condition. The multi-layer package is categorized in two type - a wide chip model in which the chip has a large width and encapsulation layer covers only the chip, and a narrow chip model in which the chip covers both the substrate and the chip with smaller width than the substrate. In the wide chip model where the external load acts directly on the chip, the encapsulation layer with high stiffness enhanced the crack resistance of the film chip as the thickness of the encapsulation layer increased regardless of loading conditions. In contrast, the encapsulation layer with high stiffness reduced the crack resistance of the film chip in the narrow chip model for the case of external tensile strain loading. This is because the external load is transferred to the chip through the encapsulation layer and the small load acts on the chip for the weak encapsulation layer in the narrow chip model. When the bending moment acts on the narrow model, thin encapsulation layer and thick encapsulation layer show the opposite results since the neutral axis is moving toward the chip with a crack and load acting on chip decreases consequently as the thickness of encapsulation layer increases. The present study is expected to provide practical design guidance to enhance the durability and fracture performance of the silicon chip in the multilayer package with encapsulation layer.

• Clinical and Experimental Pediatrics
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• v.51 no.1
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• pp.54-61
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• 2008

Purpose : This study was designed to clarify the mechanism of proteinuria in nephrotic syndrome patients by using puromycin aminonucleoside (PAN) nephrosis model. Methods : Following administration of various concentrations of PAN and antioxidants we observed the changes of podocyte cytoskeletons in cultured rat glomerular epithelial cells (GEpC) by method of scanning electron microscope, reactive oxyten species (ROS) analysis, permeability assay, confocal microscope, and Western blot assay. Results : PAN not only induced the ultrastructural changes of GEpC, such as shortening and fusion of microvilli, but also separated the intercellular gaps and linear ZO-1. PAN induced oxidative stresses in time and dose dependent manners and increases of intercellular permeability in anti-oxidants inhibitable manners. High concentration of PAN induced not only actin polymerization and disorganization, but also the conglomerulation and internal dislocation of ${\alpha}-actinin$ protein. The intensities of fluorescences of ZO-1 protein were diminished and internalized by PAN in a dose-dependent manner, which were inhibited by anti anti-oxidants. Conclusion : PAN induced the changes of podocytes cytoskeleton and junctional barriers by way of increasing ROS in GEpC that resulted in increasing their permeability in a antioxidatn-inhibitable manner. Glomerular hyperpermeability induced by PAN mediateing through oxidative stresses is thought to take part in the mechanism of proteinuria in nephrotic syndrome.