• 한국동물위생학회지
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• 제40권1호
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• pp.75-78
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• 2017

This report describes a case of pinnal fungal dermatitis caused by Arthroderma vanbreuseghemii in a Rex rabbit diagnosed by clinical signs, macro- and microscopic examination, molecular and phylogenetic analyses. This is the first description of natural A. vanbreuseghemii infection in rabbits in South Korea.

• Mycobiology
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• 제42권3호
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• pp.286-290
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• 2014

Fungi are the known sources of irritation associated with atopic diseases (e.g., asthma, allergic rhinoconjunctivitis, and atopic eczema). To quantitatively estimate their presence in the indoor environment of atopic dermatitis-inflicted child patient's houses (ADCPHs), the high-efficiency particulate air (HEPA) filters installed inside the air cleaners of three different ADCPHs were investigated for the presence of mold. The air cleaner HEPA filters obtained from the three different ADCPHs were coded as HEPA-A, -B, and -C, respectively, and tested for the presence of mold. The colony forming units (CFUs) corresponding to the HEPA-A, -B, and -C filters were estimated to be $6.51{\times}10^2{\pm}1.50{\times}10^2CFU/cm^2$, $8.72{\times}10^2{\pm}1.69{\times}10^2CFU/cm^2$, and $9.71{\times}10^2{\pm}1.35{\times}10^2CFU/cm^2$, respectively. Aspergillus, Penicillium, Alternaria, Cladosporium, Trichoderma, and other fungal groups were detected in the 2,494 isolates. The distribution of these fungal groups differed among the three filters. Cladosporium was the major fungal group in filters HEPA-A and -C, whereas Penicillium was the major fungal group in the filter HEPA-B. Nine fungal species, including some of the known allergenic species, were identified in these isolates. Cladosporium cladosporioides was the most common mold among all the three filters. This is the first report on the presence of fungi in the air cleaner HEPA filters from ADCPHs in Korea.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2017년도 춘계 종합학술대회 논문집
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• pp.105-106
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• 2017

Background: Atopic dermatitis one of the most common chronic skin diseases, is caused by various environmental and genetic factors. Methods: A total of 2609 healthy newborns who were enrolled in the COCOA study (COCOA) from 2008 to 2015 were surveyed for indoor environmental exposure to fungi during gestation and then diagnosed postnatally for atopic dermatitis. The fungi collected during the gestation of 20 normal subjects and 20 infants that developed atopic dermatitis were identified using Illumina's MiSeq platform and analyzed for their diversity and species. Results: A total of 2,609 respondents were surveyed (52.8% male and 47.2% female) Children, 1, 2, and 3 years old diagnosed with atopic dermatitis comprised 15.2%, 15.7%, and 14.1% of the respondents, respectively. The prevalence of exposure to mold during gestation was 1.46 (95% CI, 1.05-2.04) and 1.52 (95% CI, 0.95-2.43), in the first and third years after birth, respectively. One-year-old children with atopic dermatitis and no fungal markers detected in the bathroom environment during gestation accounted for less than 5% (aOR, 1.51; 95%CI, 0.96-2.38) and in the group less than 5 ~ 30% (aOR, 2.21; 95%CI, 1.00-4.89), 3-year-old children had an increased prevalence of atopic dermatitis of more than 30% (aOR, 9.48, 95%CI 1.42-63.13). Conclusions: Exposure to indoor fungi during gestation and infancy is associated with the development of atopic dermatitis in children. The phyla and genera of the fungi in the indoor house dust differed during gestation. This suggests that exposure to indoor fungi during gestation may be associated with the development of atopic dermatitis in children. Future research will be necessary to establish the underlying mechanisms.

• 대한수의학회지
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• 제39권5호
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• pp.945-950
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• 1999

A 4-year-old female American cocker spaniel was hospitalized with 6 months prolonged dermal problems in The Veterinary Medical Teaching Hospital of Seoul National University. Initial noticed signs by owner of this dog were rashes and papules on ear part and they were spreaded whole body. On initial physical examinations, papules, pustules, crusts, and erythema were presented on whole body. Diameters of focal scaly and erythematous alopetic lesions were varied ranging 1 to 4cm. Skin scraping for detecting ectoparasites and wood's light examinations for dermatophyte were negative. Any bacteria were not detected but Malassezia pachydermatis was detected on cytological examination and fungal culture. The dog was treated with Itraconazole (5mg/kg, q12h) and Cephalexin (20mg/kg, q12h) orally and then bathed with 2% chlorhexidine shampoo twice per week for 5 weeks. From 12 weeks after starting therapy, all dermal problems were disappeared although some mild pyoderma were once relapsed. Regular chlorhexidine bathing treatment so far has been continued for preventing recurrence.

• 한국임상수의학회지
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• 제32권3호
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• pp.259-262
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• 2015

아토피성 피부염 장기 치료중인 개가 식욕부진을 동반한 갑작스러운 호흡기 증상으로 내원하였다. 영상학적 진단 및 기관지 세척액의 세포검사 결과 곰팡이성 폐렴으로 진단되었다. 관찰된 곰팡이는 분자적 동정 및 계통분석학적 분석 결과 Candida catenulata로 확인되었다. 3주간의 경구 itraconazole 치료 후 환자는 회복되었다. 이 증례는 개에서 C. catenulata 감염의 첫 예이다.

• 한국임상수의학회지
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• 제25권3호
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• pp.211-214
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• 2008

This report describes a case of severe and prolonged dermatophytosis in a hedgehog that was diagnosed by PCR-RFLP, a rapid and usefulness technique for identification of many causative agents and hereditary characters. A 5-month-old female hedgehog was presented with grade 2 facial pruritus, scaling, encrustation and hemorrhage. Cytology of exudates on the face showed a suspected fungal infection. A culture and tape imprint test of the cultured colony showed many hyphae and microcornidia, suspected to belong to the Trichophyton species. In the PCR-RFLP with MvaI and Hinf I, Trichophyton mentagrophytes var. erinacei was finally identified as a causative agent. The patient completely recovered after application of nystatin cream for 17 days.

• 한국수의병리학회지
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• 제7권1호
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• pp.5-9
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• 2003

Malignant catarrhal fever (MCF) is a systemic disease of ruminants caused by a gamma herpesvirus, ovine herpesvirus 2 (OvHV-2). Four 1-year old goats (Capra hircus), which were infected with MCF virus, OvHV-2, by being housed together with MCF virus-infected seep, were referred with a I-month history of chronic dermatitis. On the other hand, MCF virus-negative goats, which were isolated for negative control, had not those kinds of skin problems. Examination of the affected goats revealed generalized alopecia, patchy erythema, and superficial erosions with histologic evidence of mural folliculitis. Fungal culture tests and external parasite tests with the scraping skin samples were negative. However, polymerase chain reaction revealed the existence of MCF virus DNAs in the lesion. These results suggested that MCF virus may induce mural folliculitis and alopecia in goat.

• 한국임상수의학회지
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• 제32권6호
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• pp.511-513
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• 2015

12살 중성화 암컷 Pomeranian이 화농성, 홍반성 피부 종괴를 주증으로 내원하였다. 본 환자는 기존에 당뇨와 부신겉질기능항진증을 진단받고 처치받고 있었다. 신체검사, 혈액검사, 영상학적 검사상 특별한 이상이 발견되지 않았고, 병변 부위의 곰팡이 배양 결과 Sporothrix schenckii가 동정되었다. Fluconazole을 7일간 처방하였으나 개선 양상이 보이지 않아, 지속적인 감염과 심부의 곰팡이 감염을 제거하기 위해 종괴의 외과적 절제를 실시하였다. 종괴의 조직학적 검사상, 심각한 다발성 농성육아종성 피부염과 지방층염을 진단하였다. 본 증례는 내분비 질환 병발 개에서 Sporothrix schenckii의 감염에 의한 다발성 농성육아종성 피부염과 지방층염의 첫번째 증례이다. 특히 동물에서 Sporothrix schenckii의 한국에서의 첫번째 보고이다.

• 한국임상수의학회지
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• 제8권2호
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• pp.147-152
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• 1991

습도가 높고 환기가 불량하며 비위생적인 우리에서 같이 사육한 두 마리의 어린 염소에서 발생한 진균성피부염의 일차원인이 Trichophyton mentagrophytes이었음을 보고하였다. 두 환축의 진단은 피부소파 시료에 KOH를 사용하여 균요소를 검출하고 3$0^{\circ}C$의 진균배지에서 순수배양하여 균을 분리하여 확인하였다. 한 마리는 안면에서 나머지 한 마리는 목과 귀에서 병변이 발견되었다. 같은 우리에서 사육 중이던 두 마리의 성축에서는 병변이 발견되지 않았다. 더욱이 염소의 주인과 주인가족들에서도 병변이 발견되지 않았다. 두 분리균주를 개량된 sunflower seed medium을 이용하여 유전적 교배실험을 한 결과 둘 다(-) mating type에 속했다. Hair performance test결과 두 균주는 모두 각질용해작용을 나타내었다. 공중위생학적인 중요성과 화학요법에 대해서도 고찰하였다. 감염경로에 대해서는 명확히 밝힐 수 없었다.

• 한국환경보건학회지
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• 제37권6호
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• pp.406-417
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• 2011

Objectives: Exposure to bioaerosols in the indoor environment could be associated with a variety adverse health effects, including allergic disease such atopy. The objectives of this study were to assess children's exposure to bioaerosol in home indoor environments and to evaluate the association between atopy and bioaerosol, environmental, and social factors in Ulsan, Korea. Methods: Samples of viable airborne bacteria and fungi were collected by impaction onto agar plates using a Quick Take TM 30 and were counted as colony forming units per cubic meter of air (CFU/$m^3$). Bioaerosols were identified using standard microbial techniques by differential stains and/or microscopy. The environmental factors and possible causes of atopy based on ISAAC (International Study of Allergy and Asthma in Childhood) were collected by questionnaire. Results: The bioaerosol concentrations in indoor environments showed log-normal distribution (p < 0.01). Geometric mean (GM) and geometric standard deviation (GSD) of airborne bacteria and fungi in homes were 189.0 (2.5), 346.1(2.0) CFU/$m^3$, respectively. Indoor fungal levels were significantly higher than those of bacteria (p < 0.001). The concentration of airborne bacteria exceeded the limit recommended by the Korean Ministry of Environment, 800 CFU/$m^3$, in three out of 92 samples (3.3%) from 52 homes. The means of indoor to outdoor ratio (I/O) for airborne bacteria and fungi were 8.15 and 1.13, respectively. The source of airborne bacteria was not outdoors but indoors. GM of airborne bacteria and fungi were 217.6, 291.8 CFU/$m^3$ in the case's home and 162.0, 415.2 CFU/$m^3$ in the control's home respectively. The difference in fungal distributions between case and control were significant (p = 0.004) and the odds ratio was 0.996 (p = 0.027). Atopy was significantly associated with type of house (odds ratio = 1.723, p = 0.047) and income (odds ratio = 1.891, p = 0.041). Some of the potential allergic fungal genera isolated in homes were Cladosporium spp., Botrytis spp., Aspergillus spp., Penicillium spp., and Alternatia spp. Conclusions: These results suggest that there this should be either 'was little' meaning 'basically no significant association was found' or 'was a small negative' mean that an association was found but it was minor. It's a very improtant distinction. Association between airborne fungal concentrations and atopy and certain socioeconomic factors may affect the prevalence of childhood atopy.