• BMB Reports
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• v.37 no.1
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• pp.28-34
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• 2004

The discovery of biochemical and cellular functions of unannotated gene products begins with a database search of proteins with structure/sequence homologues based on known genes. Very recently, a number of frontier groups in structural biology proposed a new paradigm to predict biological functions of an unknown protein on the basis of its three-dimensional structure on a genomic scale. Structural proteomics (genomics), a research area for structure-based functional discovery, aims to complete the protein-folding universe of all gene products in a cell. It would lead us to a complete understanding of a living organism from protein structure. Two major complementary experimental techniques, X-ray crystallography and NMR spectroscopy, combined with recently developed high throughput methods have played a central role in structural proteomics research; however, an integration of these methodologies together with comparative modeling and electron microscopy would speed up the goal for completing a full dictionary of protein folding space in the near future.

• Journal of Korean Physical Therapy Science
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• v.13 no.1
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• pp.61-74
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• 2006

This study about functional anatomy of the hand. hand injuries are among the most common problems confronting patient, physical therapist and physicians. physical therapist should know about normal hand function and anatomical structure for hand injury, clinical reasoning and intervention. physical therapist should know about the Skeletal of the hand, Function of The Hand, Nerves of the hand, Sensation of the Hand, Intrinsic muscle, Power and Balance and Functional Position of the Hand. In this article, we discuss the physiologic properties of hand structure, biomechanical observation in hand function, sensation and nerves, hand positioning.

• Journal of the Korean housing association
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• v.10 no.2
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• pp.175-183
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• 1999

This study aims at modeling the compositional method in the architectural space and shape. The composition of space is composed of the position and the area in space. Therefore these elements are established to the functional program applied at the behavioral data. The element of spatial structure is position and scale in space, and the composition of spatial shape is developed repitionally to the combination of build-up method. The functional program is being expertised and the scale in building being lager, the importance of functional program is increased. Applied at data of the functional program at spatial structure, the process is developed to the method of combination. The purpose of this study is approached at the degree of application in modeling on the compositional method in architectural space and shape, which is a fundamental aspect on the quantitative analysis of architectural space.

• Proceedings of the Korean Society for Language and Information Conference
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• 2007.11a
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• pp.375-384
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• 2007

This paper describes a method for automatic acquisition of wide-coverage treebank-based deep linguistic resources for Japanese, as part of a project on treebank-based induction of multilingual resources in the framework of Lexical-Functional Grammar (LFG). We automatically annotate LFG f-structure functional equations (i.e. labelled dependencies) to the Kyoto Text Corpus version 4.0 (KTC4) (Kurohashi and Nagao 1997) and the output of of Kurohashi-Nagao Parser (KNP) (Kurohashi and Nagao 1998), a dependency parser for Japanese. The original KTC4 and KNP provide unlabelled dependencies. Our method also includes zero pronoun identification. The performance of the f-structure annotation algorithm with zero-pronoun identification for KTC4 is evaluated against a manually-corrected Gold Standard of 500 sentences randomly chosen from KTC4 and results in a pred-only dependency f-score of 94.72%. The parsing experiments on KNP output yield a pred-only dependency f-score of 82.08%.

• BMB Reports
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• v.32 no.2
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• pp.181-188
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• 1999

4-Aminobutyrate aminotransferase plays an essential role in the 4-aminobutyric acid shunt, converting 4-aminobutyrate to succinic semialdehyde. Recombinant 4-aminobutyrate aminotransferases were overexpressed as their catalytically active forms in E. coli by coproduction with thioredoxin and their solubilities were also dramatically increased. In order to study the structural and functional aspects of the C-terminal domain of brain 4-aminobutyrate aminotransferase, we have constructed a C-terminal mutant of pig brain 4-aminobutyrate aminotransferase and analyzed the functional and structural roles of C-terminal amino acids residues on the enzyme. The deletion of five amino-acid residues from C-terminus did not interfere with the kinetic parameters and functional properties of the enzyme. Also, the deletion did not affect the dimeric structure of the protein aligned along the subunit interface at neutral pH. However, the deletion of the C-terminal region of the protein changed the stability of its dimeric structure at acidic pH. The dissociation of the enzyme acidic, facilitated by the deletion of five amino acids from C-terminus, abolished the catalytic activity.

• BMB Reports
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• v.54 no.5
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• pp.272-277
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• 2021

RalBP1 associated EPS domain containing 1 (REPS1) is conserved from Drosophila to humans and implicated in the endocytic system. However, an exact role of REPS1 remains largely unknown. Here, we demonstrated that mitogen activated protein kinase kinase (MEK)-p90 ribosomal S6 Kinase (RSK) signaling pathway directly phosphorylated REPS1 at Ser709 upon stimulation by epidermal growth factor (EGF) and amino acid. While REPS2 is known to be involved in the endocytosis of EGF receptor (EGFR), REPS1 knockout (KO) cells did not show any defect in the endocytosis of EGFR. However, in the REPS1 KO cells and the KO cells reconstituted with a non-phosphorylatable REPS1 (REPS1 S709A), the recycling of transferrin receptor (TfR) was attenuated compared to the cells reconstituted with wild type REPS1. Collectively, we suggested that the phosphorylation of REPS1 at S709 by RSK may have a role of the trafficking of TfR.

• 한국전기화학회:학술대회논문집
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• 2002.10a
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• pp.6-6
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• 2002

• Korean Journal of Materials Research
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• v.18 no.9
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• pp.482-485
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• 2008

Tetragonal-$Ni_{1-x}Pd_x$Si/Si (001) structure was studied by using density functional theory (DFT). An epitaxial interface between $2{\times}2{\times}4$ (001) tetragonal-NiSi supercell and $1{\times}1{\times}2$ (001) Si supercell was first constructed by adjusting the lattice parameters of B2-NiSi structure to match those of the Si structure. We chose Ni atoms as a terminating layer of the B2-NiSi; the equilibrium gap between the tetragonal-NiSi and Si was calculated to be 1.1 ${\AA}$. The Ni atoms in the structure moved away from the original positions along the z-direction in a systematic way during the energy minimization. Two different Ni sites were identified at the interface and the bulk, respectively. The two Ni sites at the interface have 6 and 7 coordination numbers. The Ni sites with coordination number 6 at the interface were located farther away from the interface, and were more favorable for Pd substitution.

• Journal of Powder Materials
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• v.18 no.4
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• pp.347-358
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• 2011

Two different schemes were adopted to fabricate ordered macroporous structures with face centered cubic lattice of air spheres. Monodisperse polymeric latex suspension, which was synthesized by emulsifier-free emulsion polymerization, was mixed with metal oxide ceramic nanoparticles, followed by evaporation-induced self-assembly of the mixed hetero-colloidal particles. After calcination, inverse opal was generated during burning out the organic nanospheres. Inverse opals made of silica or iron oxide were fabricated according to this procedure. Other approach, which utilizes ceramic precursors instead of nanoparticles was adopted successfully to prepare ordered macroporous structure of titania with skeleton structures as well as lithium niobate inverted structures. Similarly, two different schemes were utilized to obtain disordered macroporous structures with random arrays of macropores. Disordered macroporous structure made of indium tin oxide (ITO) was obtained by fabricating colloidal glass of polystyrene microspheres with low monodispersity and subsequent infiltration of the ITO nanoparticles followed by heat treatment at high temperature for burning out the organic microspheres. Similar random structure of titania was also fabricated by mixing polystyrene building block particles with titania nanoparticles having large particle size followed by the calcinations of the samples.

• Aerospace Engineering and Technology
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• v.8 no.2
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• pp.68-74
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• 2009

Infra-red earth sensors(IRES) are accommodated in a geostationary multi-functional satellite, which includes optical payloads for observing the earth, to provide pointing reference for the payloads. Even the slight pointing difference between the IRES and the payloads is so critical from the geostationary orbit that can degrade their imaging performance. Therefore, a dedicated support structure is required to guarantee the stability during the flight operation. This paper shows the design justification for the IRES support structure employed in the Communication, Ocean and Meteorological Satellite(COMS). It intends to give an overall design presentation and to justify that this design is compatible with all the requirements in terms of stiffness and strength as well as the stability.