• 제목/요약/키워드: Functional recovery

검색결과 845건 처리시간 0.034초

Recovery Levels of Clustering Algorithms Using Different Similarity Measures for Functional Data

  • Chae, Seong San;Kim, Chansoo;Warde, William D.
    • Communications for Statistical Applications and Methods
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    • 제11권2호
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    • pp.369-380
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    • 2004
  • Clustering algorithms with different similarity measures are commonly used to find an optimal clustering or close to original clustering. The recovery level of using Euclidean distance and distances transformed from correlation coefficients is evaluated and compared using Rand's (1971) C statistic. The C values present how the resultant clustering is close to the original clustering. In simulation study, the recovery level is improved by applying the correlation coefficients between objects. Using the data set from Spellman et al. (1998), the recovery levels with different similarity measures are also presented. In general, the recovery level of true clusters was increased by using the correlation coefficients.

흰쥐에서 편측 반회후두신경 재지배 후 neuronal Nitric Oxide Synthase(nNOS)의 발현과 후두기능회복과의 관계 (The Expression of neuronal Nitric Oxide Synthase in Reinnervated Recurrent Laryngeal Nerve)

  • 정성민;김성숙;조윤희;구태완;박수경;신유리
    • 대한후두음성언어의학회지
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    • 제12권1호
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    • pp.46-54
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    • 2001
  • Background and Objectives : Nitric oxide(NO) is a short-lived molecule with messenger and cytotoxic functions in nervous, cardiovascular, and immune systems. Among the three distinct NOS isoforms, the neuronal isoform is expressed in small, discrete neuronal populations of CNS and PNS. Axonal injury in adult animals results in a dramatic NOS up-regulation in many types of central and peripheral neurons which normally lack the enzyme or express it only at very low levels. In previous study, we confirmed the efficacy of PEMS on the early functional recovery in rats with surgically transected and reanastomosed recurrent laryngeal nerve. Therefore, after we obtained functionally recovered rats using PEMS in this study, we studied to evaluate the expression of nNOS through the analysis of the difference between functional recovery group and non-recovery group in the recurrent laryngeal nerve. Materials and Method : Using 84 healthy male Sprague-Dawley rats, transections and primary anastomosis were performed on their left recurrent laryngeal nerves. Rats were then randomly assigned to 2 groups. The rats in group A(n=42) received PEMS by placing them in custom cages equipped with Helm-holz coils(3 hr/day, 5 days/wk, for 12 wk). The rats in group B(n=42) were handled the same way as the group A, except that they did not receive PEMS. Laryngovideoendoscopy was performed before and after surgery and followed up weekly. Laryngeal EMG was obtained in both PCA and TA muscles. Immunohistochemisty staining using monoclonal anti-neuronal nitric oxide synthase(nNOS) antibody was performed to detect nNOS in recurrent laryngeal nerve and nodose ganglion. Results : 20 rats(63%) in group A and 5 rats(17%) in the group B showed recovery of vocal fo1d motion. The number of NOS-positive cells was increased in functionally-recovered rats. NOS-staining intensity was reduced 12 weeks after nerve injury. The difference between PEMS group and non-stimulated group was not found. Conclusion : This study shows that nNOS may exert a beneficial effect on nerve regeneration and functional repair.

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뇌혈관 질환자의 기능 회복과 체성감각 유발전위의 변화 (Changes of Somatosensory Evoked Potential and Functional Recovery in Patients of Cerebrovascular disease)

  • 김윤환;김찬규;박종항;이승엽;최원제
    • 대한물리치료과학회지
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    • 제15권1호
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    • pp.11-20
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    • 2008
  • This study was designed to test the effects of comprehensive rehabilitation management on functional recovery after attack of cerebrovascular disease. 16 cerebrovascular disease patients applied comprehensive rehabilitation management of physical therapy at department of physical Therapy, C medical center in Gwang-ju. The collection of the data had been executed for 4months(April 15, 2007${\sim}$July 15, 2007). For evaluating, Functional Independence measure(FIM) and Somatosensory Evoked Potential(SSEP) were used to assess functional recovery. The results of this study were as follows: 1. In the comparison of latency of median nerve SSEP before and after treatment, the lat. N20 and P25 increased, the ampl. P25/N20 was decreased. In the comparison difference data of median nerve SSEP, however there was no significant difference in the group(p>0.05). 2. In the comparison of latency of Post Tibial nerve SSEP before and after treatment, the lat. P40, P50, P60 increased, the ampl. P40 was decreased. In the comparison difference data of post tibial nerve SSEP, however there was no significant difference in the group(p>0.05). 3. In the comparison of FIM scores of Self-care, Sphincter Control, Mobility: Transfer, Locomotion before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was significant difference(p<0.05). 4. In the comparison of FIM scores of Communication, Social Cognition before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was no significant difference in the group(p>0.05). Based on these results, it is concluded that the comprehensive rehabilitation management for cerebrovascular disease case was not significant difference in the SSEP, was significant difference in the motor part of FIM. Further study should be done to analyze the effect of intervention duration of treatment, optimal time to apply the treatment in more long period.

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재관류액에 Latamoxef Sodium 첨가가 허혈성 심정지후 흰쥐 적출심장의 기능회복에 미치는 영향 (Effect of Reperfusate Solution with Latamoxef Sodium for Functional Recovery after Ischemic Cardiac Arrest in Sprague-dawley`s Isolated Heart)

  • 안병희;허선
    • Journal of Chest Surgery
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    • 제24권4호
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    • pp.331-337
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    • 1991
  • Recent experimental work indicates latamoxef sodium used as a broadspectrum antibiotics generates oxygen-free radicals. The present study represents an attempt to investigate whether reperfusate containing Shiomarin[85% latamoxef sodium+15% mannitol] might decrease the post-ischemic recovery of cardiac function. In the investigation, twelve isolated rat hearts were subjected to 270 minutes of cold total global ischemia. After the cold total global ischemia, six hearts[KHB group] were reperfused with Krebs-Henseleit buffer solution and the other six hearts[LMS group] with Krebs-Henseleit buffer solution containing latamoxef sodium[200ug /L]. Postischemic recovery rate of heart rate, aortic systolic pressure, aortic flow, coronary flow and cardiac output at 20 minutes reperfusion was 100.66$\pm$10.38, 85.25$\pm$7.61, 78.95$\pm$6. 02, 78.85$\pm$8.86 and 79.11$\pm$6.54 percent respectively in the KHB group and 97.96$\pm$4.19, 87. 72$\pm$4.37, 81.74$\pm$6.80, 82.69$\pm$10.01 and 81.90$\pm$6.67 percent respectively in the LMS group. The hemodynamic data revealed no significant difference in the post-ischemic recovery rate of the two groups. This finding suggests that reperfusate containing Shiomarin[latamoxef sodium, 200ug /L] does not affect the cardiac functional recovery after cold total global ischemia.

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운동에 의한 열 스트레스하에서 흡한속건성 소재 운동복 착용시의 온열생리적 반응 및 주관적 감각 (Thermophysiological Responses and Subjective Sensations when Wearing Clothing with Quickly Water-Absorbent and Dry Properties Under Exercise-Induced Heat Strain)

  • 이소진;박신정
    • 한국의류산업학회지
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    • 제8권3호
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    • pp.349-356
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    • 2006
  • The purpose of this study was to compare the thermophysiological responses and subjective sensations of clothing materials with different water transfer property investigated in exercising and resting subjects at an ambient temperature of $20^{\circ}C$ and a relative humidity of 40%. Two kinds of clothing ensemble were tested: 100% cotton with highly water-absorbent but slowly dry properties(C) and 100% polyester with quickly water-absorbent and dry properties by four capillary channels(QADP). Seven apparently healthy male participants each undertook two series of experiments comprised 10-min of rest, 20-min of exercise with 70% of $VO_{2max}$ on a treadmill and 20-min of recovery. Mean skin temperature was significantly lower in QADP than in C during exercise and recovery. Clothing microclimate temperature was significantly lower in QADP during exercise and clothing surface temperature was also lower in QADP especially during recovery. Also, clothing surface humidity was significantly higher in QADP after the later half of exercise. The concentration of blood lactic acid tended to decrease to a lower level at recovery 3 minutes when wearing QADP rather than C clothing ensemble. Metabolic energy was marginally significantly less during the second half of exercise in QADP. Body mass loss tended to be greater in C than in QADP. The participants had better scores in thermal sensation, comfortable sensation and wetness in QADP during exercise and recovery. These results show that functional materials with quickly water-absorbent and dry properties can alleviate heat strain and induce more comfortable clothing microclimates and subjective sensations in the exercise-induced hyperthermia.

트레드밀 강도에 따른 운동이 척수손상 흰쥐의 행동학적 변화와 조직학적 변화에 관한 연구 (The Study of Behavior and Histological Change on Treadmill Exercise Intensity after Spinal Cord Injury in Rats)

  • 김용억
    • 대한임상전기생리학회지
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    • 제6권1호
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    • pp.1-15
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    • 2008
  • This study was designed to investigate the effect of treadmill exercise of low-intensity and high-intensity on the functional recovery and histological change in spinal cord injury rats. Sprague-Dawley rats were experimented(n=15) for this research. Spinal cord injury was induced by the NYU drop impacter device after laminectomy. After operation, rats were test at modified Tarlov scale at 3 days, and divided into the control group(n=5), experimental group I(n=5, low-intensity treadmill) and experimental group II(n=5, high-intensity treadmill). The rats were disciplined from 7 day through 21 day. Functional recovery was evaluated by the BBB scales and the Grid Walk test for the progressive locomotor recovery at 3, 7, 14, 21 days. Histopathological studies for the muscle in order to observation the change of damage and size of the organized surface which is visible visually it executed hematoxylin & eosin stain. According to the result of 4 weeks of treadmill exercise, group II showed improvement than group I of motor behavior after spinal cord injury.

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주석도금폐액으로부터 이온교환 및 사이클론 전해채취를 이용한 고순도 주석의 회수 (Recovery of High Purity Tin from Waste Solution of the Tin Plating by Ion-exchange and Cyclone-electrowinning)

  • 강용호;신기웅;안재우
    • 자원리싸이클링
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    • 제25권4호
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    • pp.42-48
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    • 2016
  • 주석도금폐액으로부터 고순도 주석 금속을 회수하는 연구를 실시하였다. 먼저 주석도금폐액을 Iminodiacetic 관능기를 가진 이온교환수지(Lewatit TP 207)를 사용하여 1차적으로 유기물 및 Fe, Zn, Na 등의 불순물을 제거하였고, 2차적으로 Ethylhexyl-phosphate의 관능기를 가진 이온교환수지(Lewatit VPOC 1026)를 사용하여 잔류하고 있는 불순물들을 모두 제거하여 고순도의 주석용액으로 회수하였다. 회수된 주석용액으로부터 고순도 금속주석으로 회수하기 위하여 사이클론식 전해방법을 사용하였으며, 전해채취 결과 약 99.98% 순도의 주석을 회수할 수 있었다.

편마비 환자의 환측 기능회복을 위한 연구 (The study of paralytic side functional recovery on hemiplegia)

  • 김지혁;조영하;김용권
    • 대한물리치료과학회지
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    • 제9권2호
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    • pp.7-16
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    • 2002
  • This study was conducted to assess the changes in the functional levels of affected upper extremities after treating hemiplegic patients by applying constraint-induced movement therapy(CIMT). The subjects were selected from 20 hemiplegic patients with scores of 25 or more in Mini Mental State Examination(MMSE-k), transferred to the departments of physical therapy in two university hospitals in Busan from December, 2001 to march, 2002, and were divided into two groups. Eleven subjects with fixing unaffected arms by CIMT were assigned to the experimental patient group and the other 9 patients to control group without fixing unaffected arms. The function of upper arms for both groups were evaluated by using Actual Amount of Use Test(AAUT) and Motor Active Log(MAL) before and after physical therapy. The malts were as follows: The recovery rates of upper extremity by AOU(Activity of Use) and QOM(Quality of Movement) were 23.9% and 27.3% for CIMT treated group, and by 8.3% and 4.6% for the control group on the average, respectively, in AAUT after physical therapy, showing statistically significant differences between two groups. And in MAL, the average recovery rates were 27.3% by AOU and 22.6% by QOM for CIMT treated group while 3.1% by both AOU and QOM for the control group, and were significantly different between twogroups.

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척수손상 흰쥐에서 자하거 약침과 침전기 자극이 신경성장인자 발현에 미치는 영향 (Effects of Hominis Placenta Pharmacopuncture and Electroacupuncture Neuroprotection in Contused Spinal Cord of Rats)

  • 김은정;김계엽
    • 동의생리병리학회지
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    • 제25권2호
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    • pp.257-263
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    • 2011
  • This study was designed to investigate the effects of Hominis placenta pharmacopuncture treatment and electroacupuncture therapy on the functional recovery and histological change, protein expression in spinal cord injury(SCI) rats. Experimental groups were divided into the Group I(normal control rat), Group II(Non-treatment after spinal cord injury induction), Group III(Hominis placenta pharmacopuncture treatment after SCI induction), Group IV (Electroacupuncture therapy after SCI induction), Group V(Hominis placenta pharmacopuncture treatment and electroacupuncture therapy after SCI induction). After operation, rats were tested at modified Tarlov test at 1 to 3 days with divided into 4 groups, and motor behavior test(BBB locomotor rating scale, Grid walk test) was examined at 3, 7, 14, and 21 days. For the observation of damage change and size of the organized surface in muscle and spinal cord, histopathological studies were performed at 21 days by H & E stain, and BDNF & NT-3 protein expression studies were performed at 21 days. Acco rding to the results, Hominis placenta pharmacopuncture treatment and electroacupuncture therapy can play a role in facilitating recovery of locomotion following spinal cord injury. Specially, Hominis placenta pharmacopuncture treatment and electroacupuncture combimed therapy after SCI induction was most improvement in functional recovery, BDNF, and NT-3 protein synthesis.

Clinical Assessment of Pain and Sensory Function in Peripheral Nerve Injury and Recovery: A Systematic Review of Literature

  • John, Albin A.;Rossettie, Stephen;Rafael, John;Cox, Cameron T.;Ducic, Ivica;Mackay, Brendan J.
    • Archives of Plastic Surgery
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    • 제49권3호
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    • pp.427-439
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    • 2022
  • Peripheral nerve injuries (PNIs) often present with variable symptoms, making them difficult to diagnose, treat, and monitor. When neurologic compromise is inadequately assessed, suboptimal treatment decisions can result in lasting functional deficits. There are many available tools for evaluating pain and functional status of peripheral nerves. However, the literature lacks a detailed, comprehensive view of the data comparing the clinical utility of these modalities, and there is no consensus on the optimal algorithm for sensory and pain assessment in PNIs. We performed a systematic review of the literature focused on clinical data, evaluating pain and sensory assessment methods in peripheral nerves. We searched through multiple databases, including PubMed/Medline, Embase, and Google Scholar, to identify studies that assessed assessment tools and explored their advantages and disadvantages. A total of 66 studies were selected that assessed various tools used to assess patient's pain and sensory recovery after a PNI. This review may serve as a guide to select the most appropriate assessment tools for monitoring nerve pain and/or sensory function both pre- and postoperatively. As the surgeons work to improve treatments for PNI and dysfunction, identifying the most appropriate existing measures of success and future directions for improved algorithms could lead to improved patient outcomes.