• 한국식품영양학회지
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• 제34권2호
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• pp.174-180
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• 2021

The purpose of this study was to determine the optimum extraction method suitable for the availability of biological activities in unripe apples known to be rich in functional components. Unripe apples 'Hongro' picked on May 28th, 2019 were extracted by various extraction methods (hot water, ethanol, enzymatic pre-treatment, ultrasonic wave, and subcritical water) and their extracts were investigated yield, effective component contents, and antioxidant activities. Overall, the yields by the extraction solvent were higher in water than in organic solvent(ethanol) because water-soluble compounds were eluted from a polar solvent. Total phenol contents of the ultrasonic wave (ethanol) extracts were significantly higher in 6 times than hot water extract. Contents of flavonoid were highest in the ethanol extract at 29.14 mg QE/g. Contents of tannin and ursolic acid were also significantly higher in the ultrasonic wave (ethanol) extract. The DPPH radical and ABTS radical scavenging activities were the strongest in the ultrasonic wave (ethanol) extract. Correlation between effective components and antioxidant activities was high in the total phenol content with ABTS and the ursolic acid content with DPPH (p<0.01). The above results suggested that ultrasonic wave (ethanol) extract of unripe apples has the potential to act as a functional material.

• Animal Bioscience
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• 제34권2호
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• pp.265-275
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• 2021

Objective: The study developed mushroom stalk residues as feed additives in the broiler diet for improving the growth performance and immunity of broilers as well as to increase the value of mushroom stalk residues. Methods: In total, 300 ROSS 308 broilers were randomly allocated into fifteen pens with five dietary treatments: i) control, basal diet; ii) CMWM, supplemented with 1% Cordyceps militaris waster medium (CM); iii) CMPE, supplemented with 0.5% CM+0.5% Pleurotus eryngii stalk residue (PE); iv) CMPS, supplemented with 0.5% CM+0.5% Pleurotus sajorcaju stalk residue (PS); v) CMFV, supplemented with 0.5% CM+0.5% Fammulina velutipes stalk residue (FV). Results: The chemical analysis results showed that CM extracts, PE extracts, PS extracts, and FV extracts contain functional components such as polysaccharides and phenols and have both 2, 2-diphenyl-1-picryl-hydrazyl-hydrate scavenging and Ferrous scavenging capacities. The group CMWM saw increased body weight gain and feed conversion rate and the promotion of jejunum villus growth, but there is no significant difference in the intestinal bacteria phase. Antioxidant genes in the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)- antioxidant responsive element pathway among the groups are significantly higher than that of the control group, especially in group CMWM. Conclusion: The mushroom stalk residues have antioxidant functional components, can improve the intestinal health and body weight gain of chickens, and can activate the antioxidant pathway of Nrf2 to increase the heme oxygenase-1 expression. The treatment with 1% CM was the most promising as a feed additive.

• Journal of Ginseng Research
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• 제45권1호
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• pp.58-65
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• 2021

Background: Panax ginseng, as one of the most widely used herbal medicines worldwide, has been studied comprehensively in terms of the chemical components and pharmacology. The proteins from ginseng are also of great importance for both nutrition value and the mechanism of secondary metabolites. However, the proteomic studies are less reported in the absence of the genome information. With the completion of ginseng genome sequencing, the proteome profiling has become available for the functional study of ginseng protein components. Methods: We optimized the protein extraction process systematically by using SDS-PAGE and one-dimensional liquid chromatography mass spectrometry. The extracted proteins were then analyzed by two-dimensional chromatography separation and cutting-edge mass spectrometry technique. Results: A total of 2,732 and 3,608 proteins were identified from ginseng root and cauline leaf, respectively, which was the largest data set reported so far. Only around 50% protein overlapped between the cauline leaf and root tissue parts because of the function assignment for plant growing. Further gene ontology and KEGG pathway revealed the distinguish difference between ginseng root and leaf, which accounts for the photosynthesis and metabolic process. With in-deep analysis of functional proteins related to ginsenoside synthesis, we interestingly found the cytochrome P450 and UDP-glycosyltransferase expression extensively in cauline leaf but not in the root, indicating that the post glucoside synthesis of ginsenosides might be carried out when growing and then transported to the root at withering. Conclusion: The systematically proteome analysis of Panax ginseng will provide us comprehensive understanding of ginsenoside synthesis and guidance for artificial cultivation.

• 치위생과학회지
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• 제20권4호
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• pp.213-220
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• 2020

Background: The leaves of Perilla frutescens, commonly called perilla and used for food in Korea, contain components with a variety of biological effects and potential therapeutic applications. The purpose of this study was to identify the components of 70% ethanol extracted Perilla frutescens (EEPF) and determine its inhibitory effects on oral microbial activity and production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharides (LPS)-stimulated Raw264.7 macrophages, consequently, to confirm the possibility of using EEPF as a functional component for improving the oral environment and preventing inflammation. Methods: One kg of P. frutescens leaves was extracted with 70% ethanol and dried at -70℃. EEPF was analyzed using high-performance liquid chromatography analysis, and antimicrobial activity against oral microorganisms was revealed using the disk diffusion test. Cell viability was elucidated using a methylthiazolydiphenyl-tetrazolium bromide assay, and the effect of EEPF on LPS-induced morphological variation was confirmed through microscopic observation. The effect of EEPF on LPS-induced production of pro-inflammatory mediators, NO and PGE2 was confirmed by the NO assay and PGE2 enzyme-linked immunosorbent assay. Results: The main component of EEPF was rosemarinic acid, and EEPF showed weak anti-bacterial and anti-fungal effects against microorganisms living in the oral cavity. EEPF did not show toxicity to Raw264.7 macrophages and had inhibitory effects on the morphological variations and production of pro-inflammatory mediators, NO and PGE2 in LPS-stimulated Raw264.7 macrophages. Conclusion: EEPF can be used as a functional material for improving the oral environment through the control of oral microorganisms and for modulating inflammation by inhibiting the production of inflammatory mediators.

• Design & Manufacturing
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• 제15권4호
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• pp.43-50
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• 2021

Pump-cap is a device for discharging the contents stored inside a container to the outside of the container by a simple operation by a certain amount. In particular, in recent years, as the number of cosmetic products made of functional materials has rapidly increased, the development of convenient containers for functional materials is being actively conducted. Among these, there are a growing number of products that show their efficacy only by mixing two components, so the development of a dual pump cap container is necessary. However, the conventional dual pump cap container has a problem in that it is difficult to implement a quantitative discharge as solutions having different viscosities are used. Therefore, in this study, a discharge port of a dual pump cap that can apply an optimal ratio was designed by analyzing the discharge amount of two components with different viscosities through computational fluid dynamics. Since the discharge amount is affected by the size of the discharge port, the higher the viscosity of the solution, the larger the discharge port should be set. Conversely, the lower the viscosity, the smaller the discharge port should be. Through this, it is possible to dispense a fixed amount of a heterogeneous solution by one pumping, and it is determined that the user's convenience will increase.

• 한국정보전자통신기술학회논문지
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• 제16권6호
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• pp.420-433
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• 2023

ICT 기술의 발달로 데이터를 기반으로 하는 다양한 시스템과 서비스가 도입되면서 데이터, 인프라, 서비스에 대한 신뢰 제공 기술의 중요성이 대두되고 있다. 하지만 기존 ICT 서비스 환경은 특정 서비스를 구성하는 다양한 구성요소의 신뢰(콘텐츠, 인프라, 프로세스, 서비스 제공자 등)를 객관적으로 판단하고 관리할 방법이 없으며, 오로지 서비스 제공자의 자체적인 품질 기준에 의지해야만 하는 한계가 있다. 본 논문은 ITU-T 국제표준 관점의 신뢰성 있는 ICT 서비스 제공을 위한 요구사항, 기능구조, 처리절차를 제공한다. 신뢰할 수 있는 서비스 프로비저닝을 통해 기존 ICT 서비스 주체(서비스 자원, 이해관계자, 사용자)에 신뢰 제공을 위한 부가적인 기능을 추가하여, 관련정보를 수집하고, 분석하여 제공함으로써 사용자는 자신의 요구사항을 기반으로 분석된 신뢰를 기반으로 서비스 구성요소의 신뢰를 고려할 수 있다.

• Hip & pelvis
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• 제36권1호
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• pp.26-36
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• 2024

Total hip arthroplasty (THA) is a frequently performed procedure; the objective is restoration of native hip biomechanics and achieving functional range of motion (ROM) through precise positioning of the prosthetic components. Advanced three-dimensional (3D) imaging and computed tomography (CT)-based navigation are valuable tools in both the preoperative planning and intraoperative execution. The aim of this study is to provide a thorough overview on the applications of CT scans in both the preoperative and intraoperative settings of primary THA. Preoperative planning using CT-based 3D imaging enables greater accuracy in prediction of implant sizes, leading to enhancement of surgical workflow with optimization of implant inventory. Surgeons can perform a more thorough assessment of posterior and anterior acetabular wall coverage, acetabular osteophytes, anatomical landmarks, and thus achieve more functional implant positioning. Intraoperative CT-based navigation can facilitate precise execution of the preoperative plan, to attain optimal positioning of the prosthetic components to avoid impingement. Medial reaming can be minimized preserving native bone stock, which can enable restoration of femoral, acetabular, and combined offsets. In addition, it is associated with greater accuracy in leg length adjustment, a critical factor in patients' postoperative satisfaction. Despite the higher costs and radiation exposure, which currently limits its widespread adoption, it offers many benefits, and the increasing interest in robotic surgery has facilitated its integration into routine practice. Conducting additional research on ultra-low-dose CT scans and examining the potential for translation of 3D imaging into improved clinical outcomes will be necessary to warrant its expanded application.

• 한국콘텐츠학회논문지
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• 제20권4호
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• pp.601-615
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• 2020

본 연구는 개별 정부 부처를 브랜딩이 가능한 대상으로 인지하고, 중앙부처 브랜드 자산이 정부 신뢰에 미치는 영향관계를 탐색하였다. 이를 위해 문헌 연구를 토대로 측정문항과 가설적 구성차원을 수립하고 중앙부처의 브랜드 자산이 궁극적으로 정부신뢰에 미치는 영향을 검증하였다. 연구결과를 요약하면, 개별 중앙부처의 브랜드 자산 구성요소를 파악하기 위하여 선행연구를 토대로 수집한 측정문항을 정제하여, 요인분석한 결과 인지도, 기능적 자산, 감성적 자산의 세가지 차원으로 나타났다. 둘째, 개별 중앙부처의 인지도는 기능적 자산과 감성적 자산에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 개별 중앙부처의 기능적 자산과 감성적 자산은 개별 중앙부처 신뢰에 유의미한 영향을 미치는 것으로 나타났다. 마지막으로, 개별 중앙부처 신뢰는 대통령에 긍정적 영향을 미치는 것으로 나타났다. 이 연구는 중앙부처 브랜드 자산의 구성요소를 밝히고 실증 분석하여 객관적 비교가 가능한 틀을 제시했다는 점에서 의의가 있다.

• Journal of the Korean Data and Information Science Society
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• 제26권4호
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• pp.885-894
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• 2015

전력시스템의 안정적이고 효과적인 운영을 위해선 전력수요예측이 필요하다. 본 연구에서는 일별전력수요패턴의 시간에 따른 커브를 군집분석 하려고 한다. 2009년 1월 1일부터 2011년 12월 31일까지의 일별 시간단위 전력수요 자료는 추세성분 제거와 로그변환을 통해 계절성분과 오차성분으로 구성된 시계열자료로 변환되었다. 변환된 자료는 Ma 등 (2006)이 제안한 함수적 군집모형을 사용하여 분석되었고, 모수는 EM알고리즘과 일반화교차검정을 통해 추정되었다. 군집의 수는 휴일과 평일을 잘 분류하는 10개로 결정하였다. 분석결과 월요일, 평일 (화요일~금요일), 토요일, 일요일 또는 공휴일과 계절요인으로 전력수요 평균곡선이 설명된다. 함수적 군집분석을 통한 전력수요패턴의 과학적인 분류는 향후 단기전력수요예측에 활용된다.

• Journal of Acupuncture Research
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• 제23권3호
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• pp.155-163
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• 2006

Objectives : This study was designed to evaluated the effect of electro acupuncture on Heart Rate Variability of Patients with functional voiding disease. Methods: Subjects were voluntarily recruited by newspapers and internet. Electro acupuncture was performed three times a week for 3 weeks. Acupuncture point for EA group was B32, Electrical stimulation frequency was 2Hz, duration 20min, and intensity was up to pain threshold according to patients. The patients' Heart Rate Variability was measured before, after 3 weeks of treatment for 5 minutes. Results : In time domain analysis, There were significant increase of SDNN and RMSSD(p<0.05) after 3 weeks treatment. In frequency domain analysis, There were significant increase of LF and LF /HF ratio(p<0.05) after 3 weeks treatment. There were no significant changes in other components of heart rate variability. Conclusion : This study suggests that electroacupuncture treatments can be applicable to improve autonomic nervous system in patients with functional voiding disease.