• Journal of The Korea Institute of Healthcare Architecture
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• v.21 no.2
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• pp.7-15
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• 2015

Purpose: The purpose of this study is analyze linkage and spatial and structural characteristics of outpatient department and diagnosis/treatment area of geriatric hospitals based on quantitative analysis, according to function and corridor types. Methods: To examine structural characteristics and correlation of outpatient department and diagnosis/treatment area of six geriatric hospitals according to the corridor type, were systemized according to the function and corridor type and made into a j-graph, and an index was created by using space syntax to understand spatial characteristics. Results: 1) Different functional spaces are connected by a corridor, which, therefore, can be an axis of the connectivity and linkage of functional spaces and an important element in a clear hierarchy. 2) Treatment areas were disconnected from different functional spaces and, therefore, the accessibility was low. Many hospitals had an arrangement plan for treatment and diagnosis areas, and recent hospitals have segmented treatment areas within the rehabilitation space, which resulted in deeper space. 3) In terms of the level of integration, more integrated reception area meant shallower spatial depth, and deeper space for treatment and diagnosis areas. Implications: Spatial relation of outpatient department of geriatric hospitals was analyzed based on characteristics of the elderly.

• Journal of Fashion Business
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• v.11 no.4
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• pp.42-51
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• 2007

The purpose of this study is to develop clothing design for mild dementia patients who display positive action in clothing for the improvement of the quality of life of the dementia patients following the symptoms of patients in accordance with the clinical classification to provide the functional assistance for ordinary living as well as emotional stability and aesthetic functions for the dementia elderly. The method of research is performed for theories through the advanced research and documentary data, and interpreted in functional and aesthetic level on the basis of the result of advance survey related to the characteristics of the mild dementia patients and clothing conduct of elderly with light dementia to select the material, color, decoration and functional design with four pairs for women and two pairs for men. Designs for the total of six have been actually produced by making the map, including the material swatch, color and others. The questionnaire as the measuring tool is used and the assessment category is made for the adaptability of design on each category. On the six clothes that are produced for the mild dementia patients, the statistics package SPSS Ver 12.0 is used for the data analysis on questions 8-10 for the frequency analysis. In overall, the leisure clothing for mild dementia patients developed from this research are generally satisfied, and overall type, material, color, detail and arrangement are generally evaluated highly, and have the assessment of normal or better in the color size and type.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3372-3376
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• 2011

We have studied the relative stability and atomic structures of five $C_{20}X_2$ regioisomers obtained as diadducts of a $C_{20}$ cage (X = H, F, Cl, Br, and OH). All the regioisomers are geometric isomers, i.e., they differ in their spatial arrangement. Full-geometry optimizations of the regioisomers have been performed using the hybrid density-functional (B3LYP/6-31G(d, p)) method. Our results suggest that the cis-1 regioisomer (the 1,2-diadduct) is the most stable and that the second most stable is the trans-2 (1,13-diadduct) regioisomer, implying that the long-range interaction between the two adducts and the resonance effect are more pronounced than the diadduct-induced strain in the $C_{20}$ cage. The HOMO and LUMO characteristics of each regioisomer with the same symmetry of structural regioisomers except $C_{20}(OH)_2$ are topologically same. This suggests that by using an entirely different set of characteristic chemical reactions for each regioisomer, we can distinguish between the five regioisomers for each $C_{20}$ diadduct derivative.

• Plant Journal
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• v.13 no.4
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• pp.41-47
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• 2017

This paper is a study on validation model that can verify the arrangement of equipment constituting offshore plant using system engineering approach in offshore plant tender stage. In order to design offshore plant topside maintenance equipment, topside layout verification should be preceded. However, there are many errors in the bidding stage due to the FEED results that are not perfect, the verification can not be performed sufficiently due to the limitation of the bidding period and others reasons. Therefore, we propose a validation model that can effectively verify the equipment layout within a limited condition by simplifying the main process in the system engineering process, which is a multidisciplinary approach, and confirmed through the Functional Deployment Model. Also, we verified the validation model for topside equipment deployment through case studies.

• BMB Reports
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• v.56 no.5
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• pp.308-313
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• 2023

Phenotypic features such as ataxia and loss of motor function, which are characteristics of Parkinson's disease (PD), are expected to be very closely related to cerebellum function. However, few studies have reported the function of the cerebellum. Since the cerebellum, like the cerebrum, is known to undergo functional and morphological changes due to neuroinflammatory processes, elucidating key functional factors that regulate neuroinflammation in the cerebellum can be a beneficial therapeutic approach. Therefore, we employed PD patients and MPTP-induced PD mouse model to find cytokines involved in cerebellar neuroinflammation in PD and to examine changes in cell function by regulating related genes. Along with the establishment of a PD mouse model, abnormal shapes such as arrangement and number of Purkinje cells in the cerebellum were confirmed based on histological finding, consistent with those of cerebellums of PD patients. As a result of proteome profiling for neuroinflammation using PD mouse cerebellar tissues, fetuin-A, a type of cytokine, was found to be significantly reduced in Purkinje cells. To further elucidate the function of fetuin-A, neurons isolated from cerebellums of embryos (E18) were treated with fetuin-A siRNA. We uncovered that not only the population of neuronal cells, but also their morphological appearances were significantly different. In this study, we found a functional gene called fetuin-A in the PD model's cerebellum, which was closely related to the role of cerebellar Purkinje cells of mouse and human PD. In conclusion, morphological abnormalities of Purkinje cells in PD mice and patients have a close relationship with a decrease of fetuin-A, suggesting that diagnosis and treatment of cerebellar functions of PD patients might be possible through regulation of fetuin-A.

• Journal of Electrical Engineering and Technology
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• v.10 no.1
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• pp.314-319
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• 2015

The conventional geometry of a plate microstrip resonator is made up of a single metallic patch, which is printed on a monolayer dielectric substrate. Its arrangement is simple and easy to make, but it is limited in its functional abilities. Many searches have been realized to improve the bandwidth and the gain of the microstrip resonators. Among the various configurations proposed in the open literature, the stacked geometry seems to be very promising. By appropriate design, it is able to provide the operation in dual frequency mode, wide bandwidth enough and high gain. The theoretical investigations of structures composed of two stacked anti-reflection coatings, enhanced metallic coatings are available in the literature, however, for the stacked configurations involving three metallic coatings or more, not to exact or approximate analysis was conducted due to the complexity of the structure.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.4
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• pp.357-363
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• 2006

Monolithic molecularly imprinted columns were designed and prepared by an in-situ thermal-initiated copolymerization technique for rapid separation of tryptophan and N- CBZ-phenylalanine enantiomers. The influence of polymerization conditions and separation conditions on the specific molecular recognition ability for enantiomers and diastereomers was investigated. The specious molecular recognition was found to be dependent on the stereo structures and the arrangement of functional groups of the imprinted molecule and the cavities in the molecularly imprinted polymer (MIP). Moreover, hydrogen bonding interactions and hydrophobic interactions played an important role in the retention and separation. Compared to conventional MIP preparation procedures, the present method is very simple, and its macroporous structure has excellent separation properties.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.1
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• pp.229-239
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• 2003

The design process of machine tools is regarded as a sequential, discrete, and inefficient works as it requires various kinds of design tools and many working hours. This paper describes an integrated design system embedding a design methodology that can support efficiently and systematically the conceptual structural design of machine tools. The system is a knowledge-based design system and has four machine-tool-specific functional modules including configuration design, configuration analysis, structure design, and structural analysis support module. Through the configuration design and analysis module, a machine configuration appropriate for design requirements is selected, and then the arrangement of ribs fer each structural part is decided in the structure design module. Also, the structural analysis support module is used to evaluate design result by utilizing structural analysis software, ANSYS. The system is applied to design of a tapping machine, and shows that the machine structure can be designed fast and conveniently by processing each design step interactively.

• Journal of the Korean Magnetics Society
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• v.21 no.1
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• pp.1-4
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• 2011

We have studied magnetic structure and magnetic anisotropy energy of cubic transition metal mono-oxide cluster FeO and MnO using OpenMX method based on density functional method. The calculation results show that the antiferromagnetic spin arrangement has the lowest energy for FeO and MnO due to the superexchange interactions. The magnetic anisotropy is only found for antiferromagnetically ordered FeO cluster, since occupied electron of 3d down-spin level induces the spin-orbit couplings with <111> directed angular momentum.

• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.1
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• pp.35-42
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• 2010

As a functionally complicated facility, it requires rational strategy to accommodate multi-functional needs to plan a hospital. Ambulatory surgery units located in large hospitals have problems such as longer waiting time and congestion for patients due to complicated planning and organization within limited area, which raise needs for independent ambulatory surgery centers to enable smoother medical treatment for patients. To design an independent ambulatory surgery center, understanding of zoning and layout of each unit needs is particularly required. This study focuses on research of efficient zoning/organization of day surgery unit and circulation arrangements of ambulatory surgery centers by analyzing various examples abroad, which will eventually help finding appropriate way of planning domestic ambulatory surgery centers. Specific area of research includes ambulatory surgery process, programmatic requirements, spatial organization of the facility, layout of surgery unit and circulation arrangements of ambulatory surgery centers.