• 한방재활의학과학회지
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• 제18권1호
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• pp.111-123
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• 2008

Objectives : The objective of this study was to investigate the outcomes of functional electrical stimulation (FES) which was applied twice a day in patients with dysphagia after stroke. Methods : Eleven patients with dysphagia after stroke were participated. The electrical stimulator with two channels was employed for forty minutes daily or forty minutes twice a day for fifteen days. Participants were divided into two groups by random method; The FES was performed twice a day for Twice-FES group (n=6), and once a day for Standard-FES group (n=5). For evaluation of dysphagia, the functional dysphagia scale by videofluoroscopic swallowing study, and swallow function scoring system by six clinical swallowing stage were assessed at pre- and post-treatment. Results : In both groups, there was a significant decrease of total functional dysphagia scales after FES treatment (p<0.05) and the results mainly affected the pharyngeal phase of deglutition. There was no significant difference between the two groups in total functional dysphagia scales, but the Twice-FES group had a decreased residue in oral cavity compared to the standard FES group. In both groups, there were significant improvements in swallow function scoring system (p<0.05). The twice-FES group had more high clinical swallowing stages. Conclusions : The results demonstrated that FES is a clinically effective intervention in treatment of stroke patients with dysphagia. Moreover, the treatment applied twice a day had relatively positive effects on the reduction of oral cavity residue and the improvement of clinical swallowing stage.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.

• 한국세라믹학회지
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• 제40권8호
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• pp.811-817
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• 2003

최근 들어 비금속광물의 구조적 특성을 이용한 활용분야가 매우 다양해지고 있다. 특히 판상광물은 차폐(은폐)력이 매우 우수하고, 층간특성을 이용한 흡착 및 저장특성이 매우 우수하다. 본 연구에서는 이와 같은 판상광물의 기본의 특성에 또 다른 기능성 물질을 흡착시킴으로써 부가적인 새로운 기능성을 갖는 친환경성 건축소재를 개발하고자 천연산 인상흑연 및 견운모를 기능성 모소재로 사용하고 미립화 및 ABDM(Alkyl Benzyle Demethyle Ammonium Chloride)으로 흑연입자 표면을 항균처리를 하였다. 항균처리를 위한 흡착은 전위차를 이용한 1차 흡착과 ABDM 상호간의 steric 작용에 의한 2차 흡착으로 완전 이중층이 형성되어 충분한 항균효과를 나타낼 수 있었다. 제조된 기능성 재료를 모르타르로 제조하여 다양한 기능성을 측정한 결과 세균감소율 99.7% 이상과 80% 이상의 암모니아 가스 흡착(탈취) 효과 및 95% 이상의 전자파 차폐율과 5% 정도의 열저장(축열, 잠열) 효과를 갖는 것으로 나타났다.

• 한국군사과학기술학회지
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• 제20권2호
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• pp.225-230
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• 2017

To generate mechanical movements in one-shot devices such as missiles and space launch vehicles, pyrotechnic mechanical device(PMD) such as pin pullers using pyrotechnic charge has been widely used. Reliability prediction of pin pullers is crucial to successfully execute target missions for the one-shot devices. Because the pin pullers require destructive tests to evaluate their reliability, one would need about 3,000 samples of success to guarantee a reliability of 99.9 % with a confidence level of 95 %. This paper suggests the application of a probit model using the charge amount as a functional parameter for estimation of functional reliability of pin puller. To guarantee target reliability, we propose estimation methods of the lower bound of functional reliability by applying the probit model. Given lower bound of functional reliability, we quantitatively show that the optimum amount of charge increases as the number of samples decreases. Along with a variety of simulations the validity of our new model via real test results is confirmed.

• The Journal of Korean Physical Therapy
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• 제32권4호
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• pp.203-209
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• 2020

Purpose: This study examined the effects of a physical stability exercise program on the functional movement and balance of middle school volleyball players to provide future management and training data to improve the performance of volleyball players. Methods: The subjects were 20 volleyball players from Y Middle School in Mokpo. The results of comparing and analyzing the effects of the physical stability exercise program on the functional movement and balance of middle school volleyball players for 10 weeks are as follows. Results: The number of participants who showed power and agility (p<0.01) was increased significantly, and the response time was shortened significantly (p<0.01). On the evaluation of functional movement, the total score showed a significant difference between the pre-test at 10.90±1.30 points and the post-test at 13.81±.60 (p<0.001). The subjects' balance showed a significant difference from 84.11±7.53 to 97.65±8.47 (p<0.001), and the Right Composite Score showed a significant difference from 83.74±6.64 to 97.27±8.48 (p<0.001). Conclusion: The application of a physical stability exercise program for 10 weeks is effective in improving the speed, agility, functional movement, and balance to volleyball players who are weakened and at risk of injury. This is believed to prevent or reduce injury.

• Journal of the Korean Wood Science and Technology
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• 제38권6호
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• pp.480-489
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• 2010

국내 시판용 전통 목탄의 과학적인 성질 규명과 주요 기능성 분석과 이용 방안에 대한 분석을 실시하였다. 국내에서 구입 가능한 시판용 목탄의 범위 내에서 해부학적 특성, 원소 조성, 무기성분 조성, 발열량, 음이온 및 원적외선 방사량, 조습성 등의 분석을 통하여 기능성 재료로 이용 가능성에 대하여 판단하고자 하였다. 원소조성, 무기물 조성, 음이온 및 원적외선 방사량은 목탄 제조 방법과 제조회사에 따라서 큰 변이를 보였다. 특히 조습성은 흑탄의 경우 백탄이나 기계숯 보다 열등한 성능을 나타내었다. 전통숯을 기능성 재료로 사용하기 위해서는 해부학적 특성, 원소 조성, 무기물 조성, 발열량, 음이온 및 원적외선 방사량, 조습성을 분석하여 선택적 이용이 필요 할 것으로 생각한다. 또한 차후 원하는 기능에 맞는 목탄 제조 방법 기술의 개발이 필요할 것으로 생각한다.

• 대한후두음성언어의학회지
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• 제32권2호
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• pp.75-80
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• 2021

Background and Objectives Functional aphonia refers to in which by presenting whispering voice and almost producing very high-pitched tensed voices are produced. Voice therapy is the most effective treatment, but there is a lack of consensus for application of voice therapy. The purpose of this study was to examine the vocal characteristics of functional aphonia and the effect of voice therapy applied accordingly. Materials and Method From October 2019 to December 2020, 11 patients with functional aphonia were treated using voice therapy which was processing three stages such as vocal hygiene, trial therapy, and behavioral therapy. Of these, 7 patients who completed the voice evaluation before and after voice therapy was enrolled in this study. By retrospective chart review, clinical information such as sex, age, symptoms, duration, social and medical history, process of voice therapy, subjective and objective findings were analyzed. Voice parameters before and after voice therapy were compared. Results In GRBAS study, grade, rough, and asthenic, and in Consensus Auditory-Perceptual Evaluation of Voice, overall severity, roughness, pitch, and loudness were significantly improved after voice therapy. In Voice handicap index, all of the scores of total and sub-categories were significantly decreased. In objective voice analysis, jitter, cepstral peak prominence, and maximum phonation time were significantly improved. Conclusion The voice therapy was effective for the treatment of functional aphonia by restoring patient's vocalization and improving voice quality, pitch and loudness.

• Journal of Microbiology and Biotechnology
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• 제33권7호
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• pp.915-925
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• 2023

Sarcopenia is defined as loss of muscle mass and strength due to aging. Recent studies show that sarcopenia may improve via the gut-muscle axis, suggesting that gut health may affect muscle phenotypes. In this study, we aimed to investigate the ability of Lactobacillus rhamnosus JY02 as a probiotic strain isolated from kimchi to alleviate sarcopenia. L. rhamnosus JY02-conditioned medium (CM) reduced dexamethasone (DEX)-induced myotube diameter atrophy and expression of muscle degradation markers (MuRF1 and atrogin-1) in C2C12 cells. The amelioration of sarcopenia was investigated by measuring body composition (lean mass), hand grip strength, myofibril size (using histological analysis), and mRNA and protein expression of muscle-related factors in a DEX-induced mouse model. The results of these analyses showed that L. rhamnosus JY02 supplementation promoted the production of muscle-enhancement markers (MHC Iβ, MHC IIα, and Myo-D) and reduced both the production of muscle degradation markers and the symptoms of muscle atrophy (loss of lean mass and muscle strength). We also found decreased levels of pro-inflammatory cytokines (IL-6, IFN- γ) and increased levels of anti-inflammatory cytokines (IL-10) in the serum of DEX+JY02-administered mice compared to those in DEX-treated mice. Overall, these results suggest that L. rhamnosus JY02 is a potent probiotic supplement that prevents sarcopenia by suppressing muscle atrophy.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.26-36
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• 2024

Functional brain imaging techniques have been used to diagnose psychiatric disorders such as dementia, depression, and autism. Recently, these techniques have also been actively used to study hearing loss. The present study reviewed the application of the functional brain imaging techniques in auditory research, especially those focusing on hearing loss, over the past decade. EEG, fMRI, fNIRS, MEG, and PET have been utilized in auditory research, and the number of research studies using these techniques has been increasing. In particular, fMRI and EEG were the most frequently used technique in auditory research. EEG studies mostly used event-related designs to analyze the direct relationship between stimulus and the related response, and in fMRI studies, resting-state functional connectivity and block designs were utilized to analyze alterations in brain functionality in hearing-related areas. In terms of age, while studies involving children mainly focused on congenital and pre- and post-lingual hearing loss to analyze developmental characteristics with and without hearing loss, those involving adults focused on age-related hearing loss to investigate changes in the characteristics of the brain based on the presence of hearing loss and the use of a hearing device. Overall, ranging from EEG to PET, various functional brain imaging techniques have been used in auditory research, but it is difficult to perform a comprehensive analysis due to the lack of consistency in experimental designs, analysis methods, and participant characteristics. Thus, it is necessary to develop standardized research protocols to obtain high-quality clinical and research evidence.

• 한국환경농학회지
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• 제27권4호
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• pp.373-381
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• 2008

게르마늄 함유 기능성 쌀 생산을 위한 최적 품종 및 게르마늄 시비방법을 선정하기 위해 토양처리와 엽면처리로 게르마늄 시비방법을 달리하여 호평, 주남, 일미 및 동진벼 등 총4개 품종하에서 벼의 생육특성, 게르마늄 흡수 특성 및 쌀 품질특성을 각각 조사한 결과 벼의 생육은 호평벼가 타 품종에 비해 전반적으로 양호하였으며, 게르마늄 무처리와 토양처리시 벼의 생육은 엽면처리에 비해 양호하였다. 벼의 품종에 따른 쌀 생산량은 게르마늄 토양처리의 경우 호평 $\fallingdotseq$ 주남 > 일미 >> 동진벼 순이었으며, 엽면처리의 경우 주남 > 일미 $\fallingdotseq$ 호평 >> 동진벼 순이었다. 또한 쌀 생산량은 전반적으로 토양처리 > 엽면처리 순이었다. 벼 품종별 현미 중 게르마늄 함량은 토양처리의 경우 호평, 주남, 일미 및 동진벼가 각각 14.5, 8.0, 11.6 및 $10.4\;mg\;kg^{-1}$로 호평벼가 가장 높았고, 엽면처리의 경우도 유사한 경향이었다. 게르마늄의 흡수율은 전반적으로 엽면처리가 토양처리에 비해 높았으나 실제 주식으로 사용되는 현미나 백미 중의 게르마늄 흡수율은 토양처리가 엽면처리에 비해 약2배정도 높았다. 따라서 게르마늄 함유 기능성 쌀을 생산하기 위해서는 현미나 백미 중 게르마늄 흡수량을 증대시켜야 하므로 게르마늄 토양처리가 엽면처리에 비해 적합할 것으로 판단되며, 최적 품종은 호평벼이었다.