• Title/Summary/Keyword: Functional Uni

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Scheduling Scheme for Compound Nodes of Hierarchical Task Graph using Thread (스레드를 이용한 계층적 태스크 그래프(HTG)의 복합 노드 스케쥴링 기법)

  • Kim, Hyun-Chul;Kim, Hyo-Cheol
    • Journal of KIISE:Computer Systems and Theory
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    • v.29 no.8
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    • pp.445-455
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    • 2002
  • In this paper, we present a new task scheduling scheme ior the efficient execution of the tasks of compound nodes of hierarchical task graph(HTG) on shared memory system. The proposed scheme for exploitation functional parallelism is autoscheduling that performs the role of scheduling by processor itself without any dedicated global scheduler. To adapt the proposed scheduling scheme for various platforms, Including a uni-processor systems, Java threads were used for implementation, and the performance is analyzed in comparison with a conventional bit vector method. The experimental results showed that the proposed method was found to be more efficient in its execution time and exhibited good load-balancing when using the experimental parameter values. Furthermore, the memory size could be reduced when using the proposed algorithm compared with a conventional scheme.

Purification and Backbone Assignment of the Hypothetical Protein MTH1821 from Methanobacterium Thermoautotrophicum H

  • Kwak, Soo-Young;Lee, Woong-Hee;Shin, Joon;Ko, Sung-Geon;Lee, Weon-Tae
    • Journal of the Korean Magnetic Resonance Society
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    • v.11 no.2
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    • pp.73-84
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    • 2007
  • MTH1821 (UniProtKB/TrEMBL ID O27849) is a 96-residue hypothetical protein from the open reading frame of Methanobacterium thermoautotrophicum H one of the target organisms of structural genomics pilot project. Proteins which contain conserved sequence compared with MTH1821 have not been discovered yet and the functional and structural information for MTH1821 is not available. Here, we present the sequence-specific backbone resonance using multidimensional heteronuc1ear NMR spectroscopy and propose the secondary structure using GetSBY software. The backbone resonances of N, HN, $C_{\alpha}$, $C_{\beta}$, CO and $H_{\alpha}$ which are necessary for a prediction of secondary structure by GetSBY were assigned about 98% (557/568). The secondary structure of MTH1821 confirmed that it is comprised of four strand regions and two helical regions. This report will provide a valuable resource for the calculation solution structure of MTH1821 and for the other hypothetical protein that is targeted for structural-based functional discovery.

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Antimicrobial Effects and Antioxidative Activities of the Cosmetic Composition Having Natural Plant Pigments (천연색소 함유 화장료 조성물의 항균효과 및 항산화활성)

  • Boo, Hee-Ock;Shin, Ji-San;Hwang, Sung-Jin;Bae, Chun-Sik;Park, Su-Hyun
    • Korean Journal of Plant Resources
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    • v.25 no.1
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    • pp.80-88
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    • 2012
  • This study was conducted to clarify the antimicrobial effects and radical scavenging activities of the cosmetic compositions having the natural plant pigments, and to enhance the natural materials utilization of cosmetics. The antimicrobial activities of the fifteen kinds of cosmetic composition having natural plant pigments were evaluated using the agar diffusion method. Most of the cosmetic composition having the natural pigments showed the clear zone formation of growth inhibition against Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenes, Vibrio parahaemolyticus and Aspergillus flavus. Especially, purple sweet potato, bitter melon, mulberry leaf and gromwell showed the higher antimicrobial activities. All the cosmetic compositions were evaluated for their antioxidant activity using DPPH radical scavenging capacity and nitrite scavenging ability activity. Both of the free radical DPPH and nitrite scavenging ability was the highest in the cosmetic compositions of onion peel, and these antioxidant activity was significant differences according to different plant pigments. In this study, we conjectured that the plant pigment had the potent biological activities, therefore these plant resources having functional components could be a good materials for development into source of natural cosmetics.

Development of functional lighting fixture and Experiment of to the Biological effects (기능성 반사판 조명기구 개발 및 효능 실험)

  • Kim, Chang-Hwan;Kim, Hyeon-Soo;Chee, Chol-Kon
    • Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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    • 2004.11a
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    • pp.203-208
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    • 2004
  • We are living now under the bad air pollition contained the many plus(+)ion produed by the exhaust gases from automobil and Industrial plant. To be refreshe those air pollution. We developed the funtional lighting fixture which emit the lighting, negative(-)ion and Infraredray. The negative(-)ion and Infraredray refresh the air pollition and will arise nature healing power lot the human body and activate the body cell, and makes the good blood circulation and then we had the experiment to the Biological effect by the funtional lighting fixture.

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Crystal Structure and Comparative Sequence Analysis of GmhA from Colwellia psychrerythraea Strain 34H Provides Insight into Functional Similarity with DiaA

  • Do, Hackwon;Yun, Ji-Sook;Lee, Chang Woo;Choi, Young Jun;Kim, Hye-Yeon;Kim, Youn-Jung;Park, Hyun;Chang, Jeong Ho;Lee, Jun Hyuck
    • Molecules and Cells
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    • v.38 no.12
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    • pp.1086-1095
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    • 2015
  • The psychrophilic organism Colwellia psychrerythraea strain 34H produces extracellular polysaccharide substances to tolerate cold environments. Sedoheptulose 7-phosphate isomerase (GmhA) is essential for producing $\small{D}$-glycero-$\small{D}$-mannoheptose 7-phosphate, a key mediator in the lipopolysaccharide biosynthetic pathway. We determined the crystal structure of GmhA from C. psychrerythraea strain 34H (CpsGmhA, UniProtKB code: Q47VU0) at a resolution of $2.8{\AA}$. The tetrameric structure is similar to that of homologous GmhA structures. Interestingly, one of the catalytic residues, glutamate, which has been reported to be critical for the activity of other homologous GmhA enzymes, is replaced by a glutamine residue in the CpsGmhA protein. We also found differences in the conformations of several other catalytic residues. Extensive structural and sequence analyses reveal that CpsGmhA shows high similarity to Escherichia coli DnaA initiatorassociating protein A (DiaA). Therefore, the CpsGmhA structure reported here may provide insight into the structural and functional correlations between GmhA and DiaA among specific microorganisms.

Fabrication of Core-Sheath Nanocomposite Fibers by Co-axial Electrospinning (공축 전기방사를 이용한 Core-Sheath형 복합나노섬유의 제조)

  • Kang, Minjung;Lee, Seungsin
    • Journal of the Korean Society of Clothing and Textiles
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    • v.37 no.2
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    • pp.224-234
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    • 2013
  • This study investigates the fabrication of core-sheath nanocomposite fibers by locating germanium (Ge) and silicon dioxide ($SiO_2$) nanoparticles selectively in the sheath layer by co-axial electrospinning. Co-axially spun fibers were prepared by electrospinning a pure PVA solution and Ge/$SiO_2$/PVA solution as the core and sheath layer, respectively. Core-sheath nanocomposite fibers were electrospun under a variety of conditions that include various feed rates for the core and sheath solutions, voltages, and concentric needle diameters, in order to find an optimum spinning condition. Ge/$SiO_2$ nanocomposite fibers were also prepared by uniaxial electrospinning to compare fiber morphology and nanoparticle distribution with core-sheath nanofibers. Using scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray analysis, it was demonstrated that the co-axial approach resulted in the presence of nanoparticles near the surface region of the fibers compared to the overall distribution obtained for uni-axial fibers. The co-axially electrospun Ge/$SiO_2$/PVA nanofiber webs have possible uses in high efficiency functional textiles in which the nanoparticles located in the sheath region provide enhanced functionality.

Effects of a TaiChi Program for Early Mastectomy Patients (유방암 수술 후 조기 환자를 위한 타이치(Tai Chi) 운동 프로그램의 적용 효과)

  • Eom, Ae-Yong
    • Women's Health Nursing
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    • v.13 no.1
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    • pp.43-50
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    • 2007
  • Purpose: There is a need to apply the Tai Chi program to help early mastectomy patients improve their upper limb functions and for the emotional state as well. Method: Participants were recruited at breast cancer centers of two general hospitals from February 17 to April 25, 2005. Twenty-five subjects in the experimental group and 23 subjects in the control group participated for 12 weeks. The Tai chi program consisted of breast cancer self management education and a Tai Chi exercise program. Range of motion of the shoulder joint was determined by the Uni-level inclinometer, and functional assessment of the shoulder was evaluated with the tool. Data was analyzed by SPSS 11. Results: The experimental group had significantly increased shoulder range of motion, especially in external rotation, upper limb function and emotional state compared with the control group after program for 12 weeks. Conclusion: This program makes it possible to be independent and have a positive everyday life. In addition, it can help keep a healthy lifestyle in mastectomy women.

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Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors

  • Kim, Hee Ryung;Duc, Nguyen Minh;Chung, Ka Young
    • Biomolecules & Therapeutics
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    • v.26 no.2
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    • pp.101-108
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    • 2018
  • G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

The Relationship between Consumption Value of Preschooler Clothing, Purchase Satisfaction and Brand Loyalty according to the Moderating Effects of Mother's Preschooler Clothing Involvement (어머니의 유아복 관여도 조절효과에 따른 유아복 소비가치, 구매만족, 브랜드 충성도의 관계연구)

  • Lee, Joo-Yun;Rhee, Young-Ju
    • Journal of the Korea Fashion and Costume Design Association
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    • v.15 no.3
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    • pp.119-135
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    • 2013
  • The purpose of this study was to investigate the relationship between consumption values of preschooler clothing and purchasing satisfaction, company brand loyalty and involvement of preschooler clothing with the mothers of preschoolers. An online survey was adapted as methodology of this study. The collected 323 questionnaires were collected and statistically analyzed. The nine consumption value of preschooler clothing(vicarious satisfaction value, social value, functional value, convenient value, economic value, coordination value, aesthetic value, distinctive value, and fashionable value) resulted from the analysis of survey. Purchasing satisfaction, company brand loyalty, involvement of preschooler clothing was Uni-dimensional. Statistical analysis was performed with frequency analysis, descriptive statistics, exploratory factor analysis, multi-group analysis, confirmatory factor analysis, bivariate correlation analysis, distribution, structural equation, cluster analysis, independent sample t-test, one-way analysis of variance. The results of this study are as follows. In the consumption value of preschooler clothing influencing on the purchasing satisfaction was evaluated depending on the involvement of preschooler clothing group (high-involvement group, low-involvement group). In the low-involvement group, the most significant consumption value of preschooler clothing are economic value, convenient value, social value in order of importance; though in the high-involvement group, aesthetic value, social value, economic value in order of importance. Also the brand royalty was more affected by the purchasing satisfaction in the high-involvement group than in the low-involvement group. In conclusion, the relations of consumption value of preschooler clothing with purchasing satisfaction, company brand loyalty, involvement of preschooler clothing was established in study. The significances of this study is to provide the market segmentation strategy depending on the characteristics of preschooler clothing consumers and establish the information and direction to increase the company brand royalty and purchasing satisfaction.

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Pharmacological Systemic Analysis of Curcumae Radix in Lipid Metabolism (시스템 분석을 통한 지질대사에서 울금의 약리작용)

  • Jo, Han Byeol;Kim, Ji Young;Kim, Min Sung;An, Won Gun;Lee, Jang-Cheon
    • Herbal Formula Science
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    • v.26 no.3
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    • pp.237-250
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    • 2018
  • Objectives : This study is a pharmacological network approach, aimed to identify the potential active compounds contained in Curcumae Radix, and their associated targets, to predict the various bio-reactions involved, and finally to establish the cornerstone for the deep-depth study of the representative mechanisms. Methods : The active compounds of Curcumae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : The target information from 32 potential active compounds of Curcumae Radix was collected through TCMSP analysis. The active compounds interact with 133 target genes engaging in total of 885 biological pathways. The most relevant pathway was the lipid-related metabolism, in which 3 representative active compounds were naringenin, oleic acid, and ${\beta}-sitosterol$. The mostly targeted proteins in the lipid pathway were ApoB, AKT1 and PPAR. Conclusions : The pharmacological network analysis is convenient approach to predict the overall metabolic mechanisms in medicinal herb research, which can reduce the processes of various experimental trial and error and provide key clues that can be used to validate and experimentally verify the core compounds.