• 한국산학기술학회논문지
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• 제19권11호
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• pp.574-582
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• 2018

철도, 자동차, 항공 등의 시스템에서는 시스템의 고장이 사고로 이어져 심각한 인명피해와 경제적 손실로 직결되는 경우가 많기 때문에 시스템 안전의 확보가 매우 중요하다. 기존 연구들에서는 구성품 수준의 정보를 활용해서 고장 분석 및 안전조치를 도출하고 이를 통해 고장이 발생했을 때 피해를 경감시키기 위한 안전설계가 주로 수행되었다. 그러나 기능안전 개념에 의한 설계는 위험원 식별 및 평가 그리고 안전기능을 생성한 후 안전 설계를 통해 안전 목표를 달성하고자 하는 것이다. 따라서 시스템의 기능수준에서 고장의 현재 빈도를 수용 가능한 목표수준으로 빈도를 낮출 수 있는 안전기능을 결정하고 이를 설계에 반영하기 위한 방법에 대한 연구가 필요하다. 이를 달성하기 위하여 본 연구에서는 먼저 시스템모델링 언어인 SysML을 활용하여 안전기능 들에 대해 고장빈도를 반영하기 위한 고장 모델링 방법을 연구하였다. 그리고 나서 생성된 SysML 고장모델 대안들의 시뮬레이션을 통해 각 안전기능 들이 달성할 수 있는 고장빈도의 감축능력을 평가해서 안전목표를 충족하는 대안을 결정하는 방법을 제시하였다. 사례 연구로서 대표적인 안전중시 시스템인 철도신호시스템에 적용하여 유용성을 확인하였다. 철도신호시스템의 안전기능 형태의 설계 대안들에 대해 안전 목표를 충족하는 지를 M&S를 통해 비교평가 하였다. 본 연구의 결과는 시스템의 개념설계 단계에서부터 적용 가능한 방법으로 안전기능을 수행하기 위한 다양한 설계대안 들 중에서 적절한 것을 선택함으로써 안전 목표를 충족하는 시스템의 안전 설계에 유용하게 활용될 수 있을 것이다.

• Journal of Korean Biological Nursing Science
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• 제19권4호
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• pp.227-240
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• 2017

Purpose: The purpose of this review was to identify the current status of nursing studies on heart failure (HF) patients in South Korea and to suggest future study direction. Methods: A literature review of databases such as KoreaMed, KERIS and nursing and allied health journal were searched with key terms 'heart failure' and 'nursing' for the period from January 2000 to February 2017. A total of 35 studies including 28 articles and 7 theses met the inclusion criteria. Results: Twenty-seven out of 35 studies were observational studies on outpatients and most of the studies did not mention the ejection fraction and New York Heart Association functional classification class (NYHA class) in the inclusion criteria. Self-care and health-related quality of life as psychological factors, and physical activity as a biological factor, were used as main variables. However, we found it difficult to understand how much score indicates better quality of life because of an inconsistent and wide score. In quality assessment, 8 intervention studies had no serious flaws. Conclusion: Further studies should consider more biological and social factors influencing HF. The quality assessment with respect to nursing intervention studies in HF showed that randomized and double-blind trials are needed.

• Nuclear Engineering and Technology
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• 제54권8호
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• pp.2915-2923
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• 2022

There is an increasing interest in passive safety systems to minimize the need for operator intervention or external power sources in nuclear power plants. Because a passive system has a weak driving force, there is greater uncertainty in the performance compared with an active system. In previous studies, several methods have been suggested to evaluate passive system reliability, and many of them estimated the failure probability using thermal-hydraulic analyses and the Monte Carlo method. However, if the functional failure of a passive system is rare, it is difficult to estimate the failure probability using conventional methods owing to their high computational time. In this paper, a procedure for the application of the Chernoff bound to the evaluation of passive system reliability is proposed. A feasibility study of the procedure was conducted on a passive decay heat removal system of a micro modular reactor in its conceptual design phase, and it was demonstrated that the passive system reliability can be evaluated without performing a large number of thermal-hydraulic analyses or Monte Carlo simulations when the system has a small failure probability. Accordingly, the advantages and constraints of applying the Chernoff bound for passive system reliability evaluation are discussed in this paper.

• Earthquakes and Structures
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• 제20권4호
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• pp.417-430
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• 2021

Due to functional requirements, SRC column-RC beam abnormal joints with characteristics of strong beam weak column, variable column section, unequal beam height and staggered height exist in the Steel reinforced concrete (SRC) frame-bent main building structure of thermal power plant (TPP). This paper presents the experimental results of these abnormal joints through cyclic loading tests on five specimens with scaling factor of 1/5. The staggered height and whether adding H-shaped steel in beam or not were changing parameters of specimens. The failure patterns, bearing capacity, energy dissipation and ductile performance were analyzed. In addition, the stress mechanism of the abnormal joint was discussed based on the diagonal strut model. The research results showed that the abnormal exterior joints occurred shear failure and column end hinge flexural failure; reducing beam height through adding H-shaped steel in the beam of abnormal exterior joint could improve the crack resistance and ductility; the abnormal interior joints with different staggered heights occurred column ends flexural failure; the joint with larger staggered height had the higher bearing capacity and stiffness, but lower ductility. The concrete compression strut mechanism is still applicable to the abnormal joints in TPP, but it is affected by the abnormal characteristics.

• 동의생리병리학회지
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• 제21권5호
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• pp.1201-1209
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• 2007

The present study was designed to examine whether water extract of Acanthopanacis cortex(AC) has an effect on renal functional parameters in association with the expression of aquaporin 2 (AQP-2) and heme oxygenase-1 (HO-1) in the ischemia/reperfusion induced acute renal failure (ARF) rats. Polyuria caused by down-regulation of renal AQP 2 in the ischemia-induced ARF rats was markedly restored by administration of AC (200 mg/kg, p.o.) with restoring expression of AQP 2 in the kidney. Administration of AC lowered the renal expression of HO-1, which was upregulated in rats with ischemia/reperfusion-induced ARF. The renal functional parameters including creatinine clearance, urinary sodium excretion, urinary osmolality, and solute-free reabsorption were also markedly restored in ischemia-ARF rats by administration of AC. Histological study also showed that renal damages in the ARF rats were abrogated by administration of AC. Taken together, the present data indicate that AC ameliorates renal defects in rats with ischemia/reperfusion-induced ARF.

• Journal of Chest Surgery
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• 제25권2호
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• pp.149-157
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• 1992

Total 145 cases mitral vlave replacement were performed in Department of Thoracic and Cardiovascular Surgery in Chungnam National University Hospital during the period from May 1983 to July 1991. Sixty-one patients were male and 84 patients were female and the range of age was from 12 to 66 years old with the mean of 37.9[$\pm$11.6] years. Valvular lesions were 49 cases of mitral stenosis, 18 cases of regurgitation and 78 cases of combined lesion. Used valve were Ionescu-Shiley[42 cases], Bjork-Shiley[49 cases], Inact[6 cases], St. Jude Medical[11 cases] and CarboMedics[37 cases]. Mean size of valve was 29.8$\pm$1.68mm. Early morality was 13.8%[20 cases] and low output syndrome was most common cause[9 cases]. Age, functional classification and biventricular hypertrophy were risk factors. All survived cases were followed up without missing. Mean follow up period were 3 years and 3 months. Total 14 cases of death[9.7%] were observed and heart failure, unexplained sudden death and bleeding were the causes in that order. Common late complications were heart failure and bleeding related with anticoagulation. Actuarial survival rate at 5 years was 83$\pm$5.4% in overall, 78$\pm$7.2% in tissue valve group, 87$\pm$6.8% in mechanical valve group. The actuarial freedom rate from thromboembolism at 7 years was 89$\pm$8.3% in overall, 86$\pm$9.9% in tissue valve group and 97$\pm$1.9% in mechanical valve group. Actuarial freedom rate from bleeding at 5 years with anticoagulation was 88.9$\pm$4.2% in overall, 96$\pm$3.9% in tissue valve group, 86$\pm$4.6% in mechanical valve group. Reoperation was done in 3 cases with heart failure with tricuspid regurgitation and thromboembolism in 2 cases. The functional status of survived cases was I or II.

• Clinics in Shoulder and Elbow
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• 제26권3호
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• pp.276-286
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• 2023

Background: The transosseous anchorless repair (ToR) technique was recently introduced to avoid suture anchor-related problems. While favorable outcomes of the ToR technique have been reported, no previous studies on peri-implant cyst formation with the ToR technique exist. Therefore, this study compared the clinical outcomes and prevalence of peri-implant cyst formation between the ToR technique and the conventional transosseous equivalent technique using suture anchors (SA). Methods: Cases with arthroscopic rotator cuff repair (ARCR) between 2016 and 2018 treated with the double-row suture bridge technique were retrospectively reviewed. Patients were divided into ToR and SA groups. To compare clinical outcomes, 19 ToR and 57 SA cases without intraoperative implant failure were selected using propensity score matching (PSM). While intraoperative implant failure rate was analyzed before PSM, retear rate, peri-implant cyst formation rate, and functional outcomes were compared after PSM. Results: The intraoperative implant failure rate (ToR, 8% vs. SA, 15.3%) and retear rate (ToR, 5.3% vs. SA, 19.3%) did not differ between the two groups (all P>0.05). However, peri-implant cysts were not observed in the ToR group, while they were observed in 16.7% of the SA group (P=0.008). Postoperative functional outcomes were not significantly different between the two groups (all P>0.05). Conclusions: The ToR technique produced comparable clinical outcomes to conventional techniques. Considering the prospect of potential additional surgeries, the absence of peri-implant cyst formation might be an advantage of ToR. Furthermore, ToR might reduce the medical costs related to suture anchors and, thereby, could be a useful option for ARCR. Level of evidence: III.

• 대한전자공학회논문지
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• 제13권3호
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• pp.1-6
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• 1976

이 논문에서는 Boolean difference를 이용하여 combinational 및 sequential 논리회로에서 발생하는 기능적인 고장에 대한 test pattern을 얻는 방법을 연구하였다. 이 방법은 test pattern을 얻고자 하는 회로의 Boolean 함수의 Boolean difference를 계산하므로써 체계적으로 test pattern을 얻는 절차를 보여주고 있다. 컴퓨터에 의한 실험결과에 의하며 이 방법은 combinational 회로 및 asynchronous sequential 회로에 적합하며, clock이 있는 flip flop을 적당히 모형화함으로서 이 방법을 synchronous sequential회로에도 적용할 수 있음이 입증되었다. In this paper, a method of test pattern generation for the functional failure in both combinational and sequentlal logic networks by using exterded Boole an difference is proposed. The proposed technique provides a systematic approach for the test pattern generation procedure by computing Boolean difference of the Boolean function that represents the Logic network for which the test patterns are to be generated. The computer experimental results show that the proposed method is suitable for both combinational and asynchronous sequential logic networks. Suitable models of clocked flip flops may make it possible for one to extend this method to synchronous sequential logic networks.

• 한국발생생물학회지:발생과생식
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• 제15권4호
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• pp.309-313
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• 2011

SOHLH2 is a novel germ cell-specific transcription factor that is crucial for folliculogenesis in the ovary and spermatogenesis in the testis. SOHLH2 represents a candidate gene for infertility with premature ovarian failure. We analyzed whether mutations in the SOHLH2 gene in 98 Korean women with premature ovarian failure. The sequence analysis identified six novel SNPs (c.431-41G>C, c.656A>T, c.1000+27C>T, c.1000+33G>T, c1258-106G>A, and c.2094+ 11T>C) from Korean patients with premature ovarian failure. The c.656A>T found in exon 7 results in change of an amino acid, tyrosine to phenylalanine. Functional mutations in SOHLH2 gene are rare in Korean women with premature ovarian failure.

• 대한안전경영과학회지
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• 제15권1호
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• pp.11-19
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• 2013

In modern systems design and development, one of the key issues is considered to be related with how to reflect faithfully the stakeholder requirements including customer requirements therein, thereby successfully implementing the system functions derived from the requirements. On the other hand, the issue of safety management is also becoming greatly important these days, particularly in the operational phase of the systems under development. An approach to safety management can be based on the use of the failure mode effect and analysis (FMEA), which has been a core method adopted in automotive industry to reduce the potential failure. The fact that a successful development of cars needs to consider both the complexity and failure throughout the whole life cycle calls for the necessity of applying the systems engineering (SE) process. To meet such a need, in this paper a method of FMEA is developed based on the SE concept. To do so, a process model is derived first in order to identify the required activities that must be satisfied in automotive design while reducing the possibility of failure. Specifically, the stakeholder requirements were analyzed first to derive a set of functions, which subsequentially leads to the task of identifying necessary HW/SW components. Then the derived functions were allocated to appropriate HW/SW components. During this design process, the traceability between the functions and HW/SW components were generated. The traceability can play a key role when FMEA is performed to predict the potential failure that can be described with the routes from the components through the linked functions. As a case study, the developed process model has been applied in a project carried out in practice. The results turned out to demonstrate the usefulness of the approach.