• 한국산학기술학회논문지
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• 제15권8호
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• pp.5327-5332
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• 2014

우리나라 연안생태계는 백화현상(갯녹음)에 의한 해조류의 감소와 어패류 등 어업자원의 감소로 인해 연안역의 황폐화에 직면해 있다. 새로운 유형의 인공어초에 대한 안정성을 평가하기 위해 본 연구에서는 2차원 단면수조를 이용하여 새롭게 개발된 인공어초의 설치수심에 따른 재현파고, 주기, 흐름 등 외력을 변화시켜 요철형 어초의 안정 조건이 되는 한계치를 구하고, 설계외력(파랑, 흐름 등)의 안정성에 대한 검토를 수행하였다. 본 연구 결과는 새로운 인공어초의 설계 및 실해역에 시공하기 위해 구조물의 안정성을 사전에 검토할 수 있는 있는 기초자료를 제공할 수 있을 것으로 판단된다.

• 한국안전학회지
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• 제21권1호
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• pp.133-140
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• 2006

1997년 도쿄의정서(protocol)에서는 지구환경오염에 대한 오염원방지를 제안하는 협정으로 우리나라에서도 배출기준에 감소하기 위한 노력의 일환으로 건축자재에 대한 방출농도 기준을 마련하고 있는 실정이다. 그러나, 최근 건축공사에는 많은 종류의 건축자재와 내장재료가 사용되고 있으며, 특히 화학기술의 발달로 복합재료로 구성된 건축재료들에 대한사용이 증가하고 있다. 실내건축자재에서 방출되는 물질로 인하여 재실자들에게 두통, 현기증, 메스꺼움, 졸음, 집중력 감퇴 등의 각종 질병을 불러일으키는 '새집 증후군'과 같은 현상을 야기 시켜 건강 상 많은 영향을 주고 있는 것으로 조사되고 있으며, 이러한 문제 해결을 위해서는 각 나라마다 건축물에 사용되어 지는 건축자재에 대한 유기 화합물의 방출농도를 최소화하는 친환경 건축자재의 선정을 권고하는 실정이다. 이에 본 연구에서는 건축자재의 TVOCs 에 대한 HCHO의 등급기준을 제안하고자 한다.

• Reproductive and Developmental Biology
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• 제34권2호
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• pp.103-109
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• 2010

Functional regulation of a specific tissue or organ is controlled by a number of ways, including local cell-cell interaction. Of several forms of cell-cell junctional complexes, gap junctions are caught a great attention due to a formation of direct linkage between neighboring cells. Gap junctions are consisted of connexin (Cx) isoforms. In the present study, we evaluated expressional profiling of Cx isoforms in the rat initial segment (IS) of the male reproductive tract at different postnatal ages. The presence and expression of 13 Cx isoform mRNAs were determined by semi-quantitative real-time PCR analyses. A total of 8 Cx isoform mRNAs were detected in the IS of the male rats during postnatal development. The highest level of Cx30.3 mRNA was found at 5 months of age, while abundance of Cx31 mRNA was the highest at 1 year of age. Expression of Cx31.1 gene was relatively consistent during the postnatal development. Fluctuation of Cx32 and 37 gene expression was observed during the postnatal period. Significant elevation of Cx40 mRNA abundance was detected at 25 days of age and older ages. Expression patterns of Cx43 and 45 genes were similar with the highest level at 2 weeks of age, followed by gradual decreases at older ages. These results indicate differential regulation on expression of Cx isoforms in the rat IS during postnatal development. A complicated regulation of gene expression of Cx isoforms in the IS at different postnatal ages is suggested.

• 생명과학회지
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• 제21권7호
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• pp.1016-1024
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• 2011

영지버섯, 여주, 쓴메밀 및 이들 혼합 시료의 70% 메탄올 추출물을 이용하여 생리활성물질(폴리페놀 화합물 및 플라보노이드) 농도와 항산화(DPPH radical 소거 활성, 생체막 지질과산화, Fe/Cu 환원력), ${\alpha}$-glucosidase 저해, tyrosinase 저해 및 항혈전 활성에 대하여 검토하였다. 추출 수율과 폴리페놀 화합물 및 플라보노이드의 함량은 혼합 추출물에서 가장 높았다. 또한 혼합 추출물에서 ${\alpha}$-glucosidase 저해, tyrosinase 저해, 항산화, 환원력 및 항혈전 활성은 혼합 추출물에서 가장 높았으며, 이러한 효과는 처리 농도 의존적 이였다. 이상의 실험 결과에서 영지버섯, 여주, 쓴메밀의 혼합 메탄올 추출물은 폴리페놀 화합물과 플라보노이드를 많이 함유함으로서 높은 ${\alpha}$-glucosidase 저해 및 항산화 활성과 관련성이 높아 보여 항당뇨 건강 기능성식품의 소재 개발에 활용될 가능성이 높아 보인다.

• 한국수산과학회지
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• 제43권5호
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• pp.437-444
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• 2010

Extracts of the marine microalgae Nannochloropsis oculata were obtained using 80% methanol (MeOH) and water. The 80% MeOH extract was further fractionated with n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol (n-BuOH), and water to isolate the active fraction. Seven samples were prepared and their angiotensin converting enzyme (ACE), $\alpha$-glucosidase, and cancer cell growth inhibitory activities in vitro were determined. The most profound ACE inhibitory activity was observed in the chloroform fraction, while the others had moderate effects. By contrast, greater $\alpha$-glucosidase inhibitory activity was found in the EtOAc fraction, n-hexane fraction, and water extract of N. oculata. The antiproliferative effects of the extracts and fractions against HL-60, U937, CT-26, and SK-Hep1 cancer cells were also determined. The n-BuOH fraction had the strongest antiproliferative effects on CT-26 cells in a time-dependant manner (P<0.05). These results suggest that the extracts and fractions from N. oculata could be used as a potential functional food or as pharmaceutical ingredients.

• 한국조리학회지
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• 제14권3호
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• pp.136-142
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• 2008

This study was conducted to investigate the correlation of the physicochemical quality index(pH, acidity, reducing sugar content and lactic acid bacterial count) and sensory index(sourness) of Kakdugi during the fermentation at 5$^{\circ}C$, 10$^{\circ}C$ and 20$^{\circ}C$ respectively. Also, the relations between physicochemical quality index and overall acceptability were carried out. The pH range, based on the middle sour intensity point of 4.5, was 5.75 at 5$^{\circ}C$ fermentation, whereas that was 4.2 at 10$^{\circ}C$ and 20$^{\circ}C$ fermentation. The pH showing the highest overall acceptability decreased along with increased fermentation temperature. The reduced sugar content decreased rapidly up to 0.9% acidity, but after that, decreased slowly from more than 0.9% acidity at all fermentation temperatures. With increased fermentation temperature, the reduced sugar content showing the highest overall acceptability also showed the decreasing tendency. Change patterns of lactic acid bacterial count and sourness didn't coincided at 5$^{\circ}C$ fermentation, whereas those did at 10$^{\circ}C$ and 20$^{\circ}C$ fermentation. The indexes showing high significant correlations with sourness of Kakdugi fermented at 5$^{\circ}C$ were not pH and lactic acid bacterial count but acidity and reducing sugar content(p<0.05). The sourness of Kakdugi fermented at 10$^{\circ}C$ and 20$^{\circ}C$ showed high significant correlations with all of the physicochemical index(p<0.05).

• Molecules and Cells
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• 제43권6호
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• pp.581-589
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• 2020

Neurons have multiple dendrites and single axon. This neuronal polarity is gradually established during early processes of neuronal differentiation: generation of multiple neurites (stages 1-2); differentiation (stage 3) and maturation (stages 4-5) of an axon and dendrites. In this study, we demonstrated that the neuron-specific n-glycosylated protein NELL2 is important for neuronal polarization and axon growth using cultured rat embryonic hippocampal neurons. Endogenous NELL2 expression was gradually increased in parallel with the progression of developmental stages of hippocampal neurons, and overexpression of NELL2 stimulated neuronal polarization and axon growth. In line with these results, knockdown of NELL2 expression resulted in deterioration of neuronal development, including inhibition of neuronal development progression, decreased axon growth and increased axon branching. Inhibitor against extracellular signal-regulated kinase (ERK) dramatically inhibited NELL2-induced progression of neuronal development and axon growth. These results suggest that NELL2 is an important regulator for the morphological development for neuronal polarization and axon growth.

• 한국전문물리치료학회지
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• 제14권1호
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• pp.11-20
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• 2007

The objective of this study was to discern the effects of a balance training program on the performance of lower extremities in order to improve strength (muscle power, flexibility, walking power), balance control and walking ability in the elderly. The subjects selected were aged 65 years and over, with no known relevant medical history that may disturb their balance, and have also been visiting the Gimhae Senior Welfare Center. The variable group consisted of 30 subjects, of whom were people who had been participating in balance training programs (One Leg Standing; OLS, Functional Reach; FR, Timed Get Up and Go; TUG) as an intervention for 8 weeks 3 times per a week. They were examined in order to identify their balance control before and after. The control group consisted of thirty subjects who preferred to exercise without any intervention relating to balance training program. The subjects were measured before and after balance training in order to determine the effectiveness of exercise and the effectiveness of exercise combined with the aid of a Balance Performance Monitor. 1. Mean time on OLS test with left and right sided extremities in the experimental group was 35.44 sec, 42.10 sec longer than control group respectively. In FR tests applied to the left and right side, mean reaching distance was increased up to 5.56 cm, 6.73 cm in experimental group respectively. Mean time on TUG test from a chair in experimental group was decreased to 2.33 sec. 2. Mean value of decline in the level balance control, both left and right side, decreased to 2.24% as examined by the Balance Performance Monitor. Mean scores for sway level after balance training decrease to .98% and for balance control both anterior and posterior directions decreased to mean 1.07% and 1.44%, respectively.

• 한방비만학회지
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• 제14권1호
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• pp.29-35
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• 2014

Objectives: This study was to investigate how body-shape perception could influence to weight control practice both in normal and obese group. Methods: We used 2012 Korea National Health and Nutrition Examination Survey to analysis 1) weight control practices of population; 2) consistency between body-shape perception and body mass index; 3) comparison weight control practices between normal group and body mass index (BMI) obese group in perceptional obese group; 4) odds ratio of BMI obese group using herbal drugs for weight control practice in perceptional obese group. Results: We found that study population tends to choose exercise, dietary restriction, meal skip, health functional food, one-food, drug, herbal drug, fasting and self-medication in order of frequency to control weight. The agreement between body-shape perception and BMI within obese group was approximately 64% with 0.40 of Cohen's Kappa coefficient, ranging from 0.384 to 0.423. Within perceptional obese group, choosing each weight control practice methods ratios between normal BMI group and obese BMI group were not significantly different. Within perceptional obese group, obese BMI group showed significant odds ratio (2.58, 95% confidence intervals, 1.38~4.85) than normal BMI group in choosing herbal medication for weight loss when adjusting other variables. Conclusions: We concluded that body-shape perception might be an important factor for choosing weight control program, and roles of Korean medical doctors thought to be enhanced for using herbal medication for weight loss.

• 한국식품저장유통학회지
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• 제22권3호
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• pp.322-327
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• 2015

죽순분말을 첨가한 전병을 제조하여 첨가 수준별 품질특성을 조사하였다. 죽순분말 첨가 전병의 일반성분 중 조단백질, 식이섬유와 회분의 경우 죽순 분말 첨가량이 증가할수록 높아지는 경향을 보였고 조지방은 감소하였다. 유리아미노산 함량의 경우 죽순분말을 첨가할수록 증가하는 결과를 보였다. 색도에서 명도를 나타내는 L값은 죽순 분말 첨가량이 높아지면서 증가하였고, 무첨가구 시료와 타 시료간의 색차값을 비교한 ${\Delta}E$ 값의 변화는 죽순 분말 100 g 첨가구가 4.58로 나타나 죽순 분말 첨가가 전병 고유의 색에 영향을 주는 것으로 나타났다. 유리당 함량은 죽순 분말을 첨가하면서 다소 감소하는 것으로 나타났다. 관능에 따른 시료별 선호도 결과 죽순 300 g 첨가 시료가 색(color), 향미(flavor), 맛(taste), 식감(chewiness) 모두 가장 높은 값을 나타냈다. 전반적 기호도와 다양한 관능검사 결과를 종합하여 볼 때 전병에 첨가하는 죽순분말의 적정비율은 300 g 수준이 가장 좋은 것으로 나타났다.