• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.263-263
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• 2006

Poly (ethylene glycol)(PEG) - Poly (${\varepsilon}-caprolactone(CL)$) - Poly (D,L lactide(LA) (PCLA-PEG-PCLA) was synthesized by ring-opening polymerization to form temperature sensitive hydrogel triblock copolymer. The triblock copolymer was acrylated by acryloyl chloride. ${\beta}-amino$ ester was used as a pH sensitive moiety, in this study ${\beta}$- amino ester obtained from 1,4-butandiol diacrylate, and 4, 4' trimethylene dipiperidine, it have pKb around 6.6. pH/temperature sensitive penta-block copolymer (PAE-PCL-PEG-PCL-PAE) was synthesized by addition polymerization from acrylated triblock copolymer, 1,4-butandiol diacrylate, and 4, 4' trimethylene dipiperidine. Their physicochemical properties of triblock and penta-block copolymers were characterized by $^1H-NMR$ spectroscopy and gel permeation spectroscopy. Sol-gel phase transition behavior of PAE-PCL-PEG-PCL-PAE block copolymers were investigated by remains stable method. Aqueous media of the penta-block copolymer (at 20 wt%) changed from a sol phase at pH 6.4 and $10^{\circ}C$ to a gel phase at pH 7.4 and $37^{\circ}C$. The sol-gel transition properties of these block copolymers are influenced by the hydrophobic/hydrophilic balance of the copolymers, block length, hydrophobicity, stereo-regularity of the hydrophobic of the block copolymer, and the ionization of the pH function groups in the copolymer depended on the changing of environmental pH, respectively. The degradation and the stabilization at pH 7.4 and $37^{\circ}C$, and the stabilization at pH 6.4 and $10^{\circ}C,\;5^{\circ}C,\;0^{\circ}C$, of the gel were determined. The results of toxicity experiment show that the penta block copolymer can be used for injection drug delivery system. The sol?gel transition of this block copolymer also study by in vitro test ($200{\mu}l$ aqueous solution at 20wt% polymer was injected to mouse). Insulin loading and releasing by in vitro test was investigated, the results showed that insulin can loading easily into polymer matrix and release time is around 14-16days. The PAE-PCL-PEG-PCL-PAE can be used as biomaterial for drug, protein, gene loading and delivery.

• 한국구조물진단유지관리공학회 논문집
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• 제13권6호통권58호
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• pp.176-182
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• 2009

단조롭고 자연친화적이지 못한 기존 연안블록의 설계 및 시공으로 인하여, 연안침식방지 블록이 효과적으로 제 기능을 발휘하지 못하고 또 다른 피해가 발생되고 있다. 국민소득의 증대와 Waterfront 개념의 빠른 확산으로 연안 어항의 낙후된 시설개선 등에 많은 사업이 추진되고 있으나 이러한 용도에 맞는 자연 친화형 구조물이 개발된 바 없어 기존의 Solid Block, Igloo Block, Tunnel Block 등이 일부 현장에 적용되고 있는 실정이다. 선박이 계류하는 안벽이나 물양장 등에서 항내 진입파와 항파 등으로 인한 반사파의 발생에 의한 공진현상으로 항내파고가 높아져 정온도유지가 어렵고 선박의 계류 및 하역에 지장을 주게 되며, 선박과의 충돌 발생으로 인한 소형선박의 손괴 발생율이 높은 실정이므로 새로운 형태의 블록(Block)개발이 필요하다. 이에 따라 개발한 C.E.(Coastal Environments)블록을 현장에서 사용하기 위해서는 전단키 부분의 내하력 평가가 요구 된다. 따라서, 본 연구는 C.E. 블록의 연결부 시험편을 제작하여 C.E.블록 경계면의 마찰실험을 실시하였으며, 실험에서 얻은 C.E.블록 연결부의 마찰계수를 유한요소 해석에 사용하여 C.E.블록의 블록과 블록 접촉면의 마찰 계수를 산정하고자 한다.

• International Journal of Naval Architecture and Ocean Engineering
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• 제6권2호
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• pp.459-470
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• 2014

During ship design, welding-induced distortions are roughly estimated as a function of the size of the component as well as the welding process and residual stresses are assumed to be locally in the range of the yield stress. Existing welding simulation methods are very complex and time-consuming and therefore not applicable to large structures like ships. Simplified methods for the estimation of welding effects were and still are subject of several research projects, but mostly concerning smaller structures. The main goal of this paper is the application of a multi-layer welding simulation to the block joint of a ship structure. When welding block joints, high constraints occur due to the ship structure which are assumed to result in accordingly high residual stresses. Constraints measured during construction were realized in a test plant for small-scale welding specimens in order to investigate their and other effects on the residual stresses. Associated welding simulations were successfully performed with fine-mesh finite element models. Further analyses showed that a courser mesh was also able to reproduce the welding-induced reaction forces and hence the residual stresses after some calibration. Based on the coarse modeling it was possible to perform the welding simulation at a block joint in order to investigate the influence of the resulting residual stresses on the behavior of the real structure, showing quite interesting stress distributions. Finally it is discussed whether smaller and idealized models of definite areas of the block joint can be used to achieve the same results offering possibilities to consider residual stresses in the design process.

• The Korean Journal of Pain
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• 제12권2호
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• pp.238-241
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• 1999

Intractable pain arising from disorders of the viscera and somatic structures within the pelvis and perineum often poses difficult problems for the pain pratitioner. The reason for this difficulty is that the region contains diverse anatomic structures with mixed somatic, visceral, and autonomic innervation affecting bladder and bowel control and sexual function. Clinically, sympathetic pain in the perineum has a distinctly vague, burning, and poorly localized quality and is frequently associated with the sensation of urgency. Although various approaches have been proposed for the management of intractable perineal pain, their efficacy and applications are limited. Historically, neurolytic blockade in this region has been focused mainly on somatic rather than sympathetic components. The efficacy of neurolytic ganglion impar block has been demonstrated in treating perineal pain without significant somatovisceral dysfunctions for patient with advanced cancer in 1990. The introduction of superior hypogastric plexus block in 1990 demonstrated its effectiveness in patients with cancer related pelvic pain. In our report, five patients had advanced cancer (rectal caner 3; cervix cancer 1; metastases to sacral portion of renal cell cancer 1). Localized perineal pain was present in all cases and was characterized as burning and urgent with 9~10/10 pain intensity. After neurolytic block of ganglion impar, patients experiened incomplete pain reduction (7~8/10), as determined by the VAS (visual analogue scale), and change in pain site. We then treated with superior hypogastric plexus block, which produced satisfactory pain relief (to less than 4/10), without complication.

• 재활치료과학
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• 제7권1호
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• pp.63-77
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• 2018

목적 : 본 연구는 기능적 전기 자극을 병행한 과제 지향적 훈련이 불완전 경수 손상 환자의 손 기능에 미치는 영향을 알아보고자 하였다. 연구방법 : 대상자는 불완전 경수 손상 진단을 받은 성인 3명으로, ABA 설계를 사용하였으며, 연구기간 동안 기초선(A1) 5회기, 중재기(B) 20회기, 재기초선(A2) 5회기로 총 30회기 실시하였다. 중재기(B) 동안 기능적 전기 자극을 병행한 과제 지향적 훈련이 제공되었고, 모든 회기에는 손 기능을 평가하기 위해 상자와 나무토막 검사(Box and Block Test), 떨어지는 막대 잡기(Grip the falling bar)와 먹기 흉내 내기(Simulated feeding)를 측정하였으며, 기초선(A1) 전, 재기초선(A2) 후로 Canadian Occupational Performance Measure(COPM), Jebsen-Taylor Hand Function Test(JTHFT)와 Wolf Motor Function Test(WMFT)를 실시하여 중재 효과를 살펴보았다. 결과 : 모든 대상자는 상자와 나무토막 검사(Box and Block Test), 떨어지는 막대 잡기(Grip the falling bar)와 먹기 흉내 내기(Simulated feeding)를 통해 기초선(A1)보다 중재기(B)에서 우세 손 기능이 향상되었고, 재기초선(A2)에서 그 효과가 유지되었다. 재기초선(A2) 후 COPM, JTHFT와 WMFT의 결과, 우세 손 기능의 향상과 과제 수행도와 만족도의 향상을 보였다. 결론 : 기능적 전기 자극을 병행한 과제 지향적 훈련은 경수 손상 환자의 손 기능뿐만 아니라, 대상자가 선택한 훈련 과제의 과제 수행도와 만족도 향상에 효과적이다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집C
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• pp.333-338
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• 2001

Fault tree is a widely used methodology for analyzing product reliability. The fault trees are usually constructed using the experiences of expert reliability engineers in top-down approaches and have different structures according to each expert's subjectivity. In this work it is tried to find a general method for the fault tree construction based on the function tree that is the result of product function deployment. Based on the function tree, the method has the advantage of resulting an objective fault tree since the faults are defined as the opposite concept of functions. The fault tree construction of this work consists of the following steps: 1) definition of product primary function with the viewpoints of product operation and configuration, 2) construction of functional relation chart using a grouping algorithm, 3) abstraction of functional block diagram according to operation sequences and configuration of a product, 4) construction of function tree for each viewpoint, and 5) construction of fault tree by matching the function tree and simplification of the result.

• 조명전기설비학회논문지
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• 제19권3호
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• pp.44-50
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• 2005

본 논문에서는 산화아연(이하 ZnO) 피뢰기 열화진행의 한 요인으로 예측되는 전극과 ZnO소자 사이에서 발생하는 방전광 현상에 관한 연구를 수행하였다. 이를 위해 $8/20[{\mu}s]$, 최대 10[kA]의 뇌임펄스전류를 발생시키는 뇌임펄스전류 발생장치를 설계${\cdot} $제작하였다. 실험결과, 상${\cdot}$하부의 전극 부근에서 발생하는 방전광의 형상은 인가되는 뇌임펄스의 극성에 따라 다르게 나타났으며 상대적으로 (-)극의 전극부근에서 방전광이 더 강하고 활발하게 발생하는 것으로 관찰되었다. 또한 전극의 면적에 따른 방전광의 세기는 전극의 면적이 증가할수록 감소하는 것으로 관측되었다. 동시에 전극과 소자의 접촉상태도 방전광의 발생과 매우 밀접한 관계가 있는 것으로 확인되었다. 따라서 배전급 ZnO피뢰기의 기존 전극구조는 보완이 필요하며 ZnO피뢰기 제품의 성능향상 및 지속적인 성능유지를 위해서는 환형구조 대신 내부면적이 있는 원판구조로 교체하는 것이 바람직하다고 판단된다.

• The Korean Journal of Pain
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• 제7권2호
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• pp.162-169
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• 1994

Blockade of cervicothoracic sympathetic ganglion (stellate ganglion controls pain on face, head, neck, shoulder, upper limbs, and upper chest, including their viscera and sympathetically maintained pain. This procedure also increases blood flow to the above areas and relieves hyperreactivity of sympathetic nervous system. Clinically, repeated stellate ganglion blocks with local anesthetic agent may become difficult with complications such as accidental intravascular or subdural injection, recurrent laryngeal nerve or bracheal plexus paralysis, pneumothorax and edema on injection site. Therefore, at times long-term cervicothoracic ganglion block with neurolytics is necessitated but its applications are prohibited by the critical structures surrounding ganglion. There are also few reports of neurolytic stellate ganglion block. This study was performed to observe the complications, gross changes of surrounding structures, and microscopic findings of ganglion cells after neurolytic block and to certify the possibility of clinical use of neruolytic stellate ganglion block. The unilateral superior cervical sympathetic ganglion of rabbit was blocked with absolute ethyl alcohol 0.4 ml at the level of cricoid cartilage. Normal ganglion was used as a control and 5 animals were sacrificed at each intervals of 7, 15 and 50 days after block. The results were as follows; 1) All experimental animals showed no specific changes of behavior, motor function. No necrotic tissues were present in the block area during the observation period. There were some gross scar tissues along the fascia of muscles surrounding the needle injection site, but gross atrophy of muscles or injured major vessels were not found. 2) Microscopically, structures of normal ganglion of rabbit were very similar to those of humans. Seven days after absolute ethyl achohol injection there were marked edema of ganglion cells and nuclei with irregular nuclear membrane. Some of the ganglion cells lost their nuclei and showed degenerative changes. Fifteen days after block, cell edema were decreased and loss of the Nissl's body was prominant. The ganglion cell structures looked close to normal but the cytoplasm and nucleus were generally contracted 50 days after block. These results suggest absolute ethyl alcohol injection on cervical sympathetic ganglion with above method mainly blocks pre- and post-synaptic fibers and the long-term neurolytic blockade of this ganglion may be possible in rabbits.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (A)
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• pp.68-69
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• 2008

• Communications for Statistical Applications and Methods
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• 제4권1호
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• pp.49-63
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• 1997

We consider the problem of classifying a p x 1 observation into one of two multivariate normal populations when the training smaples contain a block of missing observation. A new classification procedure is proposed which is a linear combination of two discriminant functions, one based on the complete samples and the other on the incomplete samples. The new discriminant function is easy to use.