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일정한 약물 투여를 통한 HIV 감염자의 long-term Non-Progressor 전환 치료 (Treatment for HIV-Infected Patients to Induce Long-Term Non-Progressor with Constant Drug Dosage)

  • 김진영;김원희;고지현;정한별;정정주
    • 대한전기학회논문지:시스템및제어부문D
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    • 제54권4호
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    • pp.259-266
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    • 2005
  • This paper presents a therapy that uses a constant drug dosage for leading HIV-infected patient to LTNP (Long-Term Non-Progressor). Based on analysis of CTLp (Cytotoxic T Lymphocyte precursor) concentration at equilibrium point and its bifurcation, we found the therapy with a drug whose efficacy is less than a certain level brings higher CTLp concentration at the equilibrium point. We observed a treatment with constant drug dosage whose efficacy is less than full treatment may lead HIV-infected patient to LTNP. It turns out that the treatment whose efficacy is less than full treatment is better in the point of performance on controllability.

만삭아에서 발생한 상부위장관 출혈에 대한 임상적 고찰 (Upper Gastrointestinal Bleeding in Full-Term Infants)

  • 최현주;김재선;윤혜선;배선환
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제8권2호
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    • pp.164-171
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    • 2005
  • 목 적: 건강한 만삭아로 출생한 신생아에서 상부위장관 출혈의 임상적 특징, 위내시경 소견, 연관된 위험요소 등을 알아보고자 하였다. 방 법: 2002년 1월부터 2003년 12월까지 을지의과대학교 을지병원 신생아 중환자실에 토혈 혹은 혈변을 주소로 입원하여 위내시경상 출혈성 위염 또는 궤양으로 진단된 9명의 환아들을 대상으로 산전인자, 모체인자, 분만소견, 내시경 소견, 예후 등을 후향적으로 조사하였다. 결 과: 1) 9명의 환아 중 원내 출생아는 5명(5명/3,734명)으로 발생률은 0.13%였고, 모두 적정체중 만삭아로 출생 시 가사소견은 없었다. 2) 산모들의 병력상 산전에 위염, 소화성 궤양, 제산제 복용 등의 기왕력, 위장관 질환의 가족력은 없었고, 분만과정 중 특이소견 없었다. 3) 토혈, 혈변, 반복되는 구토가 주증상이었으며, 출생 후 $4.4{\pm}3.8$일에 발생하였고, 입원 시 활력증후는 양호하였고, 혈액검사소견도 정상이었다. 내시경 검사상 출혈성 위염이 6예, 위궤양이 3예였다. 4) 모든 환아는 $H_2$ 수용체 차단제 치료와 보존적 치료을 실시하였고, 치료 시작 후 $0.9{\pm}0.3$일 이내에 임상증상은 호전되었다. $H_2$ 수용체 차단제는 $18.6{\pm}5.0$일 치료하였으며 추적관찰상 증상이 재발된 환아는 없어서 추적 내시경은 실시하지 않았다. 결 론: 만삭아에서 출혈을 동반한 상부위장관 점막질환은 대부분 예후가 양호하여 임상증상이 호전된 경우에는 추적 위내시경 검사는 불필요한 것으로 사료된다.

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수치모형실험을 통한 콘크리트 구조물의 결함탐지에 관한 연구 (Numerical Experiments for Detecting Voids and Defects Inside Concrete)

  • 김용인;변중무;손권익;서백수
    • 산업기술연구
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    • 제24권B호
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    • pp.163-170
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    • 2004
  • In this study, First, the results of travel-time inversion (first arrival inversion using the travel-time of the first arrival) were compared with those of full-wave inversion for numerical data. Numerical experiments to find key parameters other than initial velocity model showed that the frequency of source has a great effect on the result of full-wave inversion. Finally, this research presented the corrected full-wave inversion applying the correction term to the final result of full-wave inversion. The corrected full-wave inversion depicted cavities inside concretes even when the inversion started with 20% error in an initial velocity model for cavities. However, full-wave inversion did not reveal cavities.

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Full-mouth disinfection의 단기간의 임상적 효과 (Clinical short-term effects of full-mouth disinfection)

  • 이신화;김옥수;김영준;정현주
    • Journal of Periodontal and Implant Science
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    • 제37권3호
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    • pp.613-624
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    • 2007
  • Full-mouth disinfection (Fdis) completes the entire scaling and root planing (SRP) in one stage within 24 hours for the prevention of microbial recolonization from untreated sites and ecological niches. The aim of this study is to compare the clinical short-term effects of modified Fdis with those of the conventional SRP in the therapy of moderate and severe chronic periodontitis. Modified Fdis group (5 patients) received the entire SRP within 24 hours using chlorhexidine solution (0.1%) and conventional SRP group (5 patients) received SRP per quadrant at one-week intervals. Clinical parameters were measured at baseline, one month and three months after both therapies. The results of this case report were as follows: 1. There were considerable decreases in sulcus bleeding index and plaque index one month after Fdis. 2. The mean probing depth of single-rooted teeth decreased more in Fdis group than conventional SRP group after therapy and, that of multi-rooted teeth decreased similarly in both groups. 3. The mean probing depth decreased 1.77mm in case of initial probing depth of 4-6mm and it decreased 4.13mm in case of initial probing depth of ${\geq}$ 7mm three months after Felis. 4. There were the smaller increases in gingival recession together with the larger gains in attachment in Fdis group than conventional SRP group after three months. Within the limitations of this study, one could conclude that Fdis has beneficial clinical effects in the treatment of moderate and severe chronic periodontitis and further research would be helpful including more subjects during a longer period to confirm the beneficial long-term effects of Fdis.

환자 및 시설 특성이 장기요양서비스 이용 노인의 자원소모량에 미치는 영향 (The Effects of Patient and Facility Characteristics On the Resource Use by the Elderly in Long-term Care Services)

  • 권순만;김홍수;김선민
    • 보건행정학회지
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    • 제12권1호
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    • pp.21-53
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    • 2002
  • The purpose of this study is to measure the resource use of the elderly in long-term care services and to examine the effects of patient and facility characteristics on their use of resources. The data were collected from 510 old people over sixty years of age, residing in five long-term care hospitals and two skilled nursing homes during the period between December 1, 2000 and February 28, 2001. For a full sample, when the first level of RUG(Resource Use Group)-III categories were employed as the proxy of patient severity, facility characteristics, such as location, size and ownership, have large effects on the resource use measured by service intensity, whereas patient characteristics such as severity have little or no effect. The resource use is significantly high if the facility: (1) is located in rural areas (gun): (2) has mare than 200 beds; (3) is a long-term care hospital; (4) is private; and (5) has a low percentage of medical aid patients. The analysis of the resource use in each RUG-III categories, for which ADL(Ability of Daily Living) were employed as the prosy of patient severity, shows a similar result. The loose relationship between the needs of residents and the resource use seems to be closely associated with the ineffective reimbursement system for providers. The current reimbursement system has no provision for quality improvement and reimburses facilities simply according to their types: fee-for-service for long-term care hospitals, and monthly-flat-rate or full-coverage-national-aid for skilled nursing facilities. It will be necessary to develop a more reasonable reimbursement system that takes patient's severity into account and gives incentives for long-term care providers to offer cost-effective services.

실대형 계단식 보강토 옹벽의 지속 하중하에서의 장기변형 거동 특성 (Long-Term Performance of Full-Scale Tiered Geogrid Reinforced Wall under Sustained Load)

  • 유충식;정혜영;이봉원
    • 한국지반신소재학회논문집
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    • 제4권2호
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    • pp.29-38
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    • 2005
  • 토목합성 보강재를 이용한 보강토 공법을 도로 혹은 철도구조물 등 영구 구조물에 적용하기 위해서는 지속하중 및 반복하중이 작용하는 보강토 구조물의 장기변형 특성을 이해하고 이를 설계/시공에 반영하는 것이 필요하다. 본 논문에서 실대형 지오그리드 보강토 옹벽에 포설된 지오그리드의 유발 인장변형율에 대한 장기계측 결과를 토대로 장기거동 특성을 분석하였다. 3년여에 걸친 계측결과를 분석한 결과 보강토 옹벽에 포설된 보강재의 유발 인장 변형율은 시공완료후 지속적으로 증가하는 경향을 보였으며 전반적으로 응력이 집중되는 위치에 포설된 보강재의 증가가 뚜렷하게 관찰되었다. 러한 결과로부터 중요 구조물의 일부로 시공되는 보강토 옹벽의 설계/시공시에는 장기변형에 대한 고려가 필요한 것으로 나타났다.

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Modification of RFSP to Accommodate a True Two-Group Treatment

  • Bae, Chang-Joon;Kim, Bong-Ghi;Suk, Soo-Dong;D. Jenkins;B. Rouben
    • 한국원자력학회:학술대회논문집
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    • 한국원자력학회 1996년도 춘계학술발표회논문집(1)
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    • pp.185-190
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    • 1996
  • RFSP is a computer program to do fuel management calculations for CANDU reactors. Its main function is to calculate neutron flux and power distributions using two-energy-group, three dimensional neutron diffusion theory. However, up to now the treatment has not been true two-group but actually "one-and-half groups". In other words, the previous (1.5-group) version of RFSP lumps the fast fission term into the thermal fission term. This is based on the POWDERPUFS-V Westcott convention. Also, there is no up-scattering term or bundle power over cell flux (H1 factor) for the fast group. While POWDERPUFS-V provides only 1.5 group properties, true two-group cross sections for the design and analysis of CAUDU reactors can be obtained from WIMS-AECL. To treat the full two-group properties, the previous RFSP version was modified by adding the fast fission, up-scatter terms, and H1 factor. This two-group version of RFSP is a convenient tool to accept lattice properties from any advanced lattice code (e.g. WIMS-AECL DRAGON, HELIOS...) and to apply to advanced fuel cycles. In this study, the modification to implement the true two-group treatment was performed only in the subroutines of the *SIMULATE module of RFSP. This module is the appropriate one to modify first, since it is used for the tracking of reactor operating histories. The modified two-group RFSP was evaluated with true two-group cross sections from WIMS-AECL. Some tests were performed to verify the modified two-group RFSP and to evaluate the effects of fast fission and up-scatter for three core conditions and four cases corresponding to each condition. The comparisons show that the two-group results are quite reasonable and serve as a verification of the modifications made to RFSP. To assess the long-term impact of the full 2-group treatment, it is necessary to simulate a long period (several months) of reactor history. It will also be necessary to implement the full two-group treatment of reactivity devices and assess the reactivity-device worths.ce worths.

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일개 시 보건소의 모자보건 선도보건사업 평가에 대한 연구 (A Study on the Evaluation of Maternal Child Health Services in Public Health Centers)

  • 김용순;박지원;방경숙;정순이;우혜숙;이혜정;장현순
    • 지역사회간호학회지
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    • 제13권2호
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    • pp.280-291
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    • 2002
  • Objectives: This study was conducted to evaluate the maternal child health services provided by public health centers in Pyungtaek city. Methods: Data were collected based on multiple sources of official records. A questionnaire survey was obtained from 50 mothers with premature babies, and 89 mothers with full- term babies, in order to compare their demographic factors, and physical, obstetrical, and emotional status. In addition, the investigators collected data on pre and post follow-up care for the remature group to evaluate the effects of home visiting services on them. Moreover, additional data were collected from 135 pregnant women and 315 mothers with infants, to assess their degree of satisfaction for prenatal education course and breast feeding practices. Results: 1) The pregnant women's satisfaction for the prenatal education course, knowledge, and practices on self care were considered to be high. 2) Of the mothers with infants, 62.9% experienced breast feeding, but only 35.9% of them did it for six months. 3) Premature birth rate in the region was 5.6%, and 75.6% of all premature babies received follow-up care. 4) The mothers with premature babies experienced premature rupture of membrane. placenta previa, preeclampsia, and cesarean section more frequently than the mothers with full-term babies. 5) At the pre-intervention data collection point. mothers with premature babies experienced significantly less social support than mothers with full-term babies. In addition, mothers with premature babies reported higher levels of stress and care-giving burdens, and lower level of self esteem, than mothers with full-term babies, although the differences were not statistically significant. 6) In the premature group, stress, care giving burdens, and postpartum depression decreased after the intervention, whereas maternal self esteem, and the husband's support were increased after the intervention. Social support from significant others were somewhat decreased. 7) Satisfaction for the home visiting service in the mothers with premature babies was very high. Conclusion: These results showed a possibility that the recently started maternal child health services provided by the public health centers may be efficient. Although statistically significant differences were not found, the investigators found a potential for changes in a positive direction. Long-term effects of the health services on maternal child health needs should be addressed in future studies.

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