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Treatment for HIV-Infected Patients to Induce Long-Term Non-Progressor with Constant Drug Dosage (일정한 약물 투여를 통한 HIV 감염자의 long-term Non-Progressor 전환 치료)

  • Kim Jinyoung;Kim Won Hee;Ko Ji Hyun;Chung Han Byul;Chung Chung Choo
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.54 no.4
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    • pp.259-266
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    • 2005
  • This paper presents a therapy that uses a constant drug dosage for leading HIV-infected patient to LTNP (Long-Term Non-Progressor). Based on analysis of CTLp (Cytotoxic T Lymphocyte precursor) concentration at equilibrium point and its bifurcation, we found the therapy with a drug whose efficacy is less than a certain level brings higher CTLp concentration at the equilibrium point. We observed a treatment with constant drug dosage whose efficacy is less than full treatment may lead HIV-infected patient to LTNP. It turns out that the treatment whose efficacy is less than full treatment is better in the point of performance on controllability.

Upper Gastrointestinal Bleeding in Full-Term Infants (만삭아에서 발생한 상부위장관 출혈에 대한 임상적 고찰)

  • Choi, Hyon Ju;Kim, Jae Seon;Yoon, Hye Sun;Bae, Sun Hwan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.8 no.2
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    • pp.164-171
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    • 2005
  • Purpose: The aim of this study was to evaluate the clinical characteristics, endoscopic findings and risk factors related to the upper gastrointestinal bleeding (UGIB) seen in full-term infants. Methods: A clinical analysis for 9 cases with UGIB confirmed by endoscopy was carried out retrospectively. Patients were admitted to the Department of Pediatrics, Eulji Hospital, from January to December 2003. Results: UGIB from gastric or duodenal mucosal lesions has been seen in 0.13% in newborns infants. All patients were full-term AGA neonates without asphyxic findings at birth. Hematemesis, melena or recurrent vomiting developed within $4.4{\pm}3.8days$ after birth. Vital sign and laboratory test was normal on admission. Endoscopic findings showed hemorrhagic gastritis in 6 cases and peptic ulcers in 3 cases. All patients were successfully managed by medical treatment for $18.6{\pm}5.0days$. On treatment, clinical symptoms improved within $0.9{\pm}0.3days$. Follow-up endoscopy was not performed because there was no recurrence of symptoms in all patients. Case mothers had no history of gastritis, ulcer or anti-ulcer medications before and during pregnancy. Conclusion: If the healthy full-term infants express UGIB within a few days after birth, it is necessary to take careful history of family, mother and delivery process and to practice endoscopy for mucosal lesions of the patients. A follow-up endoscopy dose not seem to be necessary if the infant is clinically well.

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Numerical Experiments for Detecting Voids and Defects Inside Concrete (수치모형실험을 통한 콘크리트 구조물의 결함탐지에 관한 연구)

  • Kim, Yong-In;Byun, Joong-Moo;Sohn, Kwon-Ik;Suh, Baek-Soo
    • Journal of Industrial Technology
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    • v.24 no.B
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    • pp.163-170
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    • 2004
  • In this study, First, the results of travel-time inversion (first arrival inversion using the travel-time of the first arrival) were compared with those of full-wave inversion for numerical data. Numerical experiments to find key parameters other than initial velocity model showed that the frequency of source has a great effect on the result of full-wave inversion. Finally, this research presented the corrected full-wave inversion applying the correction term to the final result of full-wave inversion. The corrected full-wave inversion depicted cavities inside concretes even when the inversion started with 20% error in an initial velocity model for cavities. However, full-wave inversion did not reveal cavities.

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Clinical short-term effects of full-mouth disinfection (Full-mouth disinfection의 단기간의 임상적 효과)

  • Lee, Shin-Hwa;Kim, Ok-Su;Kim, Young-Joon;Chung, Hyun-Ju
    • Journal of Periodontal and Implant Science
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    • v.37 no.3
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    • pp.613-624
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    • 2007
  • Full-mouth disinfection (Fdis) completes the entire scaling and root planing (SRP) in one stage within 24 hours for the prevention of microbial recolonization from untreated sites and ecological niches. The aim of this study is to compare the clinical short-term effects of modified Fdis with those of the conventional SRP in the therapy of moderate and severe chronic periodontitis. Modified Fdis group (5 patients) received the entire SRP within 24 hours using chlorhexidine solution (0.1%) and conventional SRP group (5 patients) received SRP per quadrant at one-week intervals. Clinical parameters were measured at baseline, one month and three months after both therapies. The results of this case report were as follows: 1. There were considerable decreases in sulcus bleeding index and plaque index one month after Fdis. 2. The mean probing depth of single-rooted teeth decreased more in Fdis group than conventional SRP group after therapy and, that of multi-rooted teeth decreased similarly in both groups. 3. The mean probing depth decreased 1.77mm in case of initial probing depth of 4-6mm and it decreased 4.13mm in case of initial probing depth of ${\geq}$ 7mm three months after Felis. 4. There were the smaller increases in gingival recession together with the larger gains in attachment in Fdis group than conventional SRP group after three months. Within the limitations of this study, one could conclude that Fdis has beneficial clinical effects in the treatment of moderate and severe chronic periodontitis and further research would be helpful including more subjects during a longer period to confirm the beneficial long-term effects of Fdis.

The Effects of Patient and Facility Characteristics On the Resource Use by the Elderly in Long-term Care Services (환자 및 시설 특성이 장기요양서비스 이용 노인의 자원소모량에 미치는 영향)

  • 권순만;김홍수;김선민
    • Health Policy and Management
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    • v.12 no.1
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    • pp.21-53
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    • 2002
  • The purpose of this study is to measure the resource use of the elderly in long-term care services and to examine the effects of patient and facility characteristics on their use of resources. The data were collected from 510 old people over sixty years of age, residing in five long-term care hospitals and two skilled nursing homes during the period between December 1, 2000 and February 28, 2001. For a full sample, when the first level of RUG(Resource Use Group)-III categories were employed as the proxy of patient severity, facility characteristics, such as location, size and ownership, have large effects on the resource use measured by service intensity, whereas patient characteristics such as severity have little or no effect. The resource use is significantly high if the facility: (1) is located in rural areas (gun): (2) has mare than 200 beds; (3) is a long-term care hospital; (4) is private; and (5) has a low percentage of medical aid patients. The analysis of the resource use in each RUG-III categories, for which ADL(Ability of Daily Living) were employed as the prosy of patient severity, shows a similar result. The loose relationship between the needs of residents and the resource use seems to be closely associated with the ineffective reimbursement system for providers. The current reimbursement system has no provision for quality improvement and reimburses facilities simply according to their types: fee-for-service for long-term care hospitals, and monthly-flat-rate or full-coverage-national-aid for skilled nursing facilities. It will be necessary to develop a more reasonable reimbursement system that takes patient's severity into account and gives incentives for long-term care providers to offer cost-effective services.

Long-Term Performance of Full-Scale Tiered Geogrid Reinforced Wall under Sustained Load (실대형 계단식 보강토 옹벽의 지속 하중하에서의 장기변형 거동 특성)

  • Yoo, Chung-Sik;Jung, Hye-Young;Lee, Bong-Won
    • Journal of the Korean Geosynthetics Society
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    • v.4 no.2
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    • pp.29-38
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    • 2005
  • It is essential to take consideration of long-term deformation characteristics of mechanically stabilized earth wall user sustained and repeated loads for design and construction, especially for use as part of permanent structures. This paper presents the long-term performance of a full-scale geogrid reinforced segmental retaining wall results based on the measured strains in geogrids for three years. The results indicate that the reinforcement tensile strains tend to continuously increase after wall completion with the increase being more pronounced in the reinforcement layers in the lower tier. It can be concluded that the long-term deformation should be taken in account for walls constructed as part of permanent structures for which wall deformation should be controlled.

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Modification of RFSP to Accommodate a True Two-Group Treatment

  • Bae, Chang-Joon;Kim, Bong-Ghi;Suk, Soo-Dong;D. Jenkins;B. Rouben
    • Proceedings of the Korean Nuclear Society Conference
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    • 1996.05a
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    • pp.185-190
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    • 1996
  • RFSP is a computer program to do fuel management calculations for CANDU reactors. Its main function is to calculate neutron flux and power distributions using two-energy-group, three dimensional neutron diffusion theory. However, up to now the treatment has not been true two-group but actually "one-and-half groups". In other words, the previous (1.5-group) version of RFSP lumps the fast fission term into the thermal fission term. This is based on the POWDERPUFS-V Westcott convention. Also, there is no up-scattering term or bundle power over cell flux (H1 factor) for the fast group. While POWDERPUFS-V provides only 1.5 group properties, true two-group cross sections for the design and analysis of CAUDU reactors can be obtained from WIMS-AECL. To treat the full two-group properties, the previous RFSP version was modified by adding the fast fission, up-scatter terms, and H1 factor. This two-group version of RFSP is a convenient tool to accept lattice properties from any advanced lattice code (e.g. WIMS-AECL DRAGON, HELIOS...) and to apply to advanced fuel cycles. In this study, the modification to implement the true two-group treatment was performed only in the subroutines of the *SIMULATE module of RFSP. This module is the appropriate one to modify first, since it is used for the tracking of reactor operating histories. The modified two-group RFSP was evaluated with true two-group cross sections from WIMS-AECL. Some tests were performed to verify the modified two-group RFSP and to evaluate the effects of fast fission and up-scatter for three core conditions and four cases corresponding to each condition. The comparisons show that the two-group results are quite reasonable and serve as a verification of the modifications made to RFSP. To assess the long-term impact of the full 2-group treatment, it is necessary to simulate a long period (several months) of reactor history. It will also be necessary to implement the full two-group treatment of reactivity devices and assess the reactivity-device worths.ce worths.

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A Study on the Evaluation of Maternal Child Health Services in Public Health Centers (일개 시 보건소의 모자보건 선도보건사업 평가에 대한 연구)

  • Kim, Yong-Soon;Park, Jee-Won;Bang, Kyung-Sook;Jung, Soon-Re;Woo, Hea-Suk;Lee, Hea-Jung;Jang, Hyeon-Soon
    • Research in Community and Public Health Nursing
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    • v.13 no.2
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    • pp.280-291
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    • 2002
  • Objectives: This study was conducted to evaluate the maternal child health services provided by public health centers in Pyungtaek city. Methods: Data were collected based on multiple sources of official records. A questionnaire survey was obtained from 50 mothers with premature babies, and 89 mothers with full- term babies, in order to compare their demographic factors, and physical, obstetrical, and emotional status. In addition, the investigators collected data on pre and post follow-up care for the remature group to evaluate the effects of home visiting services on them. Moreover, additional data were collected from 135 pregnant women and 315 mothers with infants, to assess their degree of satisfaction for prenatal education course and breast feeding practices. Results: 1) The pregnant women's satisfaction for the prenatal education course, knowledge, and practices on self care were considered to be high. 2) Of the mothers with infants, 62.9% experienced breast feeding, but only 35.9% of them did it for six months. 3) Premature birth rate in the region was 5.6%, and 75.6% of all premature babies received follow-up care. 4) The mothers with premature babies experienced premature rupture of membrane. placenta previa, preeclampsia, and cesarean section more frequently than the mothers with full-term babies. 5) At the pre-intervention data collection point. mothers with premature babies experienced significantly less social support than mothers with full-term babies. In addition, mothers with premature babies reported higher levels of stress and care-giving burdens, and lower level of self esteem, than mothers with full-term babies, although the differences were not statistically significant. 6) In the premature group, stress, care giving burdens, and postpartum depression decreased after the intervention, whereas maternal self esteem, and the husband's support were increased after the intervention. Social support from significant others were somewhat decreased. 7) Satisfaction for the home visiting service in the mothers with premature babies was very high. Conclusion: These results showed a possibility that the recently started maternal child health services provided by the public health centers may be efficient. Although statistically significant differences were not found, the investigators found a potential for changes in a positive direction. Long-term effects of the health services on maternal child health needs should be addressed in future studies.

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