• Clinical Endoscopy
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• v.55 no.6
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• pp.815-818
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• 2022

• Clinical Endoscopy
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• v.56 no.1
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• pp.107-113
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• 2023

Background/Aims: Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC. Methods: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018-2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA. Results: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2005.11a
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• pp.51.1-52
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• 2005

• Nuclear Engineering and Technology
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• v.46 no.2
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• pp.207-216
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• 2014

This paper revisits the Fukushima accident to draw lessons in the aspect of nuclear safety considering the fact that the Fukushima accident resulted in core damage for three nuclear power plants simultaneously and that there is a high possibility of a failure of the integrity of reactor vessel and primary containment vessel. A brief review on the accident progression at Fukushima nuclear power plants is discussed to highlight the nature and characteristic of the event. As the severe accident management measures at the Fukushima Daiich nuclear power plants seem to be not fully effective, limitations of current severe accident management strategy are discussed to identify the areas for the potential improvements including core cooling strategy, containment venting, hydrogen control, depressurization of primary system, and proper indication of event progression. The gap between the Fukushima accident event progression and current understanding of severe accident phenomenology including the core damage, reactor vessel failure, containment failure, and hydrogen explosion are discussed. Adequacy of current safety goals are also discussed in view of the socio-economic impact of the Fukushima accident. As a conclusion, it is suggested that an investigation on a coherent integrated safety principle for the severe accident and development of innovative mitigation features is necessary for robust and resilient nuclear power system.

• 대한약리학회:학술대회논문집
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• 2006.10a
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• pp.100.2-100.2
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• 2006

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2004.11a
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• pp.34-35
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• 2004

• Clinical Endoscopy
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• v.55 no.1
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• pp.160-162
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• 2022

• Asian Journal for Public Opinion Research
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• v.5 no.1
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• pp.1-14
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• 2017

The Fukushima nuclear accident caused by an earthquake and a subsequent tsunami on March 11, 2011 has seriously impacted the environment surrounding the Fukushima Daiichi nuclear power plant. While all the residents near the plant were evacuated from the area deemed uninhabitable after the accident, residents of the neighboring area outside of the evacuation zone still seem to live in fear of invisible radiation. To understand Fukushima residents' thinking about the environmental risks that accompany a nuclear disaster, we utilize a poll of the residents of Fukushima conducted in 2013. Based on the survey data, we reveal factors that seem to strongly affect their knowledge and concerns about nuclear power plants. The results of the multivariate analysis show the importance of the following two factors: (1) confidence in mass media, and (2) trust in institutions in charge of administering the accident, especially the central government, the Nuclear and Industrial Safety Agency, and Tokyo Electric Power Company. We conclude that the more people trust mass media and particular institutions, the more likely it is that they are have an elevated sense of anxiety and fear of the presence of nuclear plants.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.837-842
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• 2019

A large amount of radioactive material was released from the Fukushima Daiichi Nuclear Power Plant (FDNPP) in 2011 and dispersed into the environment. Though seven years have passed since the Fukushima Daiichi Nuclear Power Plant accident, some parts of Japan are still under the influence of radionuclide contamination, especially Fukushima Prefecture and prefectures neighboring Fukushima Prefecture. The long-term effective doses and the contributions of each exposure pathway (5 exposure pathways) and radionuclide ($^{131}I$, $^{134}Cs$, and $^{137}Cs$) were evaluated for people living in the regions of Fukushima and neighboring prefectures in Japan using a developed dose assessment code system with Japanese specific input data. The results estimated in this study were compared with data from previously published reports. Groundshine and ingestion were predicted to contribute most significantly to the total long-term dose for all regions. The contributions of each exposure pathway and radionuclide show different patterns for certain regions of Japan.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.21 no.1
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• pp.95-114
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• 2023

During the decades after the Fukushima Daiichi Nuclear Power Station (FDNPS) accident, ambient dose rates have markedly decreased when compared to those at the early state of the accident. Government projects have been continuously conducted by surveying the ambient dose rate and radiocesium distributions. Airborne surveys using crewed helicopters and unmanned aerial vehicles (UAVs) are the best methods for obtaining an overall picture of the distribution. However, ground-based surveys are required for accurate measurements near the population. The differences between these methods include the knowledge of the post depositional behavior of radionuclides in land use. The survey results form the basis for policy decisions such as lifting evacuation zones, decontamination, and other countermeasures. These surveys contain crucial findings regarding post-accident responses. This paper reviews the survey methods of government projects and current situation around the FDNPS. The visualization methods and databases of ambient dose rates are also reviewed to provide information to the population.