• 대한토목학회논문집
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• 제33권1호
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• pp.181-194
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• 2013

산사태는 토사, 거석, 유목 등 산사태 물질의 중력사면 이동현상이다. 산사태는 수리학적, 지형학적, 지반공학적 요인에 따라 다양한 흐름 및 퇴적특성을 보인다. 흐름특성은 아주 느리게 움직이는 산사태(활동, 이류 등)에서 아주 빠르게 움직이는 산사태(토석사태, 토석류 등)까지 다양하다. 이런 점에서 산사태 발생과 확산 메커니즘의 이해를 위해 전단변형률에 따른 전단강도특성에 대한 연구가 필요하다. 본 연구는 한국형 산사태에 적합한 링 전단시험장치의 개발과 활용성에 대한 것이다. 링 전단시험장치는 산사태 유형별 피해 및 영향성 평가에 사용되는 전단강도를 측정할 수 있으며, 전단속도에 따른 산사태의 유동성을 평가하기 위한 장치이다. 비배수 전단강도 측정용 링 전단시험장치는 기존에 개발된 링 전단시험기의 수정보완형으로 '포화-압밀-배수-전단' 순으로 시험조건을 자유롭게 조절할 수 있다. 링 전단상자내 흙 시료의 전단강도의 정확한 측정을 위해 미끄럼 방지, 밀폐성 및 회전성 향상 기능을 갖춘 시험장치이다. 링 전단시험장치는 모래와 자갈 시료에 대한 예비실험을 수행하였으며 기존 시험결과와 비교하여 신뢰할 만한 결과를 확인하였다. 회전속도 100 mm/sec 로 구속할 때 배수조건에 따른 일시적 액상화 현상으로 인한 강도저하 현상이 관측되며, 전단면에 따른 입자파쇄 현상이 뚜렷하게 나타났다. 마지막으로 토석류 유변학에 기초하여 링 전단시험장치를 이용한 산사태 유동성 평가기법을 제안하였다.

• Nutrition Research and Practice
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• 제5권5호
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• pp.435-442
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• 2011

At present, lifestyle-related diseases are one of the most critical health issues worldwide. It has been reported that lipopolysaccharide derived from a Gram-negative bacteria (IP-PA1) symbiotic with wheat exhibited several advantageous biological effects, such as the reduction of plasma glucose levels in NOD mice and low-density lipoprotein (LDL) levels in WHHL rabbits. In this study, the beneficial effects on plasma glucose and lipids of a tea (SI tea) consisting of IP-PA1 and Salacia (which contains an inhibitor of ${\alpha}$-glucosidase) were investigated in the KK-Ay/TaJcl type 2 diabetic model mice and in human subjects with premetabolic syndrome in a double-blind, randomized study. S1 tea significantly decreased plasma glucose levels in KK-Ay/TaJcl mice. A clinical trial of SI tea was performed with 41 subjects between the ages of 40 and 69, who belonged either to a high plasma glucose group (HG: FPG 100-125 mg/dl) or to a hyperlipidemia group (HL: TG ${\geq}$ 150 mg/dl, or LDL ${\geq}$ 120 mg/dl, or HDL <40 mg/dl). These subjects ingested either Salacia without IP-PA1 (the control) or SI tea. Blood samples were collected at 0, 30, and 60 days after initiating SI tea treatment, and were measured for FPG, HbA1c, TG, LDL, and HDL. These results showed that SI tea reduced FPG and HbA1c more rapidly than the control in the HL group, and also significantly improved LDL and HDL levels in the HG group. Thus, SI tea may be helpful in preventing lifestyle-related diseases.

• Asian Journal of Atmospheric Environment
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• 제6권3호
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• pp.234-243
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• 2012

The wintertime high loading for atmospheric pollutants is certainly expected in the Byunsan Peninsula of Korea because of a great-scale reclamation project having construction of 33 km tidal sea dike impounding an area of over 40,000 ha and long-range transport. The goal of this study is to trace the origin of this wintertime burden for ambient particulate matter (hereafter called "PM") in the Byunsan Peninsula of Korea. The size-segregated (i.e., cutoff size from 0.01 ${\mu}m$ to 4.7 ${\mu}m$) PM sampling was conducted at a ground-based site of Byunsan Peninsula located in the west coast of Korean Peninsula during the height of dike constructing. Data archived in this study are the mass concentrations of ionic, elemental, and carbonic components in size-fractioned PM. The elemental mass of individual submicrometer particles was also analyzed. The sum of 5-source (i.e., elemental carbon, organic materials, inorganic secondary pollutants, crustal matter, and sea-salts) concentrations shows the bimodal distribution (major and minor peaks formed around $D_p$, 0.65 ${\mu}m$ and $D_p$, 4.7 ${\mu}m$, respectively) by border with 0.19 ${\mu}m$ of cutoff size. The concentrations of EC in $PM_{1.1-0.01}$ in winter and spring times were 4.62 ${\mu}g\;m^{-3}$ and 3.74 ${\mu}g\;m^{-3}$, respectively. Elemental masses of submicron individual particles are classified into two groups, i.e., the major elements (Cl, Al, Si, S, and P) and the minor trace elements. Cluster analysis differentiated the elements in submicron individual particles into 4-cluster. Among them, three clusters are in agreement with the major (Al, Si, S, and P), minor (Fe, Ca, and K), and trace compositions of coal burning. Meanwhile, Cl classified as an independent cluster has different source profile which was mainly due to the Saemangeum seawall project. Some highly toxic elements (e.g., Cr, Mn, and As (and/or Pb)) were also detected in some part of submicron individual PM. As a consequence, the combination of the Saemangeum project and winter monsoon played a considerable part in the double aggravation of wintertime air pollution in the Byunsan Peninsular.

• Clinical and Experimental Reproductive Medicine
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• 제47권3호
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• pp.194-206
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• 2020

Objective: The aim of this study was to investigate microRNAs (miRNAs) related to follicle-stimulating hormone (FSH) responsiveness using miRNA microarrays and to identify their target genes to determine the molecular regulatory pathways involved in FSH signaling in KGN cells. Methods: To change the cellular responsiveness to FSH, KGN cells were treated with FSH receptor (FSHR)-specific small interfering RNA (siRNA) followed by FSH. miRNA expression profiles were determined through miRNA microarray analysis. Potential target genes of selected miRNAs were predicted using bioinformatics tools, and their regulatory function was confirmed in KGN cells. Results: We found that six miRNAs (miR-1261, miR-130a-3p, miR-329-3p, miR-185-5p, miR-144-5p and miR-4463) were differentially expressed after FSHR siRNA treatment in KGN cells. Through a bioinformatics analysis, we showed that these miRNAs were predicted to regulate a large number of genes, which we narrowed down to cytochrome P450 family 19 subfamily A member 1 (CYP19A1) and estrogen receptor alpha (ESR1) as the main targets for miR-4463. Functional analysis revealed that miR-4463 is a regulatory factor for aromatase expression and function in KGN cells. Conclusion: In this study, we identified differentially expressed miRNAs related to FSH responsiveness. In particular, upregulation of miR-4463 expression by FSHR deficiency in human granulosa cells impaired 17β-estradiol synthesis by targeting CYP19A1 and ESR1. Therefore, our data might provide novel candidates for molecular biomarkers for use in research into poor responders.

• 한국환경보건학회지
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• 제42권1호
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• pp.41-52
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• 2016

Objectives: Scrub typhus is one of the most prevalent vector-borne diseases. It is caused by Orientia tsutsugamushi, which is transmitted when people are bitten by infected chigger mites. This study aims at quantifying the association between the incidence of scrub typhus and meteorological factors in Jeollabuk-do Province over the period 2001-2015. Methods: Reported cases of scrub typhus were collected from the website of the Disease Web Statistical System supported by the Korea Centers for Disease Control and Prevention (KCDC). Simultaneous meteorological data, including temperature, rainfall, relative humidity, and sunshine duration were collected from the website of the National Climate Data Service System by the Korea Meteorological Administration. Correlation and regression analyses were applied to identify the association between the incidence of scrub typhus and meteorological factors. Results: The general epidemiological characteristics of scrub typhus in Jeollabuk-do Province were similar to those nationwide for sex, age, and geographical distribution. However, the annual incidence rate (i.e., cases per 100,000) of scrub typhus in Jeollabuk-do Province was approximately four times higher than all Korea's 0.9. The number of total cases was the highest proportion at 13.3% in Jeonbuk compared to other regions in Korea. The results of correlation analysis showed that there were significant correlations between annual cases of scrub typhus and monthly data for meteorological factors such as temperature and relative humidity in late spring and summer, especially in the case of temperature in May and June. The results of regression analysis showed that determining factors in the regression equation explaining the incidence of scrub typhus reached 46.2% and 43.5% in May and June. Using the regression equation, each 1oC rise in the monthly mean temperature in May or June may lead to an increase of 38 patients with scrub typhus compared to the annual mean of incidence cases in Jeollabuk-do Province. Conclusion: The result of our novel attempts provided rational evidence that meteorological factors are associated with the occurrence of scrub typhus in Jeollabuk-do. It should therefore be necessary to observe the trends and predict patterns of scrub typhus transmission in relation to global-scale climate change. Also, action is urgently needed in all areas, especially critical regions, toward taking steps to come up with preventive measures against scrub typhus transmission.

• 자원환경지질
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• 제26권1호
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• pp.67-81
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• 1993

This dissertation is a basic research on the degradation of rocks and aims at clarifying the relations between the progression of degree of weathering and the variation of chemical composition. The author wants to make clear the degradation of rocks and the process of formation of sedimentary rocks from a standpoint of elucidation of migration of elements. This study is considered to be significant not only as a part of research on the distribution of earth crust materials but as the petrogenesis of rocks. The chemical studies on the weathered rocks have been started relatively early and there are not a few researches on them: Goldich, 1938; Harris, et al., 1966; Ruxton, 1968; Berner, et al., 1982; Kanuss, 1983; Lasaga, 1984; Siagel, 1984. The degree of migration of elements in weathering is the composite result of various factors. Because, at the present time, it is difficult to clarify the individual and composite effects of each factor theoretically and quanititatively, we must accumulate empirical data and use them relatively. In such consideration the author acquired some data of chemical weathering from the chemical analysis of granitic and basaltic rocks in and around Fukuoka city, Japan and granitic rocks in and around Chonju and Iri cities, Korea. Because both rock types studied can be considered as representative materials of acidic and basic rocks compsing the earth crust, it is significant to examine the phenomena of weathering of both rock types. The following results are obtained from the analysis and examinations of chemical compositions of the original and weathered rocks. The loss rate of major elements has no uniformity, but the following relation holds in general; Ca, Na> K, Si> Mg> Fe, Al. As weathering proceeds, the ratio of $Al_2O_3/CaO$ shows increasing phenomena, and that of $Na_2O/CaO$ decreasing. The range of migration of composition is broad in basaltic rocks but narrow in granitic rocks. The reason is that the chemical weathering of basaltic rocks progresses more easily than that of granitic rocks. The chemical weathering potenitial index of basaltic rocks in larger than that of granitic rocks. The reason is that the chemical weathering of basaltic rocks proceeds more easily than that of granitic rocks. In weathering, the decrease of mobile cations such as $Ca^{2+}$, $Na^{2+}$, $Mg^{2+}$ and the increase of $H_2O$ in basaltic rocks are more obvious than in granitic rocks.

• 한국환경생태학회지
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• 제33권1호
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• pp.52-63
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• 2019

일본 특별천연기념물로 지정된 후쿠오카현(福岡?) 카스야군(粕屋郡) 다치바나산(立花山) 일원의 녹나무군락지를 대상으로 식생구조 특성을 분석했다. 본 조사지의 녹나무는 교목층(수고 약 30m, 평균흉고직경 92.79cm)에서 우세했으나, 아교목층과 관목층에서는 출현하지 않았다. 아교목층과 관목층에는 녹나무의 경쟁종이자 난온대 천이 후기종인 구실잣밤나무 후박나무 참식나무 생달나무 등이 주로 분포했다. 또한 이곳은 종다양성이 전반적으로 낮아, 전형적인 상록활엽수림과 다른 식생구조를 보였다. 이는 과거 귀한 가치가 있던 장뇌(樟腦)를 생산하기 위해 적극적으로 녹나무를 조림하여 보호 육성했기 때문으로 짐작된다. 이곳은 장뇌 원료를 채취하지 않으면서 90년 동안 인위적 관리가 없었는데도 독특하게 식생천이가 진행되지 않았다. 이는 녹나무가 수관층을 압도적으로 우점하여 숲틈이 발생되지 않아 식물종의 유입이 제한되고, 녹나무의 타감효과로 인해 치수 발아가 방해된 것이 원인으로 생각된다.

• 한국노년학
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• 제31권2호
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• pp.303-315
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• 2011

본 연구의 목적은 12주간 저항성훈련에 따른 노화 흰쥐의 골밀도 및 골대사 관련 지표에 미치는 영향을 관찰하는 것이다. 생후 64 주령의 Sprague-Dawley계 노화 흰쥐(체중 565±3.12)를 대조군(n=10)과 저항성 훈련군(부하 없는 저항성 훈련군(n=10)과 부하 있는 저항성 훈련군(n=10)으로 분류하여 주 4회 12주간 사다리 오르기 훈련을 실시한 후 골밀도 및 골대사 관련 지표의 변화를 측정한 결과 다음과 같은 결론을 얻었다. 대퇴골의 회분 및 칼슘 햠량은 부하 있는 저항성 훈련군>부하 없는 저항성 훈련군>대조군 순으로 유의하게 증가하였으며, 세 집단간 유의한 차이가 나타났다. 인지질 함량은 부하 있는 저항성 훈련군>부하 없는 저항성 훈련군, 부하 있는 저항성 훈련군>대조군 순서로 나타났는데, 대조군에 비교하여 부하 있는 저항성 훈련군에서만 유의한 차이가 나타났다. 골강도와 osteocalcin 농도는 부하 있는 저항성 훈련군>부하 없는 저항성 훈련군>대조군 순으로 유의하게 증가하였으며, 세 집단간 유의한 차이가 나타났다. 본 연구를 종합하면 노화 흰쥐에서 12주간 저항성훈련은 대퇴골밀도와 골대사관련 지표에 유익한 효과를 나타내는데 이러한 결과는 저항성훈련으로 인한 골밀도의 증가는 골재흡수의 지표인 osteocalcin 과 골의 기계적구조의 변화뿐만 아니라 훈련의 강도(training intensity)가 중요한 매개 요인임을 알 수 있었다.

• Journal of Gastric Cancer
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• 제23권4호
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• pp.609-621
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• 2023

Purpose: Determination of optimal treatment strategies for HER2-positive advanced gastric cancer (AGC) in randomized trials is necessary despite difficulties in direct comparison between trastuzumab deruxtecan (T-DXd) and nivolumab as third or later-line treatments. Materials and Methods: This single-institution, retrospective study aimed to describe the real-world efficacy and safety of T-DXd and nivolumab as ≥ third line treatments for HER2-positive AGC between March 2016 and May 2022. Overall, 58 patients (median age, 64 years; 69% male) were eligible for the study (T-DXd group, n=20; nivolumab group, n=38). Results: Most patients exhibited a HER2 3+ status (72%) and presented metastatic disease at diagnosis (66%). The response rates of 41 patients with measurable lesions in the T-DXd and nivolumab groups were 50% and 15%, respectively. The T-DXd and nivolumab groups had a median progression-free survival of 4.8 months (95% confidence interval [CI], 3.3, 7.0) and 2.3 months (95% CI, 1.5, 3.5), median overall survival (OS) of 10.8 months (95% CI, 6.9, 23.8) and 11.7 months (95% CI, 7.6, 17.1), and grade 3 or greater adverse event rates of 50% and 2%, respectively. Overall, 64% patients received subsequent treatment. Among 23 patients who received both regimens, the T-DXd-nivolumab and nivolumab-T-DXd groups had a median OS of 14.0 months (95% CI, 5.0, not reached) and 19.3 months (95% CI, 9.5, 25.1), respectively. Conclusions: T-DXd and nivolumab showed distinct efficacy and toxicity profiles as ≥ third line treatments for HER2-positive AGC. Considering the distinct features of each regimen, they may help clinicians personalize optimal treatment approaches for these patients.

• Journal of Periodontal and Implant Science
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• 제54권2호
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• pp.75-84
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• 2024

Purpose: This study investigated the relationship between the number of days that hospital visits were postponed and changes in clinical parameters due to the spread of coronavirus disease 2019 (COVID-19), after the Japanese government declared a state of emergency in April 2020. Methods: Regarding the status of postponement of appointments, we analyzed the patients who had visited the Nihon University Hospital at Matsudo for more than 1 year for supportive periodontal therapy (SPT) and classified them into low-, moderate- and high-risk subgroups according to the periodontal risk assessment (PRA). Clinical parameters for periodontal disease such as probing depth (PD), full-mouth bleeding score (FMBS), full-mouth plaque score, periodontal inflamed surface area (PISA), and periodontal epithelial surface area (PESA) were analyzed in 2 periods, from October 2019 to March 2020 and after April 2020. Correlation coefficients between days of deferral and the degree of changes in clinical parameters were calculated. Results: The mean age of the 749 patients was 67.56±10.85 years, and 63.82% were female. Out of 749 patients, 33.24% deferred their SPT appointments after April 2020. The average total of postponement days was 109.49±88.84. The number of postponement days was positively correlated with changes in average PD (rs=0.474) and PESA (rs=0.443) in the high-risk subgroup of FMBS, and average PD (rs=0.293) and PESA (rs=0.253) in the highrisk subgroup of tooth number (TN). Patients belonging to the high-risk subgroups for both FMBS and TN had a positive correlation between postponement days and PISA (rs=0.56). Conclusions: The findings, the spread of COVID-19 appears to have extended the visit interval for some SPT patients. Moreover, longer visit intervals were correlated with the worsening of some clinical parameters for SPT patients with high PRA.