• Maxillofacial Plastic and Reconstructive Surgery
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• 제29권6호
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• pp.548-553
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• 2007

본 과에서는 우측 악하부의 부종 및 동통을 주소로 내원한 환자를 초기에 우측 악하부 및 협부 농양으로 진단하고 절개 및 배농술을 시행하였으나 증상의 호전이 없고 고열과 림프절 비대가 지속적으로 관찰되었다. 이에 저자 등은 비대된 임프절의 적출술과 다양한 검사를 통하여 괴사성 림프절염을 조직학적으로 확인하고 최종적으로 Kikuchi Fujimoto Disease로 확진하였다. Kikuchi-Fujimoto Disease는 임파선 비대와 고열이 동반되는 원인 불명의 괴사성 임파선염으로 특징지워지는 질환으로서, 적출생검을 통해 증상이 사라지는 경우가 많으므로 상기와 같은 증상이 동반된 환자의 경우 악성 림프종이나 전신성 홍반성 루푸스등의 여러 질환과의 감별진단을 통하여 정확한 치료를 시행하는 것이 추천된다.

• 대한수학회보
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• 제59권5호
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• pp.1247-1253
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• 2022

This paper studies the uniqueness of two non-constant meromorphic functions when they share a finite set. Moreover, we will give an existence of unique range sets for meromorphic functions that are the zero sets of some polynomials that do not necessarily satisfy the Fujimoto's hypothesis ([6]).

• 한국실내디자인학회논문집
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• 제24권6호
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• pp.119-127
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• 2015

Sou Fujimoto is well known as the 3rd Japanese architect to participate in the Serpentine Pavilion project, especially youngest of all architects. His projects seem very experimental yet inviting, modern yet comforting and these feeling may be resulted in his metaphor of 'Forest' that is very often mentioned in his writings which originally comes from his personal experience of the city and nature. The purpose of this paper is to understand the Fujimoto's metaphor of 'Forest' and design language he uses to express this very idea. The researchers have analyzed Fujimoto's writings and interviews in order to understand his general design ideas and process, then extracted wordings describing 'Forest' in his works. Four main concepts were found and categorized as follows: blurring territorial boundaries, proliferation of parts, manipulating spatial relationships, and ambiguity in function. Then two or three projects were selected and analyzed in each category to understand design methods used. The results show that Fujimoto enjoys using gradation of density to blur territorial boundaries in order to express ambiguous outline of forest, and fractal reproductions in proliferation of parts to uses express wavering whole and modifying angles in manipulating spatial relationships to show hidden order.

• 한국실내디자인학회논문집
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• 제24권6호
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• pp.87-95
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• 2015

Aldo Van Eyck and Herman Hertzberger explained 'In-between space' as an intermediate space between opposite elements such as whole and parts, inside and outside, open and close, central and decentral. From this idea, the meaning of 'in-between space' has developed and applied to works of Bernard Tschumi and Sou Fujimoto. In this study, the meaning of 'in-between space' was compared and analyzed based on two architects' works to reveal the design approach in terms of 'in-between space' Final Wooden House, N House, and Serpentine Gallery Pavilion among Sou Fujimoto's work were selected and Le Fresnoy, Lerner Student Center, and Acropolis Museum among Bernard Tschumi's work were selected to analyze. To understand their design approach, their works were compared and analyzed in architectural attitude, tools, construction style and the approach, concept, theme, relation, direction of in-between space. As a result, Sou Fujimoto uses 'in-between space' as a nebulous approach as intermediate space between opposite elements. For Bernard Tschumi, 'in-between space' is also an intermediate space to emphasize and make a tension between opposite elements. It is a method of solving the contradiction condition between old city environment and new architecture.

• Childhood Kidney Diseases
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• 제16권2호
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• pp.138-141
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• 2012

리툭시맙(Rituximab)은 CD20에 대한 키메라형 IgG1 단클론 항체로 스테로이드 의존성 또는 난치성 신증후군에 대한 새로운 치료약제로 이용되고 있다. 그러나 리툭시맙의 약제 부작용에 대해서는 아직까지 더 많은 연구가 필요하다. 저자들은 스테로이드 의존성 신증후군을 앓고 있던 9세 남아에서 수차례의 리툭시맙 사용 후 기쿠치병(Kikuchi-Fujimoto disease)이 병발한 증례를 보고하는 바이다. 기쿠치병은 자연 회복의 양성 경과를 보이는 조직구 괴사성 림프절염으로 아직 원인은 알려져 있지 않다. 이 증례에서는 환자의 말초 혈액 B 면역세포 수치가 매우 감소되었을 때 발병하였으며, 이후 환자의 B 면역세포가 회복되면서 서서히 자연 소실되었다. 이 증례는 비록 병리 조직학적 진단은 뒷받침되지 못하였지만 임상적으로 진단된 기쿠치병이 리툭시맙 사용의 부작용으로 발생할 수 있다는 연관성을 시사하는 첫 번째 보고로써, 소아 신증후군에서 리툭시맙 사용의 안전성에 대한 이해의 폭을 넓히고자 하였다.

• Clinical and Experimental Pediatrics
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• 제52권5호
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• pp.622-626
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• 2009

키쿠치(Kikuchi) 병, 키쿠치-후지모토(Kikuchi-Fujimoto) 병, 혹은 조직구 괴사성 림프선염은 1972년 일본에서 키쿠치와 후지모토 두 사람에 의해 처음 기술되었으며 흔히 아시아 지역에서 30세 미만의 여성들을 주로 침범하는 자가 관해 질환으로 기술되어져왔다. 이 질환의 병인은 여전히 잘 알려져 있지 않으나 감염성(EBV, HHV-6 and -8, HTLV-1, cytomegalovirus, varicella-zoster virus, tuberculosis, toxoplasmosis, yersiniosis, cat scratch disease), 자가면역성(SLE, Kawasaki disease), 그리고 종양성 질환(lymphoma)이 포함되는 것으로 간주된다. 가장 흔한 임상증상은 발열과 통증 없는 경부 림프선염이다. 진단은 생검을 통한 조직병리학적으로 하게 되는데, 주로 풍부한 핵파괴(karyorrhexis)를 가진 피질 주위 지역에서 나타나는 국소 괴사, 괴사 지역 주위로 비정형적인 단핵구들의 집합, 중성구 및 형질 세포의 결핍, 그리고 대개 림프절 캡슐의 보존 등으로 특징 지워진다. 절대적인 치료법은 없어 대증 치료를 하게 되며 치료 없이도 대개 1-6개월 안에 자가 관해되고 재발률도 3.3%에 불과하다. 키쿠치-후지모토 병의 합병증으로 피부, 심장, 골수 등을 침범할 수 있으며 간질환, 무균성 뇌수막염, 간비비대 등이 발생할 수 있으나 드물다. 본 증례에서는 입원 당시 결핵성 임파선염과 뇌수막염으로 오인되었던 무균성 뇌수막염을 동반한 키쿠치-후지모토 병을 경험하였기에 이에 보고하는 바이다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제25권2호
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• pp.17-25
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• 2019

Purpose: The analysis of spatial composition is required for the creation of healing environment in healthcare facilities. This study has been accomplished to provide basic data for the planning and design of hospital architecture. Methods: Literature review of healing environment and investigation on characteristics of spatial composition in healthcare facilities have been conducted. The architectural plans of four Sou Fujimoto's healthcare projects have been analyzed with space syntax. Results: The result of this research can be summarized as followed. First of all, the healing environments are consisted with architectural composition in addition to physical and psychological factors for healing environment. The second one is that the characteristics of spatial composition in Sou Fujimoto's healthcare projects are different private/public/corridor relationships in program configuration, loop or one direction circulation, combined or independent corridor with program, and radical or linear connection in spatial connection methods. The third one is that the characteristics of spatial composition in selected cases through space syntax are high variation on integration, low variation on connectivity, and high distribution in main circulation on ERAM(3). Implications: In addition to the specific spatial composition in healthcare facilities of the architect's project, it is necessary to analyze the relationship with other factors and facilities to develop the planning of hospital architecture.

• 대한건축학회논문집:계획계
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• 제35권8호
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• pp.35-46
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• 2019

This study started from the interest about a theme repeated in a similar way among a group of architects in Japan. They argue that a building composed of random elements can lead to discoverable functions rather than fixed functions. Their work supports this to a certain extent, but at the same time raises the following two research questions. Can 'formal randomness' and 'functional discoverability' be completely identical? Does such a form sufficiently fulfill other functions of the building? In order to answer these two research questions, this study analyzes the relationship between form and function in the 'Children's Center for Psychiatric Rehabilitation' of Sou Fujimoto. The analysis proceeded in three steps. In the first step, I found that alcoves were the most important factor in functional discoverability by comparing scenarios with different conditions. At the same time, however, I could see that these alcoves were weakened in the process of functional adjustment. In the second step, I analyzed the final design and found Sou Fujimoto's response to the preceding problem. He thought that in-between alcoves created from formal randomness, were not enough and thus introduced a new method, cutting alcoves. This means that formal randomness alone does not fully guarantee both the functional discoverability and the fulfillment of the basic functions. In the third step, I searched for the significance of this problem through a brief comparison with other similar projects.

• 한국실내디자인학회논문집
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• 제23권4호
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• pp.72-82
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• 2014

The Contemporary paradigm to understand the complexity and diversity is moving to 'Becoming' that taken place in reviewing at the relation of various concepts. In Japan, After the collapse of modern architecture has been declared 'Metabolism' was appeared. They tried to apply organism's metabolic system to buildings based on ecological thoughts. But Metaboilsm's projects had revealed limitations of representation that the city on the mechanical system became a huge scale. As a result, It caused a break the cultural context of the region in Japan. After then, Japanese Architects expressed a pluralistic aspects of modern society for the restoration of disconnected cultural context. From this perspective, The thought of 'becoming' is a new role for Contemporary Japanese Architect. This research is focused of projects of SANAA, Ito Toyo, Sou Fujimoto, because they have spatial thought about realizing the space through the ways organizing the various potential possibilities in the simple external form not stimulated. They are realize the 'becoming-space' within the architecture. This 'becoming-space' gives people in building the new characteristics and experience that potential interactions among user, architecture and nature. It is non-representational space not fixed, but changing organically and variably.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.245-250
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• 2021

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome-HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m²/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.