• 한국콘텐츠학회논문지
• /
• 제13권2호
• /
• pp.1-7
• /
• 2013

본 연구는 골프 드라이버의 임팩트 위치에 따른 소리의 특성을 평가하고자 하였다. 일정한 임팩트 소리를 발생시키기 위하여 골프공 자유낙하 장치를 고안하여 사용하였다. 임팩트 소리의 시간에 따른 진폭과 주파수영역에서 파워의 피크값 분포가 드라이버 헤드면의 임팩트 위치에 따라 다르게 나타났으나 재현성이 부족하여 비교할 수 없었다. 드라이버의 임팩트 부위에 따른 소리를 구분하기 위하여 대안적인 방법으로 파워스펙트럼 누적합(cumsum)을 사용하였다. 파워스펙트럼 누적합의 20%, 40%, 60%, 80%에 해당하는 주파수를 비교한 결과 드라이버 면의 중앙(center)에서 발생하는 임팩트 소리의 40% 누적합주파수가 바깥쪽(toe)과 안쪽(heel)에서 발생하는 임팩트 소리에 비하여 유의하게 낮은 것을 관찰하였다. 이러한 결과는 드라이버 헤드면의 중앙이 바깥쪽 또는 안쪽에 비하여 임팩트 소리의 저주파수 성분 파워가 상대적으로 높다는 것을 시사하였다.

• 대한종양외과학회지
• /
• 제9권2호
• /
• pp.80-86
• /
• 2013

Purpose: Hypermethylation of human mut L homologue 1 (hMLH1) promoter region is known to cause sporadic microsatellite instability (MSI) colorectal cancers. 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism, acting as a methyl donor for DNA methylation. In this study, we investigate whether the polymorphism of MTHFR 677C>T plays a role in the alteration of the promoter-specific hypermethylation, predisposing to MSI colorectal cancers. Methods: Total of 487 sporadic colorectal cancer patients in CHA Bundang Medical Center were collected. MSI was identified when two or more are positive among five microsatellite markers (BAT25, BAT26, D17S250, D5S346, D2S123). The others were classified as microsatellite stable (MSS). Polymorphism of MTHFR 677C>T was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: MSI was observed in 65 of 487 patients (12.73%). MSI colorectal cancers showed similar clinicopathological features with previously reported; younger age onset, right-sided preponderance, mucinous and poorly differentiated histology, lower stage, fewer lymph node metastases than MSS tumors (each P<0.05). The frequency of MTHFR 677TT genotype was 17.7% in the MSI group higher than 14.6% in the MSS group (P=0.17). Although not statistically significant, compared to the MTHFR 677CC referent, MTHFR 677 CT+TT genotype was more likely to have MSI than MSS (odds ratio, 1.81; 95% confidence interval, 0.94 to 3.68; P=0.06). Conclusion: This study demonstrated higher frequency of MTHFR 677TT genotype in MSI colorectal cancers. Furthermore, individuals with MTHFR 677CT+TT variant type might potentially develop MSI rather than MSS colorectal cancers.

• 대한의생명과학회지
• /
• 제26권3호
• /
• pp.230-237
• /
• 2020

Staphylococcus aureus (S. aureus) is known as a bacterium that can cause skin infections, respiratory system infections, and sinusitis; however, it can exist as a normal flora rather than a pathogen. Recently, methicillin-resistant S. aureus (MRSA) infections have emerged in the community as a new variant of community-associated (CA)-MRSA. In the present study, S. aureus and MRSA were isolated and cultured by collecting samples from facilities and environments where students and educational personnel have multiple contacts on university campuses; specifically, the nostrils and hands of college students were tested from July to September of 2019. The molecular properties of the isolated MRSA were analyzed, and the one MRSA strain was isolated from the university campuses. One MRSA that was isolated and cultured on campus was the mec complex group A and staphylococcal cassette chromosome (SCC) mec type II, which is a characteristic of healthcare-associated (HA)-MRSA, and SCCmec type V, which is a characteristic of CA-MRSA. This result was similar to other studies wherein the SCCmec type II was detected in SCCmec typing analysis in CA-MRSA. To confirm whether there is a new variant of CA-MRSA in the Republic of Korea, additional follow-up studies on the analysis of virulence factors of MRSA are needed by additionally separating CA-MRSA from the body parts of university students and educational personnel.

• 한국지구과학회지
• /
• 제30권7호
• /
• pp.824-833
• /
• 2009

지진전조현상을 모니터링 하기 위해 기상청이 운영하고 있는 청양 지자기관측소에서 총 6개월간 획득된 지자기장 자료를 분석하였다. 지자기 3성분 자료로부터 지하의 전기비저항 변화를 반영하는 전달함수 및 분극값을 계산하였고, 이를 동일기간 발생한 지진이벤트와 비교하였다. 전달함수의 경우 일별 전달함수 값의 변화가 상당히 심하였으며, 발생한 지진 및 Kp 인덱스와의 상관성을 찾기 어려웠다. ULF 대역 자기장은 지진발생 전 뚜렷한 분극값의 증가가 관찰되었으나, 지진이 발생하지 않은 기간에도 이러한 변동 패턴이 나타났다. 따라서 이러한 분극값의 변화는 지진 전조현상으로 단정하기에는 한계가 있고, 향후 타 관측소 자료의 추가적인 확보 및 분석을 통해 과거 발생한 일정규모 이상의 지진과 관련성을 분석할 필요가 있다.

• 대한두경부종양학회지
• /
• 제22권2호
• /
• pp.117-122
• /
• 2006

Background and Objectives : Thyroid carcinoma is the sixth commonest cancer in Korea and the papillary carcinoma is the most common type(88%) of the malignant thyroid tumors. Bulky DNA adducts formed by the carcinogens are repaired by DNA repair process, but failure to repair this DNA damage can cause mutations in oncogenes and tumor suppressor genes resulting in tumor formation. The xeroderma pigmentosum group C(XPC) gene is essential for this repair procedure and the XPC-PolyAT(PAT) polymorphisms may alter DNA repair capacity(DRC) and genetic susceptibility to cancer. Subjects and Methods : In a case-control study of 113 Korean patients with pathologically diagnosed thyroid papillary carcinoma and 65 control subjects, we investigated the association between the three XPC-PAT gene polymorphisms and thyroid papillary cancer susceptibility. Results : The frequency of the variant XPC-PAT allele was lower in the cases(0.349) than in the controls (0.423), but the difference was not significant(p=0.140). Using logistic regression adjusting for age and sex, risk for thyroid papillary cancer was not increased in the XPC-PAT-/+ and XPC-PAT+/+ compared to XPCPAT-/-(adjusted overall odds ratio[95% confidence intervals;95%CI]=0.52[0.26-1.03] and 0.62 [0.22-1.75], respectively; trend test, p=0.167). Conclusion : There are no relationship between the XPC-PAT polymorphism and the risk of thyroid papillary carcinoma in Korean population. Based on our results, XPC-PAT polymorphism do not modulate genetic susceptibility to thyroid papillary cancer.

• 한국자동차공학회논문집
• /
• 제18권6호
• /
• pp.130-137
• /
• 2010

Due to test facility and specialty, it is physically difficult to conduct the modal tests of large-sized structures such as truck, bus and airplane. So, in case of a large-sized truck, the mode analysis on a full vehicle model comprised of reliable cabin, frame, and deck has been generally performed. However, the reliability of overall vibrational characteristics of the analytic model has not been fairly guaranteed by the testified models of each subsystem owing to the existence of cab suspension and the nonlinear mounting between a chassis frame and a special deck system. In this paper, a method to find out the modal characteristics of a large-sized military truck is presented. New modal test equipment is developed to set the boundary conditions of three military truck variants as close as a free-free condition. And the mode analysis method using coupled structure and dynamic models is established to consider the above-mentioned dynamic non-linearities of the vehicle itself. The usefulness of the suggested method is verified by comparing with the modal test results. Finally, the modal parameters of the final variant are extracted using the proved analytic method.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권23호
• /
• pp.10225-10229
• /
• 2015

Genetic polymorphisms in homologous recombination repair genes cause an abnormal development of cancerous cells. In the present study we evaluated the possibility of breast cancer association with single nucleotide polymorphisms of RAD51, XRCC2 and XRCC3 genes. Polymorphisms selected in this study were RAD51 135G/C, XRCC2 Arg188His; and XRCC3 Thr241Met. Each polymorphism was genotyped using Polymerase chain reaction-restriction fragment length polymorphism in study cohort of 306 females (156 breast cancer patients and 150 controls). We observed that heterozygous variant genotype (GC) of RAD51 135 G/C polymorphism was associated with a significantly (OR=2.70; 95%CI (0.63-1.79); p<0.03) increased risk of breast cancer. In case of the XRCC3 gene we observed that frequency of heterozygous (OR=2.88; 95%CI (1.02-8.14); p<0.02) and homozygous (OR=1.46; 95%CI (0.89-2.40); p<0.04) genotype of Thr241Met polymorphism were significantly higher in breast cancer patients. For the Arg188His polymorphism of XRCC2, ~2fold increase in breast cancer risk (OR=1.6, 95%CI = 0.73-3.50) was associated with GA genotype with a p value for trend of 0.03. Our results suggest that the 135G/C polymorphism of the RAD51, Thr241Met polymorphism of XRCC3 and Arg188His polymorphism of XRCC2 can be independent markers of breast cancer risk in Pakistan.

• The Korean Journal of Physiology and Pharmacology
• /
• 제16권5호
• /
• pp.339-342
• /
• 2012

Inter-individual pharmacokinetic variation of H2-receptor antagonist is related to genetic polymorphism of CYP2C19. We investigated the frequency of CYP2C19 genetic polymorphism and the treatment duration of cimetidine by CYP2C19 genotypes in functional dyspeptic patients without definite causes who were treated with cimetidine in Korea. One hundred subjects with functional dyspepsia participated in this study from March 1, 2010 to June 30, 2011. They were tested by upper gastrointestinal endoscopy and treated for their dyspepsia with cimetidine. The single nucleotide polymorphisms (SNPs) of CYP2C19 were genotyped using the Seeplex CYP2C19 ACE Genotyping system. There were no significant differences in the demographic, clinical, or laboratory findings among the CYP2C19 subgroups which are wild type homozygote (W/W), heterozygote (W/V), and variant homozygote (V/V). The frequencies of CYP2C19 subgroups were 33 (33%) in W/W, 49 (49%) in W/V, and 18 (18%) in V/V, respectively. The mean duration of cimetidine treatment (in weeks) was the shortest in the V/V among the CYP2C19 genotypes (W/W: $5.1{\pm}1.5$, W/V: $4.0{\pm}1.7$, V/V: $2.1{\pm}0.7$; p<0.001). This study can also act as a basis for further investigation to identify the underlying genetic, epigenetic, or environmental factors in CYP2C19 enzyme activity.

• 한국정보통신학회:학술대회논문집
• /
• 한국해양정보통신학회 2007년도 춘계종합학술대회
• /
• pp.754-757
• /
• 2007

본 논문은 시변하는 열악한 수중환경에서 복잡도를 줄이면서 강인한 수중 음향 데이터 통신 시스템의 구현내용과 천해역에서의 실해역 시험결과를 다루고 있다. 실해역 시험시의 복잡하고 시변하는 실험환경에 쉽게 적용할 수 있도록 수중음향센서와 증폭기를 제외한 모든 부분을 디지털화된 송신시스템과 수신 시스템으로 구현하였다. 프레임 동기방식으로 CAZAC 시퀀스가 사용되었고, 중심주파수 25kHz와 대역폭이 5kHz를 갖는 QPSK 변복조 방식이 사용되어 오버헤드를 포함하여 10kbps의 전송율을 가질 수 있도록 설계되었으며, 전송 효율을 향상시키기 위해서 적응 빔형성기, 적응 등화기, 컨볼루션/Viterbi 부호화기 등과 같은 여러 가지 기술이 사용되었다. 개발된 시스템의 성능검증을 위해서 거제도 장목연안의 수심 8m에서 실시간 데이터 통신 시험을 수행하였으며, 전송거리 7.4km에서 10kbps의 전송속도를 가지고 영상 데이터가 성공적으로 전송되었음을 확인하였다.

• 한국통신학회논문지
• /
• 제34권6A호
• /
• pp.476-483
• /
• 2009

최근 들어 실내에서의 고속 무선 통신과 음영지역 해소를 위한 해결책의 하나로 옥내용 기지국인 펨토셀(femtocell)을 활용하는 계층구조 방안이 제시되고 있으며, 이동통신 표준화 단체에서 관련 이슈에 대한 표준화 작업이 활발히 진행되고 있다. 그러나 펨토셀 환경에서 발생할 수 있는 여러 가지 기술적 문제들이 존재하며 그 중 가장 중요한 문제가 간섭으로 인한 시스템의 열화이다. 따라서 전체 시스템의 안정적이고 효율적인 운용을 위해 펨토셀 환경에서의 상호 간섭과 이에 따른 시스템 성능 분석이 요구된다. 본 고에서는 펨토셀 설치 주변의 다양한 전파 환경을 고려하여 매크로셀(macrocell)이나 펨토셀간 상호 간섭에 따른 시스템 용량 및 서비스 영역을 살펴본다. 특히 펨토셀의 주 설치 지역이 되는 실내 환경에서 매크로셀과 펨토셀간의 거리, 펨토셀 내에서 사용자의 위치, 옥내 구조물의 특징 등을 반영한 의전파전파 모델을 적용하고 그에 따른 주파수 효율성과 서비스 반경 등의 시스템 성능을 분석한다.