• 생명과학회지
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• 제15권4호
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• pp.553-560
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• 2005

stf 오페론은 stfA CDEFG로 구성되며, S. typhimurium과 S. choleraesuis에서는 완전하게 존재한다. 그러나 S. typhi에서는 이 오페론이 결여되어 있고 S. paratyphi A에서는 stfC의 유전자가 돌연변이 되어 있다. 이 섬모는 class 1형태의 섬모로 분류되며, StfD chaperone을 다른 섬모를 구성하는 chaperone들과 비교할 때 각 subunit들의 C-말단 잔기의 분석은 StfD chaperone이 FGS subfamily와 유사한 특성을 보였다. stf 오페론이 lacZYA 유전자와 fusion된 S. typhimurium 돌연변이 균주를 사용하여 MacConkey 고체배지에서 장시간 배양한 후 $Lac^+$ 표현형을 보이는 21 isolate들을 분리하였다. $Lac^+$ 균주들은 34 세대 당 $0.28\~1.75$의 빈도로 발생하였다. 21 isolate들은 구성적으로 stf operon을 발현했지만, 범용의 조절자인 RpoS, OmpR, CpxR등에 의해 조절되지 않았다. Mouse독성 실험에서 S. typhimurium $_X8661$은 야생형인 $_X3761$에 비교하여 6.7배의 약독화를 보였다.

• 한국산학기술학회논문지
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• 제16권11호
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• pp.7394-7402
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• 2015

본 연구의 목적은 최근 5년간(2010-2014) 뇌졸중 환자 대상 국내에서 실시된 연하재활중재 연구의 현황을 파악하고 연구의 효과를 알아보기 위해 시도된 것이다. 문헌검색은 한국교육학술정보원(www. riss4u.net), 국회도서관과 한국학술정보(kiss.kstudy.com)를 통해 검색하였으며, 총 12편의 논문을 최종 분석하였다. 간호학 전공 논문은 4편이었으며, 8편은 작업치료학과 등 타과 논문이었다. 논문의 질적 평가는 Scottish Intercollegiate Guideline Network(2013)에서 제시한 체크리스트를 참고하여 연구자가 개발한 평가 틀을 이용하였다. 논문의 질적 평가내용을 종합한 결과, 10점 만점에 7점인 연구가 4편이었으며, 5-6점인 연구는 6편, 4점인 연구가 2편이었다. 연하 재활 중재내용을 분석한 결과 평균 25분을 시행하였으며, 1주일에 평균 4.1회의 빈도로 총 시행횟수는 평균 33.7회로 진행되었다. 연구 결과 인두를 포함한 구강 운동과 호흡운동의 포괄적 중재, 직접 삼킴 훈련이 삼킴 증상 완화에 효과가 있는 것으로 나타났으며, 향후 이를 간호학 중재로 활용하여 근거기반 간호 실무의 토대를 마련할 수 있을 것이다.

• Reproductive and Developmental Biology
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• 제33권3호
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• pp.153-156
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• 2009

The purpose of this study was to assess for re-breeding concentrate period in postpartum in milking cows. The 48 cows aged $3.5{\sim}5.5$ years and of $400{\sim}600\;kg$ body weight were examined every 3rd day from 15 to 36 day postpartum. Blood samples for progesterone and estradiol $17{\beta}$ hormone analyses were withdrawn from the coccygeal vein every third day until the end of the experiment. The ovarian follicular numbers were verified and measured using a multi frequency probe. The least squares means are presented for each day by GLM of SAS. The results showed that ovary lengths (right ovary; $1.64{\pm}0.62\;cm$, left ovary; $1.44{\pm}0.46\;cm$) were similar in right and left ovary activity level during estrous cycle of postpartum cows. We were judged completed uterus on day at $2.31{\pm}0.17\;cm$ level of cervix diameter. And we were monitoring started at $6.44{\pm}2.03\;cm$ from day 15 after postpartum. The results showed that mean plasma concentration of progesterone (3.28 ng/ml) in large follicle gradually increased days 30 in postpartum. And, monitoring of estradiol 176 (22.18 pg/ml) hormone during postpartum period would be useful to predict the ovarian and uterus activity for re-breeding in postpartum milking cows. From these results, we conclude that cervix diameter (mean: 2.31 cm) was very important for reproductive organ recovery standard level of postpartum milking cows, hormone secretion level ($P_4$: 3.28 ng/ml, $E_2$: 22.18 pg/ml) and body condition score ($2.5{\sim}2.75$) level about 30 days in postpartum period.

• 보건의료산업학회지
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• 제3권1호
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• pp.14-24
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• 2009

This study aims at deriving any useful information necessary to strengthen the competitiveness for growth through empirical analyses on general hospital located in a province in order to countermeasure the opening and competition of medical markets. The characteristics of user were identified on the basis of disease groups under KCD in the research method. In addition, the analysis on the expenses of diagnosis and treatment was divided into the treatment progress and degree of hospital resource utilization And the regression was carried out to identify the impacts of characteristics of inpatient users on the degree of hospital resource utilization. As a result of major research, the inpatient users of the general hospital located in the provincial area in consideration of inpatient users were formed around the inpatient disease groups representative for Korea(diseases of the respiratory system, injury and poisoning & certain other consequences of external causes). And it was understood that most of residents within a distance of 40 minute by the public transportation were using. And mostly were under the age of 9 or over 60, and the provision of medical features such as the degree of consultation and operational functions were inadequate. When we classify inpatient treatment cost for each resource application as the medical cost being the center of patient care function, the equipment and human resource application sector are constituted over half. Accordingly, the following suggestions are made as plans to strengthen the competitiveness for the growth of general hospitals located in the provincial areas on the basis of analytical results. First, it is necessary to have the characterization matching to the age and disease groups with a high frequency. Second, it is necessary to increase the degree of hospital resource utilization according to the characterization. Third, it is necessary to concentrate on public relations. The above suggestion, as a method for securing image improvement and competitive power as a general hospital, and through expansion of social function that a regional general hospital needs to secure not only as an individual institution but also as a general hospital, it can be seen that a general improvement of image as a regional general hospital is possible.

• Journal of Korean Neurosurgical Society
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• 제60권5호
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• pp.511-517
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• 2017

Objective : Spontaneous intracerebral hemorrhage (ICH) and ischemic stroke share common vascular risk factors such as aging and hypertension. Previous studies suggested that the rate of recurrent ICH and ischemic stroke might be similar after ICH. Presence of cerebral arterial stenosis is a potential risk factor for future ischemic stroke. This study investigated the prevalence and factors associated with cerebral arterial stenosis in Korean patients with spontaneous ICH. Methods : A total of 167 patients with spontaneous ICH were enrolled. Intracranial arterial stenosis (ICAS) and extracranial arterial stenosis (ECAS) were assessed by computed tomography angiography. Presence of ICAS was defined if patients had arterial stenosis in at least one intracranial artery. ECAS was assessed in the extracranial carotid artery. More than 50% luminal stenosis was defined as presence of stenosis. Prevalence and factors associated with presence of ICAS and cerebral arterial stenosis (presence of ICAS and/or ECAS) were investigated by multivariable logistic regression analysis. Results : Thirty-two (19.2%) patients had ICAS, 7.2% had ECAS, and 39 (23.4%) patients had any cerebral arterial stenosis. Frequency of ICAS and ECAS did not differ among ganglionic ICH, lobar ICH, and brainstem ICH. Age was higher in patients with ICAS ($67.6{\pm}11.8$ vs. $58.9{\pm}13.6years$ p=0.004) and cerebral arterial stenosis ($67.9{\pm}11.6$ vs. $59.3{\pm}13.5years$, p<0.001) compared to those without stenosis. Patients with ICAS were older, more frequently had diabetes, had a higher serum glucose level, and had a lower hemoglobin level than those without ICAS. Patients with cerebral arterial stenosis were older, had diabetes and lower hemoglobin level, which was consistent with findings in patients with ICAS. However, patients with cerebral arterial stenosis showed higher prevalence of hypertension and decreased kidney function compared to those without cerebral arterial stenosis. Multivariable logistic regression analyses showed that aging and presence of diabetes independently predicted the presence of ICAS, and aging, diabetes, and hypertension were independently associated with presence of cerebral arterial stenosis. Conclusion : 19.2% of patients with spontaneous ICH had ICAS, but the prevalence of ECAS was relatively lower (7.2%) compared with ICAS. Aging and diabetes were independent factors for the presence of ICAS, whereas aging, hypertension, and diabetes were factors for the cerebral arterial stenosis.

• 대한불안의학회지
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• 제6권1호
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• pp.17-23
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• 2010

Objective : This study compared the psychological stresses of depressed patients' families with those of schizophrenic patients' families. We investigated the influence of depressive patients' clinical features and their families' demographic characteristics on the families' depressive symptoms and stresses. Methods : Participants were 23 family members of depressed patients and 20 family members of schizophrenic patients. We measured the patients' clinical features (duration of illness, number of previous hospitalizations, and satisfaction with medication), and each family member's socioeconomic status and psychological characteristics (depressive mood, anxiety, family stress, and stress response), analyzing the data via independent t-test, chi-square test, and correlation and hierarchical multiple regression analyses. Results : The depressed patients' average clinical global impression (CGI) was significantly higher than that of the schizophrenic patients. The depressed patients' family members showed stress responses significantly higher than those of schizophrenic patients' family members. Furthermore, in depressed patients, frequency of hospitalization was positively correlated with family members' stat anxiety. For both patient types, family stress was positively correlated with the patient's severity of illness and the family's state anxiety, trait anxiety, and stress response ; socioeconomic status was positively correlated with the family's depressive symptoms ; the family's state anxiety positively correlated with the family's trait anxiety and stress response ; and the family's trait anxiety positively correlated with the family's stress response. Socioeconomic status predicted the family's depressive symptoms, and socioeconomic, illness severity and stress response predicted family stress. Conclusion : These findings suggest that both depressed patients' families and schizophrenic patients' families suffer from psychological stress. The study data also have important clinical implications, in that families of depressed patients need psychiatric intervention, as well as the patients themselves. In particular, family intervention should focus on psycho-education and stress coping strategies.

• 사회복지연구
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• 제47권1호
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• pp.261-290
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• 2016

본 연구는 과거에 발생한 모(母)의 손자녀 돌봄이 이후 모와 성인자녀의 세대 간 접촉 수준에 어떠한 영향을 미치는지 살펴보는 것을 목적으로 하였다. 이를 위해 세대 간 장기적 상호 관계에 초점을 맞추었고, 연구의 수행을 위해 고령화연구패널조사(Korean Longitudinal Study of Ageing)의 1차부터 4차 연도까지의 자료를 이용하였다. 분석의 대상자는 1,925명의 노모와 7,460명의 성인자녀이었으며, 다수의 자녀가 한 명의 모에 내재되어 있는 관계적 구조를 고려하여 다수준 분석(multi-level analysis) 방법을 사용하였다. 연구의 수행을 위해 과거 발생한 모의 손자녀 돌봄은 그것의 행위 유무와 시간적 양을 이용하여 측정하였고, 세대 간 접촉 수준은 모와 성인자녀의 대면 및 비대면 접촉 수준을 통해 파악하였다. 본 연구를 통해 산출된 결과를 간략히 제시하자면 다음과 같다. 먼저, 과거 모에 의해 제공된 아동 돌봄은 그것의 행위 존재 자체만으로도 이후 성인자녀와 모 간의 접촉 빈도를 증가시킬 수 있는 것으로 나타났다. 또한 모에 의해 제공된 아동 돌봄의 시간적 양 역시 이후 모와 성인 자녀 간의 접촉 수준을 증가시키는 요인으로 작동할 수 있는 것으로 나타났다. 이와 같은 결과는 세대 간 관계에서 조모에 의한 손자녀 돌봄이 세대 간의 호혜적 관계 성립에 중요한 영향을 미칠 수 있음을 보여준다. 본 연구는 이와 같은 결과들을 기초로 하여 이론적 및 정책적, 실천적 함의를 제시하였다.

• 한국철도학회논문집
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• 제20권3호
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• pp.329-338
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• 2017

최근 철도차량용 보조전원장치는 시스템의 경량화를 위해 기존 60Hz 저주파 변압기를 제거하고 고주파 구동과 절연 특성을 갖는 '절연형 dc/dc 컨버터'를 적용하는 구조가 주목받고 있다. 본 논문에서는 '절연형 dc/dc 컨버터를 적용한 보조전원장치 구조'에 대해서 설명하고, 다양한 분석을 통해 보조전원장치의 고효율 및 경량화에 적합한 dc/dc 컨버터 및 구조를 제안하고자 한다. 대용량 IGBT 소자의 고주파 스위칭(경량화)을 위해 필수적인 '영전압-영전류-스위칭'특성을 갖는 '공진형 컨버터'를 활용하여 다양한 보조전원장치용 전력변환장치 구조(1-Stage와 2-Stage)를 제안하였고, 각각의 구조에 적합한 컨버터 회로를 선정한 후 설계 및 시뮬레이션을 통해 비교하였다. 1-Stage 구조의 경우 공진형 컨버터만을 사용하였고, 2-Stage 구조의 경우 공진형 컨버터와 공진형 컨버터의 입력전압 변동을 최소화하는 Pre-regulator를 적용하였다. Pre-regulator로서 감압 컨버터 또는 승압 컨버터를 각각 적용하여 서로 다른 2-Stage 구조를 구성하고 각 방식의 손실을 비교하였다. 회로에 사용되는 소자들의 전압 및 전류 스트레스를 고려하여 소자를 선정하고 시뮬레이션을 통해 동작을 검증하였으며, 손실 분석을 통해 고효율 및 경량화에 가장 적합한 구조 및 회로를 제안하였다.

• 대한임상독성학회지
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• 제17권2호
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• pp.118-125
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• 2019

Purpose: Non-benzodiazepine hypnotic drugs (including zolpidem) are associated with an increased risk of suicide and suicidal ideation. Considering the wide usage of zolpidem, this drug should be considered a possible etiology for stupor or coma in any patient exposed to this drug. However, there are no reports on zolpidem blood levels in emergency department patients in Korea. We therefore reviewed the analyzed data of a toxicology laboratory at one university affiliated hospital. Methods: The sex, age, chief symptoms, suspiciousness of poisoning, and presumption of poison were analyzed from January 2018 to June 2019. The detection frequency and level of zolpidem in the patient blood were compared to the mental changes presented, which is the main consequence of zolpidem. Results: A total of 229 toxicological analyses, requested to a toxicological laboratory at one university affiliated hospital, were reviewed. Among 229 patients, the mean age was 54.3±20.7 years old with 113 women and 116 men. 8.7% of patients have psychiatric illness and 39.7% were poisoned intentionally. The chief symptoms detected were: mental change 55.0%, gastrointestinal 14.4%, cardiovascular 10.5%, focal neurological 7.4%, respiratory 3.5%, none 8.7%, and unknown 0.4%. A request for detailed reports revealed that causative poisons were specified only in 20.1% cases. Zolpidem was detected in 22.3% cases (51/229), with median blood level 1.26 mg/L (interquartile 0.1, 5.06 mg/L) and urine 0.90 mg/L (interquartile 0.11, 5.6 mg/L). Furthermore, zolpidem was more frequently detected in toxicology analysis of patients where mental change was the primary symptom, as compared to other symptoms (32.5% vs. 9.7%, p<0.01). Conclusion: This study reported the blood level of zolpidem in suspected poisoning patients admitted to the emergency department.

• 한국임상약학회지
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• 제31권3호
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• pp.180-187
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• 2021

Objective: We investigated arthralgia and myalgia associated with the use of oral bisphosphonate (BP) by conducting a survey of patient. Methods: The pharmacists conducted a survey between 1 Oct 2019 and 30 Sep 2020 among patients who were dispensed BP in community pharmacies to assess their demographic and medical characteristics, and their experiences with, and process for pain. Logistic regression analyses were performed to find the risk factors associated with the pain, and the odds ratios (OR) and 95% confidence intervals (CI) were determined. Results: A total of 160 patients who used BP participated in the survey (74 [46.3%] used risedronate; 61 [38.1%] used alendronate; 23 [14.4%] used ibandronate), and 20 (12.5%) of them experienced pain. Significant statistical differences of the characteristics between patients who experienced pain or not were observed regarding menopause, and parity. Compared with women who had one or two parity, women who had more than three parity were associated with the decreased risk of pain (OR, 0.24; 95% CI, 0.04-0.98). Moreover, steady exercise was associated with the decreased risk of pain compared to less exercise (OR, 0.37; 95% CI, 0.14-0.98). Conclusion: Our findings suggest that the risk of pain in BP-treated patients might be different regarding the different ingredients of BP, and dosing frequency. This survey highlights a need for a further safety research to understand the factors influencing the pain associated with the BP treatment.