• 대한전자공학회논문지SD
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• 제46권1호
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• pp.59-67
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• 2009

본 논문에서 생체신호의 적응잡음을 제거하기 위해 개선된 비적적응필터(IMADF) 알고리즘을 제안한다. IMADF 구조는 DPCM과 Sign 알고리즘을 사용한 MADF에 1차 예측 필터를 사용한다. 그때 생체신호를 시험하기 위해서 MCG(심자도)에 기반한 심장팬텀 모델을 사용하고 신호를 분석한다. 심장팬텀의 기능들은 다극점 전류원으로부터 만들어진다. 이것은 인간의 심장과 똑같은 기능을 수행하는 역할을 한다 실험결과 IMADF 알고리즘은 곱셈동작이 없고 덧셈동작만 MADF 알고리즘보다 2개 더 늘어났으나, 훨씬 안전한 수렴특성을 나타냈고, 계산상을 복잡성도 줄이는 결과를 얻었다.

• 복식
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• 제39권
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• pp.139-166
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• 1998

This dissertation is to help understanding about the emergence of active children's clothes in the latter part of the 18th century in England. In previous ages children had not been look-ed upon as children, but as incomplete and in-ferior men and women, the costume of children had not been distinguishable from that of their elders. The early eighteenth-century chil-d could not play in comfort because they dressed like their parents. But in the third quarther of the eighteenth century children became free from their con-comfortable and became active. English chil-dren's clothes was prevailing even in Europe as well. In the background of this liberation, there were many enlightened ideas, such as philosophers of enlightenment, doctors, writers, educators. Among these John Locke and Jean Jacque Rousseau criticized openly about rampant fashion which was distorting the body by corset and hoop. Rousseau was the one who wrote$\boxDr$Emile$\boxUl$and played the most important role to free children from an old fashioned idea, and emphasized to bring up children by the natural process of mental and physical development as human beings are a part of nature. Fashion reflects politic, economic, social, ideology, culture of the days and these factor function to create fashion which shows“Time Spirit”.Children's clothes, like those of their parents, follow the fashion, but with a difference, the form of which varies with the attitude to the child. Thus this dissertation was to study in relation with the background of the times in the latter part of 18th century in England and Rousseau's Naturalism in connection with the emergence of active children's clothes. The result is that diffusion of the idea of freedom and equality, the growth of bourgeoisie, the development of clothing and tex-tile industry have influenced to the emergence of active children's clothes. Also a great deal of middle and high class parents devoted to their children's education and was influenced by Rousseau's Naturalism. Specially the bourgeoisie who made their fortune by their own effort were eager to educate their achievement and business by their children through education. This factor influenced to the children's clothes as well.

• BMB Reports
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• 제32권4호
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• pp.370-378
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• 1999

The effects of carnosine and related compounds (CRC) including anserine, homocarnosine, histidine, and ${\beta}$-alanine, found in most mammalian tissues, were investigated on in vitro glucose oxidation and glycation of human serum albumin (HSA). Carnosin and anserine were more reactive with D-glucose than with L-lysine. In the presence of $10\;{\mu}M$ Cu (II), although carnosine and anserine at low concentrations effectively inhibited formation of ${\alpha}$-ketoaldehyde from D-glucose, they increased generation of $H_2O_2$ in a dose-dependent manner. Carnosine, homocarnosine, anserine, and histidine effectively inhibited hydroxylation of salicylate and deoxyribose degradation in the presence of glucose and $10\;{\mu}M$ Cu (II). In the presence of 25 mM D-glucose, copper and ascorbic acid stimulated carbonyl formation from HSA. Except for ${\beta}$-alanine, CRC effectively inhibited the copper-catalyzed carbonyl formation from HSA. The addition of 25 mM D-glucose and/or $10\;{\mu}M$ Cu (II) to low density lipoprotein (LDL) increased formation of conjugated dienes. CRC effectively inhibited the glucose and/or copper-catalyzed LDL oxidation. CRC also inhibited glycation of HSA as determined by hydroxymethyl furfural and lysine with free ${\varepsilon}$-amino group. These results suggest that CRC may play an important role in protecting against diabetic complications by reacting with sugars, chelating copper, and scavenging free radicals.

• 대한한의학회지
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• 제28권3호통권71호
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• pp.57-69
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• 2007

Objectives : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications have shown that oxidative stress might play a major role. Therefore, many methods have been tried to regulate free oxygen radicals for treating diabetes and its complications. Ojung-hwan, composed of five crude herbs, has been considered effective for treating symptoms of aging. In male ob/ob mouse of severe obesity, hyperinsulinemia and hyperlipidemia, which are features of NIDDM, the hyperglycemic activities and mechanisms of Ojung-hwan were examined. Methods : Mice were grouped and treated for 5 weeks as follows. Both the lean (C57/BL6J black mice) and diabetic (ob/ob mice) control groups received standard chow. The experimental groups were fed a diet of chow supplemented with 30 and 90 mg Ojung-hwan per 1 kg of body weight for 14 days. The effects of Ojung-hwan extract on the ob/ob mice were observed by measuring the serum levels of glucose, insulin, lipid components, and the kidney levels of superoxide anion radical (${\cdot}\;O{_2}{^-}$), MDA+HAE, GSH/GSSG ratio, and also the enzyme activities involved in polyol pathway. Results : Ojung-hwan lowered the levels of serum glucose and insulin in a dose-dependent manner. Total cholesterol, triglyceride and free fatty acid levels decreased, while the HDL-cholesterol level increased, in Ojung-hwan treated groups. Renal aldose reductase and sorbitol dehydrogenase activities increased in the ob/ob mice, whereas they were inhibited in the Ojung-hwan treated groups. Ojung-hwan inhibited the generation of ${\cdot}\;O{_2}{^-}$ in the kidney. Finally, MDA+HAE levels increased and GSH/GSSG ratio decreased in the ob/ob mice, whereas they improved in the Ojung-hwan treated groups. Conclusions : Ojung-hwan showed antidiabetic and antihyperlipidemic activities by regulating theactivities of polyol pathway enzymes, scavenging reactive oxygen species and reducing the MDA+HAE levels in the ob/ob mice.

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1736-1745
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• 2016

The interactions of microbiota in the gut play an important role in promoting or maintaining the health of hosts. In this study, in order to investigate and compare the effects of dietary supplementation with Lactobacillus pentosus HC-2 (HC-2), Enterococcus faecium NRW-2, or the bacteria-free supernatant of a HC-2 culture on the bacterial composition of Litopenaeus vannamei, Illumina sequencing of the V1-V2 region of the 16S rRNA gene was used. The results showed that unique species exclusively existed in specific dietary groups, and the abundance of Actinobacteria was significantly increased in the intestinal bacterial community of shrimp fed with the bacteria-free supernatant of an HC-2 culture compared with the control. In addition, the histology of intestines of the shrimp from the four dietary groups was also described, but no obvious improvements in the intestinal histology were observed. The findings in this work will help to promote the understanding of the roles of intestinal bacteria in shrimps when fed with probiotics or probiotic supernatant.

• 대한약리학회지
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• 제1권1호
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• pp.37-46
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• 1965

1. In the tortoise, Amyda japonica, a cold-blooded animal readily available in this country, the role of catecholamines in the regulation of free fatty acids(FFA) metabolism was investigated in both in vivo and in vitro studies. 2. Norepinephrine elevated both FFA and glucose levels in plasma. 3. When $50{\mu}g/kg$ of Epinephrine, Norepinephrine and Isopropylarterenol were administered intravenously, the relative effectiveness of mobilizing FFA was in the descending order of potency-Epinephrine, Norepinephrine and Isopropylarterenol. 4. In order to exclude the 'tonic influence of the endogenous catecholamines', reserpine was given to some animals. Two days after the reserpine-treatment, glucose showed a significant increase over the solely vehicle treated controls, FFA but an insignificant one. Excised auricles from those animals showed a diminished response to tyramine. Seven days after the treatment, however, when the depletion of catecholamines from the tissue stores seemed to be complete, judged from the absence of the response of isolated auricles to tyramine, both FFA and glucose levels were definitely lowered. 5. In in vitro experiments Epinephrine enhanced the FFA-release from the adipose tissue. The effect increased proportionately with the concentration until a maximal effect was attained at a concentration of 1x $10^5$ g/ml. 6. The order of potency in releasing FFA from adipose tissue in vitro was the same as in vitro, i.e., Epinephrine, Norepinephrine and Isopropylarterenol, but the differences were much less marked. 7. Ergotamine exerted no lipolytic action, but inhibited the lipolytic effect ef Epinephrine significantly. 8. Nethalide showed a slight lipolytic effect per se but inhibited the Epinephrine-induced lipolysis significantly. 9. Catecholamines play an important role in regulating FFA metabolism in the cold-blooded animal, just as in the warm-blooded animals, and the tortoise, Amyda japonica, may be used in the studies of fat metabolism as well as the rat.

• Strategy21
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• 통권42호
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• pp.224-257
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• 2017

As the Trump administration withdraws the Paris Climate Agreement and shows its antipathy toward free trade, the U.S.'s soft power is most likely to weaken and its behaviors could be perceived as acts to surrender the U.S. hegemonic leadership in the world stage. Hegemonic stability theory notes that the existence of a hegemonic power contributes to international stability in the sense that it provides international public goods. A lack of the U.S's leadership in international politics, however, could be recognized as its denial of a hegemonic status. Is it intentional or accidental? The U.S's denial of hegemonic roles is the byproduct of the Trump administration's "American First" policy, not the showcase of its intention to transit hegemony to others. What is noteworthy is that China targets a niche market of hegemony as the U.S. denies its roles as the international leader. Put it another way, China attempts to ride hegemony for free when the U.S. denies its hegemonic roles accidentally. Faced with a niche market of hegemony, China has begun to accelerate its national strategy to make "Chinese Dream" come true. To that end, China promised again to keep the Paris Climate Agreement and attempts to play more active its roles in Shanghai Cooperation Organization(SCO), Asia Infra Investment Bank(AIIB), and "One Belt, One Road". Despite all these efforts, the U.S. is most likely to withdraw its denial of hegemony any time soon. The U.S's resumption of Freedom of Navigation Operations(FONOPs) could be a precursor of the return to a hegemonic power's willingness. In this vein, it is noteworthy that the South China Sea serves as a quasi-war zone for hegemonic conflict.

• The Korean Journal of Physiology and Pharmacology
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• 제18권6호
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• pp.525-530
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• 2014

Transient receptor potential vanilloid subtype 1 (TRPV1) was originally found in sensory neurons. Recently, it has been reported that TRPV1 is expressed in salivary gland epithelial cells (SGEC). However, the physiological role of TRPV1 in salivary secretion remains to be elucidated. We found that TRPV1 is expressed in mouse and human submandibular glands (SMG) and HSG cells, originated from human submandibular gland ducts at both mRNA and protein levels. However, capsaicin (CAP), TRPV1 agonist, had little effect on intracellular free calcium concentration ($[Ca^{2+}]_i$) in these cells, although carbachol consistently increased $[Ca^{2+}]_i$. Exposure of cells to high temperature (> $43^{\circ}C$) or acidic bath solution (pH5.4) did not increase $[Ca^{2+}]_i$, either. We further examined the role of TRPV1 in salivary secretion using TRPV1 knock-out mice. There was no significant difference in the pilocarpine (PILO)-induced salivary flow rate between wild-type and TRPV1 knock-out mice. Saliva flow rate also showed insignificant change in the mice treated with PILO plus CAP compared with that in mice treated with PILO alone. Taken together, our results suggest that although TRPV1 is expressed in SGEC, it appears not to play any direct roles in saliva secretion via transcellular pathway.

• Clinical and Experimental Reproductive Medicine
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• 제45권2호
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• pp.82-87
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• 2018

Objective: Concerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in ART-conceived babies. Findings regarding the health of ART-conceived babies are controversial. The present study was conducted to evaluate the prooxidant-antioxidant balance (PAB) in in vitro fertilization (IVF)-conceived mice in comparison to naturally conceived offspring. Methods: Mice (6-8 weeks) were divided into two groups (IVF-conceived and naturally conceived) matched by sex, age, weight, and litter size. A 1-mL blood sample was taken and the sera were separated. The oxidant-antioxidant balance was evaluated using a fast and reliable PAB assay. The results were expressed as $mean{\pm}standard$ deviation. Results: The mean PAB values (HK units) in the IVF-conceived and naturally conceived groups were $59.70{\pm}22.30$ and $54.70{\pm}18.22$, respectively (p= 0.82). Conclusion: Since free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured.

• 한국식품과학회지
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• 제31권5호
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• pp.1137-1143
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• 1999

볶음참깨 및 참기름 제조시 필요한 기초자료를 마련하기 위하여 볶음온도$(110^{\circ}C{\sim}230^{\circ}C)$변화에 따른 참깨의 물리적 변화 및 화학적 변화를 알아보았다. 볶음참깨의 물리적 특성에 있어서 수분함량, 부피변화, 착유수율, 참깨박함량 및 색도는 $170^{\circ}C$이상에서 유의적으로 변하였고, 참깨박 중의 지방함량 및 단백질함량은 약간 변화하였다. 착유수율과 관능적 특성을 고려할 때 볶음최적온도는 $220^{\circ}C$로 판단된다. Arginine, serine, threonine, lysine, cystine, tyrosine 등의 총아미노산과 대부분의 유리아미노산, 그리고 유리당 중의 sucrose는 $170^{\circ}C$ 및 $190^{\circ}C$ 이상에서 유의적으로 감소하였다. 이러한 당과 아미노산 함량의 감소는 볶음참깨의 갈색색소 및 고소한 맛과 풍미 형성에 중요한 역할을 한 것으로 추측한다. 이러한 반응은 비교적 높은 온도에서 수분이 적고, 기름함량이 많은 식품계에서 당과 아미노화합물의 상호작용에 의한 열분해반응임을 알 수 있었다.