• Toxicological Research
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• v.17 no.1
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• pp.33-39
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• 2001

To evaluate the skin toxicity oj topical toluene application, toluene (35 mg/$cm^2$) was sequentially applied to the portion rat skin for five days. The topical toluene application resulted in increased xanthine oxidase activity and CYP content, and significantly decreased superoxide dismutase and glutathione peroxidase activities at five days in rat skin. Especially catalase activity was remarkably decreased in toluene-applied rat skin. And benzylalcohol dehydrogenase activity showed also a significant decrease in toluene-applied skin. On the other hand, histopathological ultrastructural examination revealed disrupted epidermal basement membrane, rared intercellular adhensions and degenerated keratin layer due to topical toluene application. Increased deposit of cerrous perhydroxide resulted from reaction with $H_2O_2$was abserved in toluene-treated animals. These results indicate that oxygen free radical may be responsible for ultrastructural changes in skin tissue by toluene application to rat skin.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10a
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• pp.817-826
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• 1987

An offset-free self-tuning control with pole placement (STCPP) and a recursive parameter estimation with multiple and variable forgetting factors (REWF), together with their application to a real plant, are described. There are two different types of offset-free STCPP; their features are analysed and discussed. REMVF employs as many forgetting factors as parameter estimates. It is suitable when parameters to be estimated are changing at different rates. The offset-free STCPP and REMVF have been successfully applied to a real plant, giving excellent results.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2001.07a
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• pp.63-92
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• 2001

·EC's/Japanese environmental regulation drive the Pb-free/Halogen-free application ·Most Japanese electronics companies are preparing the green products. ·All items concerning to Pb-free/halogen-free technology should be coparallely designed and developed. ·More works need to clear the unknowns on Pb-free materials ·Need of consensus on materials and standards ·EBM (Environmental Benign Manufacturing)

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2004.09a
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• pp.93-99
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• 2004

At present, LG Electronics pushes ahead to eliminate the Pb(Lead) -a hazardous material- from all products. Especially, we have performed to select the optimum standard composition of lead free alloy for the application to products for about 3 years from 2000. These days, we have the chance for applying to the mass-production. This project constructed the system for applying the lead free solders on consumer electronic products, which is one of the major products of the LG Electronics. To select the lead free solders with corresponding to the product features, we have passed through the test and applied with Sn-3.0Ag-0.5Cu alloy system to our products, and for the application to the high melting temperature composition, we secured the thermal resistance of the many parts and substrate and optimized the processing conditions. We have operated the temperature cycling test and the high temperature storage test under the standards to confirm the reliability of the products. On these samples, we considered the consequence of our decision by the operating test. For the long life time of the product, we have operated the temperature cycling test at $-45^{\circ}C-+125^{\circ}C$, 1 cycle/hour, 1000 cycles. Also we have tested the tin whisker growth about lead free plating on lead finish. We have analyzed with the SEM, EDS and any other equipment for confirming the failure mode at the joint and the tin whisker growth on lead free finish.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2001.09a
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• pp.21-50
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• 2001

EC's/Japanese environmental regulation drive the Pb-free/Halogen-free application. Most Japanese electronics companies are preparing the green products. All items concerning to Pb-free/Halogen-ree technology should be coparallely designed and developed. More works need to clear the unknowns on Pb-free materials. Need of consensus on materials and standards. EBM (Environmental Benign Manufacturing)

• Journal of The Korean Society of Grassland and Forage Science
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• v.34 no.3
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• pp.155-162
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• 2014

This study was conducted to investigate the influence of the mixed application of chemical fertilizer (CF) and liquid swine manure (LSM) on the agronomic characteristics, dry matter yield, amino acids, minerals, and free sugars in cultivating Sorghum ${\times}$ Sudangrass hybrid (SSH) on paddy soil. The field experiment was designed in a randomized block design with three replications and consisted of CF 100% (C), CF 70% + LSM 30% (T1), CF 50% + LSM 50% (T2), CF 30% + LSM 70% (T3), and LSM 100% treatment (T4). The application of LSM was based solely on the nitrogen. Plant length, leaf length, leaf width and number of leaf were significantly higher in T4 (p<0.05), but stem diameter did not show significant differences among treatments. Stem hardness increased significantly (p<0.05) as the LSM application rate decreased, but sugar degree decreased significantly (p<0.05) as the LSM application rate decreased. Fresh yield, dry matter yield and TDN yield were the highest in T4, whereas the lowest in T2 (p<0.05). Crude protein, crude fat and crude ash were the highest in C, T4 and T2, respectively (p<0.05). However, NDF and ADF did not show significant difference among treatments. Crude fiber decreased significantly (p<0.05) as the LSM application rate increased. The total mineral content was decreased significantly (p<0.05) as the LSM application rate increased. Total amino acid content was higher in the order of T1> C> T3> T4> T2 (p<0.05). Free sugar content increased significantly (p<0.05) as the LSM application rate increased. The analysis of all the above results suggests that the application of liquid swine manure is very effective, considering the yield performance and the content of sugar degree and free sugar. In addition, liquid swine manure may be possible to grow Sorghum ${\times}$ Sudangrass hybrid without chemical fertilizer.

• Biomedical Science Letters
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• v.9 no.2
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• pp.75-84
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• 2003

To evaluate the influence of hepatic oxygen free radical systems on liver injury by topical p-phenylenediamine (PPD) application on rat skin, PPD (25 mg/16.5 $\textrm{cm}^2$) was topically applied to the abdominal region 5 times every other day and sacrificed. By PPD treatment, increasing rate of liver weight/body weight (%), serum activities of alanine aminotransferase and aspartate aminotransferase and decreasing rate of microsomal glucose-6-phosphatase activity were higher in the rats fed tungstate supplemented diet than those fed a standard diet. These findings indicate that group fed tungstate supplemented diet have more severe liver injury compared with group fed standard diet on topical PPD application. However, the activities of oxygen free radical generating enzymes such as xanthine oxidase (XO) and cytochrome P450 dependent aniline hydroxylase and those of oxygen free radical scavenging enzymes were not found to be different between these two animal groups. In the present study, a novel monitoring method to detect the generating of oxygen free radicals in liver extract was devised. Throughout this method, the oxidized PPD produced by oxygen free radicals was determined colorimetrically. The increasing rate of PPD oxidation by liver homogenate was higher in tungstate fed animals than in standard diet fed ones. Among the fractionations of liver extract, the mitochondrial and postmitochondrial fractions in the liver extract of tungstate fed animals led to a higher availability of PPD oxidation by PPD treatment compared with standard diet fed ones. In conclusion, these results suggest that an enhanced liver injury in tungstate fed animals treated with PPD may be due to oxygen free radicals produced in other systems except oxygen free radicals generating from cytosolic XO system. Especially, oxidative availability by PPD can be used for oxygen free radical detection in some tissue.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.1 s.94
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• pp.46-52
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• 2005

This paper is concerned with the application of perturbation method to the dynamic analysis of free-free beam. In general, the rigid-body motions and elastic vibrations are analyzed separately. However, the rigid-body motions cause vibrations and elastic vibrations also affect rigid-body motions in turn, which indicates that the rigid-body motions and elastic vibrations are coupled in nature. The resulting equations of motion are hybrid and nonlinear. We can discretize the equations of motion by means of admissible functions but still we have to cope with nonlinear equations. In this paper, we propose the use of perturbation method to the coupled equations of motion. The resulting equations consist of zero-order equations of motion which depict the rigid-body motions and first-order equations of motion which depict the perturbed rigid-body motions and elastic vibrations. Numerical results show the efficacy of the proposed method.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.2
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• pp.75-82
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• 2017

With the development of computational fluid dynamics (CFD), studies on shipbuilding and maritime issues including free-surface wave flow have been conducted. Although the volume of fluid (VOF) and level-set methods are widely used to study the free-surface wave flow, disadvantages exist. In particular, it takes a long time to obtain solutions. In this study, a free-surface capturing code is developed for ship and offshore structures. The developed code focuses on accuracy and computation time. Open source CFD libraries, termed OpenFOAM, are used to develop the code. The results obtained using the developed code are compared with those obtained using interFoam. The results show that the developed code could be used to capture the free-surface wave flow without numerical diffusion; moreover, the accuracy of the developed code is largely the same as that of interFoam.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.814-818
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• 2003

This paper deals with the application of numerical differentiation in free vibration analysis. In the free vibration analysis, the derivative values of the given function are certainly used in calculation of structural parameters. For deriving the derivative values, both the time and labor are needed when the structures consist of non-linear geometries such as arches or curved beams. From this viewpoint, the numerical differentiation scheme is applied into the free vibration analysis. The numerical results obtained from the numerical differentiations are agreed very well with those obtained from the exact derivatives by analytical method. It is expected that the numerical differentiations can be utilized practically in the free vibration analysis.