• Journal of Korean Neurosurgical Society
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• 제43권1호
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• pp.26-30
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• 2008

Objective : The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C. Development and verification procedures were described in this article. Methods : The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-$frame^{(R)}$ and $KOPF^{(R)}$ rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images. Results : The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma $Plan^{(R)}$. The dose distributions measured with $GAFCHROMIC^{(R)}$ MD-55 film corresponded to those of Leksell Gamma $Plan^{(R)}$ within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife. Conclusion : A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.

• 보건행정학회지
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• 제24권1호
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• pp.92-99
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• 2014

Background: Korea's primary care clinics are seeking increase in consultation fees by expanding supply within the frame of the health insurance system, but inequality of physician income between regions and individuals is exacerbating. The purpose of this study lies in analyzing the distribution of patients of primary care clinics, their specialized field, and the degree of inequality between medical fee income according to region. Data was acquired from the Health Insurance Review and Assessment Service on charged bills made by clinic-size medical institutions from 2008 to 2011. Methods: By comparing the outpatient number per clinic according to the clinic's specialized field, results showed that ophthalmology, otolaryngology, dermatology, orthopedics, and internal medicine showed high numbers whereas plastic surgery, neuropsychiatry, cardiothoracic surgery had fewer outpatients. The number of outpatients for clinic according to region showed Chuncheonnam-do, Jeju-do, Gangwon-do, Chungcheongbuk-do, Ulsan to have higher numbers of outpatients. For those four years, clinics in the Seoul area had a rather lower number. Results: As a result of comparing the decile hierarchy distribution ratio between specialized fields according to primary care clinics income from National Health Insurance, the inequality degree showed that obstetrics and gynecology and general medicine were each 0.130, 0.280 for the decile distribution ratio, which was the highest degree of inequality within the specialized field. Their Gini coefficient were also relatively high at 0.691, 0.528 respectively. On the other hand, the decile distribution ratio for otolaryngology and orthopedics were 0.510, 0.468, respectively, while their Gini coefficient each at 0.318, 0.314 makes their inequality degree relatively lower than other fields. Conclusion: This study is limited in that the data used was the health insurance charges submitted by clinics, which does not provide total information of the doctors' income. However, because most clinics are largely dependant on their income to come from health insurance reimbursements. Therefore, the results of this study can be used effectively. In the future, research that includes data on non-covered service income should be conducted to closely examine policy plans with a new medical fee policy which can resolve the medical fee income inequality issue between clinics as well as revitalize primary medical care.

• Structural Engineering and Mechanics
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• 제78권3호
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• pp.305-317
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• 2021

An AMD control system is usually built based on the original model of a target building. As a result, the fact leads a large calculation workload exists. Therefore, the orders of a structural model should be reduced appropriately. Among various model-reduction methods, a suitable reduced-order model is important to high-rise buildings. Meanwhile, a partial structural information is discarded directly in the model-reduction process, which leads to the accuracy reduction of its controller design. In this paper, an optimal technique is selected through comparing several common model-reduction methods. Then, considering the dynamic characteristics of a high-rise building, an improved balanced truncation (BT) method is proposed for establishing its reduced-order model. The abandoned structural information, including natural frequencies, damping ratios and modal information of the original model, is reconsidered. Based on the improved reduced-order model, a new reduced-order controller is designed by a regional pole-placement method. A high-rise building with an AMD system is regarded as an example, in which the energy distribution, the control effects and the control parameters are used as the indexes to analyze the performance of the improved reduced-order controller. To verify its effectiveness, the proposed methodology is also applied to a four-storey experimental frame. The results demonstrate that the new controller has a stable control performance and a relatively short calculation time, which provides good potential for structural vibration control of high-rise buildings.

• Radiation Oncology Journal
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• 제20권2호
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• pp.179-185
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• 2002

목적 : 본 교실에서 개발한 정위방사선수술 시스템의 정도관리를 위하여 다용도 팬톰을 제작하고 정위방사선수술 기법의 선량의 정확도를 확인하려 하였다. 대상 및 방법 : CL2100C 선형가속기에서 발생하는 6 MV 엑스선을 사용하여 정위적 방사선수술을 시행하였고 Farmer형 이온함, 0.125 cc 이온함, 다이오드 검출기 등을 정위 기준기구가 부착된 팬톰내에 설치한 후 선량을 측정하였다. 고정 빔, $20^{\circ}\~100^{\circ}$의 각도를 갖는 단일회전빔, 복합회전빔 등의 방사선조사 조건에서 측정기와 팬톰의 상대적 위치를 변화시키면서 측정하였다. 내경이 10, 20, 30, 40 mm인 원형의 3차 콜리메이터를 사용하였다. 결과 : 고정 빔, 단일 회전빔, 5개의 회전 빔으로 구성된 복합회전빔 등에서의 선량오차는 Farmer형 이온함으로 측정한 경우는 $0.5\%$ 이하, 0.125 cc 이온함의 경우에는 $0.5\%$, 다이오드 검출기인 경우에는 $2\%$ 이내였다. 결론 : 본 교실 개발 정위방사선수술 기법에 의한 방사선 조사선량의 정확도를 확인하였으며 이 자료는 향후 정위방사선수술 및 다분할 방사선치료의 정도관리에 유용한 기초자료로 활용될 것이다.

• Journal of Biosystems Engineering
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• 제42권2호
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• pp.117-125
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• 2017

Purpose: Damage to pulse crops by wild birds is a serious problem. The damage is to such an extent that the rate of damage during the period between seeding and cotyledon stages reaches 54.6% on an average. In this study, a crop-position detection method was developed wherein infrared (IR) sensors were used to determine the cotyledon position under a vinyl mulch. Methods: IR sensors that helped measure the temperature were used to locate the cotyledons below the vinyl mulch. A single IR sensor module was installed at three locations of the crops (peanut, red lettuce, and crown daisy) in the cotyledon stage. The representative thermal response of a $16{\times}4$ pixel area was detected using this sensor in the case where the distance from the target was 25 cm. A spatial image was applied to the two-dimensional temperature distribution using a non-integral moving-average method. The collected data were first processed by taking the moving average via interpolation to determine the frame where the variance was the lowest for a resolution unit of 1.02 cm. Results: The temperature distribution was plotted corresponding to a distance of 10 cm between the crops. A clear leaf pattern of the crop was visually confirmed. However, the temperature distribution after the normalization was unclear. The image conversion and frequency-conversion graphs were obtained based on the moving average by averaging the points corresponding to a frequency of 40 Hz for 8 pixels. The most optimized resolutions at locations 1, 2, and 3 were found on 3.4, 4.1, and 5.6 Pixels, respectively. Conclusions: In this study, to solve the problem of damage caused by birds to crops in the cotyledon stage after seeding, the vinyl mulch is punched after seeding. The crops in the cotyledon stage could be accurately located using the proposed method. By conducting the experiments using the single IR sensor and a sliding mechanical device with the help of a non-integral interpolation method, the crops in the cotyledon stage could be precisely located.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.1981-1987
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• 2014

Objective: To establish the prevalence and distribution profile of esophageal squamous cell carcinomas (ESCCs) over a 22-yr period in North China. Methods: Using endoscopy for primary diagnosis and histological analysis for the further confirmation, a total of 74,854 ESCC patients aged 20-89 between January 1985 and December 2006 were investigated to analyze the epidemiological profile including prevalence rates, distribution of age-of-onset, gender and geographical area of ESCC in Luoyang, the highest incidence area of North China. Results: A total of 4092 cases of ESCC were finally diagnosed among 74,854 patients who had their first endoscopies. The prevalence among males was higher than that among females (p<0.01), resulting in an overall male:female OR of 1.2 (95%CI, 1.2-1.3). The prevalence in rural areas was higher than in urban areas (p<0.01), resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4-2.9). The rural:urban ORs and the 95% CI increased continuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period. Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexes and in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods in the 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the area of North China, and suggest that urban areas and rural people account for a growing proportion of the ESCC patients although the prevalence of ESCC significantly declined and the median age-of-onset postponed over the 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for public health initiatives aimed at reducing risk factors of this fatal disease.

• Earthquakes and Structures
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• 제26권6호
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• pp.417-431
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• 2024

The fundamental period of vibration is one of the most critical parameters in the analysis and design of structures, as it depends on the distribution of stiffness and mass within the structure. Therefore, building codes propose empirical equations based on the observed periods of actual buildings during seismic events and ambient vibration tests. However, despite the fact that infill walls increase the stiffness and mass of the structure, causing significant changes in the fundamental period, most of these equations do not account for the presence of infills walls in the structure. Typically, these equations are dependent on both the structural system type and building height. The different values between the empirical and analytical periods are due to the elimination of non-structural effects in the analytical methods. Therefore, the presence of non-structural elements, such as infill panels, should be carefully considered. Another critical factor influencing the fundamental period is the effect of Soil-Structure Interaction (SSI). Most seismic building design codes generally consider SSI to be beneficial to the structural system under seismic loading, as it increases the fundamental period and leads to higher damping of the system. Recent case studies and postseismic observations suggest that SSI can have detrimental effects, and neglecting its impact could lead to unsafe design, especially for structures located on soft soil. The current research focuses on investigating the effect of infill panels on the fundamental period of moment-resisting and eccentrically braced steel frames while considering the influence of soil-structure interaction. To achieve this, the effects of building height, infill wall stiffness, infill openings and soil structure interactions were studied using 3, 6, 9, 12, 15 and 18-story 3-D frames. These frames were modeled and analyzed using SeismoStruct software. The calculated values of the fundamental period were then compared with those obtained from the proposed equation in the seismic code. The results indicate that changing the number of stories and the soil type significantly affects the fundamental period of structures. Moreover, as the percentage of infill openings increases, the fundamental period of the structure increases almost linearly. Additionally, soil-structure interaction strongly affects the fundamental periods of structures, especially for more flexible soils. This effect is more pronounced when the infill wall stiffness is higher. In conclusion, new equations are proposed for predicting the fundamental periods of Moment Resisting Frame (MRF) and Eccentrically Braced Frame (EBF) buildings. These equations are functions of various parameters, including building height, modulus of elasticity, infill wall thickness, infill wall percentage, and soil types.

• Communications for Statistical Applications and Methods
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• 제19권3호
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• pp.405-414
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• 2012

층화확률추출은 모집단을 어떤 층화기준에 의해 여러 층으로 분할한 다음 각 층으로부터 독립적으로 표본을 임의추출하는 방법으로 여러 가지 장점을 가지고 있어 실제 조사에서 많이 활용되고 있다. 본 연구에서는 대규모 표본조사에서 많이 사용하고 있는 층화확률추출을 사용하여 추출된 표본을 통해 모평균에 대한 붓스트랩 추정량과 신뢰구간 및 가설검정 등 통계적 추론에 대하여 연구하였다. 층화모집단에서의 모평균의 추정량과 관련된 극한 분포이론들을 기초로 붓스트랩 일치성을 근거로 층화 모평균에 대해 표준 붓스트랩 방법, 백분위수 붓스트랩 방법, 스튜던트화 붓스트랩 방법을 활용한 신뢰구간과 붓스트랩 가설검정 방법을 제안하였으며, 모의실험을 통해 신뢰구간 추정 방법들의 유효성을 확인하였다.

• Current Research on Agriculture and Life Sciences
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• 제27권
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• pp.59-67
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• 2009

The purpose of this study is to propose the methodology for introducing green infrastructure that can improve the health of citizens by promoting walkability. The methodology is composed of the following three phases: classification of the types of green spaces, selection of core green spaces with two separate analyses, and introduction of the framework of green infrastructure to promote walkability. In the first phase, the classification of the types of green spaces was carried out in order to understand existing distribution pattern of green spaces in study site. In the second phase, walkable blocks were selected by such methods as walkability value. Through these two analyses, all the blocks were divided into three groups according to the ranking figured up the second analyses' results. The blocks in the first group, the group involved in the top 30% and having the greatest ranking, were defined as walkable blocks. In the last phase, a basic frame of the green infrastructure in study site was introduced by connecting the walkable blocks with using other blocks and the green spaces over 1ha. In case study, 28 important green spaces and 35 walkable blocks were selected through the two analysis process. Then, the basic framework of green infrastructure based on the selected 28 important green spaces and 35 walkable blocks was introduced. The methodology applied to this study can be used to get the best selections of the proper green infrastructure in accordance with the purpose of the ecological and recreational local development. In particular, this study will suggest a specific analysis model to use for the ecological and walkable urban planning with green spaces existing in the city.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7125-7128
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• 2014

Background: Acquired genetic alterations and presence of sensitizing mutations in the tyrosine kinase domain of EGFR and other signaling molecules have been found in different subsets of primary lung adenocarcinoma. The commonest EGFR mutations are small in frame deletions of exon 19 and a point mutation (L858R) in exon 21, having a combined occurrence of around 90%. The objective of this study was to determine the frequency and types of EGFR mutations in primary lung adenocarcinomas in Pakistan. Materials and Methods: EGFR mutations in tumor samples were screened by multiplex real time PCR. Briefly, DNA from formalin fixed paraffin-embedded tissue was amplified with primers and probes specific to 43 different EGFR mutations in a Cobas z 480 instrument. The assay detects mutations in four exons (18-21) of the EGFR gene. Results: Out of 94 patients, 65 were males and 29 females with a M:F ratio of 2.2: 1. The median age was 62 years (range, 28 - 85 years). In our biopsy samples 70 (74%) cases were of primary lung adenocarcinoma, whereas 24 (26%) were confirmed metastatic adenocarcinoma of primary lung origin. EGFR mutation was positive in 29% of the patients. The highest frequency of L858R was observed in 48% of these, followed by deletion in exon 19 (44%). In addition, other rare mutations such as compound G718X:S768I and insertions in exon 20 insertion were detected in approximately 4% of the patients. Conclusions: This study showed that Del 19 and L858R are the most frequent mutations in Pakistani lung adenocarcinoma patients and around 29% of the patients were found eligible for erlotinib therapy.