Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지
DOI QR코드

DOI QR Code

Development of a Stereotactic Device for Gamma Knife Irradiation of Small Animals

  • Chung, Hyun-Tai (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Chung, Young-Seob (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Kim, Dong-Gyu (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Paek, Sun-Ha (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Cho, Keun-Tae (Department of Neurosurgery, Dongguk University International Hospital)
  • Published : 2008.01.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C. Development and verification procedures were described in this article. Methods : The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-$frame^{(R)}$ and $KOPF^{(R)}$ rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images. Results : The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma $Plan^{(R)}$. The dose distributions measured with $GAFCHROMIC^{(R)}$ MD-55 film corresponded to those of Leksell Gamma $Plan^{(R)}$ within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife. Conclusion : A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.

Keywords

References

  1. Andreo P, Burns DT, Hohlfeld K, Saiful Huq M, Kanai T, Laitano F, et al : Absorbed dose determination in external beam radiotherapy : An international code of practice for dosimetry based on standards of absorbed dose to water. V.11b. IAEA Technical Report Series 398. International Atomic Energy Agency. Vienna, Austria, 2004, pp1-181
  2. Araki F, Ikegami T, Ishidoya T, Kubo HD : Measurements of Gamma- Knife helmet output factors using a radiophotoluminescent glass rod dosimeter and a diode detector. Med Phys 30 : 1976-1981, 2003 https://doi.org/10.1118/1.1587451
  3. Bjarngard BE, Tsai JS, Rice RK : Doses on central axis of narrow 6MV x-ray beams. Med Phys 17 : 794-799, 1990 https://doi.org/10.1118/1.596475
  4. Bova F, Spiegelmann R, Friedman WA : A Device for experimental radiosurgery. Stereotact Funct Neurosurg 56 : 213-219, 1991 https://doi.org/10.1159/000099408
  5. Combs SE, Widmer V, Thilmann C, Hof H, Debus J, Schulz-Ertner D : Stereotactic radiosurgery (SRS) : treatment option for recurrent glioblastoma multiforme (GBM). Cancer 104 : 2168-2173, 2005 https://doi.org/10.1002/cncr.21429
  6. Heck B, Jess-Hempen A, Kreiner HJ, Schopgens H, Mack A : Accuracy and stability of positioning in radiosurgery : long-term results of the Gamma Knife system. Med Phys 34 : 1487-1495, 2007 https://doi.org/10.1118/1.2710949
  7. Hsieh PC, Chandler JP, Bhangoo S, Panagiotopoulos K, Kalapurakal JA, Marymont MH, et al : Adjuvant Gamma Knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme. Neurosurgery 57 : 684-692, 2005 https://doi.org/10.1093/neurosurgery/57.4.684
  8. Im YS, Nam DH, Kim JS, Ju SG, Lim DH, Lee JI : Stereotactic device for Gamma Knife radiosurgery in experimental animals : technical note. Stereotact Funct Neurosurg 84 : 97-102, 2006 https://doi.org/10.1159/000094367
  9. Kim JE, Paek SH, Chung HT, Kim DG, Jung HW : In vitro biological response of malignant glioma cell lines to Gamma Knife irradiation. J Korean Neurosurg Soc 35 : 599-604, 2004
  10. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, et al : Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Res 67 : 8791-8799, 2007 https://doi.org/10.1158/0008-5472.CAN-07-0477
  11. Lopez CA, Feng FY, Herman JM, Nyati MK, Lawrence TS, Ljungman M : Phenylburyrate sensitizes human glioblastoma cells lacking wildtype p53 function to ionizing radiation. Int J Radiat Oncol Biol Phys 69 : 214-220, 2007 https://doi.org/10.1016/j.ijrobp.2007.04.069
  12. Maciunas RJ, Galloway RL Jr, Latimer JW : The application accuracy of stereotactic frames. Neurosurgery 35 : 682-694, 1994 https://doi.org/10.1227/00006123-199410000-00015
  13. Mack A, Scheib SG, Major J, Gianolini S, Pazmandi G, Feist H, et al : Precision dosimetry for narrow photon beams used in radiosurgery - determination of Gamma Knife output factors. Med Phys 29 : 2080-2089, 2002 https://doi.org/10.1118/1.1501138
  14. Paxinos G, Watson C : The rat brain in stereotactic coordinates, ed 2. North Ryde : Academic Press Australia, 1986, pp7-11
  15. Rice KR, Hansen JL, Svensson GK, Siddon RL : Measurement of dose distribution in small beams of 6MV x-rays. Phys Med Biol 32 : 1087-1099, 1987 https://doi.org/10.1088/0031-9155/32/9/002
  16. Scheib SG, Gianolini S, Lomax NJ, Mack A : High precision radiosurgery and technical standards. Acta Neurochir (Suppl) 91 : 9-23, 2004
  17. Tsai JS, Rivard MJ, Engler MJ, Mignano JE, Wazer DE, Shucart WA : Determination of the 4 mm Gamma Knife helmet relative output factor using a variety of detectors. Med Phys 30 : 986-992, 2003 https://doi.org/10.1118/1.1567736