• ALGAE
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• 제31권2호
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• pp.129-136
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• 2016

The Mediterranean Sea is currently facing dramatic changes and threats, including change in native species and accidental introductions. The introduced green alga Codium fragile subsp. fragile (Suringar) Hariot influences diversity and community structure in some parts of the world. This paper documents the distribution of this species in Tunisia and provides a morphological description of C. fragile subsp. fragile in Northern Tunisia. Results confirm the identity of Tunisian specimens as the invasive subspecies C. fragile subsp. fragile. This is the first morphological characterization of this subspecies in Tunisia.

• 생명과학회지
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• 제9권6호
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• pp.704-708
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• 1999

This research was carried out for evaluating diagnostic value of antibody test in Fragile X syndrome. In antibody test of control individuals and carriers with a premutation, FMRP were detected in the lymphocytes, whereas the lymphocytes of male Fragile X syndrome patients were devoid of FMRP. Five Fragile X syndrome male patient, two Fragile X syndrome female patients, three carriers were diagnosed by southern blot. Five boys who were diagnosed as the patients by antibody test were turned out full mutation and having multiple smear beside normal single band. However, fragile site of X chromosome was not expressed in Fragile X syndrome patients by chromosome analysis. These results showed that antibody test was a fast and simple method, but the diagnostic power was "perpect" for males, whereas the results were less specific for females.r females.

• Journal of Information Processing Systems
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• 제14권2호
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• pp.510-522
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• 2018

As the major source of information, digital images play an indispensable role in our lives. However, with the development of image processing techniques, people can optionally retouch or even forge an image by using image processing software. Therefore, the authenticity and integrity of digital images are facing severe challenge. To resolve this issue, the fragile watermarking schemes for image authentication have been proposed. According to different purposes, the fragile watermarking can be divided into two categories: fragile watermarking for tamper localization and fragile watermarking with recovery ability. The fragile watermarking for image tamper localization can only identify and locate the tampered regions, but it cannot further restore the modified regions. In some cases, image recovery for tampered regions is very essential. Generally, the fragile watermarking for image authentication and recovery includes three procedures: watermark generation and embedding, tamper localization, and image self-recovery. In this article, we make a review on self-embedding fragile watermarking methods. The basic model and the evaluation indexes of this watermarking scheme are presented in this paper. Some related works proposed in recent years and their advantages and disadvantages are described in detail to help the future research in this field. Based on the analysis, we give the future research prospects and suggestions in the end.

• 대한의생명과학회지
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• 제2권1호
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• pp.127-132
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• 1996

한국인 일반 정신박약자들의 핵형 및 혈청단백질을 분석한 결과는 다음과 같다. 정신박약자 35명 중 3명에서 fragile X 염색체를 발견하였고 그 빈도는 4~l5%였다. Fragile X 증후군 환자들의 혈청단백질의 농도는 5.73$\pm$0.89(g/ dl) 이었고 albumin과 globulin의 비는 0.86$\pm$0.14 이었다. 일반 정신박약자들의 혈청단백질 농도는 6.83$\pm$0.72(g/dl) 이었고 이중 albumin과 globulin의 비는0.87$\pm$0.47 이었다. Fragile X증후군환자 및 일반정신박약자들의 혈청단백질 농도 및 albumin과 globulin의 비는 정상인 및 Down 증후군환자들 보다 낮았다.

• 한국수산과학회지
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• 제53권6호
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• pp.816-822
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• 2020

This study investigated the antioxidant activity and general and sensory properties of soybean curd supplemented with Codium fragile. The yield of soybean curd containing 0%, 20%, and 40% C. fragile was 113.62, 104.09, and 108.06, respectively. Antioxidant activities and pH were significantly increased (P<0.05) depending on the amount of C. fragile supplemented in soybean curd. Compared to that in additive-free soybean curd (control), the amount of crude ash and protein in soybean curd containing 40% C. fragile was significantly decreased (P<0.05) and increased (P<0.05), respectively. We observed a dose-dependent increase (P<0.05) in the hardness and chewiness of soybean curd concomitant with the amount of C. fragile supplemented. In contrast, we observed no significant difference (P>0.05) in soybean curd's cohesiveness between the groups. As determined by sensory evaluation based on seven-point hedonic scale, soybean curd supplemented with 20% C. fragile received an excellent score (6.55) for color. As the same method, we observed that the flavor and overall acceptability significantly increased (P<0.05) in the C. fragile content increased. Taken together, the antioxidant and sensory assays in our study make a compelling case for the practical development of soybean curd supplemented with C. fragile owing to its good antioxidant activities, general properties, and consumer acceptance.

• 환경생물
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• 제28권2호
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• pp.79-85
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• 2010

To examine the effect of Codium fragile on blood cholesterol and lipid metabolism, hyperlipidemia was induced in experimental animal rats through the administration of a hypercholesterolemic diet. Codium fragile powder was then administered to the rats for 5 weeks, after which, blood biochemical changes such as blood cholesterol, Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) enzyme activity, etc. were determined. And histological changes in liver cells were examined using an electron microscope. Codium fragile treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride and low-density cholesterol (LDL. Chol) compared to the control rats. In contrast the expression levels of high-density cholesterol (HDL. chol.) were increased. The AST value of the Codium fragile administration group was significantly reduced and the blood ALT value of the Codium fragile group showed a significant decrease in comparison to the negative control group. In summary, this study demonstrated the beneficial possibilities of Codium fragile in improving the abnormality of lipid metabolism caused by liver cell damage and hyperlipidemia.

• 한국산학기술학회논문지
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• 제17권11호
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• pp.196-201
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• 2016

디지털 워터마킹은 디지털 미디어 내부에 정보를 숨기기 위해 사용하는 기술로, 디지털 워터마킹 기술은 Robust 워터마킹 기술과 Fragile 워터마킹 기술로 분류할 수 있다. Robust 워터마킹 기술은 일반적으로 저작권을 보호하기 위한 목적으로 사용되고 있으며, Fragile 워터마킹 기술은 영상에 대한 인증과 무결성을 검증하기 위한 목적으로 사용된다. 따라서 Fragile 워터마킹 기술에서는 워터마킹 된 영상에 대해 작은 변형이라도 발생 하였을 경우 삽입된 워터마크는 쉽게 부수어져야 되는 특성을 가지고 있어야 한다. 본 논문에서는 공간 영역에서 영상의 변형 검출을 위한 효과적인 Fragile 워터마킹 방법을 제안하였으며, 본 논문에서 제안한 방법에서는 해쉬 코드와 대칭키 암호를 사용하였다. 제안 방법에서는 원 영상을 작은 크기로 구성된 여러 블록들로 분할한 후 워터마크를 삽입하기 때문에 cut and paste와 같은 공격에 취약하지 않은 특징을 가지고 있으며, 변형 검출을 위하여 워터마크가 삽입된 영상에 대해 전체 블록을 검사하지 않고도 변형이 발생된 부분만을 빠르게 검출할 수 있는 장점이 있다.

• 한국통신학회논문지
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• 제31권12C호
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• pp.1165-1172
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• 2006

소프트웨어의 발전으로 인해 디지털 컨텐츠에 대한 복사, 변경이 손쉽게 일반인들에 의해서도 가능하게 되어 컨텐츠의 제작자는 소유권 수장이나 내용의 변질에 대한 인증과 검증을 필요로 하게 되었다. 변질검증(Fragile) 워터마킹 기법은 워터마크가 삽입된 영상의 변질 및 훼손 여부를 판별할 수 있지만, 고의적이지 않은 표준화된 영상압축 등에서도 워터마크가 사라지는 문제점이 있다. 본 논문에서 JPEG 압축과 같은 영상처리에서는 강인하지만 변질에는 약한 Semi-Fragile 워터마킹 방법을 제안하였다. 제안한 방법은 블록간의 상관관계를 이용하여 워터마크를 생성하고, DCT(Discrete Cosine Transform)수행 후에 계수 값들의 양자화를 이용하여 HVS(Human Visual System)에 둔감한 부분의 계수 값에 삽입하는 방법을 제안하였다. 실험결과 공간영역 상에서 미세한 변화에도 변질여부의 검출 정도가 뛰어났으며, 변질된 부분을 블록별로 검출할 수 있어 공간상의 어떤 위치의 픽셀들이 변화하였는지를 시각적으로 확인할 수 있었다.

• Journal of Genetic Medicine
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• 제2권2호
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• pp.83-86
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• 1998

Though Fragile X syndrome is one of the most common inherited causes of mental retardation, it is not much detected yet in Korean population. One of the reason may be that the syndrome is not well known to the special education teachers as well as to the clinicians in this country. Thus, molecular test was undertaken to screen out fragile X syndrome in 122 children of two Korean schools for emotionally severely handicapped children. The subjects were all boys, previously known as having pervasive developmental disorder with or without mental retardation. Southern blot analysis of peripheral blood showed the abnormally enlarged (CGG)n repeat sequence associated with fragile X syndrome in two children. This finding suggests that the DNA testing for fragile X syndrome is warranted for Korean high risk population and that more concern about this syndrome is needed for the professionals who work for mentally handicapped children. The issues involved in genetic counseling for fragile X syndrome are discussed.

• 생명과학회지
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• 제9권6호
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• pp.639-645
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• 1999

This research was for investigating the physiological effect caused by genetic disorder and others. Serum protein, serum LDH, and serum CPK were analyzed on Fragile X syndrome patients, carriers, unclassified mental retardees, and Down's syndrome patients by cellulose acetate plate electrophoresis. Also enzyme activity of LDH and CPK were measured. Significant differences were observed between normal group and mental retardees in compositions of serum protein, serum LDH, serum CPK, and enzyme activities. Mean percentages of albumin were 53.70$\pm$7.73% for Fragile X syndrome patients, 57.09$\pm$7.73% for carriers, 47.33$\pm$6.06% for unclassified mental retardees, 50.19$\pm$ 15.72% for Down's syndrome patients. Mean percentages of ${\gamma}$-globulin were 19.64$\pm$6.71% for Fragile X syndrome patients, 19.24$\pm$3.38% for carries, 25.66$\pm$4.74 for unclassified mental retardees, 23.41$\pm$6.08% for Down's syndrome patients. Mean percentages of LDH3 were 27.76$\pm$2.72% for Fragile X syndrome patients, 22.70$\pm$2.76% for carriers, 25.42$\pm$1.26% for unclassified mental retardees, 27.72$\pm$2.58% for Down's syndrome patients. Mean percentages of LDH4 were 2.70$\pm$2.04 for Fragile X syndrome patients, 3.79$\pm$2.74% for carriers, so both of them were significantly lower than normal(P<0.05). Mean percentages of CK-MB were 3.96$\pm$5.56% for Fragile X syndrome patients, 8.80$\pm$7.92%. Mean percentages of CK-MM were 95.81$\pm$5.50% for Fragile X syndrome patients, 91.20$\pm$7.92% for carriers. These results showed that significant abnormal compositions of blood proteins might be caused by genetic disorder. However, further analysis of many patients will be needed for clear conclusion.