• ALGAE
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• v.31 no.2
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• pp.129-136
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• 2016

The Mediterranean Sea is currently facing dramatic changes and threats, including change in native species and accidental introductions. The introduced green alga Codium fragile subsp. fragile (Suringar) Hariot influences diversity and community structure in some parts of the world. This paper documents the distribution of this species in Tunisia and provides a morphological description of C. fragile subsp. fragile in Northern Tunisia. Results confirm the identity of Tunisian specimens as the invasive subspecies C. fragile subsp. fragile. This is the first morphological characterization of this subspecies in Tunisia.

• Journal of Life Science
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• v.9 no.6
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• pp.704-708
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• 1999

This research was carried out for evaluating diagnostic value of antibody test in Fragile X syndrome. In antibody test of control individuals and carriers with a premutation, FMRP were detected in the lymphocytes, whereas the lymphocytes of male Fragile X syndrome patients were devoid of FMRP. Five Fragile X syndrome male patient, two Fragile X syndrome female patients, three carriers were diagnosed by southern blot. Five boys who were diagnosed as the patients by antibody test were turned out full mutation and having multiple smear beside normal single band. However, fragile site of X chromosome was not expressed in Fragile X syndrome patients by chromosome analysis. These results showed that antibody test was a fast and simple method, but the diagnostic power was "perpect" for males, whereas the results were less specific for females.r females.

• Journal of Information Processing Systems
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• v.14 no.2
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• pp.510-522
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• 2018

As the major source of information, digital images play an indispensable role in our lives. However, with the development of image processing techniques, people can optionally retouch or even forge an image by using image processing software. Therefore, the authenticity and integrity of digital images are facing severe challenge. To resolve this issue, the fragile watermarking schemes for image authentication have been proposed. According to different purposes, the fragile watermarking can be divided into two categories: fragile watermarking for tamper localization and fragile watermarking with recovery ability. The fragile watermarking for image tamper localization can only identify and locate the tampered regions, but it cannot further restore the modified regions. In some cases, image recovery for tampered regions is very essential. Generally, the fragile watermarking for image authentication and recovery includes three procedures: watermark generation and embedding, tamper localization, and image self-recovery. In this article, we make a review on self-embedding fragile watermarking methods. The basic model and the evaluation indexes of this watermarking scheme are presented in this paper. Some related works proposed in recent years and their advantages and disadvantages are described in detail to help the future research in this field. Based on the analysis, we give the future research prospects and suggestions in the end.

• Biomedical Science Letters
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• v.2 no.1
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• pp.127-132
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• 1996

The karyotype and the concentration of serum protein were investigated in Korean unclassified mental retardees. The results were as follows. Fragile X chromosomes were identified in three patients, and the frequencies of fragile X chromosome were 4~15%. The concentration of serum protein was 5.73$\pm$0.89(g/dl), and the A/G ratio was 0.86$\pm$0.14 in fragile X syndrome patients. The concentration of serum protein was 6.83 $\pm$0.72(g/dl), and the A/G ratio was 0.87$\pm$0.17 unclassified mental retardees. The results revealed that the level of globulin concentration and A/G ratio in fragile X syndrome patients and unclassified mental retardees were lower than in normal group and Down's patients.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.53 no.6
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• pp.816-822
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• 2020

This study investigated the antioxidant activity and general and sensory properties of soybean curd supplemented with Codium fragile. The yield of soybean curd containing 0%, 20%, and 40% C. fragile was 113.62, 104.09, and 108.06, respectively. Antioxidant activities and pH were significantly increased (P<0.05) depending on the amount of C. fragile supplemented in soybean curd. Compared to that in additive-free soybean curd (control), the amount of crude ash and protein in soybean curd containing 40% C. fragile was significantly decreased (P<0.05) and increased (P<0.05), respectively. We observed a dose-dependent increase (P<0.05) in the hardness and chewiness of soybean curd concomitant with the amount of C. fragile supplemented. In contrast, we observed no significant difference (P>0.05) in soybean curd's cohesiveness between the groups. As determined by sensory evaluation based on seven-point hedonic scale, soybean curd supplemented with 20% C. fragile received an excellent score (6.55) for color. As the same method, we observed that the flavor and overall acceptability significantly increased (P<0.05) in the C. fragile content increased. Taken together, the antioxidant and sensory assays in our study make a compelling case for the practical development of soybean curd supplemented with C. fragile owing to its good antioxidant activities, general properties, and consumer acceptance.

• Korean Journal of Environmental Biology
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• v.28 no.2
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• pp.79-85
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• 2010

To examine the effect of Codium fragile on blood cholesterol and lipid metabolism, hyperlipidemia was induced in experimental animal rats through the administration of a hypercholesterolemic diet. Codium fragile powder was then administered to the rats for 5 weeks, after which, blood biochemical changes such as blood cholesterol, Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) enzyme activity, etc. were determined. And histological changes in liver cells were examined using an electron microscope. Codium fragile treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride and low-density cholesterol (LDL. Chol) compared to the control rats. In contrast the expression levels of high-density cholesterol (HDL. chol.) were increased. The AST value of the Codium fragile administration group was significantly reduced and the blood ALT value of the Codium fragile group showed a significant decrease in comparison to the negative control group. In summary, this study demonstrated the beneficial possibilities of Codium fragile in improving the abnormality of lipid metabolism caused by liver cell damage and hyperlipidemia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.196-201
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• 2016

Digital watermarking is a technique used to hide information within digital media. Digital watermarking techniques can be classified as either robust watermarking or fragile watermarking. Robust watermarking techniques are generally used for the purpose of copyright protection. In addition, fragile watermarking techniques are used for the authentication and integrity verification of a digital image. Therefore, fragile watermarks should be easily breakable for trivial tampering of a watermarked image. This paper proposes an efficient fragile watermarking method for image tamper detection in the spatial domain. In the proposed method, a hash code and symmetric key encryption algorithm are used. The proposed method of inserting a watermark by dividing the original image into many blocks of small sizes is not weak against attacks, such as cut and paste. The proposed method can detect the manipulated parts of a watermarked image without testing the entire block of the image.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.12C
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• pp.1165-1172
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• 2006

The rapid progress of the software has enabled individuals to copy and remark digital contents, which was only done by professionals. As a solution for the problems, contents producer needs to have certification and inspection of its contents and hold the proprietary right. A fragile watermarking method is able to detect the distortion and damage of watermarked image, but the watermark is also fragile on standardized image compression. That is the problem of fragile watermarking technique. We propose semi-fragile watermarking technique that is robust in the image processing such as JPEG compression used on computer, but it is fragile on the addition of noise and other attacks. In the proposed method, we can generate the watermarks of an image from the relationship between two block coefficients, also the generated watermark is inserted into insensible part of HVS(Human Visual System) after processing DCT(Discrete Cosine Transform) and using quantization. As a result, on the spatial domain, high detection of distortion has been possible even in slight changes, and could detect the corrupted blocks on image. Therefore, it is simple to judge the pixels at which some location has been changed in the space.

• Journal of Genetic Medicine
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• v.2 no.2
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• pp.83-86
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• 1998

Though Fragile X syndrome is one of the most common inherited causes of mental retardation, it is not much detected yet in Korean population. One of the reason may be that the syndrome is not well known to the special education teachers as well as to the clinicians in this country. Thus, molecular test was undertaken to screen out fragile X syndrome in 122 children of two Korean schools for emotionally severely handicapped children. The subjects were all boys, previously known as having pervasive developmental disorder with or without mental retardation. Southern blot analysis of peripheral blood showed the abnormally enlarged (CGG)n repeat sequence associated with fragile X syndrome in two children. This finding suggests that the DNA testing for fragile X syndrome is warranted for Korean high risk population and that more concern about this syndrome is needed for the professionals who work for mentally handicapped children. The issues involved in genetic counseling for fragile X syndrome are discussed.

• Journal of Life Science
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• v.9 no.6
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• pp.639-645
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• 1999

This research was for investigating the physiological effect caused by genetic disorder and others. Serum protein, serum LDH, and serum CPK were analyzed on Fragile X syndrome patients, carriers, unclassified mental retardees, and Down's syndrome patients by cellulose acetate plate electrophoresis. Also enzyme activity of LDH and CPK were measured. Significant differences were observed between normal group and mental retardees in compositions of serum protein, serum LDH, serum CPK, and enzyme activities. Mean percentages of albumin were 53.70$\pm$7.73% for Fragile X syndrome patients, 57.09$\pm$7.73% for carriers, 47.33$\pm$6.06% for unclassified mental retardees, 50.19$\pm$ 15.72% for Down's syndrome patients. Mean percentages of ${\gamma}$-globulin were 19.64$\pm$6.71% for Fragile X syndrome patients, 19.24$\pm$3.38% for carries, 25.66$\pm$4.74 for unclassified mental retardees, 23.41$\pm$6.08% for Down's syndrome patients. Mean percentages of LDH3 were 27.76$\pm$2.72% for Fragile X syndrome patients, 22.70$\pm$2.76% for carriers, 25.42$\pm$1.26% for unclassified mental retardees, 27.72$\pm$2.58% for Down's syndrome patients. Mean percentages of LDH4 were 2.70$\pm$2.04 for Fragile X syndrome patients, 3.79$\pm$2.74% for carriers, so both of them were significantly lower than normal(P<0.05). Mean percentages of CK-MB were 3.96$\pm$5.56% for Fragile X syndrome patients, 8.80$\pm$7.92%. Mean percentages of CK-MM were 95.81$\pm$5.50% for Fragile X syndrome patients, 91.20$\pm$7.92% for carriers. These results showed that significant abnormal compositions of blood proteins might be caused by genetic disorder. However, further analysis of many patients will be needed for clear conclusion.