• Clinical and Experimental Reproductive Medicine
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• v.30 no.4
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• pp.309-316
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• 2003

연구목적: 스테로이드 계통의 에스트로겐 호르몬은 막 수용체와 결합하고 DNA에 부착되어, 자궁조직에서 발현되는 많은 유전자들의 발현 양상을 조절하는 것으로 알려져 있다. 본 연구에서는 난소를 제거한 생쥐 모델을 이용하여 에스트로겐에 의해 조절되는 전사 관련 유전자(transcription factor)들을 동정하고, early up-regulation gene으로 확인된 Fos related antigen (Fra1과 Fra2) 유전자의 발현 양상을 RT-PCR과 면역염색방법으로 살펴보았다. 연구재료 및 방법: 난소 절제술을 시행한 생쥐에 에스트로겐을 피하주사하고 2, 4, 6, 12시간 간격으로 자궁조직을 적출하였다. 대조군으로는 sesame oil만을 주사한 후 2시간째에 수획한 자궁조직을 사용하였으며, 시간대별로 채취한 자궁조직(n=4)에서 RT-PCR을 수행하였다. RT-PCR을 통해 early response gene으로 확인된 Fra1과 Fra2에 대한 에스트로겐의 영향을 살펴보기 위해 estrogen receptor antagonist인 ICI 182, 780을 주사하여 유전자 발현 양상의 변화를 살펴보았다. 또한, 자궁조직내에서의 단백질 발현 부위를 관찰하기 위해 면역조직화학염색을 실시하였다. 결 과: 생쥐 자궁조직에서 에스트로겐에 의해 발현 양상의 변화가 확인된 유전자는 early up-regulation genes (CREB2, Fra-1, 2, GATA5), late up-regulation gene (E2F1), no response genes (CREB1, ATF1, GLI3, E2F3), down-regulation genes (GLI2, E2F5, GATA-2, 3, 6) 등으로 구분할 수 있었다. 그 중 early up-regulation genes에 해당하는 Fra1과 Fra2 유전자는 ICI 182, 780에 의해 그 발현이 유의하게 감소되는 것을 확인하였다(p < 0.01). 이들 단백질은 생쥐 자궁조직의 상피세포층, 기질층, 근육층에서 고루 발현되었으며, 특히 근육층에서 강한 염색정도를 관찰할 수 있었다. 결 론: 이상의 결과를 통해 Fra1과 Fra2 유전자의 발현은 에스트로겐에 의해 조절됨을 알 수 있었으며, 이들의 강한 발현이 자궁조직의 근육층에서 관찰되어 이들의 기능에 대한 연구가 필요할 것으로 생각된다.

• Journal of the Optical Society of Korea
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• v.14 no.4
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• pp.342-350
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• 2010

An optimal wideband gain flattened hybrid erbium-doped fiber amplifier/fiber Raman amplifier (EDFA/FRA) has been introduced. A new and effective optimization method called particle swarm optimization (PSO) is employed to find the optimized parameters of the EDFA/FRA. Numerous parameters which are the parameters of the erbium-doped fiber amplifier (EDFA) and the fiber Raman amplifier (FRA) define the gain spectrum of a hybrid EDFA/FRA. Here, we optimize the length, $Er^{3+}$ concentration, and pump power and wavelength of the EDFA and also pump powers and wavelengths of the FRA to obtain the flattest operating gain spectrum. Hybrid EDFA/FRA with 6-pumped- and 10-pumped-FRAs have been studied. Gain spectrum variations are 1.392 and 1.043 dB for the 6-pumped- and 10-pumped-FRAs, respectively, in the 108.5 km hybrid EDFA/FRAs, with 1 mW of input signal powers. Dense wavelength division multiplexing (DWDM) system with 60 signal channels in the wavelength range of 1529.2-1627.1 nm, i.e. the wide bandwidth of 98 nm, is studied. In this work, we have added FRA's pump wavelengths to the optimization parameters to obtain better results in comparison with the results presented in our previous works.

• Journal of Advanced Navigation Technology
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• v.15 no.1
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• pp.157-161
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• 2011

This paper explains an error process for multimedia collaboration works with session management running on vehicle network environment. This system consists of an FDA and FRA. FDA is an agent that detects an error by hooking techniques for multimedia system based on vehicle network environment with session management. FRA is a system that is suitable for recovering software error for multimedia system with session management based on vehicle network environment. This paper describes only FRA. When multiple local sessions is opened, each local session manager sends information of participant to global session manager and take current information about session of processing in network.

• Journal of Advanced Navigation Technology
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• v.14 no.1
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• pp.74-79
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• 2010

This paper explains the design and implementation of nested session management based the FRA(Fault Recovery Agent). FRA is a system that is suitable for recovering software error for multimedia remote control based on industry safety environment. In this paper, we discuss a method for increasing reliability through organization of nested session.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.467-472
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• 2007

A modern MEMS resonator is a micro-scale structure operated over a high frequency range. In order to predict its resonant behavior in a design process, High-frequency response analysis (Hi-FRA) is demanded. Algebraic substructuring (AS) is known as a fast numerical technique to construct an eigenspace for FR and frequency sweep (FS) algorithm efficiently solves the frequency response system projected on the eigenspace. However, the existing FS algorithm using AS is developed for low-FRA, say over the range 1Hz-2KHz. In this work, we extend the FS algorithm using AS for FRA over an arbitrary frequency range. Therefore, it can be efficiently applied to systems operated at a high frequency, say over the range 230MHz-250MHz. The success of the proposed method is demonstrated by Hi-FRA of a checkerboard resonator.

• Archives of Pharmacal Research
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• v.26 no.5
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• pp.375-382
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• 2003

Effects of ginsenosides on nitric oxide (NO) production induced by lipopolysaccharide plus TNF-$\alpha$ (LNT) were examined in C6 rat glioma cells. Among several ginsenosides, ginsenoside Rd showed a complete inhibition against LNT-induced NO production. Ginsenoside Rd attenuated LNT-induced increased phosphorylation of ERK. Among several immediate early gene products, only Jun Band Fra-1 protein levels were increased by LNT, and ginsenoside Rd attenuated Jun Band Fra-1 protein levels induced by LNT. Furthermore, LNT increased AP-1 DNA binding activities, which were partially inhibited by ginsenoside Rd. Our results suggest that ginsenoside Rd exerts an inhibitory action against NO production via blocking phosphorylation of ERK, in turn, suppressing immediate early gene products such as Jun Band Fra-1 in C6 glioma cells.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.4
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• pp.299-305
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• 2001

Activation of D1-like dopamine receptors by psychostimulants, such as amphetamine, upregulates the expression of immediate early gene and opioid peptide gene in the striatum. The genomic changes are regulated by phosphorylated transcription factors via complicated intracellular events. To evaluate temporal expression of the transcription factors by dopaminergic stimulation, the D1-like dopamine agonist, amphetamine or SKF82958, was systematically delivered. As intracellular markers in response to the agonist, phosphorylated cAMP response element-binding protein (pCREB), Fos-related antigens (FRA) and FosB immunoreactivity (IR) was compared at 20 and 120 min time points in the selected areas of the striatum. Semi-quantitative immunocytochemistry showed that amphetamine (5 mg/kg, i.p.) significantly increased pCREB-IR at 20 min, sustained up to 60 min and decreased at 120 min after the infusion. Like amphetamine, the full D1 agonist, SKF82958 (0.5 mg/kg, s.c.), also increased pCREB-IR at 20 min, but not at 120 min after the infusion in the dorsal striatum (caudoputaman, CPu) and shell of ventral striatum (nucleus accumbens, NAc). In contrast, FRA- and FosB-IR induced by SKF82958 was significantly increased at 120 min, but not at 20 min after the administration. These data indicate that SKF82958 mimics induction of CREB phosphorylation by amphetamine and differentially regulates temporal induction of pCREB, and FRA and FosB expression in the striatum.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.12
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• pp.2326-2339
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• 2011

To reduce the implementation complexity of the Vertical Bell Labs layered space-time (V-BLAST) systems with respect to the zero-forcing (ZF) criterion, a computationally efficient recursive algorithm is proposed. A fast implementation of the proposed algorithm is developed and its complexity is analyzed in detail. The proposed algorithm matches the ZF-OSIC detection well, and its three significant advantages can be demonstrated by analyses and simulations. Firstly, its speedups over the conventional ZF-OSIC with norm-based ordering, the original fast recursive algorithm (FRA) and the fastest known algorithm (FKA) in the number of flops are 1.58, 2.33 and 1.22, respectively. Secondly, a much simpler implementation than FRA and FKA can be expected. Finally, the storage requirements are lower than those of FRA and FKA. These advantages make the proposed algorithm more efficient and practical.

• Advances in concrete construction
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• v.13 no.1
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• pp.101-111
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• 2022

The rapid development of the construction industry in the world causes a rapid increase in the consumption of aggregate resources, which leads to the depletion of existing aggregate reserves. The use of recycled aggregate in the production of concrete and mortar may be a good solution to reduce the use of natural raw materials and to reduce demolition waste in the environment. In this study investigating the use of recycled aggregate in mortar production, mortar mixtures were produced by substituting 0%, 25%, 50% and 100% fine recycled aggregate (FRA) instead of natural aggregate. The effect of 20% and 40% fly ash (FA) substitutes on cement mortar performance was also investigated. Compressive and flexural strength, drying shrinkage, abrasion resistance, water absorption and capillary water absorption were investigated on the produced mortars. The increase in the use of FRA reduced the compressive and flexural strengths of mortars. While the capillarity coefficients, water absorption, rapid chloride permeability and drying shrinkage of the mortars increased with the increase in the use of FRA, the effect of the use of fly ash on the rate of increase remained lower. The increased use of FRA has improved abrasion resistance as well.

• Journal of the Korea Society for Simulation
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• v.26 no.3
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• pp.73-86
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• 2017

Environmental data plays an important role to enhance the reliability of experimental results in M&S(Modeling and Simulation). Especially in Military M&S, extreme weather events can be used for virtual training and simulation importantly. However, the environmental data is huge and it is dispersed among multiple organizations. It is difficult for M&S operators to select the date and area where the weather phenomenon occurs in the real environmental data and to acquire them. Environmental data retrieval technology based on Fuzzy criteria is one of the important technologies for developing Environmental Scenario Generator. As a result of this study, a fuzzy retrieval algorithm composed of four main parameters(RV, MF, FRA, and MRV) was presented. This study suggests that the RV can be used as 14 m/s for wind speed and 80 mm/d for precipitation to search the date of storm accompanied by high wind. The MF, the FRA, and MRV can be used sigmoid, 0.2, and 1 respectively. The algorithm proposed in this study is expected to be very useful for searching the date on which weather phenomena necessary for simulation occurred.