• The Plant Pathology Journal
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• 제21권1호
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• pp.59-63
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• 2005

Bacillus subtilis S1-0210 was selected as a biological agent against Botrytis cinerea in strawberry. The isolate inhibited mycelial growth of B. cinerea in vitro tests. A wettable powder formulation of B. subtilis S1-0210 significantly reduced infection rates with lower than 5%, compared with higher than 70% of infection rates in untreated control. The formulation showed 85 to 89% control efficacies of gray mold incidences on fruits of strawberry in pots. Pre-treatment of the agent was more effective in controlling gray mold on fruits and leaves than post-treatment at the early stage of disease development. The formulation also showed 70% control efficacy of gray mold incidence on fruits of strawberry in a field trial. The results indicate that B. subtilis S1-0210 in the wettable powder formulation may be a potential biocontrol agent to control gray mold on strawberry.

• Biomolecules & Therapeutics
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• 제17권1호
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• pp.104-110
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• 2009

Phenylketonuria (PKU) is an inherited metabolic disorder caused by mutations in the phenylalanine catabolic enzyme, phenylalanine hydroxylase (PAH). The use of phenylalanine ammonia-lase (PAL) by oral and parenteral routes as a therapeutic drug for PKU has been severely limited due to inactivation by intestinal proteolysis and immune reactions. PEGylation was applied to PAL to reduce the degrees of antigenicity and proteolytic inactivation. Kinetic experiments with native PAL and pegylated PALs were performed, and pH stability, temperature stability, and protease susceptibility were evaluated. Enzyme linked immunosorbent assay (ELISA) was carried out to measure the immune complex between pegylated PALs and antiserum that had been extracted from a PAL-immunized mouse. Pegylated PAL, especially branched pegylated PAL (10 kDa, 1:32), was more active for phenylalanine and more stable in pancreatic proteases than native PAL. Native PAL was optimal at pH 8.5, corresponding to the average pH range of the small intestine; the same finding was noted for pegylated PALs. All linear and branched pegylated PALs had low reactivity with mouse antiserum, especially the 1:16 formulation with linear 5-kDa PEG and the 1:32 formulation with branched 10-kDa PEG. Therefore, we suggest the 1:32 formulation with branched 10-kDa PEG as the most promising formulation for enzyme replacement therapy.

• 생약학회지
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• 제47권4호
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• pp.366-373
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• 2016

Bulhwangeumjeonggisan (BHGJGS) is a traditional herbal formulation generally used in the treatment of cold and gastritis. BHGJGS consists of eight herbal plants; Atractylodis Rhizoma, Magnoliae Cortex, Citri Pericarpium, Glycyrrhizae Radix, Agastachis Herba, Pinelliae Rhizoma, Zingiberis Rhizoma and Zizyphi Fructus. Complete standardization of this formulation has not been done yet. So, a simple and accurate method was developed and validated using Ultra Performance Liquid Chromatography (UPLC) with Diode Array Detector (DAD) for the standardization of BHGJGS. UPLC conditions were optimized using a c18 RP-Amide column with mobile phase; 0.1% phosphate buffer and acetonitrile, detection wavelength; 210 and 325 nm. The linearities of calibration curves were acceptable ($R^2$>0.9994), and the limit of detection and quantification were within the ranges of 0.011-0.091 and $0.034-0.277{\mu}g/ml$ respectively. The relative standard deviation (RSD) of intra- and inter-day precisions were under 3.61%. The RSD of repeatability was under 0.68 %. The results of recovery test were 94.4-107.9%, and the RSD were under 4.6%. The developed method was used to find the contents of standard constituents in BHGJGS mix extract powder, and two commercial formulation (A and B). The data show that the developed method was specific, sensitive, accurate, and precise for analysis of BHGJGS components.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1993년도 하계학술대회 논문집 B
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• pp.942-944
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• 1993

This paper treats of the recent trends in the development, of the Magnetically levitated vehicle(Maglev) and the propulsion system of the Maglev in the world. Consequently, the material data for the guide post in the research and formulation of development policy are prevented.

• Structural Engineering and Mechanics
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• 제42권2호
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• pp.211-228
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• 2012

Present study deals with the development of finite element based solution methodology to investigate active control of dynamic response of delaminated composite shells with piezoelectric sensors and actuators. The formulation is based on first order shear deformation theory and an eight-noded isoparametric element is used. A coupled piezoelectric-mechanical formulation is used in the development of the constitutive equations. For modeling the delamination, multipoint constraint algorithm is incorporated in the finite element code. A simple negative feedback control algorithm coupling the direct and converse piezoelectric effects is used to actively control the dynamic response of delaminated composite shells in a closed loop employing Newmark's time integration scheme. The validity of the numerical model is demonstrated by comparing the present results with those available in the literature. A number of parametric studies such as the locations of sensor/actuator patches, delamination size and its location, radius of curvature to width ratio, shell types and loading conditions are carried out to understand their effect on the transient response of piezoceramic delaminated composite shells.

• Journal of Astronomy and Space Sciences
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• 제19권2호
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• pp.107-122
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• 2002

Multi-body spacecraft attitude and configuration control formulations based on the use of collaborative control theory are considered. The control formulations are based on two-player, nonzero-sum, differential game theory applied using a Nash strategy. It is desired that the control laws allow different components of the multi-body system to perform different tasks. For example, it may be desired that one body points toward a fixed star while another body in the system slews to track another satellite. Although similar to the linear quadratic regulator formulation, the collaborative control formulation contains a number of additional design parameters because the problem is formulated as two control problems coupled together. The use of the freedom of the partitioning of the total problem into two coupled control problems and the selection of the elements of the cross-coupling matrices are specific problems ad-dressed in this paper. Examples are used to show that significant improvement in performance, as measured by realistic criteria, of collaborative control over conventional linear quadratic regulator control can be achieved by using proposed design guidelines.

• 대한교통학회지
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• 제5권1호
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• pp.47-58
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• 1987

A commodity distribution problem with intertemporal storage facilities and dynamic transportation networks is proposed. mathematical integer programming methods and multiobjective programming techniques are used in the model formulation. Dynamic characteristics of commodity distribution problems are taken into account in the model formulation. storage facility location problems and transportation link addition problems are incorporated into the intertemporal multicommodity distribution problem. The model is capable of generating the most efficient and rational commodity distribution system. Therefore it can be utilized to provided the most effective investment plan for the transportation infrastructure development as well as to evaluate the existing commodity distribution system. The model determines simultaneously the most efficient locations, sizes, and activity levels of storage facilities as well as new highway links. It is extended to multiobjective planning situations for the purpose of generating alternative investment plans in accordance to planning situations. sine the investment in transportation network improvement yields w\several external benefits for a regional economy, the induced benefit maximization objective is incorporated into the cost minimization objective. The multiobjective model generates explicitly the trade-off between cost savings and induced benefits of the investment in transportation network improvement.

• Journal of Pharmaceutical Investigation
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• 제40권5호
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• pp.297-304
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• 2010

The present work focuses on preparation of olanzapine, orally dispersing tablets by direct compression method. Effect of super disintegrant crospovidone, disintegration time, drug content on in vitro release has been studied. A factorial design was employed in formulating a prompt dispersible tablet. The selected independent variables crospovidone and fmelt showed significant effect on dependent variables i.e. disintegration time and percent drug dissolved. Disintegration time and percent drug dissolved decreased with increase in the level of crospovidone. The similarity factor $f_2$ was found to be 97.48 for the developed formulation indicating the release was similar to that of the marketed formulation. Pharmacokinetics of olanzapine after single-dose oral administration of orally disintegrating tablet in normal volunteers were evaluated and the results showed that PK parameters (Cmax, Tmax, AUC) of the designed ODT matrix were similar to those of commercial product, Zyprexa Zydis$^{(R)}$ as a reference.

• Advances in concrete construction
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• 제8권3호
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• pp.199-206
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• 2019

High performance sandcretes (HPS) are new concretes characterized by particles having a diameter less than 5 mm, as well as very high mechanical strength and durability. This work consists in finding solutions to make sandcretes with good physico-mechanical and durability properties for this new generation of micro-concrete. However, upgrading ordinary sandcrete into high performance sandcrete (HPS) requires a thorough study of formulation parameters (equivalent water/binder ratio, type of cement and its dosage, kind and amount of super plasticizer, and gravel/sand ratio). This research study concerns the formulation, characterization and durability, in a sulphate environment, of a high performance sandcrete (HPS), made from local materials. The obtained results show that the rheological properties of fresh concrete and mechanical strength differ with the mineralogy, density and grain size distribution of sands and silica fume used.

• International Journal of Computer Science & Network Security
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• 제23권7호
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• pp.193-201
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• 2023

Abstraction is the cornerstone of ideal software engineering (SWE). This paper discusses a problem of forming reasonable generalizations, representations and descriptions in various software development processes through the prism of poor-quality (rash, unconsidered, uncertain and harmful) abstractions. To do this, emphasis is made on an induced strategic connection between the required abstraction and its compact specific formulation based on existing research and the author's introspective experience. A software aim point and characteristic preservation of the solution integrity is the subject of the best formulation and a program module or code associated with it. Moreover, a personal attitude expressed by personal interest, motivation and creativity, is proclaimed to be a fundamental factor in successful software development.