• Applied Biological Chemistry
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• v.48 no.4
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• pp.352-357
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• 2005

The optimization of extraction conditions of phytoestrogen from pomegranate by hot water was conducted by analyzing the extraction characteristics. The purpose of this study was effective utilization of bioactive components of pomegranate, and the analyzing was performed with response surface methodology (RSM). This study established 10 sections based on the central composite design with the independent variables of extraction temperature (60, 70, 80, 90, $100^{\circ}C$) and extraction time (1, 2, 3, 4, 5 hr) to predict the optimal conditions for extraction of the effective components. The dependent variables were measured for extracted materials, those were, the major components such as chlorogenic acid, kaempferol, $17-{\alpha}-estradiol\;and\;17-{\beta}-estradiol$ content, and regression analysis was performed by SAS program, and optimal conditions for each characteristics were predicted, and the characteristics of extraction were analyzed by response surface methodology. It was found that chlorogenic acid, kaempferol, and $17-{\alpha}-estradiol$ content were greatly affected by extraction temperature. However, $17-{\beta}-estradiol$ content was affected significantly by extraction time. Regression formulas for each variable were elicited from this study, and the chlorogenic acid, kaempferol, $17-{\alpha}-estradiol\;and\;17-{\beta}-estradiol$ content depending on response surface methodology factor were superimposed. It was shown that optimal temperature and extraction time were $98{\sim}100^{\circ}C\;and\;3{\sim}5$ hrs, respectively.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.3
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• pp.543-560
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• 2018

With the increased development in downtown underground space facilities that vertically cross under a railway at a shallow depth, the demand for non-open cut method is increasing. However, most construction sites still adopt the pipe roof method, where medium and large diameter steel pipes are pressed in to form a roof, enabling excavation of the inside space. Among the many factors that influence the loosening region and loads that occur while pressing in steel pipes, the size of the pipe has the largest impact, and this factor may correspond to the magnitude of load applied to the underground structure inside the steel pipe roof. The super equilibrium method (SEM) has been developed to minimize ground disturbance and loosening load, and uses small diameter pipes of approximately 114 mm instead of conventional medium and large diameter pipes. This small diameter steel pipe is called an SEM pile. After SEM piles are pressed in and the grouting reinforcement is constructed, a crossing structure is pressed in by using a hydraulic jack without ground subsidence or heaving. The SEM pile, which plays the role of timbering, is a fore-poling pile of approximately 5 m length that prevents ground collapse and supports surface load during excavation of toe part. The loosening region should be adequately calculated to estimate the spacing and construction length of the piles and stiffness of members. In this paper, we conducted a comparative analysis of calculations of loosening load that occurs during the press-in of SEM pile to obtain an optimal design of SEM. We analyzed the influence of factors in main theoretical and empirical formulas applied for calculating loosening regions, and carried out FEM analysis to see an appropriate loosening load to the SEM pile. In order to estimate the soil loosening caused by actual SEM-pile indentation and excavation, a steel pipe indentation reduction model test was conducted. Soil subsidence and soil loosening were investigated quantitatively according to soil/steel pipe (H/D).

• Current Research on Agriculture and Life Sciences
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• v.3
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• pp.28-35
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• 1985

This work Was carried out to obtain the most suitable crop coefficient for the paddy rice growing in Taegu area. The result was due to the comparative measurements of evapotranspiration formula in terms of Blaney & Criddle and eight other formulas with those produced by experiment particularly in this area. The crop coefficient, evapotranspiration and transpiration ratio produced by this research are hopefully expected to be of service in the future calculation of evapotranspiration without repeating experiment respectively, whenever the water requirement of paddy rice is planned in Taegu and its vicinity. The accomplished results could be summarized as follows : The maximum amount of evapotranspiration was recorded in the early and middle parts of August. The average reading of evapotranspiration was 6.33mm/day throughout the growth. The evapotranspiration had a highly significant correlation with pan evaporation, solar radiation, sunshine hours and relative humidity of meteorological elements. K and Kc by the use of Blaney & Criddle formula calculated at 0.76 to 1.45 and 0.82 to 1.27, respectively. Its peak value appeared commonly in early August. The ratio of transpiration was 269.03.

• Journal of Nutrition and Health
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• v.40 no.7
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• pp.593-600
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• 2007

Recent studies described the ${\varepsilon}4$ allele of apoE confers a two-to fourfold increased risk for late-onset Alzheimer#s disease (LOAD), but LOAD pathology does not all fit neatly around apo E. Therefore, the goal of this study was to find the association between Alzheimer and apo E4 genotype in the 107 elderly between 50 to 64 years old who visited to FHWC of Sungshin Women#s University. We conducted the questionnaire survey (general & 24 hr dietary recall), anthropometerics (BP, waist & BMI) and blood biochemistry (FBS & lipid profiles). LDL-c and HOMA-IR were calculated by Friedwald#s and Matthew#s formulas. The apo E genotyping was performed by PCR-RFLP method and subjects were divided into three allele groups (${\varepsilon}3$; wild, ${\varepsilon}2$ & ${\varepsilon}4;$ mutants). The apo E allele frequencies were 7.0% for the ${\varepsilon}2$, 83.6% for the ${\varepsilon}3$ and 9.3% for the ${\varepsilon}4$. In comparison with biochemistry characteristics by apo E genotype, FBS was significantly higher in ${\varepsilon}4(129.2{\pm}6.8)$ than that in the others (${\varepsilon}2$: $117{\pm}7.4$, ${\varepsilon}3$: $107.3{\pm}2.2)$ (p<0.01). More than forty percents of ${\varepsilon}4$ group shown the dyslipidemia [high TG (>150mg/dl) & low HDL (<40 mg/dl:male or <50 mg/dl: female)]. The cytokines levels such as IL-1 ${\beta}$, IL-6 and $TNF-{\alpha}$ were not different among three apoE alleles. After the adjusting sex, age & dietary fiber, LDL-c level was siginificantly higher in ${\varepsilon}4$ ($108.3{\pm}7.7$) than that in ${\varepsilon}2$ ($100.4{\pm}8.4$) (p<0.05). According to food intake and the recipe on the basis of 24 hr dietary recall, the elder]y with ${\varepsilon}4$ allele took higher intake frequency of the light -colored vegetable (radish, onion & cabbage) and pan-fried foods (sauteed beef and vegetables, stir-fried vienna with vegetables) than the others. We knew that the elderly with ${\varepsilon}4$ allele had been restricted the calories intakes with high dietary fiber (33.6+2.5 g/d) to maintain the normal level of FBS and LDL-c. On next study, the prevalence of Alzheimer#s disease in this population who has ${\varepsilon}4$ allele on the condition of calories restriction will be continually follow-up.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.25 no.4
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• pp.241-250
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• 1992

This study was covered the amount of food consumed per day as well as methods estimating the daily food consumption per fish of Agrammus agrammus in natural population to understand flow of food organisms among trophic levels in bio-community of the coastal waters, Shinsudo, Samchonpo. The estimating formulas were induced from the mathematical models that representing the diurnal fluctuation of the stomach fullness of the fish. The daily food consumption could be estimated by both feeding rates and gastric evacuation rates, but it was more reasonable method that based on gastric evacuation rates than feeding rates. The daily food consumption in wet weight per fish by gastric evacuation rates were 1.9856g/day, 3.4725g/day, 4.4418g/day, 5.8168g/day, and 7.2113g/day in the order of age groups from 0 to 4. The daily rations as percentage of body weight were $9.35\%,\;6.65\%,\;5.76\%,\;4.72\%\;and\;5.31\%$ in the order of ages. The daily food consumption was proportional to the body weight of fish, but the daily food consumption per specific body weight was reciprocal to the body weight. Annual food consumption in wet weight. per fish by gastric evacuation rates were 529.98g from the age of 0.25 to 1.0, 1,269.28g from the age of 1.0 to 2.0, 1,622.76g from the age of 2.0 to 3.0, 2,125.57g from the age of 3.0 to 4.0, 1,316.09g from the age of 4.0 to 4.5 The amount of food consumed per fish during 4.25 years, from the age of 0.25 to 4.5, was 6,863.68g in wet weight. the relationships between the daily food consumption(Dr) by gastric evacuation rates and the total length(L, cm) or the body weight(W, g) were as follows: $$Dr=0.036L^{1.702}$$ $$Dr=0.254W^{0.664}$$

• Progress in Medical Physics
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• v.26 no.3
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• pp.143-152
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• 2015

In this study, we aim to design the architecture of the kV imaging system for tumor tracking in the dual-head gantry system and analyze its accuracy by simulations. We established mathematical formulas and algorithms to track the tumor position with the two-pair kV imaging systems when they are in the non-orthogonal positions. The algorithms have been designed in the homogeneous coordinate framework and the position of the source and the detector coordinates are used to estimate the tumor position. 4D XCAT (4D extended cardiac-torso) software was used in the simulation to identify the influence of the angle between the two-pair kV imaging systems and the resolution of the detectors to the accuracy in the position estimation. A metal marker fiducial has been inserted in a numerical human phantom of XCAT and the kV projections were acquired at various angles and resolutions using CT projection software of the XCAT. As a result, a positional accuracy of less than about 1mm was achieved when the resolution of the detector is higher than 1.5 mm/pixel and the angle between the kV imaging systems is approximately between $90^{\circ}$ and $50^{\circ}$. When the resolution is lower than 1.5 mm/pixel, the positional errors were higher than 1mm and the error fluctuation by the angles was greater. The resolution of the detector was critical in the positional accuracy for the tumor tracking and determines the range for the acceptable angle range between the kV imaging systems. Also, we found that the positional accuracy analysis method using XCAT developed in this study is highly useful and will be a invaluable tool for further refined design of the kV imaging systems for tumor tracking systems.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.9
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• pp.1380-1387
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• 2014

The purpose of this study was to develop a mouthwash product with solid fermented oriental medicinal herb (OMH). Solid fermentation of magnolia, liquorice, and cnidium by Phellinus linteus mycelium was carried out successfully when 30% water was added to the medium, whereas 10% brown rice powder was required as an extra nutrient for solid fermentation of mint besides water. The amount of total phenol compounds and DPPH radical scavenging activity of OMH increased significantly (P<0.05) upon solid fermentation. Anti-microbial activities of fermented OMH also increased and were approximately 100-fold greater than those of unfermented samples. Oral pathogens such as Staphylococcus epidermis, Streptococcus pyogenes, Candida albicans, or Streptococcus mutans were used for determination of anti-microbial effects of OMH. Formulation of the mouthwash was developed based on the results of the sensory evaluation. Among seven formulas, the best formula chosen by the sensory evaluation was as follows: mouthwash prepared with 0.075% ethanol extract of solid fermented OMH as a main ingredient, 83.64% hot water extract of mint and clove (100:15, v/v) as a mouthwash base component, and other miscellaneous ingredients, including sodium fluoride, menthol, and surfactants. Data from a consumer's preference test with 30 participants, overall acceptance, and willingness to buy the product developed in this study were all significantly higher for the tested mouthwash compared to mouthwash on the market manufactured with OMH but with a different formula. Duration of freshness of the mouthwash after usage as determined by Breath Checker was not significantly different between the two samples, although the duration of our product was slightly longer than that of the commercial product mentioned above.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.2
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• pp.95-109
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• 1993

In this study, the optimal configuration of arch structure has been tested by a decomposition technique. The object of this study is to provide the method of optimizing the shapes of both two hinged and fixed arches. The problem of optimal configuration of arch structures includes the interaction formulas, the working stress, and the buckling stress constraints on the assumption that arch ribs can be approximated by a finite number of straight members. On the first level, buckling loads are calculated from the relation of the stiffness matrix and the geometric stiffness matrix by using Rayleigh-Ritz method, and the number of the structural analyses can be decreased by approximating member forces through sensitivity analysis using the design space approach. The objective function is formulated as the total weight of the structures, and the constraints are derived by including the working stress, the buckling stress, and the side limit. On the second level, the nodal point coordinates of the arch structures are used as design variables and the objective function has been taken as the weight function. By treating the nodal point coordinates as design variable, the problem of optimization can be reduced to unconstrained optimal design problem which is easy to solve. Numerical comparisons with results which are obtained from numerical tests for several arch structures with various shapes and constraints show that convergence rate is very fast regardless of constraint types and configuration of arch structures. And the optimal configuration or the arch structures obtained in this study is almost the identical one from other results. The total weight could be decreased by 17.7%-91.7% when an optimal configuration is accomplished.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.1
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• pp.29-36
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• 2004

This study deals with an analysis on the sinking resistance for the model purse seine, in the case of different netting material and sinkers. The experiment was carried out using rune simplified model seines of knotless nettings. Dimension of model seines 420cm for corkline and 85cm for seine depth, three groups of models rigged 25, 45 and 60g with the same weighted sinkers in water were used. These were named PP-25, PA-25, PES-25, PP-45, PA-45, PES-45, PP-60, PA-60 and PES-60 seine. The densitie($\rho$) of netting materials were 0.91g/cm$cm^3$, 1.14g/cm$cm^3$ and 1.38g/cm$m^3$. Experiments carried out in the observation channel in a flume tank under still water conditions. Sinking motion was recorded by the one set of TV-camera for VTR, and reading coordinate carried out by the video digitization system. Differential equations were derived from the conservation of momenta of the model purse seines and used to determine the sinking speeds of the depths of leadline and the other portions of the seines. An analysis carried out by simultaneous differential equations for numerical method by sub-routine Runge-Kutta-Gill The results obtained were as follows : 1. Average sinking speed of leadline for the model seines rigged 60g with the same weighted sinkers in water was fastest for 12.2cm/sec of PES seine, followed by 11.4cm/sec of PA and 10.7cm/sec of PP seines. 2. The coefficient of resistance for netting of seine was estimated to be $K_D=0.09(\frac{\rho}{\rho_w})^4$ 3. The coefficient of resistance for netting bundle of seine was estimated to be $C_R=0.91(\frac{\rho}{\rho_w})$ 4. In all seines, the calculated depths of leadline closely agreed with the measured ones, each 25g, 45g, 60g of weighted sinkers were put into formulas meas.=1.04cal., meas.=0.99cal. and meas.=0.98 cal.

• Food Science of Animal Resources
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• v.31 no.6
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• pp.944-951
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• 2011

An improved cholesterol analysis method was developed for powdered infant formula by gas chromatographic separation after liquid-liquid extraction and partition. In the official Korea Food Standard method for cholesterol analysis, the water phase and solvent phase were not well separated in the case of emulsified foods such as powdered infant formulas and baby foods. For the rapid and simple sample preparation method, an optimized direct saponification condition was established for heating temperature, heating time, and KOH concentration. From the results, the optimum conditions were as follows: heating temperature $90^{\circ}C$, heating time 60 min, and 16 M KOH 10 mL for a 2 g infant formula sample; improved separation condition for gas chromatography was as follows: the initial oven condition was $250^{\circ}C$ for 25 min, the oven temperature was increased to $290^{\circ}C$ by $10^{\circ}C$/min ratio, and finally the oven temperature remained at $290^{\circ}C$for 9 min. The developed method could be implemented for the study of cholesterol, providing the advantages of reduced inspection time and cost in emulsified foods such as infant formula.