• Research in Community and Public Health Nursing
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• v.14 no.2
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• pp.287-298
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• 2003

The purpose of the study was to develop an integrated prevention program to strengthen elders self-care capability and to examine its effectiveness on their psychological condition. This study used one group pre- and post-test design. Subjects were 85 elderly residents (over 65 years of age) who lived alone, and received free basic medical care and social welfare services in a rural community in Korea. Subject eligibility criteria for this study were to an elders who 1) is not currently taking any anti-depressant medication 2) is able to communicate, and 3) agrees to participate in this study. The integrated program was composed of horticulture, reminiscence, and friendship activities. Twelve sessions were provided for 12 weeks in community-based partnerships to achieve better outcomes. The intervention was case-managed by a public health nurse and aided by six volunteers. The main outcome variable was depression, which was assessed by using 15 items selected from the Geriatric Depression Scale-short form Korean version. Socio-demographic characteristics, functional status, and satisfaction with social support were used as covariates. Results showed that there was a significant intervention effect at post-intervention time point compared to pre-intervention time point(E.S. 0.94). Multiple linear regression analysis showed significant interaction effects between intervention and satisfaction with social support. These findings must be interpreted within the context that an effects of an integrated program could be more synergistically increased when social support factor is considered in the program. A community-based integrated prevention program of depression is effective for vulnerable rural elderly. It is suggested that randomized controlled trials within community setting for better methodological strength as well as multi-level outcomes on community need to be conducted in future.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6755-6760
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• 2014

Background: Oral cancer is a common form of cancer in India, particularly among men. About 95% are squamous cell carcinomas. Tobacco along with alcohol are regarded as the major risk factors. Objectives: (i) To determine associations of oral squamous cell carcinoma (OSCC) with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral anatomical sites and clinico-pathological profile in OSCC patients. Materials and Methods: This is an unmatched case-control study during period January 2012 to December 2013. Total of 471 confirmed OSCC patients and 556 control subjects were enrolled. Data on socio-demography, risk habits with duration and medical history were recorded. Results: There were significant associations between OSCC with middle age (41-50years; unadjusted OR=1.63, 95%CI=1.05-2.52, p=0.02) (51-60 years; unadjusted OR=1.79, 95%CI=1.15-2.79, p=0.009) and male subjects (unadjusted OR=2.49, 95%CI=1.89-3.27, p=0.0001). Cases with both habits of tobacco chewing and smoking were at a higher risk for OSCC than tobacco chewing alone (unadjusted OR=0.52, 95%CI=0.38-0.72, p=0.0001), duration of risk habits also emerged as a responsible factor for the development of carcinoma. The majority of patients were presented in well-differentiated carcinomas (39.9%). Prevalence of advance stages (TNM stage III, IV) was 23.4% and 18.3% respectively. The buccal mucosa was the most common (35.5%) affected oral site. Conclusions: In most Asian countries, especially India, there is an important need to initiate the national level public awareness programs to control and prevent oral cancer by screening for early diagnosis and support a tobacco free environment.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1164-1171
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• 2019

Dietary supplements derived from natural sources are an essential factor in optimizing athletic performance. It has been proposed that the extract of Momordica charantia (M. charantia) that is known as a bitter melon can be potentially used as a novel supplement for health promotion. This pilot study aimed to examine the effects of the M. charantia extract when administered in the form of a sports drink, and we evaluated changes in body composition and metabolic factors in tennis players after 4-week consumption of the extract. Eight male college tennis players were instructed to consume an M. charantia extract 6 times per day (3 in the morning and 3 in the afternoon, and the total daily intake was 600 ml). Collected data were analyzed using paired t-tests to examine the changes over time after consumption of the M. charantia extract. The results revealed a significant increase in the trunk muscle mass, basal metabolic rate, and daily calorie intake (p < 0.05). Levels of protein, minerals, and total body water showed an increased tendency (not statistically significant), whereas intracellular water and extracellular water showed a decreased trend. Furthermore, fat-free mass, skeletal muscle mass, and muscle mass showed an increased tendency. In conclusion, consumption of the M. charantia extract caused an increase in parameters related to protein, muscle mass, and metabolism. It seems that follow-up studies related to fatigue, inflammation, and stress hormones related to the M. charantia extract consumption would be needed.

• Korean Journal of Oriental Medicine
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• v.6 no.1
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• pp.89-98
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• 2000

Cerebral ischemia, the most prevalent form of clinical stroke, is a medical problem of the first magnitude. Substantial efforts are being made to develop drugs which will protect the brain from the neurodegeneration followed by an ischemic stroke. A key factor in this process is the development of animal models that mimic the neuropathological consequences of stroke. Recently, there is increasing an evidence that free radical is involved in the mechanisms of ischemic brain damage. We investigated the macro scale gene expression analysis on the global ischemia induced by 4-vessel occlusion in Wister rats. The recent availability of microarrays provides an attractive strategy for elaborating an unbiased molecular profile of large number of genes during ischemic injury. This experimental approach offers the potential to identify molecules or cellular pathways not previously associated with ischemia. Ischemia was induced by 4-vessel occlusion for 10 minutes and reperfused again. RNA from sham control brain and time-dependent ischemed brain were hybridized to microarrays containing 4,000 rat genes. 589 genes were found to be at least 2 fold regulated at one or more time points. These survey data provide the foundation studies that should provide convincing proof for ischemia and oxidative stress on gene expression.

• Korean Institute of Interior Design Journal
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• v.19 no.3
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• pp.46-56
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• 2010

The nature is the foundation of human life and arts, and human beings have found order and principle amid ceaseless change and harmonization of the nature and diversified patterns and directly or indirectly applied the nature to interior through discovered principles. Interior space to which the organic factors of the nature is an expression of the vitality of the nature and expresses live forms as seen in change, development and growth of living organisms in addition to human feelings. The study aims to recognize the necessity of studies on interior space to which organic expressive characteristics of the nature are applied in uniformed space, suggest expressive characteristics and propose needed basic data required at a time of designing interior space. In this regard, the study has examined works by five contemporary designers including Zaha Hadid, Karim Rashid, Fabio Novembre and Nox with an aim to analyze expressive characteristics of interior design and figure expressive characteristics of organic design found in interior space. According to analyses on preceding literary studies and case studies (14 places), it has been found that organic expressive characteristics in interior space include vision, tactile sensation and auditory sense in terms of sensitivity, immateriality in terms of a property of matter, metaphor and abstraction in terms of the form of natural objects and non-linear curves and free curves in organic design. Organic spaces were characterized by symbolism, directionality, continuity, pattern and superimposition. This conclusion is expected to be useful in subsequent studies on the application of organic expressive characteristic factors at a time of planning interior space in the future.

• Journal of Korean society of Dental Hygiene
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• v.11 no.5
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• pp.791-799
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• 2011

Objectives : This study aimed at examining the aspects of utilization of the dental services in some regions and analyzing the related factors with a view to helping the old solve the dental problems and overcome the difficulties. Methods : This investigation was intended for 422 old people living in Jeon-ju city and Jang-su county from July 18, 2006 to August 25 by direct interviewing posing questions. The survey data sets were analyzed by chi-square, correlation, multiple regression and logistic regression. Results : 1. The average number of the existing teeth per an old person was 13.6 and the 28.8% of the old who didn't use denture called for dentures. 2. The annual coefficient of utilization in dental services for an old person was 52.3% and the annual average visits to dental clinics were 3.12 days while 38.6% of the old experienced illegal dental treatments. 3. The affecting factors on the dental utilization for treatment were as follows: family income, dental clinics available, the number of existing teeth, the days of dental trouble, the recognition of the prevention of the dental disease, the knowledge for the dental treatment and the oral health judged by himself. 4. The major variables influencing the utilization of dental services were spouse presence, form of family, income, having a regular dental care, denture presence and the experience of inconvenience in living. Conclusions : To conclude, the following suggestions could be made. First, It was necessary that enforcement practice of free dental prosthesis service and application to the national health insurance in old people's prosthetic therapy for government support because the economic factor was barrier to utilization of the dental services. Second, Dental clinic was required to the health center because availability of common dental services was big impact in utilization of the dental services.

• Reproductive and Developmental Biology
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• v.36 no.1
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• pp.21-26
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• 2012

Suspension culture is a useful tool for culturing embryonic stem (ES) cells in large-scale, but the stability of pluripotency and karyotype has to be maintained $in$ $vitro$ for clinical application. Therefore, we investigated whether the chromosomal abnormality of ES cells was induced in suspension culture or not. The ES cells were cultured in suspension as a form of aggregate with or without mouse embryonic fibroblasts (MEFs), and 0 or 1,000 U/ml leukemia inhibitory factor (LIF) was treated to suspended ES cells. After culturing ES cells in suspension, their karyotype, DNA content, and properties of pluripotency and differentiation were evaluated. As a result, the formation of tetraploid ES cell population was significantly increased in suspension culture in which ES cells were co-cultured with both MEFs and LIF. Tetraploid ES cell population was also generated when ES cells were cultured alone in suspension regardless of the existence of LIF. On the other hand, the formation of tetraploid ES cell population was not detected in LIF-free condition, in which MEFs were included. The origin of tetraploid ES cell population was turned out to be E14 ES cells and not MEFs by microsatellite analysis and the basic properties of them were still maintained despite ploidy-conversion to tetraploidy. Furthermore, we identified the ploidy shift from tetraploidy to near-triploidy as tetraploid ES cells were differentiated spontaneously. From these results, we demonstrated that suspension culture system could induce ploidy-conversion generating tetraploid ES cell population. Moreover, optimization of suspension culture system may make possible mass-production of ES cells.

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.2
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• pp.67-75
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• 2002

The human complement receptor type 1 (CR 1, C3 b/C4b receptor) is a polymorphic membrane glycoprotein expressed on human erythrocytes, peripheral leukocytes, plasma and renal glomerular podocytes, which consists of transmembrane and cytoplasmic domains with 30 repeating homologous protein domains known as short consensus repeats (SCR). CR1 has been used as an inhibitor for inflammatory and immune system for the past several years. Recently; it is reported that CRl was found to suppress the hyper-acute rejection in xeno-transplantation and can be used to cure autoimmune diseases. A soluble form of CRl, called sCRl, is a recombinant CRl by cleaving the transmembrane domain at C-terminus and has been expressed in Chinese Hamster Ovary (CHO) cells. Several purification methods for sCR1 from CHO cells have been reported, but most of them require complicated steps at high cost. Moreover, such methods are mostly performed under the pH condition apt to denaturing sCR1 and causes sCRl losing its activity. We here report a rapid and efficient method to purify sCR1 from CHO cell. The new method consists of a two-stage of cell culture by cultivating cells in serum medium followed by serum-free medium, and a two-stage of column purification by means of heparin and gel filtration column chromatography. By using this novel method, sCR1 can be purified in a simple and effective way with high yield and purity, furthermore, the purified sCR1 was confirmed to retain its activity to suppress the complement activation in vivo and ex vivo.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.5
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• pp.343-352
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• 2016

In this study, a pre-swirl duct for the 180,000 DWT bulk carrier has been designed from a propulsion standpoint using CFD. The stern duct - designed by NMRI - was selected as the initial duct. The objective function is to minimize the value of delivered power in model scale. Design variables of the duct include duct angle, diameter, chord length, and vertical and horizontal displacements from the center. Design variables of the stators are blade number, arrangement angle, chord length, and pitch angle. A parametric design was carried out with the objective function obtained using CFD. Reynolds averaged Navier-Stokes equations have been solved; and the Reynolds stress model applied for the turbulent closure. A double body model is used for the treatment of free-surface. MRF and sliding mesh models have been applied to simulate the actuating propeller. A self-propulsion point has been obtained from the results of towing and self-propelled computations, i.e., form factor obtained from towing computation and towing forces obtained from self-propelled computations of two propeller rotating speeds. The reduction rate of the delivered power of the improved stern duct is 2.9%, whereas that of the initial stern duct is 1.3%. The pre-swirl duct with one inner stator in upper starboard and three outer stators in portside has been designed. The delivered power due to the designed pre-swirl duct is reduced by 5.8%.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.19 no.1
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• pp.51-56
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• 2013

From the time the product is manufactured until it is carried and ultimately used, the product is subjected to some form of handling and transportations. During this process, the product can be subjected to many potential hazards. One of them is the damage caused by shocks. In order to design a product-package system to protect the product, the peak acceleration or G force to the product that causes damage needs to be determined. When a corrugated fiberboard box loaded with products is dropped onto the ground, part of the energy acquired due to the action of the gravitational acceleration during the free fall is dissipated in the product and the package in various ways. The shock absorbing characteristics of the packaging cushion materials are presented as a family of cushion curves in which curves showing peak accelerations during impacts for a range of static loads are shown for several drop heights. The new method for determining the shock absorbing characteristics of cushioning materials for protective packaging has been described and demonstrated. It has been shown that cushion curves can be produced by combining the static compression and impact characteristics of the material. The dynamic factor was determined by the iterative least mean squares (ILMS) optimization technique in which the discrepancies between peak acceleration data predicted from the theoretical model and obtained from the impact tests are minimized. The approach enabled an efficient determination of cushion curves from a small number of experimental impact data.