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http://dx.doi.org/10.7314/APJCP.2014.15.16.6755

Demographic Risk Factors, Affected Anatomical Sites and Clinicopathological Profile for Oral Squamous Cell Carcinoma in a North Indian Population  

Krishna, Akhilesh (Department of Physiology, King George's Medical University)
Singh, R.K. (Department of Oral and Maxillofacial Surgery, King George's Medical University)
Singh, Shraddha (Department of Physiology, King George's Medical University)
Verma, Pratima (Department of Physiology, King George's Medical University)
Pal, U.S. (Department of Oral and Maxillofacial Surgery, King George's Medical University)
Tiwari, Sunita (Department of Physiology, King George's Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6755-6760 More about this Journal
Abstract
Background: Oral cancer is a common form of cancer in India, particularly among men. About 95% are squamous cell carcinomas. Tobacco along with alcohol are regarded as the major risk factors. Objectives: (i) To determine associations of oral squamous cell carcinoma (OSCC) with respect to gender, age group, socioeconomic status and risk habits; (ii) To observe the distribution of affected oral anatomical sites and clinico-pathological profile in OSCC patients. Materials and Methods: This is an unmatched case-control study during period January 2012 to December 2013. Total of 471 confirmed OSCC patients and 556 control subjects were enrolled. Data on socio-demography, risk habits with duration and medical history were recorded. Results: There were significant associations between OSCC with middle age (41-50years; unadjusted OR=1.63, 95%CI=1.05-2.52, p=0.02) (51-60 years; unadjusted OR=1.79, 95%CI=1.15-2.79, p=0.009) and male subjects (unadjusted OR=2.49, 95%CI=1.89-3.27, p=0.0001). Cases with both habits of tobacco chewing and smoking were at a higher risk for OSCC than tobacco chewing alone (unadjusted OR=0.52, 95%CI=0.38-0.72, p=0.0001), duration of risk habits also emerged as a responsible factor for the development of carcinoma. The majority of patients were presented in well-differentiated carcinomas (39.9%). Prevalence of advance stages (TNM stage III, IV) was 23.4% and 18.3% respectively. The buccal mucosa was the most common (35.5%) affected oral site. Conclusions: In most Asian countries, especially India, there is an important need to initiate the national level public awareness programs to control and prevent oral cancer by screening for early diagnosis and support a tobacco free environment.
Keywords
Oral squamous cell carcinoma; smokeless tobacco; risk habits; histopathology;
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1 Jayalekshmi PA, Gangadharan P, Akiba S, Koriyama C, Nair RR (2011). Oral cavity cancer risk in relation to tobacco chewing, bidi smoking among men in Karunagappally, Kerala, India: Karunagappally cohort study. Cancer Sci, 102, 460-7.   DOI   ScienceOn
2 Jovanovic A, Schulten EA, Kostense PJ, Snow GB, van der Waal (1993). Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma. J Oral Pathol Med, 22, 459-62.   DOI
3 Khandekar SP, Bagdey PS, Tiwari RR (2006). Oral cancer and some epidemiological factors: a hospital based study. Indian J Community Med, 31, 157-9.
4 Kiran G, Shyam NDVN, Rao J, et al (2012). Demographics and histopathological patterns of oral squamous cell carcinoma at a tertiary level referral hospital in hyderabad, India: A 5-year retrospective study. J Orofac Res, 2, 198-201.   DOI
5 Krishna Rao SV, Mejia G, Roberts-Thomson K, Logan R (2013). Epidemiology of oral cancer in Asia in the past decade- an update (2000-2012). Asian Pac J Cancer Prev, 14, 5567-77.   과학기술학회마을   DOI   ScienceOn
6 Lin WJ, Jiang RS, Wu SH, Chen FJ, Liu SA (2011). Smoking, alcohol, betel quid, oral cancer: a prospective cohort study. J oncol, 2011, 525976.
7 Loyha K, Vatanasapt P, Promthet S, Parkin DM (2013). Risk factors for oral cancer in northeast Thailand. Asian Pac J Cancer Prev, 13, 5087-90.   과학기술학회마을   DOI   ScienceOn
8 Maasland DH, van den Brandt PA, Kremer B, Goldbohm RA, Schouten LJ (2014). Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands cohort study. BMC Cancer, 14, 187.   DOI
9 Madani AH, Dikshit M, Bhaduri D, et al (2010). Relationship between selected socio-demographic factors, cancer of oral cavity - A case control study. Cancer Inform, 9, 163-8.
10 Madani AH, Dikshit M, Bhaduri D (2012). Risk for oral cancer associated to smoking, smokeless and oral dip products. Indian J Public Health, 56, 57-60.   DOI   ScienceOn
11 Mathur A, Jain, M Shiva M, et al (2007). Tobacco habits and risk of oral cancer: a retrospective study in India. Iranian J Blood and Cancer, 3, 111-6.
12 Mehrotra R, Singh MK, Pandya S, Singh M (2008). The use of an oral brush biopsy without computer-assisted anaylsis in the oral lesions: a study of 94 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, 246-53.   DOI
13 Ministry of Health and Family Welfare, Government of India. global adult tobacco survey report, India 2009-10.
14 Mishra D, Singh HP (2003). Kuppuswamy's scocioeconomic status scale-A revision. Indian J Pediatr, 70, 273-4.   DOI   ScienceOn
15 Muwonge R, Ramadas K, Sankila R, et al (2008). Role of tobacco smoking, chewing, alcohol drinking in the risk of oral cancer in Trivandrum, India: a nested case-control design using incident cancer cases. Oral Oncol, 44, 446-54.   DOI   ScienceOn
16 Omar EA (2013). The outline of prognosis and new advances in diagnosis of oral squamous cell carcinoma (OSCC): review of the literature. J Oral Oncol, 2013, 1-13
17 PB Patil, R Bathi, S Chaudhari (2013). Prevalence of oral mucosal lesions in dental patients with tobacco smoking, chewing, and mixed habits: A cross-sectional study in South India. J Family Community Med, 2, 130-5.
18 Sanchez GS, Juarez CT, Espinel Bermudez MC, et al (2008) . Hospital discharges for oral cancer in the Mexican Institute of Social Security, 1991-2000. Rev Med Inst Mex Seguro Soc, 46, 101-8.
19 Petti S, Scully C (2005). Oral cancer: the association between nation-based alcohol-drinking profiles and oral cancer mortality. Oral Oncol, 41, 828-34.   DOI   ScienceOn
20 Rautava J, Luukkaa M, Heikinheimo K, et al (2007). Squamous cell carcinomas arising from different types of oral epithelia differ in their tumor and patient characteristics and survival. Oral Oncol, 43, 911-9.   DOI
21 Saraswathi TR, Ranganathan K, Shanmugam S, et al. (2006) . Prevalence of oral lesions in relation to habits: cross sectional study in South India. Indian J Dent Res, 17, 121-5.   DOI
22 Schmidt BL, Dierks EJ, Homer L, Potter B (2004). Tobacco smoking history and presentation of oral squamous cell carcinoma. J Oral Maxillofac Surg, 62, 1055-8.   DOI   ScienceOn
23 Sharma P, Saxena S, Aggarwal P (2010). Trends in the epidemiology of oral squamous cell carcinoma in Western UP: An institutional study. Indian J Dent Res, 21, 316-9.   DOI   ScienceOn
24 Shenoi R, Devrukhkar V, Chaudhuri, Sharma BK, et al (2012). Demographic and clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian J Cancer, 49, 21-6.   DOI
25 Sherin N, Simi T, Shameena PM, Sudha S (2008). Changing trends in oral cancer. India J Cancer, 45, 93-6.   DOI   ScienceOn
26 Arvind K, Vijayalakshmi R (2013). Early stage oral tongue cancer among non-tobacco users -an increasing trend observed in a south indian patient population presenting at a single centre. Asian Pac J Cancer Prev, 14, 5061-5.   과학기술학회마을   DOI   ScienceOn
27 Addala L, Pentapati CK, Reddy Thavanati PK, Anjaneyulu V, Sadhnani MD (2012). Risk factor profiles of head, neck cancer patients of Andhra Pradesh, India. Indian J Cancer, 49, 215-9   DOI   ScienceOn
28 Agrawal KH, Rajderkar SS (2012). Clinicoepidemiological profile of oral cancer: A hospital based study. Indian J Community Health, 24, 80-5.
29 Aruna D, Prasad KVV, Shavi GR, et al (2011). Retrospective study on risk habits among oral cancer patients in Karnataka Cancer Therapy, Research Institute, Hubli, India. Asian Pac J Cancer Prev, 12, 1561-6.
30 Avraham Z, Nasser N, Yuval V (2012) .Oral and pharyngeal cancer among the Arab population in Israel from 1970 to 2006. Asian Pac J Cancer Prev, 13, 585-9.   과학기술학회마을   DOI
31 Ayaz B, Saleem K, Azim W, Shaikh A (2011). A clinicopathological study of oral cancers. Biomedica, 27, 29-32.
32 Bagan J, Sarrion G, Jimenez Y (2010). Oral cancer: clinical features. Oral Oncol, 46, 414-7.   DOI   ScienceOn
33 Battoo AJ, Hedne N, Ahmad SZ, et al (2012). Selective neck dissection is effective in N1/N2 nodal stage oral cavity squamous cell carcinoma. J Oral Maxillofac Surg, 71, 636-43.
34 Bhurgri Y (2005). Cancer of the oral cavity - trends in Karachi south (1995-2002). Asian Pac J Cancer Prev, 6, 22-6.
35 Subapriya R, Thangavelu A, Mathavan B, Ramachandran CR, Nagini S (2007). Assessment of risk factors for oral squamous cell carcinoma in Chidambaram, Southern India: a case-control study. Eur J Cancer Prev, 16, 251-6.
36 Sudha S, Saranya R S (2014). Cytomorphological changes in buccal epithelial cells of khaini chewers in different age groups. Asian J Biomed Pharmaceut Sci. 4, 43-7.   DOI
37 Syeda AA, Vini A, Syed Z, et al (2013). Correlation of habits and clinical findings with histopathological diagnosis in oral submucosal fibrosis patients. Asian Pac J Cancer Prev, 14, 7075-80.   과학기술학회마을   DOI
38 Bektas-Kayhan K, Karagoz G, Kesimli MC, et al (2014). Carcinoma of the tongue: a case-control study on etiologic factors and dental trauma. Asian Pac J Cancer Prev, 15, 2225-9.   과학기술학회마을   DOI
39 Bhurgri Y, Bhurgri A, Hussainy AS, et al (2003). Cancer of the oral cavity, pharynx in Karachi - Identification of potential risk factors. Asian Pac J Cancer Prev, 4, 125-30.
40 Cogliano V, Straif K, Baan R, Grosse Y, et al (2004). Smokeless tobacco and tobacco-related nitrosamines. Lancet Oncol, 5, 708.   DOI   ScienceOn
41 Conway DI, Petticrew M, Marlborough H, et al (2008). Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer, 122, 2811-9.   DOI   ScienceOn
42 Chung CH, Yang YH, Wang TY, Shieh TY, Warnakulasuriya S (2005). Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan. J Oral Pathol Med, 34, 460-6.   DOI
43 Doshi Neena P, Shah Siddharth A, Patel Keyuri B, Jhabuawala Munira F (2011). Histological grading of oral cancer: A comparison of different systems and their relation to lymph node metastasis. Natl J Commun Med, 2, 136-42.
44 Funk GF, Karnell LH, Robinson RA, et al (2002). Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck, 24, 165-80.   DOI   ScienceOn
45 Gangane N, Chawla S, Anshu, Gupta SS, Sharma SM (2007). Reassessment of risk factors for oral cancer. Asian Pac J Cancer Prev, 8, 243-8.
46 Warnakulasuriya S (2009). Causes of oral cancer-an appraisal of controversies. Br Dent J, 207, 471-5.   DOI   ScienceOn
47 Su CC, Yang HF, Huang SJ, Lian leB (2007). Distinctive features of oral cancer in Changhua county: high incidence, buccal mucosa preponderance, and a close relation to betel quid chewing habit. J Formos Med Assoc, 106, 225-33.   DOI   ScienceOn
48 Udeabor SE, Rana M, Wegener G, Gellrich NC, Eckardt A. M (2012). Squamous cell carcinoma of the oral cavity and the oropharynx in patients less than 40 years of age: a 20-year analysis. Head Neck Oncol, 28, 2-7.
49 Warnakulasuriya S, Sutherland G, Scully C (2005). Tobacco, oral cancer and treatment of dependence. Oral Oncol, 41, 244-60.   DOI   ScienceOn
50 WHO (2004). The world health report 2004: changing history Geneva. http://www.who.int/whr/2004/en/report04_en.pdf
51 Hakeem AH, Pradhan SA, Tubachi J, Kannan R (2012). Outcome of per oral wide excision of T1-2 N0 localized squamous cell cancer of the buccal mucosa-analysis of 156 cases. Laryngoscope, 123, 177-80.
52 Government of India (2009-10). Annual report, ministry of health and family welfare, New Delhi, India.
53 Goyal S, Tiwari VK, Nair KS, RajS (2014). Risk Factors and costs of oral cancer in a tertiary care hospital in Delhi. Asian Pac J Cancer Prev, 15, 1659-5.   과학기술학회마을   DOI   ScienceOn
54 Gupta Bhawna (2013). Burden of smoked and smokeless tobacco consumption in india results from the global adult tobacco survey India (GATS-India)- 2009-2010. Asian Pac J Cancer Prev, 14, 3323-9.   과학기술학회마을   DOI   ScienceOn
55 Halboub ES, Al-Anazi YM, Al-Mohaya MA (2011). Characterization of yemeni patients treated for oral, pharyngeal cancers in Saudi Arabia. Saudi Med J, 32, 1177-82.
56 Hernandez-Guerrero JC, Jacinto-Aleman LF, Jimenez-Farfan MD, et al (2013). Prevalence trends of oral squamous cell carcinoma. Mexico City's General Hospital experience. Med Oral Patol Oral Cir Bucal, 18, 306-11.
57 Hosseinpoor AR, Parker LA, Tursan d'Espaignet E, Chatterji S (2012). Socioeconomic inequality in smoking in low-income and middle-income countries: results from the world health survey. PLoS ONE, 7, 42843.   DOI
58 ICMR-Indian Council of Medical Research (2011). National cancer registry programme, Indian council of medical research, New Delhi.
59 Carvalho AL, Singh B, Spiro RH, Kowalski LP, Shah JP (2004). Cancer of the oral cavity: a comparison between institutions in a developing and a developed nation. Head Neck, 26, 31-8.   DOI
60 Ariyawardana A, Sitheeque MA, Ranasinghe AW, et al (2007). Prevalence of oral cancer, pre-cancer, associated risk factors among tea estate workers in the central Sri Lanka. J Oral Pathol Med, 36, 581-7.   DOI   ScienceOn