• 한국지역사회생활과학회지
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• 제24권3호
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• pp.327-342
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• 2013

The purposes of this study were to explore consumer preference for the types of nutrition label of cereal products and to identify some influencing factors on purchase intention and choice probability of nutrition-labeled products. First, most of the respondents preferred the nutrition fact panel with traffic light-GDA(TL-GDA), while the nutrition fact panel only type and the nutrition fact panel with front-of-package(FOP) type were preferred by few respondents. However, consumers evaluated higher for TL-GDA type and FOP symbol type, while the nutrition fact panel only type was evaluated much lower. Second, consumer preference for label types was partially related with 'eating breakfast' and consumer evaluations of the types of labels for the nutrition fact panel only and the nutrition fact panel with FOP were found to be significantly different by gender. Lastly, both purchase intention and choice probability for nutrition-labeled products were found to be significantly influenced by information search and product attitude. In addition, choice probability was found to be significantly influenced by individual characteristics such as gender and grade. It is necessary to find the relationship between nutrition labels and consumer response as this can help consumers make a better choice of food as well as providing some useful information on consumers to the related parties such as companies and consumer organizations.

• 한국정보컨버전스학회논문지
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• 제1권1호
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• pp.17-24
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• 2008

영상 감시 카메라는 각종 범죄를 예방하고 범죄사건을 해결하는데 중요한 정보를 제공해 준다. 2차원 얼굴 영상을 확대 복원하기 위해서는 사용하는 보간법은 비트맵 이미지를 사용하기 때문에 높은 품질의 영상으로 복원하기에는 많은 문제점이 있다. 따라서 이러한 문제점을 보완하면서 좀 더 높은 품질의 영상을 복원하고자 벡터 이미지 방식을 도입하여 영상을 복원하고자 한다.

• International Journal of Control, Automation, and Systems
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• 제6권4호
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• pp.468-476
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• 2008

This paper presents a novel approach to economic dispatch (ED) with nonconvex fuel cost function as combinatorial optimization problems (COP) while most of the conventional researches have been developed as function optimization problems (FOP). One nonconvex fuel cost function can be divided into several convex fuel cost functions, and each convex function can be regarded as a generation type (G-type). In that case, ED with nonconvex fuel cost function can be considered as COP finding the best case among all feasible combinations of G-types. In this paper, a genetic algorithm is applied to solve the COP, and the $\lambda$-P table method is used to calculate ED for the fitness function of GA. The $\lambda$-P table method is reviewed briefly and the GA procedure for COP is explained in detail. This paper deals with three kinds of ED problems, namely ED considering valve-point effects (EDVP), ED with multiple fuel units (EDMF), and ED with prohibited operating zones (EDPOZ). The proposed method is tested for all three ED problems, and the test results show an improvement in solution cost compared to the results obtained from conventional algorithms.

• 동국한의학연구소논문집
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• 제2권1호
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• pp.155-166
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• 1993

Geukhachukeutang is used to cure blood stasis in Oriental Medicine. In order to investigate medical value on intravascula coagulation and contusion blood stasis, the effect of Platelet number, Fibrinogen quantity, Prothrombin time, FOP density, Paw edema increasing rate after prescribing Geukhachukeutang concentration liquid orally were observed. The obtained results are summerized as follows ; 1. Platelet number and Fibrinogen quantity are significantly increased, and Prothrombin time and FOP density are significantly decreased by Geukhachukeutang after inducing intravascula coagulation. 2. Platelet number and Fibrinogen quantity are not significantly increased, and Prothrombin time is not significantly decreased either, by Geukhachukeutang after inducing contusion blood stasis but Paw edema increasing rate is remarkablely decreased in three or four hours of the groups of prescribing. According to the above results, Geukhachukeutang will be used for contusion blood stasis and Intravascula coagulation effectively owing to being accepted as a favorable operation on Platelet number, Fibrinogen quantity, Prothrombin time, FDP density and Paw edema increasing rate.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1992년도 가을 학술발표회 논문집
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• pp.174-179
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• 1992

In this paper a discussion is presented about excavation responses of underground openings for radioactive waste disposal. The effects of excavation methods, stress redistribution, thermal change, and backfill materials are reviewed. Comparisons of computational models for discontinuous reek masses and discussions on numerical simulation techniques for the excavation of underground openings are also described. Finally, the application of the CAD system to the planning, design and construction of underground openings fop radioactive waste disposal is introduced.

• 대한치과교정학회지
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• 제16권2호
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• pp.99-106
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• 1986

The author studied 21 adenoid hypertrophied children and 50 normal children by the horizontal, vertical and angular measurements to analyze, the effects of the lymphadenoid hypertrophy to the tongue, mandible, and hyoid bone position. The results were as follows; 1. The tongue of the Adenoid hypertrophy children was positioned mon anterior and lower than that of the normal children. 2. The horizontal, vertical, and angular measurements of the mandible position were larger in the experimental group and especially ANS to ME, PNS to MP, PTM to MP, PP to MP, FOP to MP showed statistically significant difference. 3. The measurements of the hyoid bone position were also larger in the experimental group.

• 생명과학회지
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• 제29권8호
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• pp.871-878
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• 2019

본 연구에서는 Rhododendron brachycarpum (RB, 홍만병초)의 80% 메탄올 추출물 및 분획물의 항암 활성을 규명하고자 하였다. RB n-hexane 분획물은 HT-29 세포에서 가장 높은 활성 저해를 보였다($IC_{50}=20.2{\pm}1.2{\mu}g/ml$). 더욱이, 콜로니와 구형 형성은 수와 크기는 유의적으로 감소시켰다. RB의 n-hexane 분획물에서($0.22{\pm}0.02$ fold change) TOP / FOP 플래시 리포터 억제 활성은 추출물 및 다른 분획물 보다 낮게 나타났다. n-hexane 및 ethyl acetate 분획물은 세포 내 ${\beta}-catenin$의 발현을 조절하였다. 2 차 대사 산물이 ${\beta}-catenin$ 분해를 감소시킬 수 있는지 여부를 조사하기 위해 Western blot을 실시한 결과 n-hexane 분획물에서 $p-GSK3{\beta}$를 조절하였으며, 세포내 ${\beta}-catenin$은 핵에서 정량적인 변화를 가져왔다. 이러한 결과는 RB의 n-hexane 분획물로부터 천연 항암 물질을 포함하고 있음을 보여줍니다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.13-34
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• 2003

Fructose-1, 6-diphosphate (FOP), a glycolytic metabolite is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FOP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart. In this study, we examined whether FDP has protective effects on UV-induced oxidative damage in skin cell culture system and human skin in vivo. FDP had a protective role in UVB-induced LDH release and ROS accumulation in HaCaT although it did not show direct radical scavenging effect in the experiment using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). FDP also preserved cellular GSH content after UV irradiation in HaCaT and normal human fibroblast culture system. Cellular oxidative stress induces multiple downstream signaling pathways that regulate expression of multiple gene including MMP-1 and collagen, we examined the effects of FDP on UV-induced alteration of these protein expression in fibroblast culture and human skin in vivo. The increased MMP-1 expression in fibroblast and human skin by UV irradiation was significantly decreased by FDP. FDP also prevented the UV-induced decrease of collagen expression in fibroblast and human skin. Moreover, the decreasing the intracellular levels of reducing equivalents in human fibroblast by glutathione (GSH) depletion lowered the UVA dose threshold for reduction of procollagen expression, indicating that the differences of glutathione contents define the susceptibility of fibroblasts towards UV-induced reduction of procollagen expression. FDP also preserved cellular GSH content after UV irradiation, indicating that FDP has protective effects on UV-induced reduction of procollagen expression, which are possibly through maintaining intracellular reducing equivalent. Based on these premises, we examined the effect of daily use of a moisturizer containing FDP on facial wrinkle in comparison with vehicle moisturizer lacking FDP. In the clinical study, FDP significantly decreased facial wrinkle compared with vehicle alone after 6 months of use. Our results suggest that FDP has anti-aging effects in skin by increasing cellular antioxidant system and preventing oxidative signal and inflammatory reaction. Therefore FDP may be useful anti-aging agent for cosmetic purpose.

• Molecules and Cells
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• 제46권12호
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• pp.757-763
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• 2023

In this study, we examine whether a change in the protein levels for FOP in Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A)-deficient ependymal cells affects the intraflagellar transport (IFT) protein transport system in the multicilia. Three distinct abnormalities are observed in the multicilia of ANKS1A-deficient ependymal cells. First, there were a greater number of IFT88-positive trains along the cilia from ANKS1A deficiency. The results are similar to each isolated cilium as well. Second, each isolated cilium contains a significant increase in the number of extracellular vesicles (ECVs) due to the lack of ANKS1A. Third, Van Gogh-like 2 (Vangl2), a ciliary membrane protein, is abundantly detected along the cilia and in the ECVs attached to them for ANKS1A-deficient cells. We also use primary ependymal culture systems to obtain the ECVs released from the multicilia. Consequently, we find that ECVs from ANKS1A-deficient cells contain more IFT machinery and Vangl2. These results indicate that ANKS1A deficiency increases the entry of the protein transport machinery into the multicilia and as a result of these abnormal protein transports, excessive ECVs form along the cilia. We conclude that ependymal cells make use of the ECV-based disposal system in order to eliminate excessively transported proteins from basal bodies.

• Biomolecules & Therapeutics
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• 제24권4호
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• pp.380-386
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• 2016

Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-${\kappa}B$-mediated threonine-286 phosphorylation. However, mechanism for the inhibition of Wnt signaling by silymarin still remains unanswered. Thus, we investigated whether silymarin affects Wnt signaling in human colorectal cancer cells to elucidate the additional anti-cancer mechanism of silymarin. Transient transfection with a TOP and FOP FLASH luciferase construct indicated that silymarin suppressed the transcriptional activity of ${\beta}$-catenin/TCF. Silymarin treatment resulted in a decrease of intracellular ${\beta}$-catenin protein but not mRNA. The inhibition of proteasome by MG132 and $GSK3{\beta}$ inhibition by SB216763 blocked silymarin-mediated downregulation of ${\beta}$-catenin. In addition, silymarin increased phosphorylation of ${\beta}$-catenin and a point mutation of S33Y attenuated silymarin-mediated ${\beta}$-catenin downregulation. In addition, silymarin decreased TCF4 and increased Axin expression in both protein and mRNA level. From these results, we suggest that silymarin-mediated downregulation of ${\beta}$-catenin and TCF4 may result in the inhibition of Wnt signaling in human colorectal cancer cells.