• Archives of Pharmacal Research
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• v.15 no.1
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• pp.78-86
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• 1992

The induction of hepatic cytochromes P450 and metabolic effects have been examined in male and female Sprague-Dawley rats following treatment with either phenobarbital or 3-methylcholanthrene. Hepatic cytochrome P450 levels were higher in males than in females by ~40%. Treatment of male and female rats with phenobarbital or 3-methylcholanthrene resulted in an ~1.6 and 2-fold increase, respectively, in heptic microsomal cytochrome P450 levels in both sexes, relative to untreated animals. Immunoblot analyses were performed to compare sex-related changes in P450 levels. Hepatic P45IIB1 levels in males were greater than those in females following phenobarbital treatment. 3-Methylcholanthrene-induced male hepatic microsomes exhibited greater levels of P450 females failed to exhibit a band. Mab PCN 2-13-1 against P-45-IIIA recognized an intense in uninduced microsomes from female rats. The levels of P450IIIA in males were increased 2 to 3-fold following treatment with phenobarbital, while the increase of IIIA levels in females by phenobarbital was minimal, as monitored by immunoblot analysis. Solid phase radiommunoassay using monoclonal antibodies supported the results of immunoblot analysis. Phenobarbital treatment caused a 6.5-fold increase in the monoclonal iantibody binding to IIBI in males, whereas treatment of females with phenobarbital resulted of IA levels by 3-methylcholanthrene was also greater in females than in males (10-vs. 8-fold) although the levels of induced IA were comparable inboth sexes, as assessed by radiommunoassay. Radioimmunoassay also showed that hepatic IIEI level was 1.5-fold higher in males than in females and that either phenobarbital or 3-methylcholanthrene treatment caused 80% to 40% decrease in IIEL levels, relative to control, in both sexes. Sex-related metabolic activities were examined in hepatic microsomes. Hexobarbital hydroxylase activity was 2-to 3-fold higher in uninduced microsomes from males than that from females. This hydroxylase activity was increased 2-and 3-fold in males and females, respectively, following phenobarbital treatment, as compared to controls. Addition females produced 64% and 84% inhibition of hexobarbital oxidation, respectively. Aryl hydrocarbon hydroxylase activity was increased -12 and 26-fold in males and females respectively. Following phenobarbital treatment, as compared to controls. Addition of anti-P450IIB1 antibody to phenobarbital-induced hepatic microsomes from males and females produced 64% and 84% inhibition of hexobarbital oxidation, respectively. Aryl hydrocarbon hydroxylase activity was increased -12 and 26 fold in males and females, respectively, following 3-methylcholanthrene treatment relative to controls. The anti-P-450IA antibody inhibitable rate of aryl hydrocarbon hydroxylase activity was comparable in both sexes following 3-methylcholanthrene treatment relative to controls. The anti-P450LA antibody inhibitable rate of aryl hydrocarbon hydroxylase activity was comparable in both sexes following 3-methylcholanthrene treatment (-70%). These results demonstrate that levels of hepatic P450IIB1 or P450IA are greater in male than in female for untreated, phenobarbital-or-3-methylcholanthrene treated rats. In addition, the relative for untreated phenobarbital-or 3-methylcholanthrene treated rats. In addition, the relative increase of phenobarbital-or 3-methylcholanthrene treated rats. In addition, the relative increase of phenobarbital-or 3-methylcholanthrene treated rats. In addition, the relative increase of P450IIB1 or IA phenobarbital or 3-methylcholanthrene is more significant in females.

• The Journal of the Petrological Society of Korea
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• v.10 no.2
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• pp.82-94
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• 2001

The main geological structure of the Ogcheon belt in the Buunnyeong area, Mungyeong, which consists of three stratigraphic sequences, Joseon and Pyeongan Supergroups and Daedong Group, is characterized by the development of ESE-vergence structural unit (Dangok unit) and WNW-vergence structural units (Samsil and Bugongni units) onto an autochthonous unit (Buunnyeong unit). Three phases of deformation are recognized in this area. The lent phase of deformation coourred under the WNW-ESE compression, forming an upright-open fold (Buunnyeong-I fold) with NNE axial trend in the Buunnyeong unit. The second phase of deformation also under the WNW-ESE compression formed the Dangok, Samsil and Bugongni units, resulting in the further closing of the Buunnyeong-I open fold, the elongation of pebbles in the conglomerate rocks of a basal sequence of the Daedong Group, recumbent folds (Buunnyeong-II fold) and drag folds (Dangok fold) with NNE axial trend in the Buunnyeong and Dangok units, respectively. The third phase of deformation formed kink folds with its axis p1unging subvertically. The first and second phases of deformation took place before and after the deposition of the Daedong Group of the Upper Triassic -Lower Jurassic, respectively. These first two deformation events, which occurred under the same WNW-ESE compressional field, produced the regional NNE trend of geological structure in the Joseon and Pyeongan Supergroups of this area.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.5
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• pp.91-97
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• 2015

Papermakers wish to increase the filler content of printing and writing grades because it allows saving in production cost through fiber replacement and improving the formation, and optical and printing properties of the paper. However, high filler loading in the base paper has negative side effects. It reduces the mechanical properties of paper and induces cracking at the fold after coating process. Fold cracking is one of the most frequent quality complaints for magazines, high quality books, etc. Two approaches were examined as methods to reduce fold cracking. One approach was to use preflocculated fillers, which was expected to reduce the fold cracking because it would decrease the interfiber bonding. The other approach was to use a new coating binder that gives greater binding power and thereby provides an opportunity of reducing the fold cracking of coated paper. When filler preflocculation was employed in producing the base paper, fold cracking becomes more severe than conventional filler loading condition. On the other hand, use of nano sized binder in coating improved the tensile properties of the coating layer and thereby decreased the crack area. It was shown that tensile properties of coating layer played an important role in fold cracking of coating.

• Korean Journal of Microbiology
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• v.45 no.3
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• pp.239-245
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• 2009

Translation initiation factor eIF1A performs essential functions in various initiation steps including 43S preinitiation complex formation in eukaryotes, and contains a highly conserved oligonucleotide-binding (OB) fold. In our previous study, we discovered that eIF1A possesses RNA annealing activity and forms a stable complex with double-stranded RNA. In this study, we initiated site-directed mutations in eIF1A to find the active sites for these biochemical activities and to investigate whether they are essential functions for yeast cell growth. A truncated protein, eIF1A($\Delta$T), devoid of both N- and C-terminal domains but containing an intact OB-fold exhibited RNA annealing activity. In contrast, all point mutations in OB-fold domain, except R57D, impaired both RNA annealing and dsRNA binding activities, indicating that the intact OB-fold domain is required for both activities. Viabilities of the mutant yeast cells were not correlated with RNA annealing activity but with the in vivo protein stabilities in the case of R57D and K94D.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.30 no.2
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• pp.139-141
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• 2019

The causes of vocal cord paralysis include iatrogenic injury during thyroid or cervical surgery, heart and chest surgery, and tumorous lesion such as laryngeal cancer and lung cancer. In addition to these common causes, rarely, cardiovascular disease can also cause vocal fold paralysis. A disease known as Cardiovocal syndrome, or Ortner's syndrome, causes left vocal fold paralysis when the left recurrent laryngeal nerve is compressed by the pulmonary artery and aorta, which is occurred by pulmonary hypertension from heart disease. We report for the first case in Korea the diagnosis of vocal fold paralysis caused by Ortner's syndrome.

• Nutrition Research and Practice
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• v.1 no.2
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• pp.94-99
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• 2007

The immunostimulating activities of mucilage fraction from yam were investigated. The proliferation of BSA-primed lymph node cells was enhanced between 4.1- to 10.9-fold compare to control, when cultured with 1 to $25{\mu}g/mL$ of yam-mucilage fraction. It showed strong immunostimulating activity than ginseng extract and as remarkable as Bifidobacterium adolescentis M101-4 known as a positive immunostimulator. Mitogenicity to lymph node cells was fully induced by concanavalin A and lipopolysaccharide. The proliferation of splenocytes and Peyer's patch cells was enhanced between 5.0- to 14.1-fold and 2.4- to 6.4-fold, respectively, when cultured with 1 to $25{\mu}g/mL$ of yam-mucilage fraction. It enhanced the production of cytokines such as tumor necrosis $factor-{\alpha}$ and IL-6 in the culture of RAW 264.7 macrophage cells. In the culture of lipopolysaccharide-stimulated RAW 264.7 cells, production of cytokines was as similar as compared to controls. In unstimulated RAW 264.7 cells, both tumor necrosis $factor-{\alpha}$ and IL-6 production were enhanced between 15.6- to 60.1-fold and 2.3- to 9.1-fold, respectively. Mucilage fraction from yam is expected to be a safe immunopotentiator to maintain the host immunity and develop a physiologically functional food.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.41
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• pp.7.1-7.5
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• 2019

Background: To introduce a novel technique for advancement genioplasty helping surgeons to avoid soft tissue difficulties especially in short-faced patients with deep mentolabial fold and everted lower lip. Case presentation: In a trapezius-shaped, osteotomy was performed in the chin region. The mobilized segment was advanced, and the existing gap was grafted using interpositional allograft materials. Each side had been fixated by three-hole plates and two screws. The outcomes revealed no change in lower anterior teeth vitality. The patients did not report any changes of sensation in lower lip and chin either. The measurements indicated no increase in depth of mentolabial fold in patients undergoing this surgical technique. The postoperative evaluation showed a successful esthetic outcome for the patient and the surgeon concurrently. Conclusion: Based on our experience, the authors concluded that the Balcony technique is a simple and reliable procedure for patients with a deep mentolabial fold.

• The Journal of Korean Academy of Prosthodontics
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• v.9 no.1
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• pp.35-40
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• 1969

The author measured vertical dimension of 675(326 of male and 349 of female) in normal Korean adult from 20 to 50 years of age between upper and lower muco-buccal fold on upper and lower central incisal portion at centric occlusion state. The following results were obtained.; 1) The distances from upper muco-buccal fold on upper anterior central incisal portion to lower muco-buccal fold on lower anterior central incisal portion at centric occlusion state were 37.57mm in male, 36.80mm in female and 37.19mm in average. The distances in male were longer than those of female. 2) According to increase age(from 20 to 50 years of age), the tendencies of vertical dimensional changes were increased slightly in 30~40 years group and decreased after 40 year in both sex. 3) The distances from upper muco-buccal fold on upper anterior central portion to upper central incisal edge were 20.77mm and from lower muco-buccal fold on lower anterior central incisal portion to lower central incisal edge were 18.88mm. The ratio between maxillary distances and mandibular distances was 1.4:0.9.

• The Plant Pathology Journal
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• v.24 no.1
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• pp.63-66
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• 2008

The fermentation broth (FB) of Streptomyces griseofuscus 200401 isolated from non-farming soil showed antagonistic activity against powdery mildew fungus both in melon leaf/seedling assay and in field trials. The FB of S. griseofuscus 200401 was tested at different concentrations. In primary test, the control value of 2-fold diluted FB of S. griseofuscus 200401, compared to control, reached to 82.8%. The protective activity recorded 80.5% in 2-fold dilution of FB. The effect was reduced to 28.9% in high dilution (100-fold) treatment. The curative effect was relatively lower than protective activity. In field test, the antifungal activities of S. griseofuscus 200401 remained low in blocks sprayed with 100-fold diluted FB and the control values were 15.2 and 15.9% in 2005 and 2006, respectively. However, the activities were as high as 65% and 67.3% in the blocks treated with 2-fold dilution of FB during the same period.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.19 no.1
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• pp.58-61
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• 2008

A 66-year-old woman described a 6-month history of hoarseness after upper respiratory infection. She was a house wife and referred from an outside clinic under a diagnosis of vocal fold nodules. Strobovideolaryngoscopy revealed bilateral vocal fold lesions, and decreased mucosal wave of both vocal folds. She was brought to the operating room for microsuspension laryngoscopy. Under general anesthesia, dual intracordal cysts on left vocal fold were completely resected with microflap technique. The lesion on the right vocal fold turned out to be a reactive fibrous mass, which was also resected. Dual intracordal cysts were confirmed histopathologically. The one was an epidermoid cyst lined with squamous epithelium, and the other was a mucus retention cyst lined with cuboidal epithelium. Postoperative voice was acceptable by the patient and the mucosal vibration has much improved after the surgery.