• 한국작물학회지
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• 제42권4호
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• pp.435-445
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• 1997

최근 생활수준의 향상과 보건에 대한 관심의 증가로 약용식물 재배와 한약에 대한 연구가 증가되고 있다. 그러나 대량번식을 위한 종자번식에 있어서 많은 문제점을 안고 있다. 특히 산형과 약용식물에 있어서 시호(Bupleurum falcatum)나 회향(Foeniculum vulgare)은 발아율을 증가시키는데 있어서 만족할만한 발아율을 얻지 못하고 있기 때문에 본 연구를 수행하였다. 회향은 60%의 발아율은 나타내며 15, 20, 25, 15~2$0^{\circ}C$의 발아온도 처리간의 별다른 차이가 없었다. 호르몬 처리나 물리화학적 처리에서도 발아를 증진시킬 수 없었다. 이러한 발아불량의 원인은 시호에서와 같이 결국 무배종자가 많은 것으로 추정된다. 해부현미경과 주사현미경으로 종자의 배와 주공을 관찰한 결과 배가 있는 것과 없는 것의 비율이 1/1이며 주공자체내에는 문제가 없었다. Y자형과 일자(一字)형의 배를 가진 종자가 동시에 관찰되었다

• 한국식품영양과학회지
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• 제39권11호
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• pp.1604-1610
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• 2010

본 연구는 고지방식이에 의해 유도된 비만 마우스를 이용하여 회향종자 물 추출물을 급여한 후 체중, 간과 부고환 지방조직 무게, 혈중 지질 함량, 부고환 지방세포 크기 및 지방대사 관련 효소 활성의 변화를 측정하여 항비만 기능성 소재로서의 가능성 여부를 조사하였다. 실험군은 일반식이군 (ND), 고지방식이만을 섭취한 군(HFD), 고지방식이+0.05% orlistat군(HFDO), 고지방식이+0.5% 회향종자 물 추출물 섭취군(HFDF)으로 분류하였다. 고지방식이만을 섭취한 군은 일반식이군과 비교하여 체중, 간 무게, 부고환 지방조직무게, 혈장 지질 및 혈당 농도가 현저하게 증가하였다. 회향종자 물 추출물을 함유하고 있는 식이는 고지방식이만을 섭취한 군과 비교하여 체중 26.56%, 간 무게 22.56%, 부고환 지방조직 무게 29.19%, 혈당 16.58% 감소시켰으며, orlistat를 함유한 고지방식이군과 비교하여 혈장 총콜레스테롤과 중성지방의 수준은 유사하였다. 이로써 회향종자 물 추출물 섭취는 비만에 의해 유발되는 심혈관계 질환의 위험성을 줄여 줄 것으로 추정된다. 또한 부고환 지방세포 크기는 고지방식이만을 섭취한 군에서 일반식이군과 비교하여 현저히 증가하였고, 고지방식이에 의한 지방세포 크기 증가는 orlistat와 회향종자 물 추출물 섭취에 의해 억제되었다. 지방세포내로 지방산의 유입을 억제하는 LPD 효소 활성은 고지방식이만을 섭취한 군과 비교하여 일반식이군은 27.27%, orlistat 섭취군은 44.12%, 회향종자 물 추출물 섭취군은 33.41%로 억제되었으며, 지방이용을 자극하는 ACS 효소 활성은 일반식이군 330.99%, HFDO군 232.14%, 회향종자 물추출물 섭취군 187.39%로 현저하게 증가하였다. 결과적으로 회향종자 물 추출물 섭취는 체중 증가, 지방세포 형성 및 지방세포 크기, LPL 효소의 활성을 저해하고, ACS 효소의 활성을 증가시킴으로써 항비만 효과가 있을 것으로 사료된다.

• Food Science and Biotechnology
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• 제15권5호
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• pp.763-767
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• 2006

The anticoagulant properties of compounds derived from fennel (Foeniculum vulgare Gaertner) fruits were evaluated using a platelet aggregometer and compared with aspirin. The active constituents of fennel fruits were isolated and identified as (+)-fenchone and extragole by various spectral analysis techniques. With regard to the 50% inhibitory concentration ($IC_{50}$), (+)-fenchone effectively inhibited platelet aggregation induced by treatment with collagen ($IC_{50}$, $3.9\;{\mu}M$) and arachidonic acid (AA) ($IC_{50}$, $27.1\;{\mu}M$), and estragole inhibited collagen-induced platelet aggregation ($IC_{50}$, $4.7\;{\mu}M$). By way of comparison, (+)-fenchone and estragole proved to be significantly more potent than aspirin at inhibiting platelet aggregation induced by collagen. The inhibitory activity of (+)-fenchone toward platelet aggregation induced by AA was 1.3 times stronger than that of aspirin. These results indicate that (+)- fenchone and estragole may be useful as lead compounds for inhibiting platelet aggregation induced by arachidonic acid and collagen.

• Archives of Pharmacal Research
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• 제25권2호
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• pp.154-157
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• 2002

A phenyl propanoid derivative, dillapionall(7) was found to be a antimicrobial principle of the stems of Foeniculum vuigare (Umbelliferae) with MIC values of 125, 250 and 125/ against Bacillus subtilis, Aspergillus niger and Cladosprium cladosporioides respectively. A coumarin derivative, scopoletin(2) was also isolated as marginally antimicrobial agent along with inactive compounds, dillapiol(3), bergapten(4), imperatorin(5) and psolaren(6) from this plant. The isolates 1-6 were not active against the Escherichia coli.

• Applied Biological Chemistry
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• 제42권3호
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• pp.210-217
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• 1999

전통민속주 제조에 이용되는 부재료 가운데 휘발성 향기성분인 asarone, coumarin, thujone등 식품에 허용기준이 제한된 독성 관련 향기성분을 함유하고 있는 식물성 방향재료 및 약용재료를 확인, 분류하기 위하여 이들의 20% ethanol 추출액으로부터 고상추출(solid phase extraction) 방법을 이용하여 각 성분을 흡착, 용리시킨 후 GC-FID와 GC/MS로 검출, 확인하였다. 조사대상 87종의 식물성재료 중 창포(Acorus asiaticus Nakai), 석창포(Acorus gramineus Solander), 당귀(Angelica gigus Nakai), 백단향(Santalum album) 등 6종에서 asarone이 검출되었으며, coumarin은 소회향(Anethum graveolens), 회향(Foeniculum vulgare Gaertner), 자초(Lithosperum erythrorhizon Siebold et Zuccarinii) 등 22종에서 검출되었다. 한편, 우실(Achyranthes japonica Nakai), 사인(Amomum xanthiodes Wallich), 약쑥(Artemisia asiatia Nakai), 대마자(Cannabis sativa L.)씨, 골담초(Caragana sinica R.), 국화(Chrysanthem morifolium Ramat), 사삼(Codonopsis lanceolata Bentham et flooker), 회향(Foeniculum vulgare Gaertner) 등 24종에서는 thujone을 확인하였다.

• Journal of Ginseng Research
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• 제48권2호
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• pp.236-244
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• 2024

Background: Fusarium oxysporum (F. oxysporum) is the primary pathogenic fungus that causes Panax notoginseng (P. notoginseng) root rot disease. To control the disease, safe and efficient antifungal pesticides must currently be developed. Methods: In this study, we prepared and characterized a nanoemulsion of Foeniculum vulgare essential oil (Ne-FvEO) using ultrasonic technology and evaluated its stability. Traditional Foeniculum vulgare essential oil (T-FvEO) was prepared simultaneously with 1/1000 Tween-80 and 20/1000 dimethyl sulfoxide (DMSO). The effects and inhibitory mechanism of Ne-FvEO and T-FvEO in F. oxysporum were investigated through combined transcriptome and metabolome analyses. Results: Results showed that the minimum inhibitory concentration (MIC) of Ne-FvEO decreased from 3.65 mg/mL to 0.35 mg/mL, and its bioavailability increased by 10-fold. The results of gas chromatography/mass spectrometry (GC/MS) showed that T-FvEO did not contain a high content of estragole compared to Foeniculum vulgare essential oil (FvEO) and Ne-FvEO. Combined metabolome and transcriptome analysis showed that both emulsions inhibited the growth and development of F. oxysporum through the synthesis of the cell wall and cell membrane, energy metabolism, and genetic information of F. oxysporum mycelium. Ne-FvEO also inhibited the expression of 2-oxoglutarate dehydrogenase and isocitrate dehydrogenase and reduced the content of 2-oxoglutarate, which inhibited the germination of spores. Conclusion: Our findings suggest that Ne-FvEO effectively inhibited the growth of F. oxysporum in P. notoginseng in vivo. The findings contribute to our comprehension of the antifungal mechanism of essential oils (EOs) and lay the groundwork for the creation of plant-derived antifungal medicines.

• Advances in Traditional Medicine
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• 제7권2호
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• pp.182-190
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• 2007

Alzheimer's disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer's disease. Nootropic agents like piracetam and cholinesterase inhibitors like $Donepezil^{\circledR}$ are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anti-cholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.

• 한국식품조리과학회지
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• 제20권5호
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• pp.505-510
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• 2004

이물질 침입에 대한 인식의 결과 NO, PGE$_2$, TNF-, IL-6와 같은 여러 신호전달물질의 분비가 개시되며 이들을 억제하는 물질을 항염증제라고 볼 수 있다. 본 연구에서는 회향(Foeniculum vulgare Mill.) 열매 추출물이 mouse macrophages RAW264.7 세포에서 lipopolysaccharide(LPS)로 유도한 NO(iNOS 산물), PGE$_2$(COX-2 산물) 및 cytokines (TNF-$\alpha$, IL-6) 생성 억제에 미치는 영향을 살펴보았다. 회향 열매의 methanol 추출물 및 분획물(chloroform, butanol, and aqueous fractions)은 4～100$\mu$g/mL 농도에서 LPS가 활성화된 대식 세포에서 NO 생성을 억제하였으며 독성을 나타내지 않았다. LPS가 유도한 PGE$_2$ 생성은 butanol 분획(100 $\mu$g/mL)에 의해서만 유의적으로 감소하였다(P<0.05). 회향 열매 추출물 및 분획물은 TNF-$\alpha$의 생성을 유의적으로 감소시켰으며 IL-6의 생성은 methanol extract(4～100 $\mu$g/mL), chloroform fraction(4 $\mu$g/mL), butanol fraction(4 and 100$\mu$g/mL) 및 aqueous fraction(4～100 $\mu$g/mL)에 의해 감소되었다(P<0.05). 이는 회향 열매 추출물은 염증 상태에서 유용할 것이며 COX-2와 iNOS를 억제하는 butanol 분획은 새로운 항염증제 개발에 사용될 수 있음을 시사하여 주었다.

• 한국약용작물학회지
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• 제11권4호
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• pp.274-278
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• 2003

The various plant organs of fennel (Foeniculum vulgare Mill.) were investigated to identify their volatile components using Dynamic Headspace (purge & trap). They showed slight differences concerning the volatile components both qualitatively and quantitatively. Results revealed that trans-anethole (12.65%) was the major compound in the leaf. The highest compound was ${\alpha}-pinene$ (28.78%), and trans-anethole (7.90%) was highly detected in the stem. The maximum values were 5.64, 4.59, 1.58, 1.51, and 1.04% for ${\alpha}-pinene,\;{\gamma}-terpinene,\;{\beta}-pinene$, 1,8-cineol and fenchone, respectively in the flower. However, very little trans-anethole was detected (0.27%) in the flower. From these results, it was suggested that the major components were different depending on the plant organs. However it was demonstrated that the related plant organs like flower-fruit and leaf-stem contained the similar components.

• Archives of Pharmacal Research
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• 제8권1호
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• pp.42-44
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• 1985

Polysaccharides were isolated with alkaline extraction method from twelve pharmaceutical plants, which have been used against the various tumors in the oriental herb medicine, and examined for their antitumor activities. When the polysaccharides were administered i. p. at the dose of 10mg/kg/day for ten consecutive days to the male ICR mice, which had been implanted with $1{\times}10^{6}$ cells of sarcoma 180 twentyfour hours before the first injection of polysaccharides, those from Forsythia Corea, Curcuma, Zedoaria, Albizzia Julibrissin, Prunuts Persica, Foeniculum Vlugare and Daphne Pseudogenkwa showed inhibition ratios of 88.0%, 61.1%m 73.0%, 72.8% 55.1% and 71.7%. The significant prolongation of life span was observed only in the case of Forsythia Corea (18.1%). Other six polysaccharide fractions from Olibanum, Lonicera Japonica, Rheum Coreanum, Scirpus Maritimus, Gleditchia Officinalis and Brassica Juncea showed negligible inhibition ratios.