• 한국동물위생학회지
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• 제29권4호
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• pp.469-482
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• 2006

The term 'heat shock protein (Hsps)' was derived from the fact that these proteins were initially discovered to be induced by hyperthermic conditions. In response to a range of stressful stimuli, including hyperthermia, immobilization, UV radiation, amino acid analogues, arsenite, various chemicals, and drugs the mammalian brain demonstrates a rapid and intense induction of the heat shock protein. Moreover, Hsps were expressed on the various pathological conditions including trauma, focal or global ischemia, hypoxia, infarction, infections, starvation, and anoxia. Especially, Hsp25 has a protective activity, facilitated by the ability of the protein to decrease the intracellular levels of reactive oxygen species (ROS) as well as its chaperone activity, which favors the degradation of oxidized proteins. Recently, it has clearly demonstrated that Hsp25 is constitutively expressed in the adult mouse cerebellum by parasagittal bands of purkinje cells in three distinct regions, the central zone (lobule VI-VII) and nodular zone (lobule IX-X), and paraflocculus. The Mongolian gerbil has been introduced into stroke study model because of its unique brain vasculature. There are no significant connections between the basilarvertebral system and the carotid system. This anatomy feature renders the mongolian gerbil susceptible to forebrain ischemia-induced seizure. The present study is designed to examine the pattern of Hsp25 expression in the cerebellum of this animal in comparison with that in mouse.

• Earthquakes and Structures
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• 제17권6호
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• pp.591-598
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• 2019

The most recent shaking experiences have demonstrated that the predictions of the seismic models are not always in agreement with the registered responses, especially in the face of extreme earthquakes. Records collected from 1960 to 2011 at a rock-like site are used to develop a neural network that permits to estimate peak ground accelerations via the magnitude, the focal depth, the site-source distance and a seismogenic zone. The neural model is applied to the 8th and 19th September 2017 events that hit Mexican territory and the obtained results show that the network is flexible enough to work appropriately to various conditions of intensity and sites-sources with remarkably predictive capacity. The neural-attenuation curves are compared with those obtained from Ground Motion Prediction Equations and their performance is assessed for events, in addition to the devastating Mexican events, from Japan, Taiwan, Chile and USA.

• 한국광학회지
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• 제4권4호
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• pp.390-396
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• 1993

1차원 telecentric paraxial holographic kinoform을 푸리에변환 렌즈로 사용하는 경우에 있어서, 3가지 표면양각형태, 즉 평면-볼록면, 블록면-평면, 좌우대칭 불록면에 대하여 스넬의 법칙을 기반으로 하는 엄밀한 광성추적법을 적용하여 분석하였다. kinoform은 F/8, 초점거리 15mm이며 kinoform과 그 주변 매질의 굴절율을 변화시키므로써 zone수와 두께 그리고 포물면의 경사도를 변화시켰다. 일반적으로 좌우대칭 볼록면 형태가 가장 좋은 성능을 갖는 것으로 나타났고, 모든 경우에 있어서 포물면의 경사도가 증가함에 따라 입사각의 증가에 따른 성능이 저하되었다.

• 한국임상수의학회지
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• 제36권3호
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• pp.172-175
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• 2019

A young slaty-backed gull was found dead nearby Seongsan harbor, Seogwipo-si, Jeju. Grossly, focal ulceration and a protuberant nodule were observed in intermediated zone between proventriculus and gizzard. Numerous discrete or confluent white-yellowish nodules were scattered on the surface of liver. Caudal portion of left kidney was replaced by a white-yellowish nodule. Three raised masses were observed in the spleen. Histologically, there were severe ulceration with hemorrhage in the gizzard and multifocal granulomatous inflammations in liver, kidney, spleen, and lungs. Pink to dark-red, round to oval fungal spores and pseudohyphae in granulomatous lesions were confirmed by periodic acid-Schiff stain. Candida albicans were isolated from the lesions of liver, kidney, spleen and gizzard using fungal culture and confirmed by VITEK 2 system. Based on the gross, histopathological findings, and fungal examination, this case was diagnosed as systemic candidiasis of a wild slaty-backed gull. In our best knowledge, this is the first report for systemic candidiasis characterized by multifocal granulomatous lesions in internal organs of a wild gull in Korea.

• 한국통신학회논문지
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• 제29권4C호
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• pp.524-532
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• 2004

본 논문에서는 변형된 삼각 및 마하젠더 간섭계를 이용한 인코히어런트 홀로그래픽 3D 디스플레이 시스템의 광 입출력 장치를 구현하고 실험하였다. 먼저, 변형된 삼각 간섭계 기반의 광 입력장치를 구성하여 3차원 물체에 대한 인코히어런트 복소 홀로그램을 생성하고, LCD 공간광변조기와 위상 지연기가 추가된 마하젠더 간섭계 기반의 광 출력장치 구성을 통해 홀로그램의 실시간적 복원을 수행하였다. 즉, 100mm의 깊이감을 갖는 두 점광원에 대한 인코히어런트 홀로그램의 생성과 복원 실험을 통해 바이어스와 공액영상이 제거되고 초점에 따라 깊이감이 다른 두 영상의 복원이 가능함을 확인하였으며, 구현된 광 입출력 장치를 통해 서로 30 mm의 깊이감을 갖는 3차원 물체인 두개의 주사위에 대한 홀로그램을 실시간적으로 생성하고 복원시킴으로서 변형된 삼각 간섭계에 기반한 홀로그래픽 3차원 영상디스플레이 시스템의 광학적 구현 가능성을 제시하였다.

• 센서학회지
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• 제18권5호
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• pp.377-384
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• 2009

The ultrasonic hyperthermia for oncology has been developed and studied. The HIFU(high intensity focused ultrasound) is the most recent method to treat the tumor by using ultrasound. In this study, an insertion-type transducer for treating a prostate cancer, which can focus the ultrasonic beam mechanically and electrically, was designed and developed. The developed transducer was composed of three arrays, and each array has 32 elements. For the purpose of the mechanical focusing, both side arrays are slanted to the center array by $15^{\circ}$. With this structure, NFL(near field length) was set up as 30 mm. The PZT-4 and two matching layers were used, and the backing layer was excepted to prevent energy losses. The acoustic field analysis and the heating test were performed to evaluate the performance of developed transducer. The shape of an acoustic field, peak pressure, and acoustic pressure distribution were compared with numerical simulation. The NFL was 32 mm, the beam width was 5 mm, focal area was $40\;mm^2$, and peak pressure was 5.5 MPa. With heating by using developed transducer, the temperature increased up to $33^{\circ}C$ at focal zone. As a result of this study, the usefulness of suggested transducer for prostate cancer hyperthermia was confirmed by the acoustic field analysis and the heating test with TMM(tissue mimicking) phantom.

• 정보처리학회논문지B
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• 제14B권6호
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• pp.407-412
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• 2007

초음파 의료 영상기기나 산업용 초음파 검사 시스템의 성능은 초음파 탐촉자의 성능에 의해 크게 좌우된다. 탐촉자의 성능 특성 정보는 보통 제작자가 제공하는 반사원의 초음파 R/F 신호와 주파수 특성에 의해 기술된다. 그러나 집속형 초음파 탐촉자의 경우, 두 자료로는 선명한 C-Scan 이미지를 얻을 수 있다는 것을 보증할 수는 없다. 그래서 집속형 초음파 탐촉자의 성능 평가를 위한 새로운 척도로 상대 초점크기 및 상대 유효초점영역의 모양을 제안한다. 상대 초점의 크기와 상대 유효초점영역의 모양은 쇠구슬로부터 획득된 초음파 R/F 신호를 가상 3차원 영상 복원 프로그램으로 처리하여 얻는다. 제시된 방법은 기존 자료로는 알 수 없었던 탐촉자 성능을 정확히 평가할 수 있었으며, 방법도 간단하여 실제 탐촉자 제작시 불/양품을 쉽게 가려 낼 수 있으며, 탐촉자 경년열화에 따른 성능 저하도 검출할 수 있는 장점을 갖는다. 결과적으로 초음파 영상기기나 산업용 초음파 검사 시스템의 성능을 담보할 수 있다.

• 대한치과교정학회지
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• 제20권2호
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• pp.363-379
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• 1990

The purpose of this study was to evaluate the effects of the mandibular retractive force on the mandibular condyle of growing dog. The experimental animals were six mongrel dogs of two-month old. Their deciduous dentition were completed. Two of them was used as control group, and experimental group was composed of remaining four. Head band and chin cup were made of cotton tape, and hooks are fabricated on the chin cup and had band for closed coil. Mandibular retractive force was 100g/side and chin cap appliance was used for 14 hours/day during night. Experimental group were sacrificed at 2, 4, 6, 8 weeks from beginning of the experiment. Right TMJ was prepared for histologic study and left TMJ was examined grossly for disc, fossa, and condyle. The conclusions are: 1. Two-month old control animal showed active cartilaginous growth on the mandibular condyle, therefore showed thick proliferative and hypertrophic zones. Remodeling process in the condyle head was observed in which there were bone resorption on the anterior surface and bone apposition on the posterior surface. 2. Four-month old control animal showed marked reduction of hypertrophic zone but the condylar bone remodeling was more pronounced. 3. In experimental group, there are marked reduction of hypertrophic zone at 4 weeks from beginning of experiment, and hypertrophic zone disappeared at posterior-superior portion of condyle in 6-week experimental animal. 8 week experimental animal showed slight recovery of hypertrophic zone. 4. In experimental group, bone deposition was increased at anterior surface of condyle, and bone resorption was increased at posterior surface of condyle. 5. In control group, the glenoid fossa and surrounding bone showed mainly bone apposition. But experimental group showed bone resorption at anterior surface of articular eminence and increased bone apposition at posterior surface of postglenoid spine. 6. No marked traumatic change was seen but 4 weeks and 8 weeks experimental animal showed flattening of posterior surperior condylar surface. Bone marrow of condyle showed minute focal bleeding in 2 weeks and 4 weeks experimental animal, and congestion and depression of hematopoietic bone marrow during all experimental period.

• 대한방사선기술학회지:방사선기술과학
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• 제40권2호
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• pp.205-211
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• 2017

비알콜성 지방간에서 지방 간염으로 진행되는 확률이 높은 중등증 이상에서 적극적인 진단과 치료가 필요하다. 이에 본 연구에서는 비알콜성 지방간을 경도, 중등증, 중증으로 나누어 GLCM 알고리즘의 컴퓨터 분석기법을 이용하여 정량적인 방법으로 분류하였다. 또한 지방간 중에서 국소지방회피영역의 초음파영상의 특징을 알아보고자 하였다. 정상, 경도, 중등도, 중증지방간, 국소적 저지방영역, 각각 80증례를 대상으로 GLCM 알고리즘의 파라미터 중에 간초음파영상의 인식률이 높은 자기상관성, 편차의 제곱, 평균의 합, 분산의 합에 대한 값을 산출하였다. GLCM알고리즘의 파라미터 인식률의 결과는 평균 97.5%로 나타났다. 국소적 저지방 영상분석의 결과는 정상실질과 가장 유사한 값을 나타내었다. 초음파검사는 일차적인 선별검사법으로 쉽게 접근할 수 있지만 숙련도에 따라 검사방법의 정확도나 결과의 일치성 부분에서 차이가 있을 수 있다. GLCM알고리즘을 적용하여 지방간 정도를 정량적으로 분류할 수 있었으며, 국소적 저지방영역은 지방침착이 되지 않은 균질한 간실질임을 예측 가능하였다. 이러한 GLCM 컴퓨터영상분석이 지방간뿐만 아니라 다른 병변의 감별에도 중요한 정보를 제공할 것으로 판단한다.

• Journal of Welding and Joining
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• 제25권3호
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• pp.18-27
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• 2007

Laser welding process is widely used in the industrial field due to its numerous advantages: a small heat affected zone(HAZ), deep penetration, high welding speed, ease of automation, single-pass thick section capability, enhanced design flexibility, and small distortion after welding. The objective of this research works is to investigate the influence of the process parameters, such as the welding fur metals with CW Nd:YAG lasers. The bead-on-plate and Lap welding experiments are carried out for several combinations of the experimental conditions. In order to quantitatively examine the characteristics of the welding quality of the cross section, tensile stress behavior and the hardness of the welded part are investigated in comparison of the Nickel coated and Nickel uncoated S45C steel. As a result of experiment, nickel coated S45C Steel showed more even weld zone than Nickel uncoated counterpart upon lap welding. Also, it showed relatively small amount of internal defects and spatter, and Nickel coated S45C showed better weldability than Nickel uncoated S45C steel. The optimum welding process upon lap welding of Nickel coated S45C steel is when each laser power is 1900W; focal positions is -1mm; welding speed is $0.9{\sim}1.0m/min$. The heat input was $4.178{\sim}4.36{\times}103J/cm^2$.