• Journal of Haehwa Medicine
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• v.8 no.1
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• pp.793-825
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• 1999

For the development of drugs for alzheimer,s disease, the study was done to review the oriental pathology, clinical data, recent trends for research and strategy for future study. The results were as follows: 1. The medical term Chi-dsi implying alzheimer,s disease was referred for the first time in a medical book, Hwatasheneubijeon written by Hwa-Ta and its differentiation and treatment were studied more in Ming or Ching dynasties. Chi-dai can be differentated as weak(虛) syndrome and Shi(實) syndrome. This can be caused by deficiencies of renal Yin, renal Yang, cardiac Yin and hepatic blood, while that by deficiencies of pathological fluid(痰飮) and clotted blood(瘀血). 2. Dementia can be roughly classified as alzheimer's disease and multi-infarct disease. Its causes were known to be cholinergic transmitter, C-peptide, amyloid-${\beta}$, apolipoprotein, APP(amyloid precursor protein), TGF, MMP-9 and free radical. 3. In Korea experimental studies were chiefly done for the elimataion of C-peptide, amyloid-${\beta}$, apolipoprotein, APP for alzheimer's disease, for the development of drug inhibiting degerative change following CVA and loss of memory and also administrative measure was done by support of government. 4. Drugs of dimentia developed so far were Chi-Dai dan, extracts from aloe, mushroom, green tea, Ganoderma and also folic acid, vitamin C, DHEA and silk amino acid were reported to be effective in dimenta. 5. Future strategic research had better be done on dementia-inducing factors such as acetylcholine, C-peptide, amyloid-${\beta}$, apolipoprotein, APP, TGF, MMP-9 and free radical, development of animal model for dimentia, clinical study, epidemiology, nursing and administrative studies and also consortium for dimentia research should be formed so that repeated investment be avoided.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1951-1956
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• 2004

The transient nature and complex flow geometries of two-phase gas-liquid flows cause fundamental difficulties when measuring flow velocity using an electromagnetic flowmeter. Recently, a current-sensing flowmeter was introduced to obtain measurements with high temporal resolution (Ahn et $al.^{(1)}$). In this study, current-sensing flowmeter theory was applied to measure the fast velocity transients in slug flows. To do this, the velocity fields of axisymmetric gas-liquid slug flow in a vertical pipe were obtained using Volume-of-Fluid (VOF) method and the virtual potential distributions for the electrodes of finite size were also computed using the finite volume method for the simulated slug flow. The output signal prediction for slug flow was carried out from the velocity and virtual potential (or weight function) fields. The flowmeter was numerically calibrated to obtain the cross-sectional liquid mean velocity at an electrode plane from the predicted output signal. Two calibration parameters are required for this procedure: a flow pattern coefficient and a localization parameter. The flow pattern coefficient was defined by the ratio of the liquid resistance between the electrodes for two-phase flow with respect to that for single-phase flow, and the localization parameter was introduced to avoid errors in the flowmeter readings caused by liquid acceleration or deceleration around the electrodes. These parameters were also calculated from the computed velocity and virtual potential fields. The results can be used to obtain the liquid mean velocity from the slug flow signal measured by a current-sensing flowmeter.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.8
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• pp.861-868
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• 2011

Flowmeters that measure the amount of fluid passing through conduits must kept accurate by comparison and the periodic calibration. The reference meters used are clamp-on meters that mount sensors on the outer wall of the pipe. They are called 1-path, 2-path or 4-path flowmeters depending on the number of sensors. We selected a flowmeter mainly used for K-water as test a flowmeter. We carried out experiments to find the intrinsic error of the flowmeter and errors in the downstream of a double bent pipe. The results show that there are the sensor locations that meet the tolerance. We suggested the angle of the sensor, the straight run from the downstream of the bent pipe and the number of sensors. So it is possible to improve the water treatment process and increase the accounted water rate by upgraded flow measurement technology.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.6
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• pp.446-454
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• 2008

The purpose of this paper is to analyze two-phase flows of the hydrogen recirculation system. Two-phase flow modeling is one of the great challenges in the classical sciences. As with most problems in engineering, the interest in two-phase flow is due to its extreme importance in various industrial applications. In hydrogen recirculation systems of fuel cell, the changes in pressure and temperature affect the phase change of mixture. Therefore, two-phase flow analysis of the hydrogen recirculation system is very important. Two-phase computation fluid dynamics (CFD) calculations, using a commercial CFD package FLUENT 6.2, were employed to calculate the gas-liquid flow. A two-phase flow calculation was conducted to solve continuity, momentum, energy equation for each phase. Then, the mass transfer between water vapor and liquid water was calculated. Through an experiment to measure production of liquid water with change of pressure, the analysis model was verified. The predictions of rate of condensed liquid water with change of pressure were within an average error of about 5%. A comparison of experimental and computed data was found to be in good agreement. The variations of performance, properties, mass fraction and two-phase flow characteristic of mixture with resepct to the fuel cell power were investigated.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.2
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• pp.146-158
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• 1991

The flow around a two-dimensional foil section Is measured by a LDV(Laser Doppler Velocimetry) system which is capable of measuring the datailed flow field without interfering the original flow field. A 2-color 3-beam LDV system, which is capable of mea,;tiring 2 velocity components simultaneously and uses 2W Ar-Ion laser source, is used to measure the flow field around an NACA0012 foil section. The measured flow velocities are analysed iii order to study the boundary layer characteristics, flow separation and the detail structure of the flow near the trailing edge of the foil. The boundary layer characteristics are compared with the results by the head's momentum integral method. For the case of small angle of attack at relatively higher Reynolds number, both results show good agreements. The measured data of the velocity field around an NACA0012 foil section would be valuable data to validate the CFD(Computational Fluid Dynamic) calculation results. The developed experimental technique to evaluate the characteristics of two-dimensional foil sections is essential tool to develope new blade sections which have good lift characteristics and better cavitation performances.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.7
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• pp.528-534
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• 2011

In this paper, thermal characteristics of cylindrical grooved wick heat pipes with water-based MWCNT nanofluids as working medium are experimentally investigated. Volume fractions of nanoparticles are varied with 0.1% to 0.5%. Transient hot wire method developed in house is used to measure the thermal conductivity of nanofluids. It is enhanced by up to 29% compared to that of DI water. The thermal resistances and temperature distributions at the surface of the heat pipes are measured at the same evaporation temperature. The experimental results show that the thermal resistance of the heat pipes with water-based MWCNT nanofluids as working fluid is reduced up to 35.2% compared with that of heat pipe using DI water. The reduction rate of thermal resistance is greater than the enhancement rate of thermal conductivity. Finally, based on the experimental results, we present the reduction of the thermal resistances of the heat pipes compared with conventional heat pipes cannot be explained by only the thermal conductivity of water-based MWCNT nanofluids.

• Journal of Drive and Control
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• v.12 no.3
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• pp.52-59
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• 2015

An electro hydraulic poppet valve (EHPV) and a variable orifice poppet are assembled in a single block, which is referred to as a RHINO but is also generally called a pilot-operated flow control valve. In this study, we analyzed the structure and the operating principle for a RHINO applied in a 21-ton electric excavator system. The RHINO was experimentally tested to measure the dynamic responses and the pressure energy loss. In this test, we investigated the variation in the conductance coefficient according to the increase in the supply pressure under a constant current and a variation in the flow rate according to the increase in the current. Then, the geometrical shapes and the spring stiffness of the RHINO were considered to develop an analysis model. The characteristics (current-force and hysteresis) for the solenoid based on the experimental data were reflected in the analysis model that was developed, and the reliability of the analysis model was also verified by comparing the experimental and analytical results. The developed model is thus considered to be reliable for use in a wide range of applications, including optimum design, sensitivity analysis, parameter tuning, etc.

• Journal of Drive and Control
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• v.14 no.4
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• pp.1-8
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• 2017

The Down-the-Hole hammer is one of the pneumatic drill equipment used for grinding, drilling, and mining. One the advantages of which is that a reduction work efficiency at deep site are relatively small compared to other drilling methods. Due to the large vibration in the underground area, it is difficult to measure the performance of the hammer, and hammer testing requires substantial production cost and operating expenses so research on the development of the hammer is insufficient. Therefore, this study has developed a dynamic simulation model that apprehends the operating principles of an 8-inch DTH hammer and calculates performance data such as performance impact force, piston speed, and BPM. By using the simulation model, design factors related to strike force and BPM were selected, and the influence of each design factors on performance was analyzed through ANOVA analysis. As a result, be the most important for BPM and the strike force are position of upper port that push the piston in the direction of the bit and in BPM, the size of the empty space between the bits and the piston is the second most important design factor.

• Nuclear Engineering and Technology
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• v.42 no.4
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• pp.339-364
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• 2010

Following a joint OECD/NEA-IAEA-sponsored meeting to define the current role and future perspectives of the application of Computational Fluid Dynamics (CFD) to nuclear reactor safety problems, three Writing Groups were created, under the auspices of the NEA working group WGAMA, to produce state-of-the-art reports on different aspects of the subject. The work of the second group, WG2, was to document the existing assessment databases for CFD simulation in the context of Nuclear Reactor Safety (NRS) analysis, to gain a measure of the degree of quality and trust in CFD as a numerical analysis tool, and to take initiatives to extend the existing databases. The group worked over the period of 2003-2007 and produced a final state-of-the-art report. The present paper summarises the material gathered during the study, illustrating the points with a few highlights. A total of 22 safety issues were identified for which the application of CFD was considered to potentially bring real benefits in terms of better understanding and increased safety. A list of the existing databases was drawn up and synthesised, both from the nuclear area and from other parallel, non-nuclear, industrial activities. The gaps in the technology base were also identified and discussed. In order to initiate new ways of bringing experimentalists and numerical analysts together, an international workshop -- CFD4NRS (the first in a series) -- was organised, a new blind benchmark activity was set up based on turbulent mixing in T-junctions, and a Wiki-type web portal was created to offer online access to the material put together by the group giving the reader the opportunity to update and extend the contents to keep the information source topical and dynamic.

• Journal of Energy Engineering
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• v.27 no.4
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• pp.70-79
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• 2018

A heat pump system using the thermal effluent from the Jeju thermal power plant of KOMIPO was constructed with the capacity of 300 RT to supply cool or hot water to greenhouse facilities located 3 km from the power station. The way of transporting heat from the thermal effluent to greenhouses at a long distance was optimized, and a monitoring system to measure the water temperature and detect a leakage in a pipe conduit was also installed. This paper presents the system configuration of the constructed heat pump system for air conditioning and heating of greenhouse facilities in Jeju, and the characteristics of major components deployed in the system. The preoperational tests of the heat pump system were conducted during the summer season in 2018 for evaluation of its cooling performance. The operational stability and cooling performance of the heat pump system were confirmed by investigating the measured fluid temperature and flow rate, and COP of the heat pump in a cooling mode.