• Macromolecular Research
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• v.15 no.6
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• pp.513-519
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• 2007

Self-assembled nanoparticles have great potential to act as vehicles for hydrophobic drug delivery. Understanding nanoparticle cellular internalization is essential for designing drugs intended for intracellular delivery. Here, the endocytosis and exocytosis of fluorescein isothiocyanate (FITC)-conjugated glycol chitosan (FGC) self-assembled nanoparticles were investigated by flow cytometry and confocal microscopy. The cellular internalization of FGC nanoparticles was initiated by nonspecific interactions between nanoparticles and cell membranes. Although adsorptive endocytosis of the nanoparticles occurred quickly, significant amounts of FGC nanoparticles were exocytosed, particularly in the early stage of endocytosis. The amount of exocytosed nanoparticles was dependent on the pre-incubation time with nanoparticles, suggesting that exocytosis is dependent on the progress of endocytosis. FGC nanoparticles internalized by adsorptive endocytosis were distributed in the cytoplasm, but not in the nucleus. In vitro cell cycle analysis demonstrated that FGC nanoparticles delivered paclitaxel into the cytoplasm and were effective in arresting cancer cell growth.

• Journal of Environmental Impact Assessment
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• v.22 no.6
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• pp.695-703
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• 2013

Soil erosion and sediment delivery ratio(SDR) were estimated by using HSPF model in 3 tributaries of upper stream of Geum river-basin. Meteorological data and other input data were constructed from 2006 to 2011 year by the HSPF model. Flow and suspended solid results were relatively matched with the measurement data through the calibration and validation of the model. Soil erosion was proportional to the amount of rainfall and the area of watershed based on the results of model calibration and validation. SDR in Moojunamdea stream was the highest and one in Cho stream was the lowest. This was effected by the geographical characteristic. SDR was 17.6% Moojunamdea stream, 9.1% Cho stream and 13.2 % Bocheong stream. As the SDR was effected by watershed area and shape factor in this study area.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.493-497
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• 2011

Project delivery systems have evolved over the years. Continuous changes in technology and the increasing sophistication in buildings required specialization of design and construction services. IPD as a delivery method has been used in the USA and other countries. With the development of BIM, lots of construction companies have been realizing this method since BIM came out in China. However IPD are not considered with BIM, IPD will be an important role in management system of construction. This study introduced the definition of IPD and based on the flow process of IPD, compared the process in china and other countries. Through the real project and the condition in China this paper analyzed the feasibility of IPD in China.

• Journal of Dental Anesthesia and Pain Medicine
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• v.18 no.6
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• pp.367-373
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• 2018

Background: Fear of local anesthesia (LA) is a significant impediment to dental care as many patients delay or avoid treatment to avert pain. Computer-controlled local anesthetic delivery system (CCLAD), with constant and controlled rate of flow, present a painless alternative. The present study aimed to compare anxiety and pain perceived with conventional and computerized systems, for different stages of anesthesia delivery when administering various nerve blocks. Methods: One hundred patients requiring bilateral LA participated in the study. One side was anesthetized using one system and the contralateral side was anesthetized using the other, in two separate appointments. Patients assigned anxiety scores on a 5-point scale and used the visual analogue scale (VAS) for pain determination at needle insertion, during delivery of anesthetic solution, immediately after injection, and at the end of the periodontal procedure. Each patient's preference for the delivery system of future injections was also recorded. Results: Patients reported significantly lower anxiety levels with CCLAD compared to the syringe. Significantly lower mean VAS scores for anesthesia deposition, pain immediately after, and at the end of the periodontal procedure were also noted. However, pain at needle insertion was comparable between the two systems, with no statistical significance. Overall, 64.4% patients preferred CCLAD for future anesthesia. Conclusion: Lower pain perceived with CCLAD and higher preference for the system suggest that CCLAD should replace conventional syringes to allow pain-free dental treatment.

• The KSFM Journal of Fluid Machinery
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• v.8 no.2 s.29
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• pp.9-15
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• 2005

This paper presents an experimental and numerical study on the overall performance and local flow characteristics of sirocco fan in a range hood. Measurement of overall performance for sirocco fans were conducted based on AMCA standard 210. The effects of flow blockages due to the motor inside the fan on the fan performance were investigated by experimentally and numerically and the results were compared with each other. The numerical and experimental results show the inlet flow blockage reduces the performance (ie. fan static pressure, design flow rate, maximum efficiency and free delivery flow rate) of fan. It is found that the blockage makes the flow field highly non-uniform through the blade and cause the efficiency decrement.

• Journal of Korean Society on Water Environment
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• v.28 no.6
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• pp.833-842
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• 2012

In this study Window interface to Hydrological Simulation Program-FORTRAN (HSPF) developed by the United States Environmental Protection Agency (EPA) was applied to the upstream of Namgang watershed to estimate its applicability for estimating Delivery Ratio (DR) of water pollutants for Total Maximum Daily Load (TMDL). BASINS/HSPF which is selected in this study, is found to be appropriate for simulation of daily flow and water quality in target basins. DR was estimated utilizing discharge loads of unobserved sub-basin and delivery load of unobserved locations obtained not by actual evaluation but by simulation through validation and verification. Annual average DR of BOD, TN and TP were 0.97 ~ 1.50, 2.23 ~ 3.21, and 0.81 ~ 1.09 respectively. Net DR of dependent basins excluding influence of upstream basin was 1.50 ~ 1.70, 0.55 ~ 0.69, and 0.24 ~ 0.31, all of which are lower than those of independent basins area. Utilizing the model selected by this research, DR and Net DR of unobserved basins will be estimated, which will help determine priorities in management of basin areas.

• Journal of KIISE:Information Networking
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• v.30 no.5
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• pp.649-655
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• 2003

Network-based computing such as cluster computing requires a reliable high-speed transport protocol. TCP is a representative reliable transport protocol on the Internet, which implements many mechanisms, such as flow control, congestion control, and retransmission, for reliable packet delivery. This paper, however, finds out that Myrinet does not incur any packet losses caused by network congestion. In addition, we ascertain that Myrinet supports reliable and ordered packet delivery. Consequently, most of reliable routines implemented in TCP produce unnecessarily additional overheads on Myrinet. In this paper, we show that we can attain the reliability only by flow control on Myrinet and propose a new reliable protocol based on UDP named RUM (Reliable UDP on Myrinet) that performs a flow control. As a result, RUM achieves a higher throughput by 45% than TCP and shows a similar one-way latency to UDP.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 1998.10a
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• pp.87-91
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• 1998

Unused irrigation water due to delivery losses and overflow from paddies in an irrigation system, and groundwater releases from infiltration are eventually returned to stream. The estimate of irrigation returnflow is important to streamflow modeling and water resources planning. This study was to field monitor the irrigation water use, streamflow, lateral inflow and ground water level, and to determine the return flow of irrigation water

• Journal of Environmental Science International
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• v.16 no.2
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• pp.203-210
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• 2007

The delivery load data obtained from Nakdong river basin are used for developing the model estimating the daily delivery load on the main side streams of Nakdong River. The developed model assesses the daily contamination loads of the main thirteen side streams that contribute to the main stream of Nakdong river. It is developed that the model using the simplified equation that can estimate the daily delivery loads on the side main streams of Nakdong river for a period of having no data of the water quality and flow. The developed model for estimating the daily delivery loads from the main side streams in Nakdong river basin on each item such as BOD, TN, and TP is expressed as Daily delivery load ($\frac{kg}{day}$) = Production load $(\frac{kg}{day}){\times}(1-{\alpha}){\times}(\frac{daily\;runoff}{average\;runoff\;per\;year}){\gamma}$. The estimated values obtained by using the model are almost fit to the calculated values (real data) that have been acquired from the thirteen main side streams in Nakdong river basin. The correlation coefficient values, R, that indicate the correlation between the estimated and the calculated show over 0.7 that mean the estimated values from the used model are adapted to the real data except TN values of Nam-river, Hwang-river, Gam-river, We-river. Especially, the correlation of TP values between the estimated and the calculated implies quite a creditable data to use.

• Journal of KIISE:Information Networking
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• v.30 no.2
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• pp.143-154
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• 2003

There is a growing trend in developing system for distributed mobile system that supports services - job flow management, video conference, replicated data management and resource allocation. Supporting these services, applications have to use causally ordered message delivery. Previous proposals that provide causally ordered message delivery have problems such as communication overhead, message delaying, scalability, computing overload of mobile host. In this paper, we proposed efficient protocol for causally ordered message delivery using the methods that MSS maintains dependency information matrix between MSS and MH, Piggybacking dependency information about each immediate predecessor message. Proposed algorithm, when compared with previous proposals, provides a low message overhead, and low probability of unnecessary inhibition in delivering messages. Also, it consider resource restriction of MH and low bandwidth of wireless communication by computing most of algorithm at MSS, and reduce processing delay by executing causally ordered message delivery a unit of MH.