• Mass Spectrometry Letters
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• v.13 no.4
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• pp.158-165
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• 2022

Many therapeutic class drugs such as beta-blocker, corticosteroids, NSAIDs, etc are prohibited substances in the horse racing industry. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology makes it possible to isolate drugs from interference, enables various drug analyses in complex biological samples due to its sensitive sensitivity, and has been successfully applied to doping control. In this paper, we describe a rapid and sensitive method based on solid-phase extraction (SPE) using solid phase cartridge and LC-MS/MS to screen for different class's 35 drug targets in equine plasma. Plasma samples were pretreated by SPE with the NEXUS cartridge consisted non-polar carbon resin and minimum buffer solvent. Chromatographic separation of the analytes was performed on ACQUITY HSS C18 column (2.1 × 150 mm, 1.8 ㎛). The elution gradient was conducted with 5 mM ammonium formate (pH 3.0) in distilled water and 0.1% formic acid in acetonitrile at a flow rate of 0.25 mL/min. The selected reaction monitoring (SRM) mode was used for drug screening with multiple transitions in the positive ionization mode. The specificity, limit of detection, recovery, and stability was evaluated for validation. The method was found to be sensitive and reproducible for drug screening. The method was applied to plasma sample analysis for the proficiency test from the Association of Racing Chemist.

• Current Optics and Photonics
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• v.6 no.2
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• pp.137-142
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• 2022

Leak detection is one of the most important challenges in condition monitoring of water pipelines. Fiber Bragg grating (FBG) sensors offer an attractive technique to detect leak signals. In this paper, leak measurements were conducted on a water distribution pilot plant with a length of 270 m and a diameter of 100 mm. FBG sensors were installed on the pipeline surface and used to detect leak vibration signals. The leak was demonstrated with 1-, 2-, 3-, and 4-mm diameter leak holes in four different pipe types. The frequency response of leak signals was analyzed by fast Fourier transform analysis in real time. In the experiment, the frequency range of leak signals was approximately 340-440 Hz. The frequency shifts of leak signals according to the pipe type and the size of the leak hole were demonstrated at a pressure of 1.8 bar and a flow rate of 25.51 m³/h. Results show that frequency shifts detected by FBG sensors can be used to detect leaks in pipelines.

• Analytical Science and Technology
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• v.36 no.4
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• pp.152-160
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• 2023

Adenosine and cordycepin are bioactive compounds with health benefits. Therefore, both substances are often used to assess the quality of Cordyceps products. Optimization and validation of the HPLC/DAD method for determining two nucleosides were studied. The samples were prepared using an ultrasound-assisted extraction (ultrasonic bath). The result was optimal conditions for aqueous extraction, an extraction time of 35 min, and an extraction temperature of 40 ℃. The Chromatographic separation was achieved using a reverse phase column (InfinityLab Poroshell 120 EC-C18, 4.6 × 250 mm, 2.7 ㎛) at 30 ℃ with a mobile phase gradient elution of water and methanol at a flow rate of 0.7 mL/min. The eluents were monitored via a diode array detector at 260 nm. Two nucleosides were separated by less than 12 min after injection. The developed method was found to be excellent linear (r² > 0.9999), accurate (% recovery 95.34-98.51), and precise (% relative standard deviation < 2.0). The limit of detection (LOD) and quantification (LOQ) were 0.45 and 1.38 mg/mL for adenosine and 0.47 and 1.43 mg/mL for cordycepin, respectively. This method was satisfactory for simultaneously quantitating two nucleoside contents, which were used to evaluate Cordyceps products.

• New & Renewable Energy
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• v.18 no.1
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• pp.1-16
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• 2022

Climatic characteristics were described using the LiDAR (Light Detection and Ranging) and the met-mast on Dongbok·Bukchon region. The influences of meteorological conditions on the power performance of wind turbines were presented using the data of Supervisory Control And Data Acquisition (SCADA) and met-mast of the Dongbok·Bukchon Wind Farm (DBWF) located in Jeju Island. The stability was categorized into three parameters (Richardson number, Turbulence intensity, and Wind shear exponent). DBWF was dominant in unstable atmospheric conditions. At wind speeds of 14 m/s or more, the proportion of slightly unstable conditions accounted for more than 50%. A clear difference in the power output of the wind turbine was exhibited in the category of atmospheric stability and turbulence intensity (TI). Particularly, a more sensitive difference in power performance was showed in the rated wind speeds of the wind turbine and wind regime with high TI. When the flow had a high turbulence at low wind speeds and a low turbulence at rated wind speeds, a higher wind energy potential was produced than that in other conditions. Finally, the high-efficiency of the wind farm was confirmed in the slightly unstable atmospheric stability. However, when the unstable state become stronger, the wind farm efficiency was lower than that in the stable state.

• Analytical Science and Technology
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• v.20 no.3
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• pp.251-254
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• 2007

In this study, a convenient, fast and accurate inductively coupled plasma atomic emission spectrometry (ICP-AES) method has been optimized for the determination of osmium in aqueous solutions. The method makes use of the reaction of sulfurous acid with osmium to quantitative conversion of volatile Os(VIII) to non-volatile Os(IV) in the pH range 2-10. The response was found to be stabilized immediately after sulfurous acid reacted with osmium. The precision was calculated to be 0.5-4.5 % (RSD) under various ICP-AES conditions. The detection limit was 2.5-57.7 ng/g based on $3{\sigma}$ of the blank response (n=3) using a concentric flow nebulization.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.10a
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• pp.294-296
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• 2022

Atherosclerosis is a chronic vascular inflammatory disease in which plaque builds up in the arteries and impairs blood flow. This can lead to heart disease and stroke. Since most people do not have any symptoms until the artery is severely narrowed, early detection of atherosclerosis is critical. In this paper, in order to effectively detect atherosclerotic lesions in tube-shaped blood vessels, polar conversion is applied to MRI images based on the vessel center. We then propose a SE-LSTMNet model using continuous signal information for each angle of a polar coordinate image. The trained model showed classification performance of 0.9194 accuracy, 0.9370 sensitivity, 0.8796 specificity, 0.8700 F1 score, and 0.9719 AUC on the validation data.

• Proceedings of the Korean Society of Computer Information Conference
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• 2024.01a
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• pp.131-134
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• 2024

본 논문에서는 기존 철도 운영 및 관리시에 철도 주변환경으로 부터 발생하는 소음, 진동, 미세먼지 센서에서 다양한 실시간 스트림 데이터를 감지하고 정형화된된 데이터 패턴을 인식하고 분석할 수 있도록 데이터를 구성 및 저장하고 분석된 데이터를 표현할 수 있도록 시각화 지원을 위한 모니터링 시스템 플랫폼을 구현하였다. 데이터 전송을 위해 시리얼 통신 기법을 주로 적용하였으나, 센서와 디바이스의 증가로 인해 시리얼 통신의 한계가 나타났다. 따라서, 본 연구에서는 기존의 아두이노와 서버 간의 직접 통신 방식 대신 라즈베리파이를 도입하여 MQTT Broker(브로커)를 설치하고 통신을 진행하였다. 철도 데이터 모니터링 시스템 플랫폼은 NoSQL 데이터베이스인 MonGoDB와 데이터 시각화할 수 있는 Grafana를 이용하여 구축하였다.

• Journal of the Korea Safety Management & Science
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• v.25 no.4
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• pp.67-72
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• 2023

Human and material damage can be reduced if the risk is evaluated by engineering analysis of fire combustion products, smoke concentration, and smoke movement speed in the event of a fire in apartment houses and officetels. In this study, a lot of research on related safety evaluation in the basement needs to be studied and reflected in design, so experimental research was conducted to analyze the flow of smoke through computer simulation and provide analysis data through evacuation safety evaluation. First of all, the five-story underground parking lot subject to simulation has a large floor area, which is advantageous for improving evacuation safety performance, but it uses temperature detectors to increase detection time and fire spread speed. Second, it was analyzed that the evacuation time at all evacuation ports did not exceed the evacuation time, and as the time from the start of evacuation to the evacuation time was 216.9% compared to the travel time, it was evaluated that the safety performance of the evacuation was secured. Third, the above simulation results are a comprehensive safety evaluation based on the non-operation of fire extinguishing facilities in the fire room to increase safety, which means that smoother evacuation safety performance can be secured by linking fire extinguishing facilities.

• Journal of Radiation Protection and Research
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• v.22 no.2
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• pp.111-117
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• 1997

Recently, the conclusion of Comprehensive Test Ban Treaty(CTBT) is globally constructing a network system for nuclear test monitoring. The radionuclide experts of the Conference on Disarmament recommended that the detection of nuclear debris in the atmosphere was an essential factor of nuclear test monitoring and proposed the technical requirements. Based on those requirements, atmospheric radionuclide monitoring system to detect nuclear debris generated from the nuclear explosion test was composed. The system is comprised of high volume air sampler(HVAS), filter paper presser and high purity germanium detector(HPGe). Minimum detectable concentrations(MDCs) of the key nuclides requiring in CTBT monitoring strategies are determined by considering of decay time, counting time and flow rate of the high volume air sampler for the rapid explosion and the optimum measurement condition. The results were selected $10{\pm}$2h, $20{\pm}$2h and $850{\pm}50m^3$/h as parameters, respectively. The relation between the natural air-borne radionuclide concentration of $^{212}Pb$ and MDC were calculated which gave effect in the Compton continuum baseline due to those nuclides in the gamma-ray spectroscopy. These results can be used as an actually tool in the CTBT monitoring strategies.

• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.137-142
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• 2005

A rapid, selective and sensitive reversed-phase HPLC method for the determination of glipizide in human serum was validated and applied to the pharmacokinetic study of glipizide. Glipizide and internal standard, tolbutamide, were extracted from human serum by liquid-liquid extraction with benzene and analyzed on a Nova Pak $C_{18}\;60{\AA}$ column with the mobile phase of acetonitrile-potassium dihydrogen phosphate (10 mM, pH 3.5) (4:6, v/v). Detection wavelength of 275 nm and flow rate of 0.7 ml/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^3$ factorial design using a fixed glipizide concentration (500 ng/ ml) with respect to its peak area and retention time. And also, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of 10-1000 ng/ml with correlation coefficient greater than 0.999. The lower limit of quantitation using 0.5 ml of serum was 10.0 ng/ml, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the quality control samples ranged from 82.6 to 105.0% for glipizide with overall precision (% C.V.) being 1.13-13.20%. The percent recovery for human serum was in the range of 85.2 93.5%. Stability studies showed that glipizide was stable during storage, or during the assay procedure in human serum. The peak area and retention time of glipizide were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of glipizide in human serum samples for the pharmacokinetic studies at three different laboratories, demonstrating the suitability of the method.