• 한국산학기술학회논문지
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• 제16권11호
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• pp.7549-7554
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• 2015

본 이 연구의 목적은 부유 기술을 이용하여 제형이 위에 더 오래도록 머무르면서 약물을 지속적으로 방출하는 이중정을 개발하는 것이다. 실험방법으로는 메트포르민을 주 약물로 선정하였는데, 그 이유는 메트포르민은 주로 소장 상부에서만 흡수되는 좁은 흡수 영역 대를 가지고 있는 점, 용해도가 매우 높아 약물 방출을 조절하는 것이 쉽지 않은 점 등 때문이다. 정제의 부유를 위한 가스를 생성하는 부분과 약물의 방출을 조절하는 부분의 간섭을 최소화하기 위해 이중정 타정 기를 사용해 이중정으로 제조하였으며, 정제의 모양, 질량 및 경도를 측정하였고, 부유정의 중요한 요소인 부유 촉발시간과 부유유지 시간을 평가하였다. 또, 약물의 방출 조절을 평가하기 위해 용출시험을 시행하였으며, 그 결과를 시판되고 있는 메트포르민 서방성 제제인 Glucopharge XR$^{(R)}$과 비교평가 하였다. 그 결과, 부유 촉발제인 $NaHCO_3$ 및 약물 방출 조절제인 hydroxypropyl methylcellulose (HPMC)의 사용량에 따라 13초의 부유 촉발시간, 10시간 이상의 부유 유지시간 및 시판 제제와 매우 유사한 약물 방출 거동을 확인할 수 있었다 ($f_2$: 89.6). 결론적으로 메트포르민을 함유한 위 체류 이중정을 성공적으로 개발할 수 있었으며, 그로 인해 메트포르민의 치료효과도 극대화 할 수 있을 것으로 예상된다.

• KSBB Journal
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• 제31권4호
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• pp.219-227
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• 2016

Valsartan, a drug for the treatment of cardiovascular disease, exhibited low bioavailability which was caused by, at least in part, limited solubility at low pH. Present investigation deals with the preparation and characterization of gastro-retentive drug delivery system (GRDDS) using valsartan solid dispersion. We prepared solid dispersion using surfactants (Poloxamer 407) and alkalizer ($Na_2CO_3$) which may to be useful for improving solubility of valsartan at low pH and evaluated by saturated solubility of valsartan in distilled water. Valsartan gastro-retentive (GR) tablets containing solid dispersion prepared and evaluated by weight variation, floating time and dissolution rate. Compression at lower pressures resulted in the tablets floating over simulated gastric fluid (pH 1.2) for more than 17 h. In vitro release of valsartan from GR tablet was dependent on the amount of poloxamer 407 and hydroxypropyl methylcellulose. On the basis of evaluation parameter, formulation E-3 was selected as a final formulation. Therefore, it can be concluded that the GR tablets containing solid dispersion may be exploited successfully for the delivery of poorly drug such as valsartan.

• 한국구조물진단유지관리공학회 논문집
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• 제14권2호
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• pp.137-144
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• 2010

팽이기초에 대한 일본과 국내에서 현재까지 공통적으로 연구되고 있는 것은 팽이기초의 현장재하실험에 대한 지지력과 침하량에 주목되어 있다. 그러나 팽이기초에서 선행되어야할 연구는 공법 자체가 상재하중을 하부에 어떠한 원리로 전달되는 지에 대한 분석이 수행되어야 한다. 이에 본 연구에서는 일본에서 개발된 Top-Base Foundation과 국내에서 개발된 부양형 팽이기초의 응력전달 메커니즘을 수치해석 및 실내모형실험을 통하여 분석하였다. 팽이기초의 하중전달 메커니즘을 분석한 결과 상재하중에 대한 팽이기초 자체의 하중저감 분담률은 주로 팽이기초와 쇄석사이에서 발생하는 주면마찰력이 가장 크게 나타났다. 또한, 팽이기초의 내부응력분산효과를 포함한 Top-Base Foundation의 총 응력분산각은 $41.8^{\circ}$이며, 부양형 팽이기초의 총 응력분산각은 $44.5^{\circ}$로 산정되었다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.139-144
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• 2002

Two types of alginate gel beads capable of floating in the gastric cavity were prepared. The first, alginate gell bead containing olive oil(Al-Oil), is a hydrogel bead and its buoyancy is attributable to olive oil held in the alginate gel matrix. The model drug, metronidazole(MZ), contained in Al-Oil was released gradually into artificial gastric fluid. The profiles of MZ release from Al-Oil shown initial burst and after 90 min they were about 100%. The second, alginate gel bead containing curdlan microsphere(Al-C), is a gel bead with curdlan-MZ microsphere in the matrix. To sustained release rate of drug, alginate bead were prepared curdlan microsphere containing MZ. Results demonstrated that sustained delivery of MZ over 2h can be easily achieved while the bead remained float. The release properties of prepared alginate beads are applicable not only for sustained release of drugs but also for targeting the gastric mucosa.

• International journal of advanced smart convergence
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• 제9권1호
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• pp.163-171
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• 2020

There are many differences in narrative delivery between common movies and Virtual Reality(VR) films due to their differences in the appreciation structure. In VR films, scene changes by cuts have hindered the immersion of the audience instead of promoting narrative delivery. There are a range of experiments on narratives and immersion to solve this issue in VR films. Floating Tent applies hand gestures and immersive effects found in game elements and does not disturb narrative delivery by setting proper spaces and employing a direction technique to enable the melting of narratives into the characteristics of the spaces. There are time limits to offsound and mission performance, and devices fit for apocalyptic spatial expressions are made through a program. One of measures for the increasingly growing interactive storytelling in VR films is effective immersion. In narrative delivery, it is important to consider spatial setting and immersion to enable active intervention into events for immersion rather than passive audience only supposed to watch characters' acting.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 세계 도시지반공학 심포지엄
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• pp.430-440
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• 2009

Top-Base Foundation(TBF) was developed in Japan as a factory made concrete product. It is actively used in 6,000 sites by the end of 1980s in Japan and applied for a domestic patent in 1985. It is a shallow foundation whose effectiveness is proven by many relevant researchers and engineers. TBF was introduced to Korea in 1991 and has been applied mainly to architectural structures to date. Currently, the effectiveness in bearing capacity and settlement of TBF is being underestimated for civil engineering structures. Characteristics of Top-Base Foundation studied in Japan and Korea is known as follows: (1) as concrete part and crushed stone behave together, they perform the function of rigid mat; (2) the conical part and pile part of TBF disperses load by interaction with the crushed stone; (3) by preventing lateral strain and differential settlement on lower ground, it improves bearing capacity and constrains settlement at the same time. In Korea, it is used mostly in clayey soft grounds. The formula of bearing capacity and settlement of TBF suggested in Japan give the values of the underestimated. bearing capacity while its settlement is overestimated in comparison with the values measured from the field loading test. Therefore, in this study, the stress delivery mechanism of Top-Base Foundation developed in Japan and Floating Top Base developed in Korea is investigated through numerical analysis and laboratory model test.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.103-112
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• 2010

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

• International Journal of Naval Architecture and Ocean Engineering
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• 제4권4호
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• pp.437-446
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• 2012

An ocean buoy energy farm is considered for Green energy generation and delivery to small towns along the Korean coast. The present study presents that the floating buoy-type energy farm appears to be sufficiently feasible for trapping more energy compared to affixed cylinder duck array. It is also seen from the numerical results that the resonated waves between spaced buoys are further trapped by floating buoy motion.Our numerical study is analyzed by a plane-wave approximation, in which evanescent mode effects are included in a modified mild-slope equation based on the scattering characteristics for a single buoy.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.550-553
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• 2004

Recently, the demand for the Floating, Production, Storage, and Offloading facility (FPSO) which has some economic and technical advantages, has increased in offshore oil production areas. The 36,8000 DWT class FPSO was built in Hyundai Heavy Industries and will be installed in Offshore Angola. She dose not have self-propulsion system, but has additional facilities for oil production and positioning system. Main noise sources are contributing to the cabin noise of the accommodation are classified into three classes such as the machinery in the engine room and the deckhouse, HVAC system, and the topside equipments. In general, the noise regulation for the offshore structure is severer than that of the cargo ship and acceptable noise limit of cabin is specified as 45 dB(A). This paper describes the procedure of noise analysis, the countermeasures of noise control, and the measurement results of the quay trial. In order to minimize the noise levels, careful attention have to be paid by the special committee of experts from the initial design stage to the delivery. Proper countermeasures, considering the characteristics of sources and receiver spaces, were applied from the noise prediction and various experiment results. Finally, this ship was successfully delivered with excellent noise properties. The technology to minimize the noise levels for FPSO has been established throughout the construction of this ship.

• 산업공학
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• 제17권spc호
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• pp.28-36
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• 2004

The main purpose of this study is to find out the optimal solution of the vehicle routing problem considering heterogeneous vehicle(s), double-trips, and multi depots. This study suggests a mathematical programming model with new numerical formula which considers the amount of delivery and sub-tour elimination and gives optimal solution by using OPL-STUDIO(ILOG). This study also suggests modified genetic algorithm which considers the improvement of the creation method for initial solution, application of demanding point, individual and last learning method in order to find excellent solution, survival probability of infeasible solution for allowance, and floating mutation rate for escaping from local solution. The suggested modified genetic algorithm is compared with optimal solution of the existing problems. We found the better solution rather than the existing genetic algorithm. The suggested modified genetic algorithm is tested by Eilon and Fisher data(Eilon 22, Eilon 23, Eilon 30, Eilon 33, and Fisher 10), respectively.