• Title/Summary/Keyword: Fixed-Effects Model

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Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Behavior in Sapsaree Dog (Canis familiaris)

  • Ha, J.H.;Alama, M.;Lee, D.H.;Kim, J.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.7
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    • pp.936-942
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    • 2015
  • The purpose of this study was to characterize genetic architecture of behavior patterns in Sapsaree dogs. The breed population (n=8,256) has been constructed since 1990 over 12 generations and managed at the Sapsaree Breeding Research Institute, Gyeongsan, Korea. Seven behavioral traits were investigated for 882 individuals. The traits were classified as a quantitative or a categorical group, and heritabilities ($h^2$) and variance components were estimated under the Animal model using ASREML 2.0 software program. In general, the $h^2$ estimates of the traits ranged between 0.00 and 0.16. Strong genetic ($r_G$) and phenotypic ($r_P$) correlations were observed between nerve stability, affability and adaptability, i.e. 0.9 to 0.94 and 0.46 to 0.68, respectively. To detect significant single nucleotide polymorphism (SNP) for the behavioral traits, a total of 134 and 60 samples were genotyped using the Illumina 22K CanineSNP20 and 170K CanineHD bead chips, respectively. Two datasets comprising 60 (Sap60) and 183 (Sap183) samples were analyzed, respectively, of which the latter was based on the SNPs that were embedded on both the 22K and 170K chips. To perform genome-wide association analysis, each SNP was considered with the residuals of each phenotype that were adjusted for sex and year of birth as fixed effects. A least squares based single marker regression analysis was followed by a stepwise regression procedure for the significant SNPs (p<0.01), to determine a best set of SNPs for each trait. A total of 41 SNPs were detected with the Sap183 samples for the behavior traits. The significant SNPs need to be verified using other samples, so as to be utilized to improve behavior traits via marker-assisted selection in the Sapsaree population.

The Impact of International Integration on the Inequality of Income between Rural and Urban Areas in Vietnam

  • NGUYEN, Thi Thanh Huyen;NGUYEN, Thi Thu Hien;NGUYEN, Thi Le Hang;NGUYEN, Van Cong
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.3
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    • pp.277-287
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    • 2020
  • The study examines the impact of international integration on Vietnam's rural and urban income inequalities using the regression model. The data used for this study is based on the results of the Vietnam Household Living Standards survey from 2008 to 2016 of the General Statistics Office. These surveys conducted nationwide with a sample size of 46,995 households in 3,133 communes/wards which were representative at national, regional, urban, rural and provincial levels. The level of international economic integration used in the study is the proportion of import and export turnover of GDP, the proportion of FDI and GDP by province. Due to the heterogeneity and unobservableness of the single observant in the data set, we selected the models of random and fixed effects. The research results show that during the economic integration process, the Export/GDP factor is negatively related to income inequality. The remaining factors (GDP per capita, FDI/GDP, Educational level of households, Percentage of internet users, Aggregation of foreign cash inflow and GDP of the province) are all positively related to income inequality. The findings help assess the impact of international integration on rural-urban income inequality, but also provides a concrete basis to help policymakers address income inequality in the integration process.

Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs

  • Guan, Tian;Wang, Jian;Yang, Muqun;Zhu, Kai;Wang, Yong;Nie, Guohui
    • Journal of the Optical Society of Korea
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    • v.20 no.2
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    • pp.269-275
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    • 2016
  • This study has investigated the feasibility of 980-nm low-energy pulsed near-infrared laser stimulation to evoke auditory responses, as well as the effects of radiant exposure and pulse duration on auditory responses. In the experiments, a hole was drilled in the basal turn of the cochlea in guinea pigs. An optical fiber with a 980-nm pulsed infrared laser was inserted into the hole, orientating the spiral ganglion cells in the cochlea. To model deafness, the tympanic membrane was mechanically damaged. Acoustically evoked compound action potentials (ACAPs) were recorded before and after deafness, and optically evoked compound action potentials (OCAPs) were recorded after deafness. Similar spatial selectivity between optical and acoustical stimulation was found. In addition, OCAP amplitudes increased with radiant exposure, indicating a photothermal mechanism induced by optical stimulation. Furthermore, at a fixed radiant exposure, OCAP amplitudes decreased as pulse duration increased, suggesting that optical stimulation might be governed by the time duration over which the energy is delivered. Thus, the current experiments have demonstrated that a 980-nm pulsed near-infrared laser with low energy can evoke auditory neural responses similar to those evoked by acoustical stimulation. This approach could be used to develop optical cochlear implants.

Improvement plan for vegetables by introducing the production and shipment stabilization policy

  • Ryu, Sangmo;Han, Sukho;Jang, Heesoo;Kim, Donghwan
    • Korean Journal of Agricultural Science
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    • v.46 no.4
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    • pp.813-825
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    • 2019
  • This paper investigated the effects of a government production and shipment stabilization policy and the improvement plan for vegetables in Korea. In this study, a simulation focused on the changes in farm income for Chinese cabbages & radishes using scenarios. The result shows an increase in farm income according to the government policy. In the short-term, demand and supply are fixed, and the policy effect is positive due to the price support effect of the project. However, for mid- to long-term, the price decreases due to the expansion of supply by business beneficiaries, which is likely to be adversely affected by an unstable supply and demand. This increases the burden of government and local government subsidies. This phenomenon is expected to be amplified as the ratio of production and shipbuilding stabilization programs and items expand. When expanding items and adjusting and setting the percentage of participation in the project, it is desirable to set and operate the appropriate business ratio taking into consideration the demand. To improve the effectiveness of the policy, the following remedies were suggested. First, national supply and demand guidelines should be set up, and the autonomous supply and demand control of the producers should be guided by the different preservation according to the implementation of the supply and demand control obligation. As for detailed equipment, it is necessary to establish the reproduction price for each item, set the base price for each wholesale market, increase the incentive for the producers to participate, and fund a business budget to secure business stability.

Voice Recognition Performance Improvement using the Convergence of Voice signal Feature and Silence Feature Normalization in Cepstrum Feature Distribution (음성 신호 특징과 셉스트럽 특징 분포에서 묵음 특징 정규화를 융합한 음성 인식 성능 향상)

  • Hwang, Jae-Cheon
    • Journal of the Korea Convergence Society
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    • v.8 no.5
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    • pp.13-17
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    • 2017
  • Existing Speech feature extracting method in speech Signal, there are incorrect recognition rates due to incorrect speech which is not clear threshold value. In this article, the modeling method for improving speech recognition performance that combines the feature extraction for speech and silence characteristics normalized to the non-speech. The proposed method is minimized the noise affect, and speech recognition model are convergence of speech signal feature extraction to each speech frame and the silence feature normalization. Also, this method create the original speech signal with energy spectrum similar to entropy, therefore speech noise effects are to receive less of the noise. the performance values are improved in signal to noise ration by the silence feature normalization. We fixed speech and non speech classification standard value in cepstrum For th Performance analysis of the method presented in this paper is showed by comparing the results with CHMM HMM, the recognition rate was improved 2.7%p in the speech dependent and advanced 0.7%p in the speech independent.

Development of Bench Tester for Designing the Passive Anti-Rolling Tanks (수동형 감요수조 설계를 위한 벤치테스터 개발)

  • Lew, Jae-Moon;Kim, Hyochul
    • Journal of the Society of Naval Architects of Korea
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    • v.52 no.6
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    • pp.452-459
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    • 2015
  • It is important to use bench test results in the design process of anti-rolling tanks. Traditional bench tester is usually designed to perform only roll motions about a fixed axis and relatively small so that the viscous effects may not be neglected. Novel bench tester which could adjust the motion center to realize the coupled motion of sway and roll has been devised and manufactured therefore, large scaled bench tester could be utilized for designing the passive anti-rolling tanks. The time history of the reference signal from the rotation sensor of the bench tester have been recorded and processed to determine the phase angle to derive the Response Amplitude Operator(RAO) of the stabilized ship. The breadth of ART tank model should be large up to 2 m to diminish viscous scale effect and the vertical position of the tank can be varied with the ship's center of motion. The periods and the amplitude of roll motion can be varied from 1.5 sec to 5 sec and up to ±20°, respectively. The components of the tester was expressed in three dimensional digital mockup (DMU) and assembled together in the CAD space. The final configuration of the bench tester has been determined by confirming the smooth operation of the moving parts without interference through the animation in CAD space. New analytic logic are introduced for the determination of hydrodynamic moment and phase difference due to fluid motion in ART and verified through the test. The developed bench tester is believed to be effective and accurate for the verification of stabilization effect of ART taking into the consideration of the sway effect in the design stage.

CHEK2 1100delC Variant and Breast Cancer Risk in Caucasians: A Meta-analysis Based on 25 Studies with 29,154 Cases and 37,064 Controls

  • Yang, Yuan;Zhang, Fan;Wang, Yang;Liu, Sheng-Chun
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.7
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    • pp.3501-3505
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    • 2012
  • Links between the CHEK2 1100delC heterozygote and breast cancer risk have been extensively explored. However, both positive and negative associations with this variant have been reported in individual studies. For a detailed assessment of the CHEK2 1100delC heterozygote and breast cancer risk, relevant studies published as recently as May 2012 were identified using PUBMED and EMBASE and selected using a priori defined criteria. The strength of the relationship between the CHEK2 1100delC variant and breast cancer risks was assessed by odds ratios (ORs) under the fixed effects model. A total of 29,154 cases and 37,064 controls from 25 case-control studies were identified in this meta-analysis. The CHEK2 1100delC heterozygote was more frequently detected in cases than in controls (1.34% versus 0.44%). A significant association was found between CHEK2 1100delC heterozygote and breast cancer risk (OR=2.75, 95% CI: [2.25, 3.36]). The ORs and CIs were 2.33 (95% CI: [1.79, 3.05]), 3.72 (95% CI: [2.61, 5.31]) and 2.78 (95% CI: [2.28, 3.39]) respectively in unselected, family, early-onset breast cancer subgroups. The CHEK2 1100delC variant could be a potential factor for increased breast cancer risk in Caucasians. However, more consideration is needed in order to apply it to allele screening or other clinical work.

Chronic Exposure to Chlorophenol Related Compounds in the Pesticide Production Workplace and Lung Cancer: A Meta-Analysis

  • Zendehdel, Rezvan;Tayefeh-Rahimian, Raana;Kabir, Ali
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5149-5153
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    • 2014
  • Background: Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. PAs and CPs exposure is associated with risk of cancer, but the situation regarding lung cancer has not been clearly defined. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer. Materials and Methods: After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were collected from the papers. We used random or fixed-effects models, Egger test, funnel plot and meta regression in our analysis. Results: Five papers with six reports were included in the final analysis. The standardized mortality rate for lung cancer from the random model was 1.18 (95% CI: 1.03-1.35, p=0.014) with moderate heterogeneity. Publication bias was not found for included studies in meta-analysis (p=0.9). Conclusions: Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs).

Source of the Variation in Meat and Bone Meal Nutritional Quality

  • Hendriks, W.H.;Cottam, Y.H.;Morel, P.C.H.;Thomas, D.V.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.1
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    • pp.94-101
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    • 2004
  • The gross composition, gross amino acid content, apparent ileal amino acid digestibility and apparent ileal digestible amino acid content from 64 commercially produced meat and bone meals were statistically analysed. The samples were produced by 22 plants over a 2.5 year period with eight plants using batch dry rendering and 14 plants using low temperature rendering. A linear model with method and time of year (period) as fixed effects, plant within method as a random effect and sheep percent as a covariate was fitted to the composition data. The majority of the variation in the gross composition, amino acid digestibility and digestible amino acid content was explained by differences between plants using the same method. Neither rendering season nor origin of the raw materials contributed significantly to the observed variation in meat and bone meal protein quality. Rendering method (low temperature or batch rendering) had a significant effect on the variation observed in gross fat content, gross energy content, pepsin nitrogen digestibility, protein solubility and total lanthionine content. The digestibility of a number of amino acids and the apparent digestible content of arginine, cysteine, aspartic acid, proline and hydroxyproline were also significantly affected by rendering method. On average, batch dry and low temperature rendering systems produce meat and bone meals of similar nutritional quality. The variation between plant and within plant, however, is large, indicating that purchasing meat and bone meal from the same plant does not guarantee a consistent quality.

Effects of the Length and Diameter of Shock Tube on the Shock Train Phenomenon (충격파관의 길이와 직경이 Shock Train 현상에 미치는 영향)

  • Kim, Dong Wook;Kim, Tae Ho;Yoon, Young Bin;Kim, Heuy Dong
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.41 no.9
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    • pp.615-622
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    • 2017
  • A normal shock wave is initially formed in the shock tube that migrates towards the closed end of the tube, which, in turn, leads to the reflection of shock. Due to the interaction of the reflected shock with the boundary layer, bifurcation of the shock wave takes place. A shock train will be generated after the bifurcated shock wave approaches the contact surface. Until now, only a few studies have been conducted to investigate this shock train phenomenon inside the shock tube. For the present study, a CFD analysis has been performed on a two dimensional axisymmetric model of a shock tube using unsteady, compressible Navier-Stokes equations. In order to investigate the detailed characteristics of the shock train phenomenon, quantitative studies have been performed by varying shock tube length, diameter under fixed diaphragm, and pressure ratio inside a shock tube.