• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2917-2922
• /
• 2014

Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

• 한국음향학회지
• /
• 제22권7호
• /
• pp.554-561
• /
• 2003

음원과 수신기 사이의 거리가 고정된 상태에서 측정한 광대역 천이 신호의 스펙트럼에 나타나는 간섭 패턴으로부터 모드차단 주파수를 인식하고 이로부터 해저면 음속을 추정하기 위해 수치 모의 및 실험 결과 분석을 통해 고찰하였다. Pekeris 도파관 환경에 대한 수치 모의 결과는 주파수 변화에 따른 전달 손실 및 간섭 패턴 변화가 모드 차단 주파수와 밀접한 관련이 있으며 간섭 패턴의 변화로부터 모드 차단 주파수를 인식하는 것이 가능할 수 있음을 보여주었다. 수치 모의를 통해 고찰한 개념을 해상 실험을 통해 획득한 신호에 적용하여 모드 차단 주파수를 인식하고 해저면 음속을 추정하였다. 추정된 음속을 모델 입력 인자로 이용하여 예측한 전달 손실은 손실 수준 린 간섭 패턴에서 실험 결과 분석을 통해 산출한 것과 매우 유사한 결과를 나타내었다.

• 콘크리트학회지
• /
• 제9권1호
• /
• pp.105-113
• /
• 1997

콘크리트 실린더 공시체의 크기에 따른 압축강도의 감소현상은 많은 관심을 받아 왔으나, 지금까지도 이에 대해 제시된 모델식이 없는 실정이다. 기존의 연구결과에 의하면 콘크리트의 강도는 부재의 크기가 증가할수록 감소하며 그 파괴거동을 규명하기 위해서는 비선형 파기역학 이론을 적용해야 함을 알 수 있다. 이전의 연구에서 표준형 콘크리트 실린더 공시체의 크기에 따른 압축강도의 변화를 파괴역학 이론에 따라 연구하고 실용적인 예측 모델식을 제시한 바 있다. 이 논문에서는 높이/직경의 비가 2/1이 아닌 비표준형 실린더 공시체를 고려하여 보다 일반적인 실린더 압축강도 에측 모델식을 제시하고자 한다. 이를 위하여 최대골재크기가 미소균열영역에 미치는 영향을 이론적으로 고찰하였으며, 특성길이의 개념을 새로이 도입하여 일반화된 크기효과에 대한 모델식을 제시하였다. 이 연구의 결과는 기존 구조물에서 채취한 다양한 크기의 콘크리트 코아 강도 등을 예측하는데도 매우 실용적으로 사용될 수 있을 것이다.

• Structural Engineering and Mechanics
• /
• 제48권3호
• /
• pp.367-382
• /
• 2013

Different types of long slender pile shall buckle with weak soil and liquefied stratum surrounded. Different from considering single side earth pressure, it was suggested that the lateral earth pressure can be divided into two categories while buckling: the earth pressure that prevent and promotes the lateral movement. Active and passive earth pressure calculation model was proposed supposing earth pressure changed linearly with displacement considering overlying load, shaft resistance, earth pressure at both sides of the pile. Critical buckling load calculation method was proposed based on the principle of minimum potential energy quoting the earth pressure calculation model. The calculation result was contrasted with the field test result of small diameter TC pile (Plastic Tube Cast-in-place pile). The fix form could be fixed-hinged in the actual calculation assuring the accuracy and certain safety factor. The contributions of pile fix form depend on the pile length for the same geological conditions. There exists critical friction value in specific geological conditions that the side friction has larger impact on the critical buckling load while it is less than the value and has less impact with larger value. The buckling load was not simply changed linearly with friction. The buckling load decreases with increased limit active displacement and the load tend to be constant with larger active displacement value; the critical buckling load will be the same for different fix form for the small values.

• 응용통계연구
• /
• 제28권2호
• /
• pp.289-294
• /
• 2015

생동성 시험과 같은 임상약리학분야의 연구는 일반적으로 한 개체 내에서 반복하여 측정된 자료구조를 사용하므로 선형혼합모형을 이용하여 분석하는 것이 보편적이다. 이러한 모형에서 랜덤효과는 개체 내 관측 자료 사이의 상관관계를 설명하고, 공분산행렬은 개체-내 변동을 설명한다. 생동성 분석은 두 약물의 약동학적 변수인 Cmax와 AUC의 기하평균비에 대한 90% 신뢰구간이 동등성 한계인 [0.8, 1.25] 범위에 드는지 알아보는 분석으로, 고정효과에는 시기, 순서군, 치료효과를, 랜덤효과에는 개체효과를 가지는 선형혼합모형을 이용하여 분석한다. 이러한 분석이 적용된 실제 예를 살펴보기 위하여 레보플록사신 연구의 자료를 활용하였다.

• 한국해양공학회지
• /
• 제32권6호
• /
• pp.433-439
• /
• 2018

An investigation was conducted to determine whether the changes in the maneuvering forces and moments acting on a hull could be affected by changing the vertical center of gravity (VCG) of a tanker. The changes in the hydrodynamic forces and moment acting on a hull according to the restraint conditions of motion were examined using CFD for cases where the VCG was located at the design draught (100% of draught), under the design draught (75% of draught), and at half of the design draught (50% of draught). The following motion restraint conditions were selected: (1) fixed restraints for everything; (2) heave, pitch, and roll free restraint; and (3) heave and pitch free restraints. It was found that restraint condition (2) had the best agreement with the model experiment results. In addition, it was found that the hydrodynamic forces and moment acting on the hull with restraint condition (2) could be greatly affected in the model tests and CFD calculations by the various configurations for the vertical center of gravity of the hull. Finally, it was concluded that the location of the vertical center of gravity of the hull could be an important factor when more accurate hydrodynamic maneuvering forces and moment are estimated.

• Journal of Korea Trade
• /
• 제24권8호
• /
• pp.121-132
• /
• 2020

Purpose - The principle aim of this study is to further investigate the relationship between market diversity and export performance. We examine the benefits and costs of geographic market diversity regarding the number of countries exported to by firms on their export performance. Based on the financial risk reduction model and the entry costs model, we propose a way to incorporate the costs and benefits aspects of market diversity. Design/methodology - To empirically investigate our research question, the curvilinear relationship between market diversity and export performance, we built a secondary panel data set between 2015 and 2019, containing 17,863 observations of Korean exporting companies. A generalized least squares panel estimator with fixed effects was employed to test the hypothesis, and the statistical package, Stata 14, was used. Findings - Our main findings are as follows: As market diversity increases, export performance increases because exporters can diversify and reduce financial risks in export markets. However, the relationship between the two does not grow. As it peaks, the entry costs increase due to the high market diversity, thereby outweighing the benefits, leading, eventually to decrease in the export performance. Consequently, there is an inverted U-shaped relationship between market diversity and export performance. Originality/value - In the export and trade literature, the impact of market diversity on export performance has not been addressed yet, despite the importance of this subject. Many scholars have assumed a positive linear relationship between the two, considering only the decrease in market risks as the number of overseas markets increases, without examining the increase in the entry and management costs. Therefore, our study contributes by providing a new perspective for analyzing the characteristics and outcomes of market diversity.

• Journal of Korea Trade
• /
• 제24권3호
• /
• pp.37-54
• /
• 2020

Purpose - This study is to investigate the determinants of suppliers' dependence on buyers in the home country by developing a theoretical model of innovative activities. The high dependence of auto parts suppliers on a single local buyer in South Korea due to firm ownership issues and incremental innovation is examined using data from a set of organizations that supply intermediate goods to this automotive manufacturer. Furthermore, we tested the moderating effect of FDI and global knowledge sourcing on the relationship between firm ownership and suppliers' dependence on the local buyer. Design/methodology - To test the hypotheses, we examined a sample of 101 suppliers over 10 years in the Korean automobile parts industry. In this empirical analysis, we utilized a fixed-effects generalized least squares model using panel data. Findings - In this study, domestic firms (automobile parts suppliers) were more dependent on a single local buyer (automobile assembler) than foreign-owned suppliers operating in Korea. In addition, incremental innovation was the mediating mechanism between domestic firms and dependence on the local buyer. To reduce this dependence on the buyer, we suggest two different international strategies: geographical diversification through FDI and global knowledge sourcing. Originality/value - Previous studies showed that asymmetric dependence between firms has many adverse effects. This study proved that domestic and foreign-owned suppliers have different levels of dependence on local buyers due to their heterogeneous characteristics and business strategies. We distinguish two different types of innovation - radical innovation and incremental innovation - that previous studies have often treated as equal when it comes to firm autonomy. Finally, we propose that both FDI and international knowledge sourcing as global strategies to weaken suppliers' asymmetric dependence on a single buyer.

• Journal of Animal Science and Technology
• /
• 제65권3호
• /
• pp.588-595
• /
• 2023

The aim of this study was to investigate the effects of heat stress on milk traits in South Korea using comprehensive data (dairy production and climate). The dataset for this study comprised 1,498,232 test-day records for milk yield, fat- and protein-corrected milk, fat yield, protein yield, milk urea nitrogen (MUN), and somatic cell score (SCS) from 215,276 Holstein cows (primiparous: n = 122,087; multiparous: n = 93,189) in 2,419 South Korean dairy herds. Data were collected from July 2017 to April 2020 through the Dairy Cattle Improvement Program, and merged with meteorological data from 600 automatic weather stations through the Korea Meteorological Administration. The segmented regression model was used to estimate the effects of the temperature-humidity index (THI) on milk traits and elucidate the break point (BP) of the THI. To acquire the least-squares mean of milk traits, the generalized linear model was applied using fixed effects (region, calving year, calving month, parity, days in milk, and THI). For all parameters, the BP of THI was observed; in particular, milk production parameters dramatically decreased after a specific BP of THI (p < 0.05). In contrast, MUN and SCS drastically increased when THI exceeded BP in all cows (p < 0.05) and primiparous cows (p < 0.05), respectively. Dairy cows in South Korea exhibited negative effects on milk traits (decrease in milk performance, increase in MUN, and SCS) when the THI exceeded 70; therefore, detailed feeding management is required to prevent heat stress in dairy cows.

• Asian-Australasian Journal of Animal Sciences
• /
• 제28권12호
• /
• pp.1696-1702
• /
• 2015

The objective of this study was to compare the effects of body weight growth adjustment methods on genetic parameters of body growth and tissue among three pig breeds. Data collected on 101,820 Landrace, 281,411 Yorkshire, and 78,068 Duroc pigs, born in Korean swine breeder farms since 2000, were analyzed. Records included body weights on test day and amplitude (A)-mode ultrasound carcass measures of backfat thickness (BF), eye muscle area (EMA), and retail cut percentage (RCP). Days to 90 kg body weight (DAYS90), through an adjustment of the age based on the body weight at the test day, were obtained. Ultrasound measures were also pre-adjusted (ABF, EMA, AEMA, ARCP) based on their test day measures. The (co)variance components were obtained with 3 multi-trait animal models using the REMLF90 software package. Model I included DAYS90 and ultrasound traits, whereas model II and III accounted DAYS90 and pre-adjusted ultrasound traits. Fixed factors were sex (sex) and contemporary groups (herd-year-month of birth) for all traits among the models. Additionally, model I and II considered a linear covariate of final weight on the ultrasound measure traits. Heritability ($h^2$) estimates for DAYS90, BF, EMA, and RCP ranged from 0.36 to 0.42, 0.34 to 0.43, 0.20 to 0.22, and 0.39 to 0.45, respectively, among the models. The $h^2$ estimates of DAYS90 from model II and III were also somewhat similar. The $h^2$ for ABF, AEMA, and ARCP were 0.35 to 0.44, 0.20 to 0.25, and 0.41 to 0.46, respectively. Our heritability estimates varied mostly among the breeds. The genetic correlations ($r_G$) were moderately negative between DAYS90 and BF (-0.29 to -0.38), and between DAYS90 and EMA (-0.16 to -0.26). BF had strong $r_G$ with RCP (-0.87 to -0.93). Moderately positive $r_G$ existed between DAYS90 and RCP (0.20 to 0.28) and between EMA and RCP (0.35 to 0.44) among the breeds. For DAYS90, model II and III, its correlations with ABF, AEMA, and ARCP were mostly low or negligible except the $r_G$ between DAYS90 and AEMA from model III (0.27 to 0.30). The $r_G$ between AEMA and ABF and between AEMA and ARCP were moderate but with negative and positive signs, respectively; also reflected influence of pre-adjustments. However, the $r_G$ between BF and RCP remained non-influential to trait pre-adjustments or covariable fits. Therefore, we conclude that ultrasound measures taken at a body weight of about 90 kg as the test final should be adjusted for body weight growth. Our adjustment formulas, particularly those for BF and EMA, should be revised further to accommodate the added variation due to different performance testing endpoints with regard to differential growth in body composition.