• Journal of Korean Medical classics
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• v.30 no.1
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• pp.167-184
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• 2017

Objectives : The paper attempted to analyze the contents found in the networks of five viscera in Yixuerumen's Zangfutiaofen published by Li Chan in 1575, and tried to reveal the body structure dealt in the contents through anatomical verification. Methods : Books such as Huataxianshengneizhaotu, Tushupian, and Shisijingfahui were used to compare, understand, and interpret the original texts and annotations of Yixuerumen in an attempt to verify these through anatomy reference texts and computer programs. Results : In Yixuerumen, some contents of the networks of five viscera were revised to see feixi as not one but two, and explained the relationship of intestinal organs through heart and lung. Anatomically speaking, the networks of five viscera has a vertical structure that unfolds top to bottom centering on aorta, and has many organs connected to it such as trachea, esophagus, splenic artery, pulmonary trunk, ureter, mesentery arteriovenous, gonadal artery, and ductus deferens. Conclusions : The networks of five viscera has a great significance in that it is the fruit of much efforts where oriental medicine tried to explain not only the functions of five viscera, but also the creation and circulation of qi, blood, and bodily fluids through anatomical observation.

• Radiation Oncology Journal
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• v.32 no.4
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• pp.238-246
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• 2014

Purpose: To evaluate the clinical outcome of high-dose-rate (HDR) interstitial brachytherapy (IBT) in patients with oral cavity cancer. Materials and Methods: Sixteen patients with oral cavity cancer treated with HDR remote-control afterloading brachytherapy using $^{192}Ir$ between 2001 and 2013 were analyzed retrospectively. Brachytherapy was administered in 11 patients as the primary treatment and in five patients as salvage treatment for recurrence after the initial surgery. In 12 patients, external beam radiotherapy (50-55 Gy/25 fractions) was combined with IBT of 21 Gy/7 fractions. In addition, IBT was administered as the sole treatment in three patients with a total dose of 50 Gy/10 fractions and as postoperative adjuvant treatment in one patient with a total of 35 Gy/7 fractions. Results: The 5-year overall survival of the entire group was 70%. The actuarial local control rate after 3 years was 84%. All five recurrent cases after initial surgery were successfully salvaged using IBT ${\pm}$ external beam radiotherapy. Two patients developed local recurrence at 3 and 5 months, respectively, after IBT. The acute complications were acceptable (${\leq}grade$ 2). Three patients developed major late complications, such as radio-osteonecrosis, in which one patient was treated by conservative therapy and two required surgical intervention. Conclusion: HDR IBT for oral cavity cancer was effective and acceptable in diverse clinical settings, such as in the cases of primary or salvage treatment.

• The Korea Journal of Herbology
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• v.28 no.6
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• pp.39-45
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• 2013

Objectives : This study was conduct to compare of histological changes on four target organs which related with diabetes in streptozotocin-induced diabetic rats. Methods : Diabetes was induced in male Sprague-Dawley rats by consecutive injection of streptozotocin (STZ) at different doses of 30, 40 and 50 mg/kg for 5 days. After 4 weeks, all rats were sacrificed, five different organs such as pancreas, liver, kidney, and lung were isolated and observed their histological changes by hematoxylin and eosin (H&E), Periodic acid-Schiff (PAS) and Masson's trichrome staining. The changes of body weight, blood glucose, and food and water intake were also measured. Results : The multiple administration of STZ was induced diabetes in rats with hyperglycemia, decrease of body weight, increase water and food intake, and histopathological changes of target organs, compared with those of normal rats in both dose-dependent and time-dependent manner. In histological analysis, pancreas was showed decrease of the islet numbers with beta-cell loss. Kidney showed morphological damage with glomerulus hypertrophy, and also lung was showed bronchial epithelial damage with inflammatory cells infiltration. In liver, the portal vein and hepatic artery could not observed, and showed inflammatory cell infiltration with liver fibrosis. Conclusions : These results suggest that the increase of the capacity of STZ, each of the more chronic disease, it can be seen that the damage was deep. Thus, evaluate the resulting drug appropriate depending on the purpose of the model is expected to be selected.

• Journal of Korean Medical classics
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• v.22 no.3
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• pp.271-289
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• 2009

This thesis intend to help the eastern medical doctor to understand body condition from interpretation of perspirations(汗出) in daily time cycle. The conclusion is followed. 1. In most Eastern Medical classic and clinic literatures, the time of fever and perspirations are described as a result of disease's position at human body. Following this description, in daytime the perspirations must come from the Gi phase and night time the perspirations must come from the blood phase. Because in daytime the skin pores are opening and the defensive Gi is going out to the superficial portion of the body. In night time the skin pores are shutting and the defensive Gi is going in to the five solid organs. So a sweat in daytime comes out from the Gi phase and superficial portion of the body. And in night time comes out from the blood phase and five solid organs. But in recent real clinic cases, in daytime, there are so many perspirations from the five solid organs. Comparatively, the perspirations from the superficial portion of body are very little. And in same daytime perspirations, when the heat pathogens mixed with moist, the symptom revelation time delay to the afternoon. Therefore it can be concluded that the time of perspirations are combination of disease's Gi or blood phase and characteristics of pathogens. The position of disease at human body cannot simply judge the symptom revelation time. 2. The exchange of climate following time cycle of a day effect to the condition of human body. At same time it activates or not activates the pathogens in human body. So we can consider the kinds and characteristics of pathogens by distinguishing the symptom revelation time. In general differentiation of syndromes[辨證] pathogen's kinds and location are generally judged. By understanding the characteristics of pathogen, doctor can devise more correct and delicate prescription.

• Journal of Korean Medical classics
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• v.23 no.2
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• pp.1-13
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• 2010

We get following conclusion in relationship of emotions and several diseases from the viewpoint of Gi(氣) movements. "Naegyeong(內經)" state mainly relationship of emotions and five organs, relationships of emotion and Gi(氣) movements in detail, but refer about symptoms of diseases that happen by anger, fear, and astonishment. "Yumunsachin(儒門事親)" supplement the relationships of emotions and five organs in "Naegyeong(內經)", and "Uihak-ipmun(醫學入門)" present medical treatments for each symptom of diseases that is led by emotion. According to "Naegyeong", as well as emotions can lead to various symptoms of diseases by affecting Gi(氣) movements, particular symptoms of diseases can affect in emotions by affecting Gi (氣) movements. Because emotions can affect to symptoms of diseases through Gi(氣) movements, we can treat with drugs that control Gi(氣) as well as with methods that control emotions in case of emotions leading to particular symptoms of diseases. Because particular symptoms of diseases can affect to emotions through Gi(氣) movements, we can treat with methods that control emotions as well as with drugs that control Gi(氣) movements in case of particular symptoms of diseases leading to emotions. We think the theory of Gi(氣) movements can be used as a principle of acupuncture as well as of drugs by examining the relationship of emotions and symptom of diseases from the viewpont of Gi(氣) movements.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.596-599
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• 2005

Human health is affected by not only physical conditions but also mental and social well-being. Changes of human emotions show up as gestures, facial expressions and sweating. Human emotions are affected by such automatic nerve system functions as blood pressure, blood circulation speed, heart beats, pupillary reflex, fluid transfusion, muscular contraction and digestive organs, all of which influence the holistic diseases. The Oriental Medicine sees from a perspective of unity of divinity and men that human life activities are united in terms of their physical and mental functions. From such a perspective, human Five Organs are linked with Five Mental(五神) and Seven Emotions(七情), while they are affected by each other, influencing the life activities both directly and indirectly. Based on Confucianism, Sa-Sang Theory argues that human emotions can be categorized into four energy states and therefore, that human diseases and physiological conditions there of may be determined differently depending on the Four Energies(四氣). There seems to be some common points between Sa-Sang Theory and the conventional Oriental Medicine in that human emotions affect individuals' health conditions, so there seems to be much room for mutual complementation.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.617-623
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• 2003

The following conclusions are drawn from a review on the theory of correlation between the jang-bu organs in 'Ojangchunchaklon(五臟穿鑿論)' which is quoted in 'Uihakipmoon(醫學入門)' and 'Donguibogam(東醫寶鑑)'. The three yangs and three yins are trisections each of yang ki and y1n ki. They represent three aspects of change in powers of yin ki and yang ki. The theory of Kaehapchu(開闔樞 the opening, closing and pivot) is thought to be the concept which explains the three states of jang-bu organs and meridians in terms of three yangs and three yins. The three yangs and three yins are assigned to twelve months according to the generation, prosperity and vanishment of the water, the fire, the wood and the metal in the circulation of nature with the lapse of time. Most of all, the change of the water and the fire is the main guide to the assignment. Both the theory of exterior-interior relations in jang-bu organs and meridians and the theory of Kaehapchu are founded on the assignment of three yangs and three yins to twelve months. The correlation between jang-bu organs is based on the monthly assignment of three yangs and three yins described in 'Internal classic(內經)' and the theory of Kaehapchu. In the correlations between jang-bu organs and meridians, the exterior-interior relations are the correspondences of Hand to Hand and Foot to Foot. but the relations of Kaehapchu are those of Hand to Foot and Foot to Hand. Jeesan's diagram of pulse is grounded on the correlations between jang-bu organs. On the left of the diagram, jang organs are arranged in the order of hierarchic positions in body. On the right, bu organs are disposed according to the correlations with the jang organs. Jeesan's diagram includes the principles of triple harmony and diagonal groups in twelve earthly branches(十二支). Jeesan's diagram is the frame through which correlations of jung-ki-shin-hyul, five jang and six bu organs, twelve meridians and six intrinsic factors can be observed at once.

• The Journal of Korean Medicine
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• v.35 no.3
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• pp.70-92
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• 2014

Objectives: Due to advance of science and IT technology, high tech imaging equipment like ultrasonography, CT, MRI and PET scan is constantly being developed and progressed; use of these techniques is needed for Korean medicine. Methods: Historical study was undertaken on the evidence of using ultrasonography. Normal organs and various sorts of diseases were also observed by ultrasonography. Results: Korean medicine judges disease of internal organs and condition of health by symptoms of functional disease and organic disease based on anatomical theory. Ultrasonography based on anatomical theory is non-invasive and free from radiation exposure and can be performed directly from clinical practice in real-time. Ultrasonography can be a big help for securing the stability of the internal organs in inserting needles in the thorax and abdomen as well as diagnosing functional and organic diseases based on anatomical theory. Conclusion: We look forward to a great development of scientification and objectification of Korean medicine by using and researching imaging equipment based on anatomical theory as well as ultrasonography.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2619-2623
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• 2012

The prevalence of human papillomavirus genotypes differs in various target organs. HPV16 is the most prevalent genotype in the cervix while genotypes 6 and 11 are highly prevalent in skin and aero-digestive tract infections. In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing. Five HPV11 whole genomes were characterized, consisting of two cervical specimens, two laryngeal specimens and one lung specimen. The results showed high homology of HPV11 in these organs. Phylogenetic analysis showed that all HPV11 derived from various organs belonged to the same lineage. Molecular characterization and functional studies can further our understanding of virulence, expression or transmission. Additional studies on functional protein expression at different organ sites will also contribute to our knowledge of HPV infection in various organs.

• Korean Journal of Veterinary Service
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• v.13 no.1
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• pp.1-20
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• 1990

In order to determine the levels of trace elements in livestock products surveys have been conducted in Inchon area. The samples were obtained from cattle organs, swine organs, chicken organs, eggs and milk. The levels of nine harmful trace elements(As, Cd, Cr, Cu, Fe, Hg, Mn, Pb, Zn) and three trace elements(Ca, Co, Na) were determined by ICP spectrometry, 1. In the survey on 9 harmful metals with 20 cattle, the highest level was 56.90ppm(Fe, liver) and the lowest level was 0.10ppm (Cd, muscle). 2. In the survey on 9 harmful metals with 31 swine, the highest level was 169.71ppm(Fe, lung) and the lowest level was 0.02ppm(Cd, heart). 3. In the survey on 9 harmful metals with 20 chickens, the highest level was 42.64ppm(Fe, liver) and the lowest level was 0.00ppm (Hg, entire organs). 4. In the survey on 9 harmful metals with 23 eggs, the highest level was 26.08ppm(Fe, yolk) and the lowest level was 0.00ppm (Hg, yolk and white). 5. In the survey on 9 harmful metals with 20 cases of milk, the highest level was 6.02ppm(Zn) and the lowest level was 0.04ppm(Cd). 6. In cattle the mean concentrations were highest in seven elements and in milk the mean concentrations were lowest in five elements.