• Archives of Craniofacial Surgery
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• v.18 no.3
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• pp.207-210
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• 2017

Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas of unknown origin. Of the fewer than 6% of sarcoidosis cases that occur in subcutaneous tissue, most occur on the face or forearm, but rarely in the toe. A 33-year-old man was admitted to our institute with a 2-cm mass on his chin and a 0.5-cm mass on his right fourth toe. Based on preoperative ultrasonography, epidermal cysts were suspected, and histopathological tests were performed after removing the masses. Histopathologically, the chin and toe tissue samples showed chronic granulomatous inflammation, without necrosis, indicative of sarcoidosis. Chest computed tomography revealed a large number of small nodules in both the interlobar fissures and the peribronchial area, and a large number of small lymph nodes in both the hilar and interlobar node areas. On the basis of the histopathologic and imaging findings, the patient was diagnosed with sarcoidosis. This very rare case of sarcoidosis, occurring in both chin and toe, suggests that thorough evaluation is needed to find other mass when we find sarcoidosis in facial area.

• Earthquakes and Structures
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• v.24 no.1
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• pp.53-64
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• 2023

Earth fissures with several kilometers will inevitably approach or cross the metro line, significantly threatening the safety of the underground structure in the earth fissure site. However, the influence of the earth fissure site's amplification effect on the metro station's dynamic response is still unclear. A representative earth fissure in Xi'an was taken as an example to establish a numerical model of a metro station in the earth fissure site. The dynamic response characteristics of the metro stations at different distances from the earth fissure under various seismic waves were calculated. The results show that the existence of the earth fissure significantly amplifies the dynamic response of the nearby underground structures. The responses of the axial force, shear force, bending moment, normal stress, horizontal displacement, inter-story drift, and relative slip of the metro station were all amplified within a specific influence range. The amplification effect increases with the seismic wave intensity. The amplification effect caused by the earth fissure has relatively weak impacts on the axial shear, shear force, bending movement, normal stress, and horizontal movement; slightly larger impacts on the inter-story drift and acceleration; and a significant impact on the relative slip. The influence ranges of the axial force and normal stress are approximately 20 m. The influence ranges of the acceleration and inter-story drift can reach 30 m. Therefore, the seismic fortification level of the underground structure in the earth fissure site needs to be improved.

• Geomechanics and Engineering
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• v.31 no.3
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• pp.281-289
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• 2022

Bio-CaCO₃ is a blowout environment-friendly materials for soil improvement and sealing of rock fissures. To evaluate the chemical characteristics, shape, size and productivity of soybean urease induced CaCO₃ precipitates (SUICP), experimental studies were conducted via EDS, XRD, FT-IR, TGA, BET, and SEM. Also, the conversion rate of SUICP reaction at different time were determined and analyzed. The Bio-CaCO₃ product obtained by SUICP is comprehensively judged as calcite based on the results of EDS, XRD and FT-IR. The SUICP calcite precipitates are detected as spherical or ellipsoidal particles 3-6 ㎛ in diameter with nanoscale pores on their surface, and this morphology is novel. The median secondary particle size d₅₀ is 39-88 ㎛, indicating the agglomeration of the primary calcite particles. The Bio-calcite decomposes at 650-780℃, representing a medium thermal stability. The conversion rate of SUICP reaction can reach 80% in 24h, which is much more efficient than microbially induced CaCO₃ precipitation. These results reveal the knowledges of SUICP, and further direct its engineering applications. Moreover, we show an economic channel to obtain porous spherical calcite.

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.62-66
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• 2019

Harlequin ichthyosis (HI, OMIM #242500) is one of the most severe skin diseases among the autosomal recessive congenital ichthyoses, with high morbidity and mortality, particularly in newborns. Clinically, it is characterized by a typical appearance of generalized, thick, yellowish, hyperkeratotic plates with deep erythematous fissures on the skin. Herein, we present the case of a newborn girl with HI that was genetically confirmed by targeted gene panel analysis. The premature baby was encased in an opaque white membrane with erosion covering the skin of the entire body except the lips, with her hands and feet restricted by the membrane. Humidification, emollient, and retinoic acid treatment were started; the thick ichthyosis gradually peeled off and the underlying skin was only covered with thin scales. Targeted gene panel analysis using next-generation sequencing and validation with Sanger sequencing and quantitative polymerase chain reaction analyses confirmed compound heterozygous mutations of the ABCA12 gene (p.N1380S and a partial gene deletion encompassing exon 9). The parents were carriers for each of the identified mutations. Early recognition of the genetic etiology of congenital ichthyosis can, thus, facilitate genetic counseling for patients and their families.

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.49-54
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• 2019

Purpose: Potocki-Lupski syndrome (PTLS), is a recently identified, rare genomic disorder. The patients are affected by infantile hypotonia, poor growth and developmental delay. Facial dysmorphism may not be obvious in some patients. PTLS is associated with microduplication at chromosome 17p11.2. In the current study, three Korean patients are reported with their clinical and genetic features. Materials and Methods: The clinical findings of each patient were reviewed. Karyotyping and multiplex ligation-dependent probe amplification (MLPA) analyses were done for genetic diagnoses. Results: All the patients did not have the characteristic dysmorphic features, such as broad forehead, triangular face, asymmetric smile and palpebral fissures. On the other hand, all three patients were affected by variable degree of developmental delay, poor oral intake, failure to thrive, and language development disorders. Chromosome 17p11.2 duplication was identified by conventional karyotyping analysis only in one patient, whereas the other confirmed by MLPA analyses. Conclusion: Delayed development was mostly commonly observed in our patients without distinct dysmorphic facial features. In this respect, genomic screening in patients with developmental delay would identify more cases with PTLS to understand their long-term clinical courses with the development of adequate psychological and rehabilitation education program.

• Geomechanics and Engineering
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• v.22 no.2
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• pp.133-142
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• 2020

The evolution of the mining-induced fracture network formed during longwall top coal caving (LTCC) has a great influence on the gas drainage, roof control, top coal recovery ratio and engineering safety of aquifers. To reveal the evolution of the mining-induced stress and fracture network formed during LTCC, the fracture network in front of the working face was observed by borehole video experiments. A discrete element model was established by the universal discrete element code (UDEC) to explore the local stress distribution. The regression relationship between the fractal dimension of the fracture network and mining stress was established. The results revealed the following: (1) The mining disturbance had the most severe impact on the borehole depth range between approximately 10 m and 25 m. (2) The distribution of fractures was related to the lithology and its integrity. The coal seam was mainly microfractures, which formed a complex fracture network. The hard rock stratum was mainly included longitudinal cracks and separated fissures. (3) Through a numerical simulation, the stress distribution in front of the mining face and the development of the fracturing of the overlying rock were obtained. There was a quadratic relationship between the fractal dimension of the fractures and the mining stress. The results obtained herein will provide a reference for engineering projects under similar geological conditions.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.13 no.2
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• pp.104-107
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• 2017

Kabuki syndrome is characterized by typical facial features (elongated palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows; short columella with depressed nasal tip; large, prominent, or cupped ears), minor skeletal anomalies, persistence of fetal fingertip pads, mild to moderate intellectual disability, and postnatal growth deficiency. A 6-year-old male with kabuki syndrome was referred from the local dental clinic for left facial swelling and dental caries on all primary molars. He was treated for acute periapical abscess with incision and drainage under physical restraint, and left maxillary second primary molar was extracted. Other caries treatment was performed under general anesthesia. As the syndrome involves many different medical problems, special cares should be considered. Dental treatment should be carried out in comprehensive consultation system.

• Journal of the Mineralogical Society of Korea
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• v.5 no.2
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• pp.93-101
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• 1992

Several "Napseok" mines are distribute in the Miryang area where the volcanic rocks are hydrothermally altered. The "Napseok" are pyrophyllite and dickite, with a small amount of silicates such as quartz, illite, tosudite and dumortierite. Other associated minerals are oxides, hydroxides, sulfides, sulfates and phosphates. Pyrophyllite which occurs as 2M polytype exhibits that the basal spacing increases due to dehydroxylation at 750${\circ}C$. Halloysite shows tubular forms. Wavellite is precipitated in fissures during the latest stage of the hydrothermal alteration process. Five mineral zones, that is pyrophyllite-deckite, illite, halloysite, silica, and albite-chlorite zones, are recognized with decreasing alteration degree. Clay minerals were formed by leaching of Si and alkali ions fron the country rocks, considering mineral assemblages, pyrophyllite polytype and thermodynamical data reported in the literature, temperatures of formation of main clay deposits are assumed to be 270 to 350${\circ}C$.

• Journal of Korean Neurosurgical Society
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• v.41 no.3
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• pp.171-176
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• 2007

Objective : The purpose of this study was to characterize the Rolandic fissure[Rf] and was to identify the Rf using the surface bony landmarks which can be usually exposed on craniotomy. Methods : After morphological evaluation of the Rfs using 21 Korean adult formalin fixed cadavers, craniometric measurement was carried out from the surface bony landmarks of nasion, glabella, bregma, and lambda. Results : The Rfs of both hemispheres did not show the mirror image. The Rfs ran forward and downward toward the sylvian fissure keeping the mean angle of $67^{\circ}$ from mid-sagittal line as elongated S-shape in left and the elongated reverse S-shape in right hemisphere. Connections between the Rf and the longitudinal fissure and between the Rf and the sylvian fissure were found in 3 [7.1%] and 2 [4.8%] of 42 hemispheres, respectively. Most Rfs extended superiorly to 2-3mm lateral to the most superomedial surface of hemispheres and extended inferiorly to 3-5mm superior to the sylvian fissures. The mean distances from the nasion, glabella, bregma, and lambda to the most superomedial aspect of the Rf were $18.8{\pm}0.9cm,\;16.6{\pm}0.8cm,\;5.2{\pm}0.6cm$, and $6.9{\pm}1.0cm$, respectively. The mean distance measured between the Rf and the nasion using traditional method was $18.4{\pm}0.6cm$. Conclusion : The distance between the Rf and the nasion roughly correspond within the range of mean 4 mm compared with that measured by the traditional measurement. These data may be more helpful to delineate the Rf after the placement of drapes for craniotomy.

• Economic and Environmental Geology
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• v.31 no.1
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• pp.1-10
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• 1998

Copper mineralization of the Donghwa and Hwanghagsan mines was deposited in hydrothermal quartz veins which filled fissures in Cretacous sedimentary rocks. Ore minerals are pyrite, sphalerite, chalcopyrite, bornite, galena, wittichenite and unidentified Cu-Bi-Pb-Sb-S mineral. On the basis of salinities and homogenization temperatures for fluid inclusions, the Donghwa deposit was deposited from $300^{\circ}C$ to $220^{\circ}C$ with 2.5 to 0.2 wt.% eq. NaCl, and the Hwanghagsan deposits was deposited from $300^{\circ}C$ to $160^{\circ}C$ with 4.0 to 0.0 wt.% eq. NaCl. Evidence of boiling suggests pressure of 170 to 60 bar, these pressures correspond to 1700 m to 600 m. The ${\delta}^{34}S_{H_2S}$ values of the Donghwa deposit (4.8~7.4%) are higher than those of the Hwanghagsan deposit (3.5~4.5%), sulfur isotope compositions indicate that ore fluids partially reacted with meteoric water and wall-rock. Equilibrium thermodynamic interpretation indicates that the temperature versus $fs_2$ of the Donghwa deposit (> $420^{\circ}C$, $10^{-3.2}atm$) is higher condition than that of the Hwanghagsan deposit (> $290^{\circ}C$, $10^{-7.0}atm$). K-Ar ages for biotite granite and quartz porphyry in the study area are 64.7 Ma, and 60.9 Ma, reapectively. Mineralization age using sericite in the Donghwa deposits is 59.8 Ma. Therfore, Copper mineralization in the study area was associated with acidic igneous activity such as biotite granite or quartz porphyry.