• Animal cells and systems
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• v.12 no.1
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• pp.23-33
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• 2008

The Zic family is a group of genes encoding zinc finger proteins that are highly expressed in the mammalian cerebellum. Zic genes are the vertebrate homologue of Drosophila pair-rule gene, odd-paired(opa), which plays important roles in the parasegmental subdivision as well as in the visceral mesoderm development of Drosophila embryos. Recent studies on human, mouse, frog, fish and ascidian Zic homologues support that Zic genes are involved in a variety of developmental processes, including neurogenesis, myogenesis, skeletal patterning, and left-right axis establishment. In an effort to explore possible functions of Zic proteins during vertebrate embryogenesis, we initially examined more detailed expression pattern of zebrafish homologue of zic3(zic3z). zic3z transcripts are detected in the neuroectoderm, neural plate, dorsal neural tube, and brain regions including eye field during early embryonic development. Marker DNA studies found that zic3z transcription is modulated by BMP, Wnt, and Nodal signals particularly in the dorsal and vegetal neuroectoderm at gastrula. Interfering with zic3z translation with zic3z-specific morpholino causes abnormal brain formation and expansion of the optic stalk cells. Retinal ganglion cells(RGCs) undergo abnormal neuronal differentiation. These findings suggest that zic3z defines the dorsal and vegetal neuroectoderm to specify brain formation and retinal neurogenesis during early embryonic development.

• Journal of Environmental Health Sciences
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• v.39 no.2
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• pp.130-137
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• 2013

Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program. Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity. Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%). Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.

• Development and Reproduction
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• v.18 no.1
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• pp.33-41
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• 2014

We investigated the process of yolk absorption in Korean rose bitterling, Rhodeus uyekii, and determined the changes in its morphometric characteristics. The R. uyekii from 1 days post hatching (DPH) to 21 DPH, the eye diameter (ED) was 5.4 at 5 DPH. Thereafter, the ED/total length (TL) ratio increased to 10.7 at 21 DPH (p<0.05). The yolk length (YL) decreased from 95.4 to 1.1 by 21 DPH, and this rate of decrease was greater than that for any other dimension (p<0.05). 12 morphometric dimensions/TL for the R. uyekii were measured at each sampling day from 21 DPH to 170 DPH. At just hatching, the average TL and BW were $6.1{\pm}0.09mm$ and $4.9{\pm}0.07mg$, respectively. At 53 DPH, the average TL was $12.9{\pm}0.28mm$ and the average BW was $14.7{\pm}0.72mg$; the total length growth equation was $TL=5.507e^{0.038t}$ ($R^2=0.916$). Further, the body weight growth equation was $BW=3.3647e^{0.0296t}$ ($R^2=0.9354$). The dimensions with regard to body depth showed the greatest growth rates in the external characteristics of the fish (p<0.05). The patterns of the morphometric characteristics measured in this study can be classified in three ways. The patterns were shown to be increased (y=0.0992x+12.07, $R^2=0.8333$), decreased (y=-0.0569x+42.029, $R^2=0.8395$) or maintained (y=0.005x+18.263, $R^2=0.3678$) from 21 DPH to 170. These results will provide useful indices for the successful rearing of the R. uyekii.

• Journal of Digital Convergence
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• v.15 no.12
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• pp.543-548
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• 2017

$360^{\circ}$panoramic image can give people an unprecedented visual experience, and there are many different ways to make a $360^{\circ}$panoramic image. In this paper, we will introduce two easy and effective methods from those many ways. The first one is through 48 photos to make a $360^{\circ}$panoramic image, the second way is through 6 photos to make a $360^{\circ}$panoramic image. We will compare those methods and tell the audience which one suits themselves. Through those easy design methods introduced above, we can see VR works design became easy and popular, normal people can also make $360^{\circ}$panoramic image, and it promotes the industry of VR image contents.

• Animal cells and systems
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• v.14 no.2
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• pp.137-145
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• 2010

Four specimens of unknown Coilia sp. were collected for the first time from the Yellow Sea in 2008 and compared with Coilia mystus and Coilia nasus. Coilia sp. showed similar morphology to C. mystus and C. nasus, but differed in that its tail was considerably shorter. We conducted an analysis of the morphological and genetic characteristics in an effort to clarify the taxonomic position of Coilia sp. In counts and measurements, Coilia sp. were well distinguished from C. nasus by the number of scutes (42-44 in Coilia sp. vs. 40-45 in C. mystus vs. 45-55 in C. nasus), ratio of dorsal base length to head length (43.4-47.6 vs. 37.9-47.6 vs. 33.0-41.0), and eye length to head length (19.2-20.8 vs. 17.0-22.4 vs. 13.8-18.2). In caudal skeleton of Coilia sp., urostyle, hypural and epural bones were not observed; instead of them, caudal fin rays were supported by the last vertebra, neural and haemal spines' extension. The molecular phylogenetic relationship was analyzed using 414 base-pair 12S rRNA mitochondrial DNA sequences. The Kimura-2-parameter distance between Coilia sp. and C. mystus was 0.3%, but was 1.3% between Coilia sp. and C. nasus. Both the neighbor-joining tree and maximum-likelihood tree showed that Coilia sp. are closely clustered with C. mystus. Therefore, our results suggest that the Coilia sp. may be a deformed fish of C. mystus.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.9
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• pp.1119-1129
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• 2011

Shot-peening effects on the fatigue behavior of bearing steel were investigated under the high cyclic loading. Hourglass shape specimens were made of bearing steel(JIS-SUJ2) for rotary bending fatigue tests. Two kinds of treatments were performed : a heat treatment and a shot-peened surface treatment after the heat treatment. The fracture surfaces of specimens were classified into two types of fracture mode : the surface fracture mode induced by a surface defect and the internal fracture mode induced by a nonmetallic inclusion. Inclusion depth and shape affected considerably the fatigue life. Shot-peening treatment improved much the fatigue life of the bearing steel under low and high levels of cyclic loads. Probabilistic-stress-life (P-S-N) curves were suggested for the reliable fatigue life estimation of the improved bearing steel.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1089-1101
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• 2006

Following conclusions are drawn from study about Yukmigiwhangwon through referring to literatures and reviewing in the point of Hyungsang medicine. Yukmigiwhangwon was prescribed by Jeon Eul in order to cure five kinds of flaccidity of infants, but after since then it has been basically applied to symptoms which was caused by deficiency of the kidney not only infants but also adult. The deficiency of kidney is the lack of vital essence and body fluid stored in kidney, it happens because infants are born in the conditions of lack of receiving in the womb. And it happens because adults infringe the rules of life, especially the sexual life. Main symptoms of the poverty of renal functions are emptiness of the brain marrow, dizziness, forgetfulness, tinnitus, deafness, vertigo and dim eyesight, insomnia, the low back and knees aching and limping, heat on the legs, tibia aching, nocturnal emission, dry mouth, reddened tongue and little coating or non coating of the 'tongue, weak blood meridians. the treating method is nourishing Eum and supplementing kidney. In Dongeuibogam Yukmigiwhangwon is mentioned in the parts of vital essence, blood, voice, kidney, urine, eye, ear, the low back, hair, fire, exhaustion syndrome, cough, polydipsia, infant, etc. The shapes which Yukmigiwhangwon is applied to are the Dam Body Doing deficiency of Eum due to excess of Yang, man, infant, Jung type, Fish group, reverse triangular shape, big headed man, big eared man, big mouthed man, man having prominent cheekbones, man having long waist, man having big hips, man with thick hair or white hair, man with bald on the head, etc. In color it is applied to darkish complexion, flushed tip of the nose, or flushed cheek bones. Through inquiring into the clinical cases on the points of Hyungsang medicine Yukmigiwhangwon is efficacious cure to lumbago, symptoms of tendons and bones, symptoms of eyes and ears, symptoms of respiratory organs, dermatopathia, headache, polydipsia, urinary disorders, etc.

• Journal of the Optical Society of Korea
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• v.17 no.4
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• pp.336-343
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• 2013

Recently various types of driver assistance systems have been used for automobiles. In 2008, the U.S Congress passed a law which required that most cars be equipped with devices to warn objects behind the vehicle. Because of that, market of rear view cameras is expected to rise dramatically. Therefore many suppliers try to provide a wide angle camera for car makers. But a high distortion is caused by the wide angle might result in lower image quality. In order to improve the image quality, normally we use an algorithm to correct a distortion. Though we can improve the distorted image by correction algorithm, we must pay more cost to use it. In this paper, we propose a new optical system reducing a distortion in contrast to a conventional lens without cost. In other words, we can see only an area of interest. That is similar to reducing a field of view. Using a new optical system, we can get a less distorted image. In order to view an area of interest, we introduce an off axis optical system having refractive surfaces and reflective surfaces. In this paper, we describe the results of design and, evaluation of an off axis wide angle compact imaging system. In comparison to conventional wide angle lens, we can get the improvement of MTF, distortion, and lateral color aberrations. And we also can reduce a total cost because we don't need the outer apparatus or bracket to mount on the car.

• Journal of the Korean Applied Science and Technology
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• v.39 no.3
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• pp.442-453
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• 2022

Various animal models have been used to study the efficacy and action mechanisms of human diseases and medicines. Zebrafish (Danio rerio) is increasingly and successfully used as a model in translational research on human diseases. We obtained necessary information from original peer reviewed articles published in scientific 54 journals, such as Pubmed, Google Scholar, Scopus scince their inception until Dec, 2020 using the following terms: zebrafish animal models, herbal medicine, in vivo screening. In this review, we discuss the recent contributions of the various zebrafish disease models to study of herbal medicines. We focused on cancer, eye diseases, vascular diseases, diabetes and its complications, and cosmetic dermatology. We also highlight the molecular action mechanisms of medicines against these disease, demonstrated using zebrafish embryo. Zebrafish can be pivotal in bridging the gap from lab to clinical bedside. It is used as a model to understand human diseases pathogenies with further scope for drug development. Furthermore, zebrafish can reduce rat and mouse animals in biomedical research.

• Korean Journal of Ichthyology
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• v.35 no.4
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• pp.366-371
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• 2023

A shrimp goby, Amblyeleotris japonica is reported firstly from Korea, based on a single specimen (70.3 mm in SL) collected at a depth of 14 m in the southern Jejudo Island. The species is characterized by having a lower number of scales in longitudinal series, a rather compressed body, anterior limit of opercular opening located below between posterior margin of eye and preopercle, second dorsal fin with a single spine and 13 soft rays, anal fin with a single spine and 14 soft rays, and five brownish vertical bands on lateral body between head and caudal peduncle when fresh. New Korean names, "Se-u-but-i-mang-dug-sog" and "Bulg-eun-dong-gal-se-u-but-i-mang-dug", are proposed for the genus and the species, respectively.