• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.38-38
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• 2003

The electrical properties of neurons are produced by the coordinated activity of ion channels (Hille, 1992). $K^{+}$ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance $Ca^{2+}$-activated $K^{+}$ (S $K_{Ca}$ ) channels are involved in modulating the slow component of afterhyperpolarization (AHP) (Kohler et al., 1996). Here we examine whether rat type 2 S $K_{Ca}$ (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intraburst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15, Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic S $K_{Ca}$ channels play an important role in regulating the filing pattern and the shape of the action potential.ntial.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.3
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• pp.297-305
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• 1998

This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of the commissural pathway. Cells in control group typically fired in a tonic discharge mode with an average firing frequency of $2.4{\pm}0.9$ Hz. Neuron in MK-801 treated group (0.2 mg/kg, i.p.) had an average input resistance of $3.28{\pm}5.7\;M{\Omega}$ and a membrane time constant of $7.4{\pm}1.8$ ms. These neurons exhibited $2.4{\pm}0.2$ ms spike durations, which were similar to the average spike duration recorded in the neurons of the control group. Slightly less than half of these neurons were firing spontaneously with an average discharge rate of $2.4{\pm}1.1$ Hz. The average peak amplitude of the AHP following the spikes in these groups was $7.4{\pm}0.6$ mV with respect to the resting membrane potential. Cells in MK-801 and lidocaine treated group (5 mg/kg, i.c.v.) had an average input resistance of $3.45{\pm}6.0\;M{\Omega}$ and an average time constant of $8.0{\pm}1.4$ ms. The cells were firing spontaneously at an average discharge rate of $0.6{\pm}0.4$ Hz. Upon depolarization of the membrane by 0.8 nA for 400 ms, all of the tested cells exhibited accommodation of spike discharge. The most common synaptic response contained an EPSP followed by early-IPSP and late-IPSP. Analysis of the voltage dependence revealed that the early-IPSP and late-IPSP were putative $Cl^--and\;K^+-dependent$, respectively. Systemic injection of the NMDA receptor blocker, MK-801, did not block synaptic responses to the stimulation of the commissural pathway. No significant modifications of EPSP, early-IPSP, or late-IPSP components were detected in the MK-801 and/or lidocaine treated group. These results suggest that MK-801 and lidocaine manifest their CNS effects through firing pattern of hippocampal pyramidal cells and neural network pattern by changing the synaptic efficacy and cellular membrane properties.

• Journal of Environmental Science International
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• v.14 no.8
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• pp.801-810
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• 2005

The phosphor and ITO(Indium Tin Oxide) films for video phone tube (VPT) were simply prepared by the screen printing and thermal transfer methods. The increasing order of thermal firing of acrylic binder for phosphor and ITO was M6003 < M6664 < A/A 1919 < M500l < M670 1 and all mass of binders were perfectly decomposed at lower temperature than $400^{\circ}C.$ After thermal firing of phosphor paste, the residual of binder on the surface of phosphor could not be found by SEM. Aerosil as thickner provides the thixotropy property for phosphor paste but decrease the brightness of phosphor screen as residual after thermal firing. Since the thixotropy of M5001 binder without aerosil was shown and the storage modulus of phosphor paste by increasing the angular frequency was not nearly changed and the decrease of the storage modulus of phosphor paste by increasing the strain was remarkably shown. It was possible to prepare the phosphor paste which was predominant in the plate separation and the reproduction of pattern after the screen printing. Since the addition of dispersing agent to improve the printing process decreases the electrical conductivity and light transmission of ITa film, it could be found to be necessary the development of binder for phosphor paste that decreases the amount of dispersing agent possibly and does not use the aerosil as additive.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.05a
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• pp.558-559
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• 2007

The detection of neural spike activity is a technical challenge that is very important for studying many types of brain function. On temporal recordings of firing events or interspike interval series of neural signal, spike pattern correspond to action will be repeated in the presence of background noise and they need to be detected to develop higher applications. We will introduce new method to find these patterns in raw multitrial data and is tested on surrogate data sets with the main target to get meaningful analysis of electrophysiological data from microelectrode arrays (MEA).

• Journal of the military operations research society of Korea
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• v.3 no.1
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• pp.97-107
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• 1977

This report examines several models, such as random or area bombardment, salvo fire and pattern fire, for the computation of target coverage when multiple rounds are fired at a target. Fractional kill of a fragment sensitive target by a fragmenting projectile as a function of the number of rounds fired is compared for two salvo fire models. The first is a standard salvo fire model in which N rounds are fired at the same aim point, in the second model single kill probability is computed for a fragment sensitive target and then fractional kill from the firing of N rounds is computed according to the assumption that the effects of each round are independent. Because the method of solution becomes very laborious for large patterns, this report gives a method only for the case of evaluating the effectiveness of stick and trianglar pattern fire. The need for the sophisticated and complicated target coverage models is demonstrated by the results of computations performed in this report.

• Journal of the Korea Institute of Military Science and Technology
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• v.13 no.4
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• pp.511-519
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• 2010

This paper presents the modeling and validation of a pile-driver breech fatigue testing system model to replicate actual high pressure in a large caliber gun barrel. A hysteresis damping function was incorporated in the nonlinear impact force model. Test of real pile-driver breech fatigue testing system had been performed for model validation. Comparison of the experimental result and model simulation during impact were made. Numerical studies were performed to evaluate how the actual chamber pressure pattern in the live firing of gun barrel was affected by parameters' variation. Some of the parameters simulated included input velocity, damping coefficient and stiffness. As a result, a variety of actual chamber pressure pattern could be reproduced and controlled through current simulation model.

• Fire Science and Engineering
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• v.23 no.6
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• pp.98-110
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• 2009

The burned patterns of fire are changed very diversely according to the direction of wind, conditions of combustibles, shape of buildings and so on in the fire scenes. And careful attentions are required on the determining of ignition point and fire causes. In this study, we examined that the burned pattern of fuel controlled fires and ventilation controled fires that impose a heavy burden on fire investigators, carbonized marks of floor, formed by flammable liquids, and combustion marks of falling firing materials through the fire cases. We suggest a proper fire investigation method.

• Journal of the Korean Ceramic Society
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• v.46 no.3
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• pp.313-316
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• 2009

A zinc borosilicate glass having a low softening temperature of $490^{\circ}C$ has been investigated as a protective layer for Ag patterns against chemical reactions with a $I^-/I_3^-$ electrolyte in dye-sensitized solar cells (DSSCs). A thick glass layer was prepared by the typical screen printing and firing processes to obtain a final thickness of ${\sim}5{\mu}m$. The chemical leaching performance of the glass layer in the electrolyte revealed that the reactive Ag pattern can be significantly protected by utilizing the low softening protective layer. The electrical resistance of the FTO-coated glass substrate was effectively maintained at a low value of ${\sim}27{\Omega}$ as long as the glass layer was well densified at a sufficiently high temperature of ${\sim}520^{\circ}C$. The transmittance of the layer was near 60%, depending on the firing temperature of the glass layer.

• Journal of Biomedical Engineering Research
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• v.36 no.5
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• pp.221-227
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• 2015

In this study, Multi-Array Electrodes (MAE) and Programmable Multi-channel Electrical Stimulator (PMES) were implemented for firing Trigger Points (TPs) of the patient with Myofascial Pain Syndrome (MPS). MAE has 25 Ag/AgCl electrodes arranged in the form of array ($5{\times}5$) fabricated with flexible pad, which are applicable to be easy-attached to curved specific region of the human body. PMES consisted of 25 channels. Each channel was to generate various electric stimulus patterns (ESPs) by changing the mono-phasic or bi-phasic of ESP, On/Off duration of ESP, the interval between ESP, and amplitude of ESP. PMES hardware was composed of Host PC, Stimulation Pattern Editing Program (SPEP), and Multi-channel Electrical Stimulator (MES). Experiments were performed using MAE and PMES as the following. First experiment was performed to evaluate the function for each channel of Sub- Micro Controller Unit (SMCU) in MES. Second experiment was conducted on whether ESP applied from each channel of SMCU in PMES was focused to the electrode set to the ground, after applying ESP being output from each channel of SMCU in PMES to MAE.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.1
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• pp.195-200
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• 1996

In this paper, to eliminate some selected harmonics, we implement PWM inverter which can be able to control in real-time. Using walsh function, which is one of the ordered orthogonal functions, we propose a new method to calculate firing angles, and implement logic circuits which can be calculate firing angles in real-time and be applicable to 1- and 3-phase circuits. Finally, using simulation circuits which accept the outputs obtained from the implemented logic circuits as the inputs, we confirmed the characteristics in steady state of the proposed method for PWM inverter.