• 대한두경부종양학회지
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• 제15권2호
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• pp.177-181
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• 1999

Objective: The clinical significance of mass screening for thyroid carcinoma remains unclear. This study was carried out to clarify the value of mass screening for thyroid carcinoma. Materials and Methods: From December 1997 through July 1998, a total of 1,401 subjects who were enrolled to receive breast screening or follow-up examination for breast cancer were included in this study. Thyroid glands were examined by 10 MHz ultrasonography by one experienced radiologist. The patients with thyroid nodules were classified into 2 groups according to their potential risk of malignancy by ultrasonographic findings(high-risk : hypoechogenicity, microcalcification, irregular margin, taller than wider shape). High-risk patients were advised to undergo fine-needle aspiration biopsy and thyroidectomy. The characteristics of the thyroid cancers detected by ultrasonographic mass screening were compared by those of clinical thyroid cancer excluding male patients during the same period. Results: Thyroid nodules were detected in 353(25.2%) of the subjects and 259(73.4%) were listed in the low-risk group and 94(26.6%) in high-risk group. Among 94 patients in the high-risk group, 43 underwent thyroidectomy and 37 turned out to have thyroid carcinomas. Thus, the detection rates for carcinoma were 2.6% of all subject, 10.5% of the detected nodules, 36.4% of the high risk women and 86.0% of the operated cases. The tumor size was significantly smaller in the mass-screening group than in the clinical cancer group(p<0.05). However, there was no statistical differences between two groups in the prevalences of neck node involvement and extracapsular invasion and the patients distributions by AMES score, MACIS score and TNM stage. Conclusion: Ultrasonogrpahic mass screening may be useful for the early detection of thyroid carcinoma in women who are scheduled to have breast examination.

• 대한임상검사과학회지
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• 제36권1호
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• pp.38-42
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• 2004

Because of the lack of resources on the importance of cell block, the diagnosis of cytologic specimen has been overlooked. Out of 1,243 cases of non-gynecologic cytology specimen, about 87.1% has been proven to be diagnostically useful. About 0.9% of those were rendered diagnostic by cell block alone. If cell block was not made it could have resulted in misdiagnosis. The effect on making cell block might not be directly linked to the patient but to the pathologist, it can be a helpful secondary tool in lowering the chance of giving false negative results hence. Giving the patient the opportunity of an adequate treatment. This study has proven that cell block has diagnostic value in non-gynecologic cytology. We are doing our best to increase the production rate of cell block and to improve the quality of cytology smears and cell block, so that we can increase the accuracy of diagnosis.

• Advances in pediatric surgery
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• 제6권2호
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• pp.95-99
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• 2000

Thyroid carcinoma is relatively rare in children. Eight cases of thyroid carcinoma were among 18 patients operated upon for thyroid tumors at Pediatric Surgery, Asan Medical Center in 11 years' period between 1989 and 2000. Five patients were boys and three were girls. The age distribution ranged from 10 to 14 years with a median age of 11.6 years. We studied clinical presentations, diagnostic workup, pathology, treatment, and follow-up (recurrence, mortality, and survival). All patients presented with anterior neck mass but one with multiple cervical lymph nodes enlargement. Familial history of thyroid cancer was seen in one case. All patients had a cold nodule by 1-131 thyroid scan. Fine needle aspiration (FNA) biopsy was performed in all patients. The right lobe was involved in four patients and the left lobe in two. Two had both lobes involvement. Pathologically, six cases were papillary carcinoma, one was follicular carcinoma, and one insular carcinoma. Four patients underwent unilateral lobectomy and isthmectomy. Total thyroidectomy was performed in three patients. The insular carcinoma case was preoperatively diagnosed as follicular neoplasm by FNA. After confirmation of the pathology by initial right thyroid lobectomy, total thyroidectomy was subsequently done. Cervical lymph node metastases were presented in three cases (37.5%), and lung metastasis in two cases (25%). Three patients received postoperative I-131 ablation. After a median follow-up of 53 months, all patients were alive without evidence of recurrence. In conclusion, thyroid carcinoma in children is frequently associated with lymph nodes involvement and distant metastasis, however, the prognosis is relatively good.

• 한국임상수의학회지
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• 제22권3호
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• pp.288-295
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• 2005

Five dogs at the age of 2-13 years, with variant respiratory signs like as dry cough, dyspnea, exercise intorelance and lameness were presented. On thoracic radiographs, all dogs had abnormalities such as soft tissue density, round mass image, increased pulmonary infiltration and pleural effusion. All dogs were diagnosed as adenocarcinoma on cytopathologic examinations by fine needle aspiration with ultrasound guidance. Computed tomography was performed in three cases to evaluate clinical stage. Primary papillary adenocarcinoma was confirmed after necropsy in one case.

• 한국임상수의학회지
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• 제25권1호
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• pp.48-51
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• 2008

심한 복부팽만과 호흡 곤란 증세를 보이는 10살의 요크셔 테리어가 내원하였다. 방사선과 초음파 검사로 우심방과 주폐동맥에 인접한 대동맥 주위로 고에코성의 큰 종괴를 확인하였다. 확인된 종양은 심장 기저부 주위에 존재하는 확장성 종양으로 삼첨판 역류, 대량의 복수와 간정맥 확장을 동반한 간종대와 같은 우심 부전 소견을 보였다. 전산화단층촬영법으로 확인된 이 종괴는 전대정맥에서 후대정맥까지 위치한 심장 기저부 주위에 존재하는 크고 비균질성을 띤 종괴였다. 이 종괴는 전대정맥, 심장, 후대정맥 및 흉벽까지 침습되어 있었으며, 세침흡입술을 통한 잠정적인 진단은 Chemodectoma였다. 본 증례로 다양한 진단 영상학적 수단을 통한 심기저부 종양에 대한 특징 및 역할을 알 수 있었다.

• 한국임상수의학회지
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• 제29권5호
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• pp.400-403
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• 2012

10년령의 수컷 푸들이 복부팽만, 등쪽 몸통 부위 탈모, 간비대와 혈청 알칼리인산분해효소의 지속적인 상승으로 전북대학교 수의과대학 동물병원에 내원하였다. 간 생검 및 미세침흡인세포 검사법과 PAS 염색을 실시한 결과 공포성 간병증 및 간세포에 글리코겐이 침착된 것을 확인 하였다. ACTH 자극 시험 실시 전 후 코티솔 및 부신과 관련된 성 호르몬의 농도를 측정하였다. 측정결과 안드로스텐디온, 프로게스테론 및 수산화 프로게스테론의 상승을 관찰할 수 있었으며 코티솔농도는 정상 범위내에 존재하였다. 진단은 성호르몬과 관련된 비정형의 부신피질 기능 항진증으로 내렸으며 치료는 트릴로스탄으로 하였다. 치료 8주 후 등 부위의 탈모를 포함한 임상증상들이 개선되었다.

• 한국임상수의학회지
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• 제29권2호
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• pp.173-176
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• 2012

6 년령의 수컷 시츄 견이 복부 팽만을 주 호소로 내원하였다. 복부 방사선 검사와 초음파 검사에서 많은 양의 액체를 포함하고 있는 연부조직 밀도의 종괴가 발견되었다. 종괴의 세포학적 검사를 위해 초음파 유도 세침흡인을 실시하였으며, 세포학적 검사 결과 섬유화가 동반된 육아조직이 의심되었다. 종괴의 확인과 수술적 제거를 위해 진단적 개복술을 실시하였다. 개복시 원위 공장부위에 인접한 장간막의 뿌리에서 유래한 종괴가 확인되었고 종괴는 원위공장 부위에 부착되어 있었다. 종괴와 부착 부위의 분리가 어려웠기 때문에 종괴와 부착 부위를 모두 수술적으로 제거하였으며 장문합술을 실시하였다. 종괴의 조직병리학적 검사 결과 저 악성도 점액육종이 진단되었으며, 종양 세포는 알시안 블루 염색에 양성 반응을 보였다. 추가로 실시한 Ki67 항체를 이용한 면역조직화학 염색 결과 Ki-67 지수는 2.5 였다. 환축은 절제술 실시 후 현재까지 30개월 동안 전이와 재발의 증거 없이 살고 있다.

• 한국임상수의학회지
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• 제28권3호
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• pp.303-306
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• 2011

프로게스테론 제제를 복용해 오던 12세령의 암컷 잡종 견이 복부 종괴의 평가를 위해 내원하였다. 복부 초음파 검사와 방사선 검사를 통해 확장된 자궁과 관련된 종괴를 확인하였다. 혈청 화학 검사에서는 고글로불린혈증이 나타났으며, 전기영동 검사상 급성 염증 패턴으로 판단되었다. 초음파 유도하에 종괴의 세침흡인을 실시하였으며 세포학검사를 통해 선암종이 진단되었다. 탐색적 개복을 실시하였으며 장구체의 종괴를 발견하여 자궁과 함께 종괴를 제거하는 수술을 실시하였다. 조직병리 검사결과 자궁 선암종이 진단되었으며 종양세포의 에스트로겐 수용체와 프로게스테론 수용체 발현 여부 평가를 위해 면역 염색을 실시하였다. 면역염색결과 종양세포는 두 항체에 대해 음성 결과를 보였으며, 정상 간엽세포에서만 양성 결과가 나타났다. 수술 후 1주일에 재검을 위해 내원하였는데 컴퓨터 단층촬영 검사결과 폐 전이가 확인되었다. 환자는 수술 후 40일경에 폐사하였다.

• 한국임상수의학회지
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• 제26권3호
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• pp.263-267
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• 2009

A 9-year-old, female, Maltese Dog(2.15 kg of body weight) was referred to the Veterinary Medical Teaching Hospital, Chungnam National University with cervical masses, abdominal masses and petechia. Physical examination showed masses in mandibular, prescapular, inguinal, popliteal lymph node and abdominal subcutaneous hemorrhage. This case was diagnosed as the multicentric lymphoma by physical examination, laboratory examination, radiography, ultrasonography, CT, fine needle aspiration and histopathologic examination. This dog was treated by low-budget protocol with lomustine and prednisolone. The dog show that response duration and survival time is 143days and 263 days, respectively.

• 대한수의학회지
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• 제45권3호
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• pp.445-450
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• 2005

A 1.35 kg, three-year-old, female, Yorkshire terrier was referred to the veterinary medical teaching hospital of Chungnam National University with an alopecia, scale, polydipsia and polyuria. During hospitalization, the patient revealed swelling and pain of all four foot pads. The hematology indicated nonregenerative anemia. Blood serum chemistry revealed elevation of BUN, serum creatinine and phosphorus contents. Radiographs of feet revealed increased radiodensity in the soft tissue of the foot pad. In ultrasonographs of abdomen, kidneys showed diffusely echodense renal cortex with loss of the normal corticomedullary boundary. Fine needle aspiration of the swollen pad cysts contained a amorphous basophillic chalky, white and pasty material. The culture result was negative for bacteria. In conclusion, it was diagnosed as metastatic calcinosis circumscripta secondary to chronic renal failure. An oral charcoal absorbent and aluminum hydroxide were used to treat this condition. After six weeks treatment, hyperphosphatemia was corrected and metastatic calcinosis circumscriptawas not presented any more.