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Stress concentration factors test of reinforced concrete-filled tubular Y-joints under in-plane bending

  • Yang, Jun-fen;Yang, Chao;Su, Ming-zhou;Lian, Ming
    • Steel and Composite Structures
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    • 제22권1호
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    • pp.203-216
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    • 2016
  • To study the stress concentration factors (SCFs) of concrete-filled tubular Y-joints subject to in-plane bending, experiments were used to investigate the hot spot stress distribution along the intersection between chord and brace. Three concrete-filled tubular chords forming Y-joints were tested with different reinforcing components, including doubler-plate, sleeve, and haunch-plate reinforcement. In addition, an unreinforced joint was also tested for comparison. Test results indicate that the three different forms of reinforcement effectively reduce the peak SCFs compared with the unreinforced joint. The current research suggests that the linear extrapolation method can be used for chords, whereas the quadratic extrapolation method must be used for braces. The SCF is effectively reduced and more evenly distributed when the value of the axial compression ratio in the chord is increased. Furthermore, the SCFs obtained from the test results were compared to predictions from some well-established SCF equations. Generally, the predictions from those equations are very consistent for braces, but very conservative for concrete-filled chords.

Anti-VEGF Therapy with Bevacizumab - Limited Cardiovascular Toxicity

  • Yu, Jing;Cao, Xu-Fen;Zheng, Ye;Zhao, Rong-Cheng;Yan, Li-Qiu;Zhao, Lei;Wang, Jia-Wang
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권24호
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    • pp.10769-10772
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    • 2015
  • Purpose: This analysis was conducted to evaluate cardiovascular toxicity of commonly used anti-VEGF therapeutic agent, bevacizumab, in treating patients with cancer. Methods: Clinical studies evaluating the efficacy and safety of bevacizumab-based regimens on response and safety for patients with cancer were identified using a predefined search strategy, allowing cardiovascular toxicity and other side effects of treatment to be estimated. Results: In bevacizumab based regimens, 4 clinical studies including 282 patients with advanced cancer (including gliomas, cervical, breast and ovarian cancer) were considered eligible for inclusion. These bevacizumab-based regimens included docetaxel, irinitecan and carboplatin. Systematic analysis suggested that, of 282 patients treated by bevacizumab based regimens, hypertension and thrombo-embolism occurred in 2.5% (7/282), while only 3 patients reported cardiovascular events (1.1%). No treatment related death occurred in bevacizumab based treatment. Conclusion: This systemic analysis suggests that bevacizumab based regimens are associated with reasonable and accepted cardiovascular toxicity when treating patients with gliomas, cervical, breast and ovarian cancer.

Optimization of Triple Response Systems by Using the Dual Response Approach and the Hooke-Jeeves Search Method

  • Fan, Shu-Kai S.;Huang, Chia-Fen;Chang, Ko-Wei;Chuang, Yu-Chiang
    • Industrial Engineering and Management Systems
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    • 제9권1호
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    • pp.10-19
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    • 2010
  • This paper presents an extended computing procedure for the global optimization of the triple response system (TRS) where the response functions are nonconvex (nonconcave) quadratics and the input factors satisfy a radial region of interest. The TRS arising from response surface modeling can be approximated using a nonlinear mathematical program involving one primary (objective) function and two secondary (constraints) functions. An optimization algorithm named triple response surface algorithm (TRSALG) is proposed to determine the global optimum for the nondegenerate TRS. In TRSALG, the Lagrange multipliers of target (secondary) functions are computed by using the Hooke-Jeeves search method, and the Lagrange multiplier of the radial constraint is located by using the trust region (TR) method at the same time. To ensure global optimality that can be attained by TRSALG, included is the means for detecting the degenerate case. In the field of numerical optimization, as the family of TR approach always exhibits excellent mathematical properties during optimization steps, thus the proposed algorithm can guarantee the global optimal solution where the optimality conditions are satisfied for the nondegenerate TRS. The computing procedure is illustrated in terms of examples found in the quality literature where the comparison results with a gradient-based method are used to calibrate TRSALG.

PREDICTING CORPORATE FINANCIAL CRISIS USING SOM-BASED NEUROFUZZY MODEL

  • Jieh-Haur Chen;Shang-I Lin;Jacob Chen;Pei-Fen Huang
    • 국제학술발표논문집
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    • The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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    • pp.382-388
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    • 2011
  • Being aware of the risk in advance necessitates intricate processes but is feasible. Although previous studies have demonstrated high accuracy, their performance still leaves room for improvement. A self-organizing feature map (SOM) based neurofuzzy model is developed in this study to provide another alternative for forecasting corporate financial distress. The model is designed to yield high prediction accuracy, as well as reference rules for evaluating corporate financial status. As a database, the study collects all financial reports from listed construction companies during the latest decade, resulting in over 1000 effective samples. The proportion of "failed" and "non-failed" companies is approximately 1:2. Each financial report is comprised of 25 ratios which are set as the input variable s. The proposed model integrates the concepts of pattern classification, fuzzy modeling and SOM-based optimization to predict corporate financial distress. The results exhibit a high accuracy rate at 85.1%. This model outperforms previous tools. A total of 97 rules are extracted from the proposed model which can be also used as reference for construction practitioners. Users may easily identify their corporate financial status by using these rules.

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${\ll}$상한론(傷寒論)${\gg}$ 궐음병(厥陰病) 제강(提綱)의 침구학적(鐵灸學的) 분경(分經) 및 정증(定證)의 운용(運用) 방법(方法)에 관(關)한 연구(硏究) (The Study on Acupuncture Operation Method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經變證))

  • 정미경;오세형;윤종화
    • Journal of Acupuncture Research
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    • 제23권4호
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    • pp.39-47
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    • 2006
  • Objectives : The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu- Jing-Bian-Zheng(六經辯誇). Methods : Based on tile documents quoted in ${\ll}$Sang Hang Za Bing Lun Xu Wen(傷寒雜病論 序文)${\gg}$ of 'Zhang, Zhong-Jing(張仲景)', the relativity of the theory of Jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused Jue-yin-Bing(厥陰病) to form was studied on the basis of acupuncture medicine publications and e commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results : 1. ${\ll}$Sang Han Lun${\gg}$ Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) of ${\ll}$Su Wen Re Lun(素問 熱論)${\gg}$. In addition, the summary of Liu-Jing-Bing became the general pnnciple of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫癩) and Eating(雜病). 2. Most commentators of ${\ll}$Sang Han Lun${\gg}$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$ interpreted the Jue-Yin-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the Sim Po and Liver meridian. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treaaent of Jue-Yin-Bing is treated with the needle from the point of view of Bing-fheng-Lun-fhi(辨證論治) with the basis of the important region of acupuncture of the Sim Po of meridian and Liver of meridian.

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(${\ll}$상한론(傷寒論)${\gg}$ 소양병(少陽病) 제강(提綱)의 침구학적(鍼灸學的) 분경(分經) 및 정증(定證)의 운용(運用) 방법(方法)에 관(關)한 연구(硏究) (The Study on Acupuncture Operation Method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辯證))

  • 조정식;이준범;황민섭;윤종화
    • Journal of Acupuncture Research
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    • 제24권3호
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    • pp.119-126
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    • 2007
  • Objectives: The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辯證). Methods: Based on the documents quoted in ${\ll}$Sang Han Za Bing Lun ${\cdot}$ Xu Wen(傷寒雜病論 ${\cdot}$ 序文)${\gg}$ of "Zhang, Zhong-Jing(張仲景)", the relativity of the theory of Jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused So-Yang-Bing(少陽病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results: 1. ${\ll}$Sang Han Lun${\gg}$ Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) of ${\ll}$ Su Wen ${\cdot}$ Re Lun(素問 ${\cdot}$ 熱論)${\gg}$. In addition, the summary of Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili and Zabing(雜病). 2. Most commentators of $\ll$Sang Han Lun$\gg$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$interpreted the So-Yang-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the bladder meridian that oversees the skin of the human body. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treatment of So-Yang-Bing is treated with the needle from the point of view of bing-Zheng-Lun-Zhi(辯證論治) with the basis of the important region of acupuncture of the Triple Energizer meridian and Gallbladder of meridian.

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${\ll}$상한론(傷寒論)${\gg}$ 소음병(少陰病) 제망(製網)을 이용(利用)한 침구학적(鍼灸學的) 정증(定證) 및 분경(分經)의 운용(運用) 방법(方法)에 관한 연구(硏究) (The Study on Acupuncture Operation Method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辯證) - Based on the Study of So-Yin-Bing(少隆病) -)

  • 이성수;황민섭;이준범;윤종화
    • Journal of Acupuncture Research
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    • 제22권5호
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    • pp.21-28
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    • 2005
  • Objectives : The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辯證). Methods : Based on the documents quoted in ${\ll}$Sang Hang Za Bing Lun Xu Wen(傷寒雜病論 序文)${\gg}$ of 'Zhang, Zhong-Jing(張仲景)', the relativity of the theory of Jin-Mai(硬脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-Jing-Bing(六經病), the origin and implication that caused so-Yin-Bing(少陰病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results : 1. ${\ll}$Sang Han Lun${\gg}$ Liu-Jing-Bian-Zheng has succeeded and was developed based on Liu-Jing-Fen-Zheng(六經分證) Of ${\ll}$Su Wen Re Lun(素問 熱論)${\gg}$. In addition, the summary of Liu-Jing-Bing became the general principle of Fen-Jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili(疫?) and Eating(雜病). 2. Most commentators of ${\ll}$Sang Han Lun${\gg}$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$ interpreted the so-yin-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the Heart and Kidney meridian. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treatment of So-yin-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the heart of meridian Kindey of meridian.

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(${\ll}$)상한론(傷寒論)${\gg}$ 양명병(陽明病) 제강(提綱)의 침구학적(鍼灸學的) 분경(分經) 및 정증(定證)의 운용방법(運用方法)에 관(關)한 연구(硏究) (The Study on Acupuncture Operation Method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-Jing-Bian-Zheng(六經辨證);Based on the Study of Yang-Ming-Bing(陽明病))

  • 김효정;정미경;이승우;백성욱;정기진;정웅채;황민섭;윤종화
    • Journal of Acupuncture Research
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    • 제24권2호
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    • pp.203-210
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    • 2007
  • Objectives: The following study was undertaken in order to seek the acupuncture operation method of ${\ll}$Sang Han Lun(傷寒論)${\gg}$ Liu-jing-Bian-Zheng(六經辨證) Methods : Based on the documents quoted in ${\ll}$Sang Han Lun ${\cdot}$ Xu Wen(傷寒雜病論 ${\cdot}$ 序文)${\gg}$ of "Zhang, Zhong-jing(張仲景)", the relativity of the theory of jing-Mai(經脈) and Liu-Jing-Bian-Zheng of convalescence, and from the Liu-jing-Bing(六經病), the origin and implication that caused Yang-Ming-Bing(陽明病) to form was studied on the basis of acupuncture medicine publications and the commentary writing of ${\ll}$Sang Han Lun${\gg}$. Results: 1. ${\ll}$Sang Han Lun${\gg}$ Liu-jing-Bian-Zheng has succeeded and was developed based on Liu-jing-Fen-Zheng(六經分證) of ${\ll}$Su Wen ${\cdot}$ Re Lun(素問 ${\cdot}$ 熱論)${\gg}$. In addition, the summary of Liu-jing-Bing became the general principle of Fen-jing(分經) and Ding-Zheng(定證) that may be applicable to Fenghan(風寒), Wenre(溫熱), Lili and Zabing(雜病). 2. Most commentators of ${\ll}$Sang Han Lun${\gg}$ in the Song, Ming and Ching Dynasties of ${\ll}$Sang Han Lun${\gg}$ interpreted the Yang-Min-Bing in physiological and pathological aspects of Rong-Wei(榮衛) as the disease of the Stomach meridian and Large Intestine meridian. 3. From the Liu-Jing-Bing of ${\ll}$Sang Han Lun${\gg}$, the region of acupuncture treatment of Yang-Min-Bing is treated with the needle from the point of view of Bing-Zheng-Lun-Zhi(辨證論治) with the basis of the important region of acupuncture of the Stomach of meridian ${\cdot}$ Large Intestine of meridian.

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Postmortem Proteolysis of Breast and Leg Muscles from Taiwan Colored Chickens and Silkie Bantams

  • Tsai, Shih-Fen;Lin, Chia-Ying;Lu, Jin-Jenn;Chou, Rong-Ghi R.
    • Asian-Australasian Journal of Animal Sciences
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    • 제19권5호
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    • pp.739-743
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    • 2006
  • Postmortem proteolysis of breast (BM) and leg (LM) muscles from Taiwan colored chickens (TCC) and silkie bantams (SB) at $5^{\circ}C$ were compared. Myofibrils were prepared from BM and LM samples that were randomly taken from the carcasses of SB and TCC after 0, 1, 3, 7 and 14 days of storage at $5^{\circ}C$. pH of samples was determined, and degradation of myofibrillar proteins was analyzed by the SDS-PAGE and western blots. The results showed that pH was lower in BM than in LM samples from both avian strains. Appearance of 30 kDa components and disappearance of titin and nebulin were more rapidly as seen on SDS-PAGE in BM than in LM samples. Western blots labeled with a monoclonal antibody to desmin also demonstrated that desmin degraded more quickly in BM samples. Our data might suggest that postmortem proteolysis occurred more rapidly in BM than in LM from both TCC and SB.

Pilot scale membrane separation of plating wastewater by nanofiltration and reverse osmosis

  • Jung, Jaehyun;Shin, Bora;Lee, Jae Woo;Park, Ki Young;Won, Seyeon;Cho, Jinwoo
    • Membrane and Water Treatment
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    • 제10권3호
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    • pp.239-244
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    • 2019
  • Plating wastewater containing various heavy metals can be produced by several industries. Specifically, we focused on the removal of copper (Cu2+) and nickel (Ni+) ions from the plating wastewater because all these ions are strictly regulated when discharged into watershed in Korea. The application of both nanofiltration (NF) and reverse osmosis (RO) technologies for the treatment of wastewater containing copper and nickel ions to reduce fresh water consumption and environmental degradation was investigated. In this work, the removal of copper (Cu2+) and nickel (Ni+) ions from synthetic water was studied on pilot scale remove by before using two commercial nanofiltration (NF) and reverse osmosis(RO) spiral-wound membrane modules (NE2521-90 and RE2521-FEN by Toray Chemical). The influence of main operating parameters such as feed concentration on the heavy metals rejection and permeate flux of both membranes, was investigated. Synthetic plating wastewater samples containing copper ($Cu^{2+}$) and nickel ($Ni^{2+}$) ions at various concentrations(1, 20, 100, 400 mg/L) were prepared and subjected to treatment by NF and RO in the pilot plant. The results showed that NF, RO process, with 98% and 99% removal for copper and nickel, respectively, could achieve high removal efficiency of the heavy metals.