• Journal of Yeungnam Medical Science
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• v.38 no.3
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• pp.251-257
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• 2021

Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

• The Journal of Korean Society for School & Community Health Education
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• v.22 no.3
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• pp.1-15
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• 2021

Objectives: The purpose of this study was to examine whether demographic and socio-economic characteristics, health behaviors are related overweight and obesity in Korean adolescents. Methods: Data from the 15^th Korea Youth Risk Behaviors web-based Survey(KYRBWS) administered in 2019 were analyzed: 60,100 students in middle and high school participated in the survey. But except 1,555 missing value, 55,748 students were analyzed. It was conducted frequency analysis, Rao-Scott chi-square test and multiple logistic regression analysis. Results: The significant influencing factors on overweight and obesity of adolescents were gender, economic status, father's educational background, alcohol experience, fastfood consumption, muscle strengthening exercise, stress perception(p<.001). The odds ratio for overweight and obesity of male adolescents compared to female adolescents were 1.19(p<.001). and The odds ratio for overweight and obesity of perceived stress adolescents compared to those who without stress were 1.13(p<.001). Conclusions: I found that adolescents' some undesirable health behaviors affect their overweight and obesity, I recommend that school health promotion programmes should be implemented in schools to form good health behaviors such as healthy eating habits, physical exercise and managing stress.

• Journal of the Korean Society of School Health
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• v.34 no.3
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• pp.151-160
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• 2021

Purpose: The purpose of this study was to identify predictors of suicidal attempts in adolescents over 5 years after school dropout. Methods: The data of the Panel Survey of School Dropouts (of 2013 to 2017) conducted by the National Youth Policy Institute were analyzed. The analysis used the 2013 survey data as the baseline and examined suicidal attempts from 2013 to 2017. A total of 776 adolescents were included in the analysis. Descriptive statistics, 𝝌² test, t-test, and multiple logistic regression were carried out using SAS 9.2. Results: About 11% (87 out of 776) of the adolescents with an experience of dropout attempted suicide between 2013 and 2017. The risk of suicidal attempts was significantly lower in female (AOR: 0.57, 95% CI: 0.87~0.93) than in male adolescents. The higher the self-esteem, the lower the risk of suicidal attempts (AOR: 0.87. 95% CI: 0.78~0.97). The higher the depression level (AOR: 1.10, 95% CI: 1.05~1.16) and the rate of parental abuse (AOR: 1.09, 95% CI: 1.02~1.18), the higher the risk of suicidal attempts. Conclusion: The findings of the study suggest that those who are male, depressed, have low self-esteem or have been abused by their parents are at high risk of suicidal attempts among the adolescents with dropout experiences. Therefore, early intervention is necessary for those at high risk.

• Journal of Korean society of Dental Hygiene
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• v.22 no.6
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• pp.521-529
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• 2022

Objectives: The purpose of this study was to determine the factors affecting periodontal disease-related symptoms in adolescents using raw data from the 16th (2020) online survey on adolescent health. Methods: Data were collected from the survey entries, and analyzed using IBM SPSS Statistics 21.0. A multi-sample chi-square test was performed to determine periodontal disease-related symptoms according to demographic characteristics, lifestyles, exercise habits, and psychological factors. Logistic regression analysis was performed to determine factors affecting periodontal disease-related symptoms. Results: Periodontal disease-related symptoms were higher in female, high school-age adolescents, and those with lower economic status. Increased alcohol intake, having breakfast 3 days or less a week, ingesting sweet drinks and fast food three or more times a week, and zero water intake were found to have a greater effect on periodontal disease-related symptoms. Higher levels of stress, fewer hours of sleep, and feeling less healthy were also factors leading to increased periodontal disease-related symptoms. Conclusions: Adolescents have various factors that are associated with periodontal disease. A method to reduce rates of periodontal disease in adolescents should be developed, along with a school oral health education program.

• The Korean Journal of Pain
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• v.36 no.2
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• pp.230-241
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• 2023

Background: This study aimed to determine the prevalence of chronic pain and its contributing factors among teenagers aged 12-21 years in Shiraz, Iran. Methods: This cross-sectional study was conducted on adolescents aged 12-21 years. Demographic variables of the adolescents and their parents as well as the pain characteristics were assessed. Descriptive statistics, multinomial logistic regression, and regression models were used to describe the characteristics of the pain and its predictive factors. Results: The prevalence of chronic pain was 23.7%. The results revealed no significant difference between the male and female participants regarding the pain characteristics, except for the home medications used for pain relief. The results of a chi-square test showed that the mother's pain, education, and occupation, and the father's education were associated significantly with chronic pain in adolescents (P < 0.05). Multinomial logistic regression also showed the mother's history of pain played a significant role in the incidence of adolescents' chronic pain. Conclusions: The prevalence of chronic pain was relatively high in these adolescents. The results also provided basic and essential information about the contributing factors in this area. However, consideration of factors such as anxiety, depression, school problems, sleep, and physical activity are suggested in future longitudinal studies.

• Korean Journal of Culture and Social Issue
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• v.10 no.spc
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• pp.55-68
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• 2004

Recently, rates of depression and suicide of adolescents in industrialized countries, including Korea, were rapidly increasing. Adolescent depression was often associated with anxiety disorder, eating disorder, attention deficits hyperactivity/disruptive behavior disorder. and suicidal attempts. Epidemiological data about depression and suicide of adolescents are reviewed. Psychological theories of depression and suicide are integrated in terms of a control theory interpretation. Issues about 'relationships between depression and anxiety' 'relationships between depression and suicide' 'the reason why rates of depression and suicide are rapidly increasing at adolescence' 'the reason why the different prevalence of depression between female and male is conspicuous at adolescence' and 'Korean culture associated with depression and suicide of adolescents' are discussed in terms of the revised control theory interpretation.

• The Korean Journal of Emergency Medical Services
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• v.28 no.1
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• pp.21-34
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• 2024

Purpose: This study aimed to observe change in factors over time in the first cohort of the 2018 Children and Adolescent Panel Middle School. In addition, this study attempted to examine the causal relationship and influence between variables by setting a time gap between independent and dependent variables. Methods: Frequency and descriptive statistical analyses were conducted to determine the general characteristics of the study participants. Hierarchical regression analysis was conducted to analyze the effects of smartphone dependence on health, sleep quality, and depression. After inputting the control variables (Model 2), the influence of the variables was identified based on the input model. Results: Smartphone dependence positively impacted depression in both male and female students and negatively impacted sleep and health. Conclusion: Smartphones are closely associated with teenagers' lives. Additionally, as adolescents experience various psychological anxieties owing to rapid physical changes, there are concerns that psychological dependence may increase, considering that adolescence is the most emotionally unstable period. Therefore, the results of this study consistently prove that smartphone dependence has a causal relationship with emotion-related variables, such as emotional stress, depression, and anxiety.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.163-174
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• 1997

This study was to know the influence of familial environment and moral development on conduct disorder. Subjects were composed of 47 male and female patients with conduct disorder(patients group), 113 general male and female students(normal group), and 173 juvenile prisoners(JP group). The Korean Form of the Family Environment Scale(FES) was used to assess the family environment of the subjects and the Korean Defining Issues Test(DIT) was used to assess the moral development. Conduct disorder was diagnosed with the DSM-III-R criteria for conduct disorder. The influence of familial environment and moral development on conduct disorder was analyzed with ANOVA and the differences among groups were verified with Scheffe test. There was no difference in the socioeconomic status and the physical abuse by the parents among the three groups. But the rates of divorce or separation of the parents were significantly highest in the JP group and higher in the patients group than in the normal group. Especially the subjects of the JP group experienced the divorce or separation of their parents during the preschool or the elementary school periods. In regard to the family environment, there was no difference among the three groups in the Subscales of Expressiveness, Independence, Intellectual-cultural orientation, Moral-religious emphasis, Organization, and Control. ‘Cohesion Subscale’ was significantly higher in the normal group than in the JP group. ‘Conflict Subscale’ was significantly higher in the JP and patients groups than in the normal group. ‘Achievement orientation Subscale’ was significantly lower in the JP group than in the patients and normal groups. ‘Activerecreational orientation’ was significantly lower in the normal group than in the JP and patients groups. In gegard to the moral developmental stage, the lower moral developmental step was higher in the JP and patients groups than in the normal group. The higher steps were significantly higher in the normal group than in the JP group. There was no significant correlation between the degree of ‘Moral-religious emphasis Subscale’ and the moral development. The clinical implication and limitation of present study were listed and discussed.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.2
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• pp.113-118
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• 2010

The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have revealed that deprivation of specific sensory experiences can modify the structure and function of the central nervous system; however, the effects of sensory overload remains unclear. Here we studied the effect of overloading the taste sense in the early period of life on the synaptic plasticity of rat hippocampus and somatosensory cortex. We prepared male and female Sprague Dawley rats with ad libitum access to a 0.1% saccharin solution for 2 hrs per day for three weeks after weaning on postnatal day 22. Saccharin consumption was slightly increased in males compared with females; however, saccharin intake did not affect chow intake or weight gain either in male or in female rats. We examined the effect of saccharin-intake on long term potentiation (LTP) formation in hippocampal Schaffer collateral pathway and somatosensory cortex layer IV - II/III pathways in the 6-week old saccharin-fed rats. There was no significant difference in LTP formation in the hippocampus between the control group and saccharin-treated group in both male and female rats. Also in the somatosensory cortex, we did not see a significant difference in LTP among the groups. Therefore, we conclude that saccharin-intake during 3~6 weeks may not affect the development of physiological function of the cortical and hippocampal synapses in rats.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.4
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• pp.937-944
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• 2012

Smoking in adolescence can cause other health risks such as drinking and abusing drugs. Besides, it goes on adulthood so it can threaten their health all days. This study want to know the relationship between smoking and internet addiction in mid- and highschool students in Korea. It conducted for 38,409 middle school students and 36,657 highschool student in Korea. Smoking and internet addiction was investigated by chi-squared test and the relation between them was done by a Logistic Regression Analysis. The statistical significance is under 0.05. The percentage of smoking is 34.2% in male student and 19.7% in female student. The percentage of internet addiction is 17.6% in male student and 11.4% in female student and it is higher in students who smoked by 1.06 times for male student and 1.62 times for female student. This result shows that smoking which is non-healthy habit is related with internet addiction significantly. Smoking can cause high stress and this stress is shown to be developed in internet addiction. In conclusion, smoking and internet addiction in adolescence are bad habits and they are affect each other. Therefore we have to consider a measure by looking as smoking, stress and internet addiction are complex health risks rather than trying to prevent and treat them individually.