• 대한정형외과 초음파학회지
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• 제5권2호
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• pp.112-117
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• 2012

신생아 주관절에 발생한 화농성 관절염은 드물지만 관절에 심각한 손상을 입힐 수 있어 발견과 치료에 매우 주의를 요하는 질환이다. 하지만 신생아들은 급성 감염의 증후나 증상이 잘 나타나지 않아 조기 진단이 어려운 경우가 많다. 이러한 경우 관절 천자는 관절 감염을 확인할 수 있는 매우 중요한 검사 방법중의 하나이다. 많은 임상 의사들이 그 결과를 중요하게 생각함에도 불구하고 저자들은 신생아에서 주관절 내 농양이 완전히 고형화되어 관절천자에서 음성 소견을 보임을 경험하였다. 초음파 검사는 주관절 내에 일반적인 관절 삼출액과는 다른 신호 강도의 관절 팽대 소견을 보여주어 빠른 수술적인 치료를 결정하는데 주요한 지침이 되었다. 모호한 증상과 비특이적인 검사 소견을 보여 치료 결정이 어려운 신생아들에게 초음파 검사는 빠르고 쉽게 시행할 수 있는 좋은 검사 도구이기는 하지만 비특이적인 경우 반드시 MRI 등의 추가적인 검사를 시행하여야 할 것으로 생각된다.

• 정신신체의학
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• 제7권2호
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• pp.149-157
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• 1999

인간은 에너지 섭취와 소모에 있어 변동이 심한 편이지만 비교적 일정한 체중을 유지하고 적절하게 섭식행동을 조절한다. 그러나 이러한 조절기전에 문제가 발생하면 비만이나 그 이외의 다른 섭식장애를 일으키게 되며 다양한 후유증을 야기한다. 본 논문에서는 최근에 소개되기 시작한 호르몬인 leptin이 섭식의 조절과 에너지의 항상성을 조절하는데 있어 어떻게 중요한 작용을 하게되는지 조사하여 주로 정신과 영역에서 관심을 기울일 만한 부분에 대해 고찰하고자 한다. Leptin이 처음 발견되었을 때 그 역할은 주로 음식의 섭취를 제한하고 에너지의 소모를 증가시키는 호르몬으로 소개되었지만, 점차 그 이외의 다른 신체 기능 즉, 생식주기나 신경대분기계에도 영향을 미치는 것으로 보고되면서 정선과 영역에서 차지하는 비중도 확대되고 있다. 그러나 leptin의 작용기전은 매우 복잡하며 많은 부분이 아직도 불분명한 상태에 있다. 이에 저자들은 중추신경계에서 현재까지 알려진 leptin의 작용기전에 대해 살펴보고 섭식과 관련된 그 밖의 다른 신경전달물질들과의 상호작용 그리고 섭식장애와의 관련성에 대해서 최근 문헌들을 조사하여 함께 고찰하고자 한다.

• 한국식품영양과학회지
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• 제30권1호
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• pp.92-96
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• 2001

갈화와 갈근의 에탄올성 간손상 흰쥐의 혈액학적 성분에 미치는 영향을 구명하기 위하여 에탄올을 투여한 흰쥐에게 갈화와 갈근을 수준별로 5주간 급여한 후 효과를 관찰하였다. 간손상 지표 효소인 혈청 AST, ALT, ALP와 ${\gamma}-GTP$ 활성은 에탄올 투여로 증가되었으나 칡추출물 급여로 감소 되였으며, ${\gamma}-GTP$의 경우 갈화추출물이 갈근추출물에 비하여 유의적이지는 않지만 활성 감소효과가 큰 것으로 관찰되었다. 혈청 혈당치와 간조직의 글리코겐 함량은 에탄올 투여시 정상군에 비하여 유의적인 감소가 관찰되었으며 힘추출 물급여시 증가되었다. 힘의 부위에 따른 차이는 갈근추출물에 비해 갈화추출물이 함량 증가효과가 큰 것으로 나타났다. 알부민 함량은 대조군이 정상군에 비하여 유의적으로 감소되였으며 칡추출물 급여에 의한 유의적인 차이는 나타나지 않았다. 총빌리루빈, 직접 빌리루빈, 간접 빌리루빈, 크레아 티닌과 요산 함량은 정상군에 비하여 에탄올군에서 유의적으로 증가되였으며 갈화와 갈근급여군에서 감소되었다. 이상의 결과에서 갈화와 갈근추출물이 에탄올 투여로 인한 간조직 손상 지표효소의 활성을 감소시켜 에탄올성 간손상의 예방 및 치료에 효과적일 것으로 사료된다.

• 대한장애인치과학회지
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• 제7권1호
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• pp.38-43
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• 2011

Treatment of the mandibular fracture consists of reduction and fixation. Primary wire & Arch bar are perhaps the ideal method for intermaxillary fixation. But, daily feeding, swallowing, speech, and in some instances, respiration is difficult to maintain during the period of intermaxillary fixation, owing to muscle weakness, emotional disorder and poor oral hygiene in a position of the long-term bed disabled patient with multiple injuries. Therefore, Intermaxillary fixation is not applied in the disabled bed patient, the alternative methods must be obtained. In the case of the mandibular fracture, because of the absence of weight bearing, osseous union may eventually occur even without immobilization if the patient is maintained without wound infection on a controlled soft diet. For the purpose of the prevention of the wound infection, the establishment of an drainage on the oral lacerated wound is necessary for the removal of the hematoma & seroma in the fracture site. This is the report of a case that was managed conservatively without the intermaxillary fixation in the long-term disabled bed patient with a mandibular compound fracture.

• 대한장애인치과학회지
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• 제14권1호
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• pp.31-35
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• 2018

부산대학교 치과병원 소아치과에 내원한 Shell teeth에 이환된 소아 환자를 전신마취 하에 치료하였다. 임상검사시 다수 치아의 치관 파괴와 치수 노출 및 상악 유전치 잔존치근이 관찰되었다. 방사선검사상 전반적인 유치열에서 정상보다 큰 크기의 치수강과 넓은 치근관 및 얇은 경조직 층이 존재했으며 발생중인 영구치 치배의 형태이상이 관찰되었다. 환자의 언니와 아버지를 포함한 부계 가족 구성원 일부에서 상아질형성부전증 병력이 조사되었다. 치료시 수복이 불가능한 치아는 발거하였고 보존 가능한 치아는 치수치료 및 기성금속관, 복합레진 수복치료를 시행하였다. 치료 결과 환자의 통증이 감소하였고 저작능력이 회복되었다. 주기적인 내원 및 경과관찰이 요구된다.

• 대한한방소아과학회지
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• 제13권2호
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• pp.41-77
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• 1999

The purpose of this research is that infant artificial feeding products is used in clonic with the study on characteristic, ingredients and indication of geneal and special modified milks. The result is as follows. 1. The main ingredients of four company products-Maeil , Namyang, Pasteur, Aebout is similar but the functional is different 2. General infant formula is divided into 100days, 5-6months, 12months, 24months and 36months out of consideration for growth and development of infant. 3. The indication and sorts of the special infant formula used at a hospital is as follows. PKU-1, PKU-2 formula is available for phenylketonuria. MPA formula is available for propionic acidemia and methylmalonic acidomia. UCD is available for urea cycle disorder Leucine-free formula is available for isovaleric acidemia. Maeil LP is available for hypocalcemia. MCT formula is available for indigestion and malabsorption of fat. BCAA-free formula is available for Maple syrup urine disease. Protein-free formula is available for limit of protein uptake or mixture of peculiar amino acid or higher uptake of mineral, vitamin, calory. Methionine-free formula is available for homocystinuria and hypermethioninemia. Premature infant is available for premature and low birth weight. 4. The special infant formula published in nation is as follows. Maeil soy A, Maeil MF1, Namyang hope doctor and Maeil HA is available for diarrhea. Maeil HA, Maeil HA-21 and Namyang hope allergy is available for hypoallergy. Maeil soy A is available for diarrhea of milk allergy. Maeil MF1 or Namyang hope doctor is available for acute bacterial or viral temporal diarrhea. Maeil HA is available for allergic chronic diarrhea. Maeil HA and Namyang hope allergy as eHP-formula is available for chronic diarrhea for lactose intolerance and milk allergy. Maeil-21 as pHP-formula for neonates with allergy family, allergic symptoms such as atopic dermatitis, asthma except digestive system.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.139-149
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• 2008

Objectives : The aim of this study was to compare the effect of needle retention(NR) and electro-acupuncture of low(EA(L)) and high(EA(H)) frequencies at $SP_6$ and Sham point in rats. Methods : Intestinal hypermotility was induced by feeding carbachol and experimental groups divided mainly into 7 groups which were normal, holder, control, acupuncture in normal state of rats, pre-treatment of acupuncture(NR, EA) in hypermotility, post-treatment of acupuncture(NR, EA) in hypermotility. We fed charcoal to them after the treatment and measured the travel rate of charcoal in the gastrointestinal track so that which treatment affected more in intestinal hypermotility. Results : As the following study, each acupuncture ways of EA(L) had significant effect of decreasing travel rate on intestinal hypermotility than EA(H) and NR. The comparison between pre-treatment and post-treatment, pre-treatment had slight more effect than post-treatment but not significantly. There was more affected at $SP_6$ than Sham point on this study. Conclusions : There were 21 groups to find out which treatment was best to slow down the intestinal motility and $SP_6$-EA(L)-C had significant effect compared with control group at the figure than any other groups. That meant $SP_6$ had effect on gastric disorder such as intestinal hypermotility and its' effect had more prevention than cure. Further study was needed to have more precise effect of EA and $SP_6$.

• Clinical and Experimental Pediatrics
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• 제62권2호
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• pp.55-61
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• 2019

Purpose: Myotonic dystrophy, also known as dystrophia myotonica (DM), is an autosomal dominant disorder with 2 genetically distinct forms. DM type 1 (DM1) is the more common form and is caused by abnormal expansion of cytosine/thymine/guanine (CTG) repeats in the DM protein kinase (DMPK ) gene. Our study aimed to determine whether the age of onset is correlated with CTG repeat length in a population of pediatric patients with DM1. Methods: We retrospectively identified 30 pediatric patients with DM1 that underwent DMPK testing, of which the clinical data of 17 was sufficient. The cohort was divided into 2 subgroups based on the clinical phenotype (congenital-onset vs. late-onset) and number of CTG repeats (<1,000 vs. ${\geq}1,000$). Results: We found no significant difference between the age of onset and CTG repeat length in our pediatric patient population. Based on clinical subgrouping, we found that the congenital-onset subgroup was statistically different with respect to several variables, including prematurity, rate of admission to neonatal intensive care unit, need for respiratory support at birth, hypotonia, dysphagia, ventilator dependence, and functional status on last visit, compared to the late-onset subgroup. Based on genetic subgrouping, we found a single variable (poor feeding in neonate) that was significantly different in the large CTG subgroup than that in the small CTG subgroup. Conclusion: Clinical variables exhibiting statistically significant differences between the subgroups should be focused on prognosis and designing tailored management approaches for the patients; our findings will contribute to achieve this important goal for treating patients with DM1.

• 한국동물생명공학회지
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• 제37권1호
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• pp.27-33
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• 2022

Functional dyspepsia (FD) is a gastrointestinal disorder with diverse symptoms but no structural or organic manifestations. Benachio-F^® (herein named 'BF-1') is an over-the-counter liquid digestive formulated with multiple herbal extracts, which has been reported to improve symptoms of FD. A total two experiments were conducted. First, we examined whether BF-1 can modulate the progression of FD through two experimental rat models. A total of three doses (0.3x, 1x, 3x of the human equivalent dose) were used. In the gastric emptying model, both 1x (standard) or 3x (3-fold-concentrated) BF-1 enhanced gastric emptying was compared with that of vehicle-treated animals. In a feeding inhibition model induced by acute restraint stress, treatment with 1x or 3x BF-1 led to a similar degree of restoration in food intake that was comparable to that of acotiamide-treated animals. Among the constituents of BF, fennel is known for its choleretic effect. Thus, we next investigated whether a novel BF-based formula (named 'BF-2') that contains an increased amount of fennel extract (3.5-fold over BF-1), has greater potency in increasing bile flow. BF-2 showed a superior choleretic effect compared to BF-1. Furthermore, the postprandial concentration of serum secretin was higher in animals pretreated with BF-2 than in those pretreated with BF-1, suggesting that the increased choleretic effect of BF-2 is related to secretin production. Our results demonstrate that BF-1 can modulate the pathophysiological mechanisms of FD by exerting prokinetic and stress-relieving effects, and that BF-2 has a better choleretic effect than BF-1.

• Clinical Nutrition Research
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• 제12권3호
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• pp.169-176
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• 2023

Glucose transporter type 1 (GLUT1) deficiency syndrome (DS) is a metabolic brain disorder caused by a deficiency resulting from SLC2A1 gene mutation and is characterized by abnormal brain metabolism and associated metabolic encephalopathy. Reduced glucose supply to the brain leads to brain damage, resulting in delayed neurodevelopment in infancy and symptoms such as eye abnormalities, microcephaly, ataxia, and rigidity. Treatment options for GLUT1 DS include ketogenic diet (KD), pharmacotherapy, and rehabilitation therapy. Of these, KD is an essential and the most important treatment method as it promotes brain neurodevelopment by generating ketone bodies to produce energy. This case is a focused study on intensive KD nutritional intervention for an infant diagnosed with GLUT1 DS at Gangnam Severance Hospital from May 2022 to January 2023. During the initial hospitalization, nutritional intervention was performed to address poor intake via the use of concentrated formula and an attempt was made to introduce complementary feeding. After the second hospitalization and diagnosis of GLUT1 DS, positive effects on the infant's growth and development, nutritional status, and seizure control were achieved with minimal side effects by implementing KD nutritional intervention and adjusting the type and dosage of anticonvulsant medications. In conclusion, for patients with GLUT1 DS, it is important to implement a KD with an appropriate ratio of ketogenic to nonketogenic components to supply adequate energy. Furthermore, individualized and intensive nutritional management is necessary to improve growth, development, and nutritional status.