• 대한지리학회:학술대회논문집
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• 대한지리학회 2006년도 연례 학술대회
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• pp.123-124
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• 2006

• 농촌의학ㆍ지역보건
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• 제44권1호
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• pp.1-10
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• 2019

이 연구는 국내의 대표적인 가을철 발열성 질환으로 고위험군 중 재배농업인을 대상으로 선택하여 가을철 발열성 질환에 감염실태와 위험요인, 인지도을 조사하여 질병에 대한 증거기반에 전략을 제공하고자 이 연구를 수행하게 되었다. 농업인 감염병 실태조사 방법은 지역사회에 일부 재배농업인 841명을 혈청학적 검사와 설문조사를 시행하였고, 혈청학적 기준은 수동혈구응집법과 면역크로마토그래피법으로 시행되었다. 혈청감염에 영향을 주는 일반적 특성으로는 쯔쯔가무시증이 나이가 증가할수록 혈청반응이 증가하였고, 렙토스피라증은 과거병력과 가족병력이 혈청반응이 유의하게 높았다. 그리고 신증후군출혈열은 종사기간이 증가할수록 혈청반응이 증가하였다. 또 다른 결과로는 혈청감염에 영향을 미치는 위험요인으로는 쯔쯔가무시증은 진드기에 물린 적이 있는 경우 혈청반응이 높았고, 렙토스피라증은 과수재배 관련된 일을 하는 경우 혈청반응이 높았다. 또한 신증후군출혈열은 비닐하우스 관련된 일을 한 적이 있는 경우 혈청반응이 높았다. 결론적으로 취악한 직업인 재배농업인 감염병에 대한 인식 형성 할 수 있도록 정부에서 효율적이고 효과적인 방법을 개발해야 할 것이다. 그리고 질병에 대한 조기 발견과 치료로 합병증 없이 건강한 삶을 살 수 있도록 주민들 인식에 영향을 줄 수 있는 교육과 홍보 그리고 질병 특성에 맞는 특정 예방 전략을 개발해야 할 것으로 생각한다.

• Journal of Yeungnam Medical Science
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• 제17권2호
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• pp.99-107
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• 2000

Kawasaki disease, an acute febrile illness which primarily affects in children under the age of six, was first described by Tomisaku Kawasaki in 1967. It has been reported that Kawasaki disease is probable driven by abnormalities of the immune system after an infectious insult, but this has not been confirmed. It mainly affects small and medium-sized arteries, particularly the coronary arteries. Deaths may occur at any time with cardiovascular complications. The early recognition and treatment with follow-up evaluation for the coronary arterial lesion is very important in a case of Kawasaki disease.

• Clinical and Experimental Pediatrics
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• 제55권4호
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• pp.147-150
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• 2012

Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial neurologic sequelae. Here, we describe a case of a comatose 22-month-old girl who was admitted to our hospital because of febrile illness and seizures. On day 13 of her illness, she died from ANE associated with infection from parainfluenza virus. Brain MRI results indicated diffuse bilateral symmetric signal changes in both basal ganglia, thalami, periventricular white matter, pons, and cerebral white matter, as well as generalized swelling of the brain.

• Pediatric Infection and Vaccine
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• 제4권2호
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• pp.303-307
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• 1997

Hand-Foot-Mouth disease, which has a various enanthem-exanthem complex at the tongue, buccal mucosa, hands and feets and buttock area with febrile illness, is usually caused by Coxscakie virus type A(16). Generally, this disease shows self limited course and good prognosis without neurologic manifestations. However, enterovirus 71, which was newly discovered and reported in 1974, can cause the striking features of Hand-Foot-Mouth disease outbreaks and has neuropathogenic potentials of polio-like paralytic illness including aseptic meningitis, meningoencephalitis and respiratory disease. We experienced a case of Hand-Foot-Mouth disease with polyradiculitis manifestations, and a case of Hand-Foot-Mouth disease with meningoencephalitis. Therfore, we report these cases with brief review of related literatures.

• 대한수의학회지
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• 제31권2호
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• pp.189-194
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• 1991

Getah virus is known as a causative agent of recognized febrile illness of horses characterized by fever, rash and edema. A serological survey indicated that hemagglutination inhibition antibody against Getah virus was detected in 34% of 464 racehorses from Korean Horse Affairs Association and 57% of 262 ponies from Cheju island, respectively. Several field strains of Getah virus isolated were from the racehorse that have been shown fever and febrile signs in 1989. The field isolates produced cytopathic effect in Vero, MA-104, BHK-21 cell cultures. Especially, they multiplied to the highest titer($10^6TCID_{50}/0.1ml$) in Vero cell cultures. When day-old mice were inoculated with field isolates by the intracerebral route, they showed a typical paralysis sign and died within seven days after inoculation. The guinea pig exhibited skin rash and edema, and died with neural signs after inoculation with the field isolates. In the cross neutralization test and indirect immunofuorescent assay, the field isolates were proved to be closely related to the Sakai strain of Getah virus antigenically.

• Clinical and Experimental Pediatrics
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• 제50권2호
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• pp.132-137
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• 2007

Patients with febrile illness and skin rashes need full and immediate attention. In general, these diseases show mild manifestations and good prognosis. However, causalities of some diseases with fever and rash may be life threatening or trivial. So, the differential diagnosis for those patients is extensive. A through history, a careful physical examination and close observation of clinical progress are very helpful and essential to confirming the diagnosis. Histories of recent travel, drug or specific food ingestion, exposure to human or an animal source of infection may be useful to discover the cause. Although laboratory tests can be useful in making the diagnosis, laboratory results usually are not available immediately. Knowledge and experiences of such diseases may be helpful to reduce the differential diagnosis to a few major possibilities. Rashes can be categorized as petechial, maculopapular, vesicular, urticarial and erythematous. Potential causes include infectious pathogens such as virus, bacteria, rickettsiae, spirohetes, connective tissue diseases, allergic diseases and heamto-oncologic diseases. Because the severity of these diseases can vary mild to life threatening, physicians must perform prompt management decisions regarding empirical therapies. In this article, the differential etiological diagnosis of each type rash is reviewed and discussed, and with emphasis on intensive care of life threatening febrile diseases with rashes that are seen in our country.

• Tuberculosis and Respiratory Diseases
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• 제63권4호
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• pp.378-381
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• 2007

Tsutsugamushi disease (Scrub typhus) is an acute, febrile illness caused by Orientia tsutsugamushi, which is transmitted to humans through chigger bites. Leptospirosis, a febrile disease caused by various pathogenic Leptospira, and is acquired by exposure to contaminated water and soil. Both diseases have been the most common acute febrile diseases in the autumn in Korea for many years. Concomitant leptospirosis and scrub typhus is quite rare. We report a case of a coinfection with leptospirosis and scrub typhus in a 51-year-old male who presented with fever, abdominal pain and acute dyspnea. The patient was diagnosed with as acalculous cholecystitis, acute respiratory distress syndrome, and septic shock caused by the infection. This is the first case report of a coinfection with leptospirosis and scrub typhus in Korea.

• Clinical and Experimental Pediatrics
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• 제50권10호
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• pp.982-986
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• 2007

목 적 : 특발성혈소판감소성자반증의 치료로 정주용 면역 글로불린을 사용한 후 절대 중성구치의 변화에 대하여 조사하였다. 방 법 : 내원 당시 발열이나 CRP 증가, 스테로이드 사용 등 백혈구수치에 영향을 받을 수 있는 인자를 가지지 않은 특발성혈소판감소성자반증 환아 26례를 대상으로 사용된 정주용 면역 글로불린의 용량과 사용중 발열 여부 등에 따라 정주용 면역 글로불린을 1일간 사용한 전후의 절대 중성구 수치의 변화를 후향적으로 관찰하였다. 결 과 : 특발성혈소판감소성자반증의 치료로 면역 글로불린을 사용한 후 1일이 지났을 때 절대 호중구 수치는 감소되었던 경우가 많았고 절대 호중구 수치의 감소 정도는 면역 글로불린의 용량과 관계가 있었다. 면역 글로불린 사용 후 절대 호중구 수치가 증가되었던 경우는 면역 글로불린 사용 중 발열을 동반하거나 저용량의 면역 글로불린을 사용하였던 경우들이었다. 절대 호중구 수치가 감소된 경우에도 감염성 합병증이 있었다고 기술되었던 경우는 찾을 수 없었다. 결 론 : 특발성혈소판감소성자반증의 치료에 면역 글로불린을 사용하고 1일 후 절대 호중구 수치가 감소되는 현상을 관찰할 수 있었다. 심각한 감염성 합병증이 있었다는 기록은 찾기 어려웠으나 이러한 현상이 환자에게 어떤 영향을 미치는지에 대해서는 앞으로 계속 관찰할 필요가 있겠다.

• Clinical and Experimental Pediatrics
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• 제55권3호
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• pp.83-87
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• 2012

Several authors suggested that the clinical characteristics of incomplete presentation of Kawasaki disease are similar to those of complete presentation and that the 2 forms of presentation are not separate entities. Based on this suggestion, a diagnosis of incomplete Kawasaki disease in analogy to the findings of complete presentation is reasonable. Currently, the diagnosis of incomplete Kawasaki disease might be made in cases with fewer classical diagnostic criteria and with several compatible clinical, laboratory or echocardiographic findings on the exclusion of other febrile illness. Definition of incomplete presentation in which coronary artery abnormalities are included as a necessary condition, is restrictive and specific. The validity of the diagnostic criteria of incomplete presentation by the American Heart Association should be thoroughly tested in the immediate future.