• Radiation Oncology Journal
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• v.19 no.1
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• pp.66-73
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• 2001

Purpose : For the research of Boron Neutron Capture Therapy (BNCT), fast neutrons generated from the MC-50 cyclotron with maximum energy of 34.4 MeV in Korea Cancer Center Hospital were moderated by 70 cm paraffin and then the dose characteristics were investigated. Using these results, we hope to establish the protocol about dose measurement of epi-thermal neutron, to make a basis of dose characteristic of epi-thermal neutron emitted from nuclear reactor, and to find feasibility about accelerator-based BNCT. Method and Materials : For measuring the absorbed dose and dose distribution of fast neutron beams, we used Unidos 10005 (PTW, Germany) electrometer and IC-17 (Far West, USA), IC-18, ElC-1 ion chambers manufactured by A-150 plastic and used IC-l7M ion chamber manufactured by magnesium for gamma dose. There chambers were flushed with tissue equivalent gas and argon gas and then the flow rate was S co per minute. Using Monte Carlo N-Particle (MCNP) code, transport program in mixed field with neutron, photon, electron, two dimensional dose and energy fluence distribution was calculated and there results were compared with measured results. Results : The absorbed dose of fast neutron beams was $6.47\times10^{-3}$ cGy per 1 MU at the 4 cm depth of the water phantom, which is assumed to be effective depth for BNCT. The magnitude of gamma contamination intermingled with fast neutron beams was $65.2{\pm}0.9\%$ at the same depth. In the dose distribution according to the depth of water, the neutron dose decreased linearly and the gamma dose decreased exponentially as the depth was deepened. The factor expressed energy level, $D_{20}/D_{10}$, of the total dose was 0.718. Conclusion : Through the direct measurement using the two ion chambers, which is made different wall materials, and computer calculation of isodose distribution using MCNP simulation method, we have found the dose characteristics of low fluence fast neutron beams. If the power supply and the target material, which generate high voltage and current, will be developed and gamma contamination was reduced by lead or bismuth, we think, it may be possible to accelerator-based BNCT.

• Journal of Radiation Protection and Research
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• v.30 no.2
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• pp.55-60
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• 2005

The evaluation of neutron flux distribution was performed for the ex-core detector design of SMART-P. DORT and MCNP code were used for the calculation of energy-dependent neutron flux distribution at 100% full power condition. Two code results show that maximum thermal flux appears at the $1^{st}$ water region in IST region and agree within 10% difference. In addition, another evaluation was performed code with assumptions that cote was composed of fission source and control rod without fuel assemblies. These assumptions make neutron count rate to be minimized. As a results, maximum thermal flux showed $6.99{\times}10^{-2}(n/cm^2-sec)$, when the strength of initial fission source was assumed as $1.0{\times}10^8(n/sec)$. The main reason of these results is due to the thermalization of fast neutrons in the water region and thermal flux is proportional to 80% of total neutron flux. Therefore, optimization of filler material of detector guide tube, position of installation and axial length of detector segments is necessary for the design of ex-core detector to enhance the neutron count rate and above results could be used in ex-core detector design as a fluence requirement.

• Journal of the Korean Chemical Society
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• v.64 no.5
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• pp.304-317
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• 2020

This study was conducted on four 11^th grade students at a high school in a small town to determine the effectiveness of responsive teaching. The three phases of the responsive teaching method proposed in the previous study were subdivided into six stages; Step 1 is elicitation of students' thoughts related to macroscopic world, Step 2 is drawing of students' early thoughts related to microscopic world, Step 3 is disciplinary connections with ideas of the particle, Step 4 is to clarify the learner's thoughts on the particle by the teacher's involvement, Step 5 is deepening students' thoughts, and Step 6 is expanding ideas. In Step 4, students came to the recognition that the cause of mass was atoms and that the cause of volume was molecules. In Step 5, students led to a shift in thinking that could ignore the volume of the molecules themselves through the properties of protons and neutrons that affect mass from a particle perspective. In the Step 6 of expanding ideas, students explained molecular motion by the concept of material point which ignores the volume of particles. This steps gave students perspectives on the relationship between the mass and volume of particles required by Avogadro's law. The students recognized that some systems could be studied only indirectly because they were too small, too large, too fast, or too slow to observe directly.

• Korean Journal of Veterinary Research
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• v.41 no.4
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• pp.571-578
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• 2001

To evaluate if the apoptotic fragment assay could be used to estimate the dose prediction after radiation exposure, we examined apoptotic mouse crypt cells per 1,000 cells after whole body $^{60}Co$ $\gamma$-rays and 50MeV ($p{\rightarrow}Be^+$) cyclotron fast neutron irradiation in the range of 0.25 to 1 Gy, respectively. The incidence of apoptotic cell death rose steeply at very low doses up to 1 Gy, and radiation at all doses tigger rapid changes in crypt cells in stem cell region. These data suggest that apoptosis may play an important role in homeostasis of damaged radiosensitive target organ by removing damaged cells. The curve of dose-effect relationship for the data of apoptotic fragments was obtained by the linear-quadratic model $y=0.18+(9.728{\pm}0.887)D+(-4.727{\pm}1.033)D^2$ ($r^2=0.984$) after $\gamma$-rays irradiation, while $y=0.18+(5.125{\pm}0.601)D+(-2.652{\pm}0.7000)D^2$ ($r^2=0.970$) after neutrons in mice. The dose-response curves were linear-quadratic, and a significant dose-response relationship was found between the frequency of apoptotic cell and dose. These data show a trend towards increase of the numbers of apoptotic crypt cells with increasing dose. Both the time course and the radiation dose-response curve for high and low linear energy transfer (LET) radiation modalities were similar. The relative biological effectiveness (RBE) value for crypt cells was 2.072. In addition, there were significant peaks on apoptosis induction at 4 and 6h after irradiation, and the morpholoigcal findings of the irradiated groups were typical apoptotic fragments in crypt cells that were hardly observed in the control group. Thus, apoptosis in crypt cells could be a useful in vivo model for studying radio-protective drug sensitivity or screening test, microdosimetric indicator and radiation-induced target organ injury. Since the apoptotic fragment assay is simple, rapid and reproducible in the range of 0.25 to 1 Gy, it will also be a good tool for evaluating the dose response of radiation-induced organ damage in vivo and provide a potentially valuable biodosimetry for the early dose prediction after accidental exposure.